10-Deacetylbaccatin III (10-DAB)

Sharaxaad Gaaban:

10-Deacetylbaccatins waa taxane dabiici ah oo xidhiidh dhow la lehxeryahooda organicka go'doonsan geedka yew (GeneraTaksi). 10-Deacetylbaccatin III waa horudhac u ah dawada ka hortagga kansarkadocetaxel(Taxotere).

10-deacetylbaccatin III 10-O-Acetyltransferasewaxay u badashaa 10-deacetylbaccatinbaccatin III:

10-Deacetylbaccatin III, oo sidoo kale loo yaqaan 10-DAB ama 10-DAB III, waa xeryahooda dabiiciga ah ee dabiiciga ah si dhow ula xiriira oo ka go'doonsan cirbadaha la qalajiyey iyo laamo yaryar oo geed yuurub ah (Taxus baccata) .10-Deacetylbaccatin III waa horudhac u ah daawada kansarka ka hortagga docetaxel (Taxotere). pacitaxel (taxol); cabazitaxel. 10-10-deacetylbaccatin III ayaa la ogaadey in ay si xushmad leh u joojiso koritaanka L. DONOVANI intracellular amastigotes gudaha J774 murine macrophages in vitro at nanomolar fiirsashada oo leh IC (50) qiimaha 70 nM.