Lebitso la sehlahisoa: 4-Butylresorcinol phofo
Tlhaloso: 98% min
Nomoro ea CAS: 18979-61-8
Mantsoe a tšoanang a Senyesemane: N-BUTYLRESEOCINOL;4-N-BUTYLRESORCINOL;4-BUTYLRESORCINOL;4-phenylbutane-1,3-diol;2,4-DIHYDROXY-N-BUTYLBENZEN
Foromo ea molek'hule: C10H14O2
Boima ba molek'hule: 166.22
Sebaka se qhibilihang: 50 ~ 55 ℃
Sebaka se belang: 166 ℃/7mmHg(lit.)
Litekanyetso: 0.1-5%
Pakete: 1kg, 25kg
4-Butylresorcinol ke eng
Lebitso la molao la lik'hemik'hale ke 4-n-butyl resorcinol, empa ka kakaretso, bohle ba rata ho nolofatsa ho ngola butyl resorcinol.Ea pele ea ho e kenyelletsa sehlahisoa sa ho soeufala ke POLA ea Japane, um~ e itšetlehileng ka pilisi e soeufatsang mollong oa malapeng.
E khetholloa ka ho fokola ha metsi ka metsing le ho qhibiliha ka ethanol.
Ketso ea mekhoa ea 4-Butylresorcinol
- Tyrosinase e bapala karolo ea bohlokoa tlhahisong ea melanin hobane e laola sekhahla sa tlhahiso ea melanin.
- 4-n-butylresorcinol e na le phello e thibelang tlhahiso ea melanin ka ho thibela ka ho toba mosebetsi oa lisele tsa tyrosinase le B16 tse lebelo le letšo tse thibelang motsoako oa tyrosinase ntle le ho baka cytotoxicity leha e le efe.
- Lithutong tse ling tsa in vitro, 4-n-butylresorcinol e bontšitsoe ho thibela tlhahiso ea melanin, hammoho le mosebetsi oa tyrosinase le TRP-1.
- Inhibitor e matla ea tyrosinase le peroxidase
- Setsi se sebetsang hantle sa ho soeufatsa letlalo le toner e tloaelehileng ea letlalo
- Setsi se sebetsang sa ho soeufala ha letlalo la letlalo
- E sebetsa khahlano le chloasma (letlalo le pepeneneng le pepesitsoeng letsatsing)
- E na le ts'ireletso e matla ts'enyong ea DNA e bakoang ke H2O2.
- Ho netefalitsoe hore e na le phello ea anti-glycation
Melemo ea 4-Butylresorcinol
Hobaneng u lokela ho khetha 4-Butylresorcinol
Taba ea pele, re hloka ho tseba hore na ke hobane'ng ha resorcinol e le teng.
Lipofuscin ke e 'ngoe ea tse thata ho sebetsana le melanin.Ka kakaretso, hydroquinone e sebelisoa botleng ba bongaka.
Hydroquinone ke ntho e sebetsang haholo ea bosoeu.Mokhoa o mosoeu o thibela ka ho feletseng mosebetsi oa tyrosinase mme o thibela ho thehoa ha melanin, 'me phello e tsoteha haholo.
Leha ho le joalo, litla-morao tsa eona li hlakile ka tsela e tšoanang, 'me melemo e kotsi haholo ho feta melemo ea ho soeufala.
- E na le oxidizable haholo moeeng, 'me e tlameha ho sebelisoa ha e eketsoa ho litlolo.
- e ka baka bofubelu ba letlalo;
- Haeba mahloriso a feta 5%, a tla etsa hore motho a be le maikutlo, 'me ho na le mehlala ea kliniki ea leukoplakia.Hajoale, Tsamaiso ea Lijo le Lithethefatsi ea US e bolela hore lihlahisoa tsa hydroquinone tse nang le khatello e kholo ho feta 4% ke tsa maemo a bongaka 'me ha lia lumelloa ho rekisoa.
Litsebi tsa lik'hemik'hale le litsebi tsa meriana li fetotse moriana o matla oa hydroquinone ho fumana 4-hydroxyphenyl-beta-D-glucopyranoside, e leng seo re atisang ho se utloa ka "arbutin".Phapano lipakeng tsa hydroquinone ke hore arbutin e na le mohatla o monyane - glycoside ho feta hydroquinone.Ke masoabi hore phello e tšoeu e fokotsehile haholo.
Lilemong tsa morao tjena, metsoako e tsebahalang haholo ea lihlahisoa tse kholo ke lihlahisoa tse fapaneng tsa benzenediol.
Empa botsitso bo bobebe ba arbutin bo fokola haholo mme bo sebetsa bosiu feela.
Tšireletseho ea 4-n-butyl resorcinol e fetohile ntlha e hlahelletseng.Ntle le litla-morao tsa hydroquinone, e na le phello e betere ea ho folisa ho feta tse ling tse tsoang ho resorcinol.
Tekong ea thibelo ea ts'ebetso ea tyrosinase, data ea eona e betere ho feta mor'abo rona e moholo phenethyl resorcinol, e leng makhetlo a 100 ~ 6000 a mosoeu oa setso joalo ka kojic acid arbutin!
Joale tlhahlobong e latelang ea melanin B16V e tsoetseng pele, e boetse e bonts'a molemo o tloaelehileng oa li-derivatives tsa resorcinol - ho thibela tlhahiso ea melanin maemong a sa hlahiseng cytotoxicity.
Ho feta moo, ho na le liteko tse ngata tsa batho ho 4-n-butyl resorcinol.Ho bakuli ba bang ba 32 ba nang le chloasma, 0.3% 4-n-butylresorcinol le placebo li ile tsa sebelisoa marameng ka bobeli.Habeli ka letsatsi bakeng sa likhoeli tsa 3, phello e bile ho fokotseha ho hoholo ha pigment ho sehlopha sa 4-n-butylresorcinol ho feta sehlopheng sa placebo.Ho na le batho ba etsang liteko tsa inhibition tsa pigmentation ea maiketsetso kamora ho chesoa ke letsatsi ka maiketsetso, hmm~ sephetho se setle haholo ~
Thibelo ea tyrosinase ea motho ka 4-butylresorcinol
4-butylresorcinol, kojic acid, arbutin le hydroquinone li bonts'a tšebetsong ea L-DOPA oxidase ea tyrosinase.E khethoa ke likhakanyo tse fapaneng tsa li-inhibitors ho lumella ho baloa ha IC50 values.Lintlha tsena ke karolelano ea liteko tse tharo tse ikemetseng.
Thibelo ea tlhahiso ea melanin mefuteng ea letlalo ea MelanoDerm ka 4-butylresorcinol
Bapisa le 4-butylresorcinol, kojic acid, arbutin le hydroquinone tlhahiso ea melanin.Boikemisetso ba melanin ea mefuta ea letlalo bo ile ba bonts'oa kamora matsatsi a 13 a ho lema ka boteng ba likhakanyo tse fapaneng tsa inhibitor.Lintlha tsena ke karolelano ea liteko tse hlano tse ikemetseng.
Ho khantša lilemo ka 4-butylresorcinol
Bapisa le 4-butylresorcinol, kojic acid, arbutin le hydroquinone.Phekola matheba habeli ka letsatsi bakeng sa libeke tse 12 ka inhibitor e fapaneng.Lekola katleho ka mor'a libeke tse 4, 8 le 12.Lintlha li emela moelelo oa lithuto tse 14.*P <0.05: lipalo-palo tsa bohlokoa khahlano le mabala a lilemo tsa taolo e sa alaoeng.
Tekanyo le tšebeliso ea 4-Butylresorcinol
Tekanyetso e khothalletsoang ke 0.5% -5%.Le hoja ho na le lithuto tsa Korea tse nang le phello e itseng ho tranelate ea 0.1%, 'me India e na le lipatlisiso tsa 0.3% tranelate empa' maraka ke haholo-holo 0.5% -5%.E tloaelehile haholo, 'me mokhoa oa Sejapane o ntse o sa hlaka, empa POLA e sebelisitsoe.'Me liphetho le thekiso li khahla haholo.
Joalokaha ho boletsoe ka holimo, 4-Butylresorcinol e ka sebelisoa ka litlolo, empa ha e qhibilihe ka metsing.Tse ling tse kang litlolo, litlolo le li-gel le tsona lia fumaneha.POLA le Eucerin ka bobeli li na le lihlahisoa tsa 4-Butylresorcinol.
