Zita rechigadzirwa:Stearoyl Vanillylamide(SVA）
Rimwe Zita:C18-VA, N-Vanillyloctadecanamide,Capsaicin AnalogiCAS Number:58493-50-8
Botanical Source:Piper Longum Linn
Chiyero: 98%
Yemahara Sample:Inowanikwa
Chitarisiko:chena kusvika paupfu chena
Benefits: Anti-cancer, anti-kuchembera, senolytic
Sherufu Hupenyu: 2 makore
Stearoyl vanillylamide ndeimwe yeanonyanyo zivikanwa capsaicin analogues uye inongo itikawo capsaicin analogi inowanikwa mumhando dzemhiripiri tsvuku.Capsaicin ndiyo inokonzera kupisa / kupisa kunzwa kunokonzerwa ne pepper.Kusiyana nemamwe marudzi e capsaicin ari muboka rimwechete, Stearoyl vanillylamide yakasiyana pakuti haisi-steroidal, zvinoreva kuti haibudisi "zvinonhuwira" kana kuti zvinogumbura zvinokonzerwa ne capsaicin.
Kazhinji, kufanana nemamwe ma capsaicin analogues, musanganiswa uyu unoshanda nekusimudzira kuburitswa kwe epinephrine uye norepinephrine.Aya mahomoni anodiwa kumutsa maitiro akasiyana etsitsi emuviri senge metabolism.Naizvozvo, stearoyl vanillylamide inozopedzisira yakonzera kupisa kwemafuta ebrown mune adipose tishu kana subcutaneous tishu.
Ndezvipi zvakanakira kushandisa Stearoyl Vanillylamide?Iko kuiswa kwe stearic acid amide kune zvakati wandei zvakanakira mukugadzirira kwehutano hwekuwedzera.Sezvo zvidzidzo zvakawanda zvichiri kuenderera mberi, masayendisiti ari kutarisira kuwana mamwe mabhenefiti ekushandisa musanganiswa uyu.Izvi zvinotevera zvimwe zvakanakira izvo zvinozivikanwa nekushandisa Stearoyl vanillylamide:
Inonyatso kuputsa mudumbu mafuta
Stearoyl vanillylamide inoshanda seisingatsamwisi capsaicin inogona kukurudzira brown adipose tishu kana mafuta ebrown (mafuta anowanikwa zvakanyanya mumitochondria uye anogadzira kupisa mumuviri).Mafuta anowanikwa munzvimbo dzese dzemuviri, kusanganisira maoko, zvidya, dumbu uye gluteal tsandanyama.Kunyange zvazvo vanhu vakawanda vanogona kukurumidza kubvisa mafuta mune dzimwe nzvimbo, kupisa mafuta emudumbu kunoonekwa semutoro chaiwo.Zvidzidzo zvakaratidza kuti kutora Stearoyl vanillylamide kunogona kubatsira kuputsa mafuta anonyanya kuwanikwa mudumbu.Izvi zvinowanikwa nekuita TRPV1, enzyme inodzivirira kugadzirwa kwemafuta emudumbu uye kuumbwa kwemafuta.Pamwe chete ne capsaicin, Stearoyl vanillylamide inoonekwa seimwe yevamiririri vanonangidzira uye kumisa TRPV1 (inononoka receptor inogona vanilloid) iri mu plasma membrane (kunze kwe endogenous ligands, inflammatory mediators uye kwete-selective stimuli).Inoita basa rekuvhara iyo yakakosha membrane protein senzira yeion.Apo TRPV1 inonyanya kushandiswa pamagetsi ekunzwa uye masero asina-neuronal, zvichaguma nekuwedzera kwe calcium uye sodium, iyo inofanirwa kuti membrane depolarization (polarity transition; kubva kune yakaipa kusvika kune yakanaka, zvichiita kuti zvive zvakanaka Positive effects) kutaurirana.
Inonyatso kuputsa mudumbu mafuta
Stearoyl vanillylamide inoshanda seisingatsamwisi capsaicin inogona kukurudzira brown adipose tishu kana mafuta ebrown (mafuta anowanikwa zvakanyanya mumitochondria uye anogadzira kupisa mumuviri).Mafuta anowanikwa munzvimbo dzese dzemuviri, kusanganisira maoko, zvidya, dumbu uye gluteal tsandanyama.Kunyange zvazvo vanhu vakawanda vanogona kukurumidza kubvisa mafuta mune dzimwe nzvimbo, kupisa mafuta emudumbu kunoonekwa semutoro chaiwo.Zvidzidzo zvakaratidza kuti kutora Stearoyl vanillylamide kunogona kubatsira kuputsa mafuta anonyanya kuwanikwa mudumbu.Izvi zvinowanikwa nekuita TRPV1, enzyme inodzivirira kugadzirwa kwemafuta emudumbu uye kuumbwa kwemafuta.Pamwe chete ne capsaicin, Stearoyl vanillylamide inoonekwa seimwe yevamiririri vanonangidzira uye kumisa TRPV1 (inononoka receptor inogona vanilloid) iri mu plasma membrane (kunze kwe endogenous ligands, inflammatory mediators uye kwete-selective stimuli).Inoita basa rekuvhara iyo yakakosha membrane protein senzira yeion.Apo TRPV1 inonyanya kushandiswa pamagetsi ekunzwa uye masero asina-neuronal, zvichaguma nekuwedzera kwe calcium uye sodium, iyo inofanirwa kuti membrane depolarization (polarity transition; kubva kune yakaipa kusvika kune yakanaka, zvichiita kuti zvive zvakanaka Positive effects) kutaurirana.
