Arachidonoyl Ethanolamide, arachidonoylethanolamide, N-arachidonoylethanolamine, uye AEA ese akaenzana neanandamide pachayo.Sezvineiwo, (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide izita remakemikari eanandamide (zita reIUPAC) uye rinogona kungoshandiswa muzvinyorwa zvesainzi.Nekudaro, 94421-68-8 ndiyo yakasarudzika kemikari ID (CAS Registry Nhamba).Sezvo AEA iri izwi ripfupi reanandamide, tinogona kushandisa AEA kazhinji kureva anandamide mumagwaro nemifananidzo anotevera.
Product Name:BulkAnandamide powder
Anoreva zvakafanana:Arachidonoyl Ethanolamide, AEA powder, arachidonoylethanolamide, (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide,N-arachidonoylethanolamine
Nhamba yeCAS:94421-68-8
Chikamu Chekudyara Chinoshandiswa:Leaf
Ingredient:Apigenin
Assay: AEA mafuta: 90%
AEA poda: 50%
Ruvara:Yellowish powder
yellowish-brown mafuta
Kurongedza: mune 25kgs fiber zvigubhu
Kuchengeta: Chengetedza mudziyo usina kuvhurwa munzvimbo inotonhorera, yakaoma, Chengetedza kure nechiedza chakasimba
Sherufu Hupenyu: Mwedzi makumi maviri nemana kubva pazuva rekugadzirwa
Sekureva kweWikipedia, anandamide ndeye endogenous inoitika cannabinoid neurotransmitter muuropi, zvinoreva kuti uropi hwemunhu hunokwanisa kugadzira anandamide pasina kutora chikafu chine AEA.Uropi hwemhando dzinoyamwisa uye cocoo yakasvibira inosimbiswa kuve ine imwe huwandu hweanandamide.
Zvokudya zvekudya zveanandamide
Iko hakuna akawanda akananga masosi masosi eanandamide, uye chokoreti nematruffles zviri pamusoro pazvo.Truffle inodhura zvakanyanya kuti utore anandamide, uye chokoreti inoita kunge ndiyo yakavimbika sosi yezvakakura zvakakura kubva muzvikafu.
Anandamidenemachokoreti
Cacao bhinzi, kunobva machokoreti, zvakare inopfuma sosi yeanandamide.Kune zvinopfuura mazana matatu emakemikari zvinoumba muchokoreti.Caffeine, theobromine, uye phenylethylamine zvinhu zvinozivikanwa zvinosimudzira manzwiro edu.Iyo theobromine inobatsira kukurudzira uropi kuburitsa mamwe anandamide kutiita kuti tinzwe kufara.
Nei anandamide iri kuwedzera mukurumbira mumakore achangopfuura?
Tisati tapindura mubvunzo uyu, tinoda kutaura nezve cannabis, THC & CBD (Cannabidiol) kutanga.
Cannabis, inozivikanwawo sembanje, chirimwa chinotumbuka, uye vanhu vanoishandisa semushonga wepati kana kuiputa kugadzira kunzwa "kwepamusoro" kana "kutemwa nematombo".
Iyo inoshanda mu cannabis inoita kuti iwe ukwire ndeye THC, ine zita rakazara se delta 9-Tetrahydrocannabinol.Kana vanhu vachiputa mbanje, iyo tetrahydrocannabinol mu cannabis inokurudzira iyo cannabis receptor, ichiita kuti vanhu vanzwe pfungwa yekufara uye kugara zvakanaka kwepfungwa.
Cannabis haisi pamutemo munyika dzakawanda sezvo vanhu vakawandisa vanozopindwa muropa nayo.
Nekudaro, Uruguay ndiyo nyika yekutanga kuita zviri pamutemo cannabis mugore ra2013.
Musi wa17 Gumiguru 2018, hurumende yeCanada yakazivisa kuti cannabis ive pamutemo muCanada yese.
MuUnited States, matunhu gumi neDunhu reColumbia zvakabvumidza kushandiswa kwekunakidzwa kwecannabis kunyangwe zvichiramba zviri pamutemo.
Anandamide vs THC
Cannabis chirimwa chinobva THC.
Anandamide ndiyo vhezheni yemunhu yeTHC.
Sainzi akawana AEA muna 1992 uye THC muna 1964.
Anandamide inoburitsa makemikari ekusimudzira mafungiro kubva kuhuropi, uye maitiro ayo ehupenyu akafanana neayo e tetrahydrocannabinol mu cannabis.
Ehe, ivo vanonanga imwechete cannabis receptor, uye isu tichataura nezve mashini yeAEA munguva pfupi.
Nekudaro, iyo potency yeTHC yakasimba zvakanyanya kupfuura AEA.Manzwiro ekutora AEA haanakidze kupfuura aya ekuputa cannabis sezvo anandamide inogadzika nekukurumidza mumuviri, pamwe mukati me30 mins.
Sezvo cannabis ichirambidzwa munyika zhinji, zvekuwedzera, chikafu, zvinwiwa kana zvizorwa zvine THC hazvisi pamutemo.Mupfungwa iyi, anandamide inguva yemberi.
Anandamide vs CBD
Chirimwa chembanje chine 400+ makomisheni, uye anopfuura makumi matanhatu akasiyana cannabinoids anosunga kune zvinogamuchirwa mumuviri wedu.
CBD ipfupi fomu ye cannabidiol uye ndeimwe yeaya makumi matanhatu cannabinoids.CBD ndeye phytocannabinoid mu cannabis.Inopfuura 40% ye cannabis yakabudiswa ndeye CBD.
Masayendisiti uye vanachiremba vakawana kuti CBD inokwanisa kuvandudza nhanho yeanandamide muuropi synapses seanandamide reuptake uye breakdown inhibitor.Fatty acid amide hydrolase, inozivikanwawo seFAAH kwenguva pfupi, is enzyme inoputsa AEA.Ndiyo nzira iyo CBD inhibisa FAAH uye inovandudza AEA nemasikirwo.
CBD inogona kuita zvakawanda kupfuura izvozvo.CBD inogona kubatsira kune yese Endocannabinoid System
Maitiro ekuita kweanandamide
Anandamide inoshanda sei?Zvakaoma chokwadi.Iwe unogona kutanga wada kuziva nezve endocannabinoid system, iyo CB1 receptor, uye CB2 receptor.
CB1
THC ine hukama hwepamusoro hweCB1 receptor, inosunga zvakasimba kune receptor.
Uye zvakare, anandamide inokonzeresa "yakakwirira" kunzwa nekukanganisa iyo CB1 receptor, activate uropi mubairo system uye kugadzira mafaro makemikari akadai dopamine Hormone.
CB2
Unogona kuwana CB2 receptors mumasero ekudzivirira muviri mumuviri wako wese.Iyo CB2 receptor inotarisira mhinduro dzeurouroprotective uye kurwisa kuzvimba.Masayendisiti anotenda kuti CB2 receptor inobatsira pakubvisa marwadzo.
CB1 receptors yakanangidzirwa zvakanyanya muuropi uye CNS system, nepo CB2 receptors inonyanya kuwanikwa mune immune system.
Endocannabinoid System (ECS)
Usati wakurukura nezve endocannabinoid system (ECS), zvakakosha kuti unzwisise zvikamu zvayo.Iyo ECS inoumbwa ne cannabinoid receptors, endogenous ligands (anosunga mamorekuru) kune izvo zvinogamuchira, uye ma enzymes anogadzira uye anoderedza ligand.
| classical ECS | Yakawedzerwa ECS | |
| cannabinoid receptors | CB1, CB2 | PPAR, GPR, TRPV, FLAT, FABP |
| endogenous ligands | AEA, 2-AG | OEA,PEA,2-AGE,NADA,VA,EPEA,SEA,OA,DHEA |
| Enzymes inoderedza ligands | FAAH,MAGL | ABHD6,COX-2,ABHD12 |
| Enzymes synthesizing ligands | DAGL,NAT,NAPE-PLD | SHIP1,PTPN22,PLC,GDEI,ABHD4 |
iye wemukati denderedzwa (mwenje grey) inomiririra iyo 'classical' endocannabinoid system.Denderedzwa rekunze (rakasviba grey) rinosanganisira zvikamu zveyakawedzerwa endocannabinoid system.Sezvaunogona kuona, PEA, SEA, uye OEA zvakare inosanganisirwa mune endocannabinoid system.
MaEC ane central nervous system (CNS) mavambo uye anosanganisira anandamide (AEA), 2-arachidonoylglycerol (2-AG), noladin ether, virodhamine uye N-arachidonylodopamine (NADA).Uye anandamide ndiyo yekutanga uye zvakare yakakosha ligand mune endocannabinoid system.
Anandamide uye 2-AG
Sezvataurwa pamusoro apa, anandamide (AEA) uye 2-arachidonoylglycerol (2-AG) ndiwo maviri ekutanga ligand muECS system.Iyo ECS inobatsira kudzora mabasa akadai sekurara, immune system, uye marwadzo modulation.
Masayendisiti akawana Anandamide mugore ra1992 uye 2-AG makore matatu gare gare.AEA uye 2-AG ine yakanyatsofanana mamorekuru chimiro uye nekudaro zvakafanana zvemuviri nemakemikari zvimiro.
Anandamide inonyanya kunanga iyo receptor CB1 muuropi, nepo 2-AG inonanga zvese CB1 uye CB2 receptors (mune immune system).
Ose Anandamide uye 2-AG akagadzirwa kubva arachidonic acid, iyo Omega-6 fatty acid, ine nzira dzakasiyana uye synthesizing enzymes.Kusvibisa enzyme FAAH (Fatty Acid Amide Hydrolase) yeAEA uye 2-AG ne MAGL enzyme (Monoacylglycerol Lipase).
Anandamide Benefits
Humbowo hwesainzi hunoratidza kuti anandamide inogona kunge yakanaka kune anti-kushushikana, hutano hwepfungwa, kugadzirisa ndangariro, kudzora havi yekudya, kunyaradza kurwadziwa, neuroprotection, nezvimwe.
Anandamide uye kushushikana
Vanhu vanodana Anandamide "kufadza molecule" nekuti AEA inokwanisa kuita kuti unzwe kufara.
Kushandura humbowo hunoratidza kuti iyo endocannabinoid sisitimu chinhu chakakosha cheeuronal substrates inobatanidzwa muuropi mubairo maitiro uye manzwiro ekupindura kushushikana.
Pharmacological blockade ye enzyme fatty acid amide hydrolase (FAAH), iyo inokonzera intracellular anandamide degradation, inogadzira anxiolytic-sezvinoita mumakonzo pasina kukonzera kuwanda kwemaitiro ekuita maitiro akajairika e-direct-acting cannabinoid agonists.
Izvi zvakawanikwa zvinoratidza kuti anandamide inobatsira kudzora manzwiro uye kufunganya uye kuti FAAH inogona kunge iri chinangwa cheboka rinoverengeka rezvinodhaka anxiolytic.
Kuti uwane rumwe ruzivo rwakadzama rweanandamide mhedzisiro pakufunganya, ndapota verenga zvinyorwa pazasi:
- Iyo endogenous cannabinoid anandamide ine mhedzisiro pakukurudzira uye kusagadzikana izvo zvinoratidzwa nemafuta acid amide hydrolase (FAAH) inhibition.
- Anandamide hydrolysis: chinangwa chitsva chemishonga inorwisa-kufunganya?
- Kuderedza kuzvidya mwoyo-kufanana nemaitiro anokonzerwa nemajini uye pharmacological inhibition ye endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) inopindirana neCB1 receptors.
Anandamide uye kunyaradza kurwadziwa
ome uchapupu hwezvesayenzi hunoratidza kuti inhibition ye FAAH (iyo enzyme inoderedza anandamide muuropi) yakaderedza zvikuru mhinduro dze nociceptive mumhando dzakawanda dzinorwadza.
FAAH inhibitors inowedzera zvakanyanya anandamide mazinga muuropi uye inonyanya kukonzeresa CB1receptor-mediated antinociception, zvichiratidza kuti endogenous anandamide, kana yakadzivirirwa kubva mukuora, inogona kuburitsa antinociception kuburikidza neCB.1receptors.
Palmitoylethanolamide (PEA) chinhu chinogara chiripo chinowedzera anandamide chiitiko.Muviri wemunhu unobereka PEA kurwisa kuzvimba uye kurwadziwa.Vanopfuura varwere ve800,000 vanga vari mapiritsi ePEA uye zvekudya zvinowedzera kurapa marwadzo munyika.
Kuti udzidze zvakawanda nezve PEA, ndapota shanya yeduPEA peji.
Anandamide uye mumhanyi akakwira
Ngatitangei titarise tsananguro yekuti chii chinonzi mumhanyi wepamusoro: kunzwa kufara nekufunganya kwakadzikira uye kusanzwa kurwadziwa.Mushure menguva refu yekurovedza muviri, iwe uchaona chiitiko chinofadza chakadaro panguva yekufamba kwenguva refu.
Mumakumi emakore adarika, vatsvakurudzi vakafunga kuti endorphin ndiyo chete chinhu chinokonzera vamhanyi vakakwirira sezvo kuwedzera kwemazinga e-β-endorphins anowanikwa nyore muropa.Sezvaungave uchiziva, endorphin ine kugona kwekusimudzira manzwiro edu uye kugadzira manzwiro euphoric.
Nekudaro, masayendisiti izvozvi anotenda kuti ndiyo endocannabinoid system (ECS) uye anandamide iyo inokonzera mumhanyi kukwira.Anandamide inokwanisa kuyambuka ropa-brain barriers uye inopa iyo yepakati mhedzisiro yeperipheral opioid.Asi endorphin haigone.
Kana iwe uchida kudzidza nezve kuyedza nezve mumhanyi wepamusoro, verenga zvinyorwa izvi:Kukwirira kwemumhanyi kunoenderana ne cannabinoid receptors mumakonzo
Nutritionists vanoona kuti anandamide inogona zvakare kuve yakanaka yekuda kudya.Anandamide inogona kumutsa nzara yako uye chishuwo chekudya zvakanyanya.Kana iwe uri munzira yekuderedza uremu, nyatsofunga usati watora AEA.
Zvekuwedzera zvine anandamide
Uri kutsvaga anandamide supplements kana anandamide mapiritsi?
Zvinosuruvarisa, hapana kwenguva ino.Anandamide chinhu chakadai sechinyorwa zvekuti hapana chekudya chekuwedzera mabhureki akambozviedza mune zvazvino mafomula.
Unogona kuwana kambani inonzi Sun Potion iri kutengesa anandamide poda paAmazon.Zvisinei, ichocho hachisi chokwadi.Ingori mbishi cacao poda, asi kwete yakamisikidzwa anandamide yakatorwa.Uye iyo inoshanda yemukati mufomu yehupfu yakadzikira, uye haugone kuona kushanda kweAEA.
Ehe, iwe unogona kuona kuti vamwe vatengesi vari kutengesa anandamide referensi zviyero kana reagents.Chinhu chakaipa ndechekuti vanongotengesa pa5mg, 25mg, uye chete nekutsvaga chete.Hapana ruzivo rwakawanda rwemafuta eAEA runowanikwa zvachose.
Nhau dzakanaka ndedzekuti vagadziri vezvekuwedzera muUnited States nenyika dzeEurope dzakaita seGermany, France, Netherland, UK, Spain, Italy, etc. .
Anandamide tsanangudzo
Bulk anandamide mafuta uye anandamide poda zvese zviripo kuCima Science.
Mafuta eAnandamide: 70%, 90%
Anandamide powder: 50%
