Oleanolic acid inova matatu pentacyclic triterpenoids yakaparadzaniswa kubva kuGentianaceae zvirimwa zveSwertia mileensis huswa hwose kana privet muchero, ine muviri wakasununguka uye glycosides mumiti yakawanda.Oleanolic acid ine huwandu hwakasiyana-siyana mumiti, uye huwandu hwehuwandu huri 0.2% - 2%.Cucurbitaceae high content is 1.5% ~ hunchback bottom 2%, privet fruit content ye 0.6% ~ 0.7%.Oleanolic acid imhando yepentacyclic triterpenoid compound yakaparadzaniswa nemuchero we genus Asteraceae, Syzygium sylvestris, kana Ligustrum lucidum.Icho chirwere chechiropa adjuvant uye kiriniki inoshandiswa pakurapa chirwere.Acute jaundice hepatitis ine mabudiro ari pachena pakuderedza alanine aminotransferase uye yellowing.Oolic acid is a pentacyclic triterpenoids yakaparadzaniswa nemuchero we swertia chinensis kana fructus ligustris kubva kune gentianaceae chirimwa.Oleanolic acid inowanikwa zvakanyanya mumiti, ine huwandu hwakawanda hwe 0.2% ~ 2% [1].Izvo zviri pasi pe calabash zvaive 1.5% ~ 2%, uye zvirimo zvemuchero wefructus ligustris zvaive 0.6% ~ 0.7%.Oleanolic acid ichena acicular crystal (ethanol), haina kunhuwa uye haina kunaka.Kusagadzikana kune asidhi nemabhesi.Kunyunguduka kwe308 ~ 310 ℃, [alpha] 20 d + 73.3 ° (c = 0.15, chloroform, isinganyunguriki mumvura, inonyungudika mu methanol, ethanol, ethyl ether, acetone uye chloroform.Oleanolic acid is a naturally distributed , triterly distributed mumiti yezvokudya nemishonga, yakabatana nebetulinic acid Inogona kuwanikwa muPhytolacca americana (American pokeweed), uye Syzygium spp, garlic, etc. Iyo inenge isiri-chepfu, hepatoprotective, uye inoratidza antitumor uye antiviral properties.
Oleanolic acid yakawanikwa kuratidza yakasimba anti-HIV chiitiko, iyo yakabatana komisheni betulinic acid yakashandiswa kugadzira yekutanga yekutengesa maturation inhibitor mushonga.Yakatanga kudzidzwa uye yakaparadzaniswa nezvirimwa zvakati wandei, kusanganisira Rosa woodsii (mashizha), Prosopis glandulosa (mashizha nematavi), Phordendron juniperinum (chirimwa chose), Syzygium claviflorum (mashizha), Hyptis capitata (chirimwa chose), uye Ternstromia gymnanthera (mumhepo). chikamu).Mamwe marudzi eSyzygium anosanganisira java apple (Syzygium samarangense) nemaapuro akasimuka anemo.
Zita reChigadzirwa:Oleanolic Acid98%
Tsanangudzo: 98% neHPLC
Botanic Source: Olea Europea Extract
Kemikari Zita:(3β)-3-Hydroxyolean-12-en-28-oic acid
Nhamba yeCAS:508-02-1
Chikamu Chinoshandiswa:Leaf
Ruvara: Ichena poda ine hunhu hwemunhuwi uye kuravira
GMO Mamiriro:GMO Yemahara
Kurongedza: mune 25kgs fiber zvigubhu
Kuchengeta: Chengetedza mudziyo usina kuvhurwa munzvimbo inotonhorera, yakaoma, Chengetedza kure nechiedza chakasimba
Sherufu Hupenyu: Mwedzi makumi maviri nemana kubva pazuva rekugadzirwa
Chiioleanolic acid?
Oleanolic acid (OA), yakasikwa hydroxyl pentacyclic triterpenoid acid (HPTA) yakafanana nebetulinic acid, ursolic acid;ine mabhenefiti akaita seantibacterial, anti-inflammatory, antitumor mabasa.
Ungawane kupioleanolic acid?
Oleanolic acid yakashandiswa netsika kurapa zvirwere zvakasiyana-siyana, unogona kuiwana muchikafu nezvirimwa zvakanyanya.
Mimwe michero yakaita semaapuro, pomegranate, ndimu, bilberries, maorivhi ane oleanolic acid zvakare.
| Herb Name | Oleanolic acid content | Test method |
| Ligustrum lucidum Ait | 0.8028% | HPLC |
| Verbena Officinalis L | 0.071%-0.086% | HPLC |
| Prunella vulgaris L | 3.47% -4.46% | HPLC |
| Hemsley Chinensis Cogn. | 1.5%～2% | HPLC |
Parizvino, Chinese herbHemsley Chinensis Cognichiri iyo yakanyanya kutengeserana mbishi yezvinhu zvekutora oleanolic acid.
Hemsley Chinensis Cogn.Nhanganyaya
Hemsleya chinensis Cogn.mushonga unokwira usingaperi, zvakare ndiwo mushonga wechinyakare weChinese.
Mhuri: Cucurbitaceae
Tribus: Gomphogyneae
Genus: Hemsleya
Zvisikwa: H. amabilis
Mishonga inoparadzirwa mumapurovhinzi Guangxi, Sichuan, Guizhou, Yunnan, Hubei, etc. Akazvarwa mumucheto wesango uye makwenzi emipata panzvimbo yakakwirira ye2,000 mamita.
Active ingredients: ine Hemslolide Mal, Ma3, H1;Chikusesusaponin-Iva;dihydro cucurbitacin F-25-acetate;dilydrocucurbitacin F;oleanolic acid-beta-Hlucosyloleanolate;Hemsamabilinin A;Cu-curbitacinⅡb-2-beta-D-glucopyranoside.
Mishonga Yakakosha:
Hemsleya chinensis Cogn.inonyanya kuburitsa, sterilization, anti-inflammatory, kusimbisa dumbu uye kubvisa marwadzo.Parizvino, kune maextracts poda, kana macompound gadziriro akadai semacapsules, mahwendefa, egastrointestinal mapiritsi, nezvimwewo, ayo anoshandiswa zvakanyanya mumakiriniki maitiro.
Kubviswa kweOleanolic acid kubvaHemsleya Chinensis Cogn.
Mafomula ane Oleanolic acid muChikafu chekuwedzera
Takaona kuti iyo oleanolic acid inoshandiswa muhutano hwekuwedzera inowanzobva kumhando nhatu dzezvinomera zvirimwa: Loquat shizha rinobvisa, Hemsley Chinensis inobvisa, uye tsvene basil inobvisa.
- Holy Basil hupfu (shizha) (0.4% Ursolic acid uye Oleanolic acid, 2.0 mg)
- Holy Basil supercritical CO2 extract (shizha) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid uye Oleanolic acid, 1.5 mg)
- Loquat Extract (michero) (inopa Ursolic acid, Oleanolic Acid) (Yakagadzirirwa kuUrsolic acid Per Serving 125mg)
Oleanolic asidhi VS Ursolic asidhi
Oleanolic acid (OA) uye ursolic acid (UA) ndiwo masikirwo ematriterpenoids ane chimiro chakafanana chemakemikari.
Aya ma triterpenoids makomisheni anozivikanwa kuve aripo mumishonga yemishonga uye chikafu.
Vane zvakawanda zvakajairika zvemishonga yemishonga: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV chiitiko, antioxidant, uye antifertility zviitiko.
OA uye UA musiyano:
| Product Name | Oleanolic acid | Ursolic acid |
| CAS NO. | 508-02-1 | 77-52-1 |
| Pentacyclic triterpenes | β-Amyrin | α-Amyrin |
| Herb sources | Loquat leaf, Holy Basil, Rosemary, Olive leaf.etc. | |
| Zvinotsanangurwa | 40%,98%hupfu | 15%, 25%, 50%, 98% upfu |
| Chitarisiko (ruvara uye kunhuwa) | 40% yakareruka yero98%chena hupfu husina kunhuhwirira | 15% -50% yebrown-yellow kana yero98%white powderCharacteristic |
| Kusiyanisa | IR:(1355~1392cm-1) nhongonya mbiri(1245~1330cm-1) nhongonya nhatuNMR:δ(C12)122.1,δ(C13)143.4 | (1355 ~ 1392cm-1) nhongonya nhatu(1245~1330cm-1) nhongonya nhatuδ(C12)125.5,δ(C13)138.0 |
| Derivatives | Oleanolic sodium munyuOleanolic acid phosphate disodium munyu3-oxo oleanolic acid bardoxolone methyl (CDDO-Me) | Ursolic sodium munyu uye dicarboxylic acid yayo hafu ester derivativesUrsolic acid ketene derivatives3-carbon ursolic acid 3-acetoxyursolic acid |
| Inogona anticancer | UA inonyanya kufarirwa kupfuura OA. | |
Biological Mabasa eOleanolic Acid
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Anti-Tumour/Anti-Cancer Migumisiro
Inhibitory mhedzisiro yeoleanolic acid pane hepatocellular carcinoma kuburikidza neERK-p53-mediated cell cycle kusungwa uye mitochondrial-inotsamira apoptosis.
– na Xin Wang, Hua Bai, etc. Vanotsvakurudza
OA yakaratidza inhibitory mhedzisiro paHCC kuburikidza nekumisikidzwa kweapoptosis uye sero kutenderera kusungwa zvese mumamota akaisirwa uye mumaseru eHepG2.
OA yakakonzera apoptosis kuburikidza nemitochondrial nzira, inoratidzirwa nekudziviswa kweAkt / mammalian chinangwa cherapamycin nzira.
OA yakakonzera G2/M cell cycle kusungwa kuburikidza nep21-mediated down-regulation ye cyclin B1/cdc2.
OA yakaratidza zvakakosha antitumor zviitiko muHCC mu vivo uye in vitro modhi.Aya data anopa ruzivo rutsva mumagadzirirwo ari pasi peiyo antitumor athari yeOA.
Pamusoro pezvo, tsvagiridzo inoratidza kuti OA uye inotorwa Oleanolic acid methyl ester zvakare ine mhedzisiro pagomarara rezamu, kenza yemapapu, dundira, kenza yechibereko, pancreatic cancer maseru…
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Antimicrobial Activity
OA inotarisirwa kuve nemishonga inorwisa utachiona hwakasiyana-siyana hwehutachiona nekuti inoita basa rakakosha mukudzivirira utachiona hwezvirimwa.
OA yakaratidza kuita kuri pakati nepakati pakurwisa Staphylococcus aureus uye Bacillus Thuringiensis pa62.5 µg/mL uye Escherichia coli, Salmonella Enterica, uye Shigella dysentery pa31.2 µg/mL minimum inhibitory concentration (MIC).
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Hepatoprotective Ability
Imwe yeanozivikanwa bioactivities yeOA kuchengetedzwa kwechiropa kubva kune chepfu uye parizvino iri kushandiswa sepamusoro pehepatic counter drug muChina.
MuWistar albino rats, OA kubva kuFlaveria Trinervia yakashandiswa uye yakanga ine simba guru rekudzivirira pane ethanol-induced chiropa chepfu nekudzorera hepatotoxic serum marker enzyme levels.Ichi chidzidzo chakaratidza kugona kwe antioxidant kweOA seimwe nzira inogoneka yekugona kwayo hepatoprotective.
Oleanolic Acid uye zvinobva kwayo
Oleanolic Acid Clinical Miedzo
Oleanolic acid (yakatorwa kubva kumuorivhi), kune angangoita mazana mashanu akanyoreswa miedzo yekiriniki, yakaratidza kuti yaive nemhedzisiro mukuyedzwa kwekiriniki pachirwere cheitsvo chisingaperi, chirwere cheshuga mellitus type 2, uye mamwe mamiriro ekuzvimba senge arthritis.
Zvakanyanya kufarirwa zvinobva mumakiriniki miedzo ndeye bardoxolone methyl (CDDO-Me).CDDO-Me yakaongororwa mune bundu biopsies, uye inogona kukwanisa kuita basa mukurapa kwechirwere cheitsvo chisingaperi, parizvino chiri kuongororwa mumhedzisiro yehypertension.
Chinese Pharmacopoeia Standard yeOleanolic Acid
| Product name | Oleanolic Acid |
| Identification | (1) Tora 30mg yechigadzirwa ichi, uise mu test tube, wedzera 3ml ye chloroform kuti iparadze, wedzera madonhwe maviri e sulfuric acid, zunza maminetsi mashanu, chloroform layer iri yepepuru-tsvuku. |
| (2) Tora inenge 20mg yechigadzirwa ichi, wedzera 1ml yeacetic anhydride, iputse nekupisa zvishoma, wedzera sulfuric acid kune ruvara rwepepuru, uye kusviba mushure mekuisa. | |
| (3)Tora inenge 10mg yechigadzirwa ichi, wedzera vanillin glacial acetic acid solution (tora vanillin 0.5g, wedzera 10ml yeglacial acetic acid kuti inyunguduke, kureva) 0.2ml, wedzera 0.8ml yeperchloric acid, uye inopisa kwemaminitsi akawanda. mukugeza nemvura.Fuchsia, wedzera 2ml ye ethyl acetate, yepepuru-tsvuku yakanyungudutswa mu ethyl acetate, yakaiswa pasina kushanduka. | |
| (4) Iyo infrared absorption spectrum yechigadzirwa ichi inofanirwa kuenderana neiyo control spectrum. | |
| Kutsunga kwekuongorora | Tora 0.15g yechigadzirwa ichi, kunyatsoyera uremu, wedzera 30ml ye ethanol, zunza, kupisa mumvura inodziya yekugezera kuti inyunguduke, rega kutonhorera kusvika kune imwe tembiricha, wedzera madonhwe matatu ephenolphthalein indicator solution, ita potassium hydroxide solution ne ethanol ( 0.05mol/L) Titrate nekukasira uye gadzirisa bvunzo isina chinhu.Potassium hydroxide solution (0.05 mol/L) pa1 ml ye ethanol inoenderana ne22.84 mg yeC.30H48O3. |
Oleanolic acid inokurudzira dosage
Maererano neChinese Pharmacopoeia Standard, Oleanolic acid Oral dose ndeye 20 ~ 80mg panguva, 60 ~ 240mg pazuva.
Oleanolic acid side effects
Oleanolic acid inoshandiswa senge pamusoro pekaunda (OTC) hepatoprotective mushonga kwemakumi emakore muChina.
Kana kuwandisa kana kutadza, nhamba diki yevarwere vane muromo wakaoma, manyoka, ekumusoro abdominal kusagadzikana, uye inogona kupera mushure mekurapa kwechiratidzo.
Ndapota bvunza chiremba wako kana wemishonga usati washandisa chigadzirwa ichi.
Basa:
1.Oleanolic acid inenge isiri-chepfu, antitumor, uye hepatoprotective, pamwe chete nekuratidzira antiviral properties.
2.Oleanolic acid yakawanikwa kuratidza simba rinopesana neHIV.
3.Oleanolic acid ndiyo mudziviriri mukuru wemasero anopikisa oxidative uye electrophile stress.
4.Oleanolic asidhi ine simba guru pakubata hutachiona hepatitis, acute icteric hepatitis uye chisingaperi hepatitis.
Application:
1. Inoshandiswa mumunda wekudya, inogona kuita seyakagadzirwa tei kuderedza phlegm;
2. Inoshandiswa mumunda wemishonga, inova mushonga mutsva unopesana nekenza ine muchetura wakaderera;
3. Inoshandiswa mumunda wekuzora, inogona kusimbisa kutenderera kweropa uye kubvisa chinwiwa.
| Mamwe ruzivo nezve TRB | ||
| Regulation certification | ||
| USFDA,CEP,KOSHER HALAL GMP ISO Zvitupa | ||
| Kuvimbika Hunhu | ||
| Anoda kusvika makore makumi maviri, kunze kwenyika makumi mana nematunhu, mabheji anopfuura zviuru mazana maviri anogadzirwa neTRB haana chero matambudziko emhando, nzira yekucheneswa, kusachena uye kuchena kutonga zvinosangana neUSP, EP uye CP. | ||
| Comprehensive Quality System | ||
|
| ▲ Hunhu Hwekusimbisa Sisitimu | √ |
| ▲ Kudzora zvinyorwa | √ | |
| ▲ Validation System | √ | |
| ▲ Kudzidzisa System | √ | |
| ▲ Internal Audit Protocol | √ | |
| ▲ Suppler Audit System | √ | |
| ▲ Equipment Facilities System | √ | |
| ▲ Material Control System | √ | |
| ▲ Kugadzira Kudzora System | √ | |
| ▲ Packaging Labeling System | √ | |
| ▲ Laboratory Control System | √ | |
| ▲ Verification Validation System | √ | |
| ▲ Regulatory Affairs System | √ | |
| Dzora Manyuko Akazara uye Maitiro | ||
| Yakanyatso kudzora zvese mbishi zvinhu, zvishongedzo uye kurongedza zvinhu. Preferred raw materials uye zvishongedzo uye kurongedza zvinhu mupepi neUS nhamba yeDMF.Several raw material suppliers serubatsiro rwevimbiso. | ||
| Strong Cooperative Institutions kutsigira | ||
| Institute of botany/Institution of microbiology/Academy of Science and Technology/University | ||
