Magaca Alaabta:CMS121
Magaca kale:CMS-121;
1,2-Benzenediol,4-[4- (cyclopentyloxy) -2-quinolinyl] -;
4- (4- (cyclopentyloxy) quinolin-2-yl) benzene-1,2-diol (CMS121);
ACC, AcetylCoenzymeACarboxylase, cudur, neuroprotective, ka hortagga, anti-bararka, mitochondrial, Alzheimers, antioxidative, acetylation, Inhibitor, H3K9, Acetyl-CoACarboxylase, CMS121, waallida, ACC1, CMS-121
CAS NO.:1353224-53-9
Qiimaynta: 98.0% Min
Midabka: budo huruud ah oo khafiif ah
Xidhmada:25kg/DRUMS
4- (4- (cyclopentyloxy) quinolin-2-yl) benzene-1,2-diol waa xarun sidoo kale loo yaqaan CMS121. Kakanaanta dhisme ee xarunta ayaa soo jeedinaysa inay yeelan karto sifooyin gaar ah iyo isticmaalyo suurtagal ah. Si loo fahmo muhiimada ay leedahay, waxay kaa caawinaysaa in la aqoonsado kooxaha shaqaynaya ee jooga oo la falanqeeyo saamayntooda iman karta
CMS121 waa quin oline oo la beddelay oo leh neuroprotective, anti-bararka, antioxidative, iyo waxqabadyo dib-u-celin ah. Waxay ilaalisaa heerarka glutathione (GSH) ee unugyada HT22 jiirka hippocampal ee vitro ee joogitaanka glutamate, waxay keentaa kala duwanaanshiyaha unugyada PC12, waxay ka hortagtaa LPS-induced N9 microglial activation by 82% ee N9 microglia, waxayna baabi'isaa xagjirka bilaashka ah ee firfircoonida Trolox u dhigma. (TEAC) qiimayn. CMS121 waxay ka ilaalisaa ischemia iyo oxytosis ee shaashadaha phenotypic ee unugyada HT22 ee vitro oo leh EC50 qiyamka 7 iyo 200 nM si looga hortago iodoacetic acid- ama dhimashada unugyada glutamate, siday u kala horreeyaan. Sidoo kale waa dib-u-celin, hoos u dhigista miisaanka kelyaha iyo hoos u dhigista muujinta TNF-α, caspase-1, iyo nit ric oxi de synthase (iNOS) ee qaabka jiirka SAMP8 ee cudurrada kelyaha ee joogtada ah ee la xidhiidha gabowga degdega ah marka la qaato qiyaasta. ee 10 mg/kg maalintii laga bilaabo da'da sagaal bilood.
4- (4- (cyclopentyloxy) quinolin-2-yl) benzene-1,2-diol waa xarun sidoo kale loo yaqaan CMS121. Kakanaanta dhisme ee xarunta ayaa soo jeedinaysa inay yeelan karto sifooyin gaar ah iyo isticmaalyo suurtagal ah. Si loo fahmo muhiimada ay leedahay, waxay kaa caawinaysaa in la aqoonsado kooxaha shaqaynaya ee jooga oo la falanqeeyo saamayntooda iman karta. Joogitaanka giraanta quinoline waxay soo jeedinaysaa in xaruntu ay noqon karto mid bayooloji ahaan firfircoon. Unugyada ka soo jeeda Quinoline waxaa lagu yaqaanaa sifooyin bayooloji oo kala duwan, oo ay ku jiraan hawlaha bakteeriyada iyo ka hortagga bararka. Lifaaqa kooxda cyclopentyloxy waxay gacan ka geysan kartaa milanka xarunta ama waxay kor u qaadi kartaa dhaqdhaqaaqeeda bayooloji iyada oo loo marayo saameyn aan fiicneyn. Daraasadaha ku saabsan unugyada HT22, CMS-121 waxay muujisay saameyn weyn oo neuroprotective ah, oo si wax ku ool ah uga ilaalinaysa unugyadan ischemia iyo waxyeelada oksida. Intaa waxaa dheer, CMS-121 waxay leedahay sifooyin muhiim ah oo ka hortagga bararka, taas oo muujinaysa awoodda ay u leedahay inay wax ka beddesho jawaabaha bararka. Marka sidaas la sameeyo, CMS-121 waxay awood u leedahay inay yareyso bararka unugyada iyo xubnaha kala duwan. CMS-121 waxay leedahay firfircooni dawooyin xoog leh oo ka hortag ah acetyl-CoA carboxylase 1 (ACC1). Saameynteeda xakamaynta xoogga leh ee ACC1 waxay ka dhigaysaa xarun rajo leh
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