Product name:Nicotinamide riboside chloride poda
Rimwe zita:3-(Aminocarbonyl) -1-PD-ribofuranosyl-pyridinium chloride(1 :1);Nicotinamide
Riboside.Cl;3-Carbamoyl-1-beta-D-ribofuranosyl-pyridinium chloride;NR, vhitamini NR; Niagen, TRU NIAGEN
CASNO:23111-00-4
Molecular formula: C11H15N2O5.Cl
Molecular Weight: 90.70 g / mol
Kuchena: 98%
Kunyungudika:115℃-125℃
Chitarisiko:Kubva Kuchena kusvika Pale Yellow Powder
Shandisa: Inosimudzira NAD + mazinga, Inotsigira hutano Kuchembera uye huropi / kugona
Zvishandiso: sechikafu chekuwedzera, chikafu chinoshanda, uye zvinwiwa
Inokurudzirwa dosage: kwete kupfuura 180 mg / zuva
Nicotinamide riboside ichangobva kufarirwa fomu yeVitamin B3, ine yakasarudzika zvivakwa;inzira yepamutemo yeNAD +.
Nicotinamide riboside (NR), yakatanga kutsanangurwa muna 1944 sechinhu chinokura (Factor V) yeHaemophilus furuwenza, uye muna 1951, NR, yakatanga kuferefetwa semhedzisiro yemetabolism mumamatishu emumamali.
Sezvaungaona kuti, kune maviri mafomu eNR aripo, imwe iNicotinamide Riboside, uye imwe yacho Nicotinamide Riboside chloride.
Kutaura nekemikari, iwo maviri makomisheni akasiyana zvachose sezvo aine akasiyana nhamba dzeCAS, NR ine 1341-23-7 nepo NR chloride ine 23111-00-4.NR haina kugadzikana pakudziya kwekamuri, nepo NR chloride yakagadzikana.Yakakurumbira patent Brand inonzi NIAGEN®, yakaburitswa neChromadex Inc muna 2013, imhando yeNicotinamide riboside chloride, ichivavarira kudzosera zviratidzo zvekuchembera kubva mukati memuviri wako.Nicotinamide Riboside inogadzirwa kubva kuCima Science iri zvakare mune chloride poda fomu.Kana zvisina kutaurwa, NR ichanongedzera kuNR chloride fomu muchinyorwa chiri pazasi.
Nicotinamide riboside chikafu masosi
Huwandu hweNR muzvikafu iminiti, zvichienzaniswa neiyo mune zvinovaka muviri zvinowedzera.Nekudaro, ndezvipi zvekutanga zvekudya zvine nicotinamide riboside (NR)?
Mukaka wemombe
Mukaka wemhou kazhinji une ~ 12 μmol NAD (+) precursor mavitamini / L, iyo 60% yaivepo se nicotinamide, uye 40% yaive ikozvino seNR.(Conventional mukaka waive neNR yakawanda kupfuura yeorganic milk), chidzidzo chakabudiswa neYunivhesiti yeIowa, muna 2016.
Mbiriso
Chidzidzo chekare chakati, "Imwe inhibitory chinhu chakasarudzika kubva mbiriso uye chakawanikwa chiri nicotinamide riboside, inogona kunge ichibva kuNAD (P) panguva yekugadzira mbiriso yakatorwa, kana kubva mukudya mbiriso yekuwedzera panguva yekugaya mu vivo."Nepo pasina huwandu hwe data pane mbiriso
Doro
Doro rine huwandu hwakaringana hwecarbs uye kunwa avo vari muchimiro chemvura saizvozvi zvichave nemhedzisiro yeglycemic;mapepa ekutsvagisa akasiyana akataura doro sechikafu chenicotinamide riboside.
Zvakare, panogona kuve nekuteedzera huwandu hweNR senge whey protein, howa, nezvimwe.
Kune vanhu vazhinji, dairy inorambidzwa kune zvimwe zvikonzero.Iyo chikafu masosi e nicotinamide riboside inogona kubatsira, asi haina kunyatso shanda pane yeNR yekuwedzera.
Nei Nicotinamide Riboside (NR) ichisarudza seyechokwadi NAD + precursor vhitamini invertebrates?
Pane mitsetse mishanu yekufunga inotsigira:
Haemophilus furuwenza, bhakitiriya rinokonzera furuwenza, iro risina de novo nzira uye risingakwanise kushandisa Na kana Nam, rinotsamira paNR, NMN, kana NAD+ pakukura muropa rinenge riripo.
Mukaka tsime reNR.
NR inodzivirira murine DRG neurons mune ex vivo axonopathy assay kuburikidza nekunyorwa kwekunyora kwe nicotinamide riboside kinase (NRK) 2 gene.
Exogenously yakawedzera NR uye zvinobva kunze zvinowedzera NAD + kuunganidza mune dosi-inotsamira fashoni mumitsetse yemasero emunhu.
Candida glabrata, mukana wefungus unoenderana neNAD + precursor mavhitaminzi pakukura, inoshandisa NR panguva yekuparadzira hutachiona.
Nicotinamide Riboside VS Nicotinamide VS Niacin
Niacin (kana kuti nicotinic acid), musanganiswa uye chimiro chevhitamini B3, chikafu chakakosha chemunhu.Iyo ine fomula C6H5NO2.
Nicotinamide kana kuti niacinamide imhando yevhitamini B3 inowanikwa muchikafu uye inoshandiswa sekuwedzera kwechikafu uye mushonga.Iyo ine fomula C6H6N2O.
Nicotinamide riboside ipyridine-nucleoside fomu yevhitamini B3 inoshanda seyakatangira nicotinamide adenine dinucleotide kana NAD+.Iyo ine fomula C11H15N2O5+.
Nicotinamide Riboside Hutano Mabhenefiti
Nicotinamide Riboside inobatsira kugadzirwa kwesimba
Mumhuka, NR supplementation yakaderedza kushandiswa kweNAD, iyo yakavandudza mitochondrial basa, nekukurumidza kudzoreredzwa kwemhasuru, uye kuchengetedza simba NAD mazinga uye vhoriyamu yekurovedza muviri mumakonzo akwegura, kubatsira kuchengetedza mhasuru uye kushanda, inotsigira chizvarwa chesimba.
Nicotinamide Riboside inovandudza kugona kwekuziva
NR inochengetedza masero etsinga muuropi nekuita iyo SIRT3, Supplementation inomutsa nzira dzeNAD uye inobatsira kudzivirira kudzikira mupfungwa.
NR yakawedzera cognitive basa uye kunonoka kufambira mberi kwechirwere cheAlzheimer mumakonzo akapihwa NR kwemwedzi mitatu.
Nicotinamide Riboside inodzivirira kurasikirwa kwekunzwa
Nekumisikidza iyo SIRT3 nzira, ongororo yeUNC yakaona kuti yakabatsira kuchengetedza makonzo kubva mukurasikirwa kwekunzwa kunokonzerwa neruzha.
Nicotinamide Riboside inochengetedza chiropa
Kutorwa NR nemuromo kunowedzera NAD mumuviri, iyo inobatsira kuchengetedza chiropa.NR yakamisa kuunganidzwa kwemafuta, kuderedza oxidative kusagadzikana, kudzivirira kuzvimba, uye kuvandudza insulin senitivity muchiropa chembeva.
Uyezve, NR inogona kuwedzera hupenyu hurefu, Inowedzera metabolism, inotsigira kurwisa kenza, kuderedza zviratidzo zvechirwere cheshuga, inowedzera metabolism, inogona kubatsira nekurasikirwa nehuremu.
Nicotinamide Riboside Yakachengeteka?
Hongu, NR yakachengeteka.
NR ine matatu akaburitswa miedzo yekiriniki inosimbisa kuti yakachengeteka kudyiwa nevanhu.
Kunyatsoongorora nekusimbisa ruzivo rwese rwepreclinical uye rwekiriniki rwunowanikwa paNR vimbisa kuti yakachengeteka uye inotenderwa zvakanaka.
Niagen yakachengeteka uye GRAS, uchishandisa maitiro esainzi, pasi peFederal Food, Drug, and Cosmetic Act (FFDCA).
Nicotinamide Riboside Miedzo Yevanhu
Pane zvakawanda pre-kiriniki zvidzidzo zvakaitwa kuyedza NR mune akasiyana mamodhi masisitimu.
Muna 2015, zvidzidzo zvekutanga zvekiriniki zvevanhu zvakapera, uye mhedzisiro yakaratidza kuti NR zvakachengeteka uye zvinobudirira inosimudzira mazinga eNAD muvanhu vane hutano vanozvipira.
A placebo-inodzorwa nekiriniki yekuedza ye nicotinamide riboside muvarume vakafutisa ne randomized: kuchengeteka, insulin-sensitivity, uye lipid-mobilizing migumisiro.
-Yakabudiswa muAmerican/Journal of Clinical Nutrition
Results: 12 wk yeNR supplementation mumadhora e2000 mg / d inoratidzika yakachengeteka, asi haina kuvandudza insulin senitivity uye muviri wose weglucose metabolism mune obese, insulin-resistant varume.
Chronic nicotinamide riboside yekuwedzera inoregererwa uye inosimudza NAD + mune hutano hwepakati-kati uye vakuru vakuru.
-Rakadhindwa muNature Communications
Nicotinamide Riboside is Kunyanya uye Nemuromo Bioavailable muMice uye Vanhu.
-Rakadhindwa muNature Communications
Pano tinotsanangura iyo nguva uye dosi-inotsamira mhedzisiro yeNR paropa NAD metabolism muvanhu.Chirevo chinoratidza kuti ropa revanhu NAD rinogona kukwira senge 2.7-yakapetwa nekamwe muromo dosi yeNR mukutyaira tsvakiridzo yemunhu mumwechete uye iyo yemuromo NR inosimudza mbeva hepatic NAD neinooneka uye yepamusoro pharm.
