Magaca Alaabta:YDL223C (HBT1) budada

Magac kale:HBT1,YDL223C

CASNo:489408-02-8

Tilmaamaha:99.0%

Midabka:Adag huruud khafiif ahoo leh ur iyo dhadhan sifo

GMOXaalada:GMO Bilaash

Xirmooyinka: 25kgs durbaannada fiber-ka

Kaydinta: Weelka ha furin meel qabow oo qalalan, ka fogow iftiinka xooggan

Life Life:24 bilood laga bilaabo taariikhda wax soo saarka

HBT1 waa molecule kaliya oo ku xidhi kara goob gaar ah oo ku taal borotiinka AMPA-R marka glutamate uu jiro, xidhitaankani wuxuu caawiyaa nidaaminta dhaqdhaqaaqa borotiinka. Soo-dhoweynta AMPA waxaa lagu muujiyaa dhammaan habka dhexe ee neerfayaasha waxayna door muhiim ah ka ciyaaraan isgaarsiinta neerfaha, habka dareenka, barashada, xusuusta, iyo balaastikada synaptik. Soo-dhoweynta AMPA ayaa ah kuwa ugu weyn ee wax ku biiriya neurotransmission excitatory, dhexdhexaadin degdeg ah, si deg deg ah dareenka dareenka ee synapses badan, oo waxay ku lug leeyihiin jawaabaha hore ee glutamate ee gobollada synaptik. Soo-qabayaasha AMPA waxaa inta badan lagu muujiyaa soo-qabayaasha NMDA ee synapses, waxayna si wadajir ah kor ugu qaadaan hababka balaastikada synaptik ee ku lug leh barashada, xusuusta, excitotoxicity, iyo neuroprotection. Maskax-derived neurotrophic factor (BDNF) waa arrin neurotrophic ah oo door muhiim ah ka ciyaara dayactirka iyo ballaarinta neerfayaasha waxayna leedahay saameyn xoog leh oo badan oo ku saabsan kororka, kala duwanaanta, badbaadada iyo dhimashada unugyada neerfaha iyo kuwa aan neerfaha ahayn. , modulator neurotransmitter kaas oo gacan ka geysta balaastikada neerfaha ee waxbarashada iyo xusuusta. Sidaa darteed, waxay lagama maarmaan u tahay caafimaadka iyo fayoobaanta habdhiska dareenka.

Hawlaha:

1. Cadaadiska garaaca genomic ee khamiirka
   2. borotiinka caarada Shmoo, substrate of Hub1p ubiquitin-la mid ah borotiinka; mutants ayaa cillad ku ah samaynta saadaasha lammaane, sidaas darteed
   ku lug yeelashada Hbt1p ee morphogenesis unugga kala-soocida; HBT1 waxay leedahay paralog, YNL195C, kaas oo ka soo kacay dhammaan nuqullada genome-ga
   3. Laga codsado goobta daawada.
   4. Kobcinta garaadka maskaxda.
   5. Kor u qaad xusuusta iyo awoodaha tiirsanaanta.
   6. Kor u qaad heerka dhiirigelinta.
   7. Kor-u-qaadista xakamaynta habka maskaxda kortikal/hoosaadka hoose.
   8. Hagaajinta dareenka dareenka.
   9. Hagaajinta awooda maskaxda si aad u xalliso dhibaatooyinka oo aad uga ilaaliso kiimiko ama jidh kasta.

Codsiyada:

HBT1 waa awood cusub AMPA-R [alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) reseptor] awood leh saameyn hoose oo agonist marka la barbar dhigo LY451395 iyo OXP1, waxay keentaa wax soo saarka maskaxda ka soo jeeda. factor neurotrophic (BDNF) oo muujiya saameyn yar oo agonist ah ee neerfayaasha asaasiga ah. HBT1 waxay ku xidhan tahay ligand-binding domain ee AMPA-R ee manne ku tiirsanaanta glutamater