Arachidonoyl Ethanolamide, arachidonoylethanolamide, N-arachidonoylethanolamine, le AEA kaofela li lekana le anandamide ka boeona.Ha e le hantle, (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide ke lebitso la lik'hemik'hale la anandamide (lebitso la IUPAC)' me le ka sebelisoa feela libukeng tsa saense.Leha ho le joalo, 94421-68-8 ke ID ea eona e ikhethang ea lik'hemik'hale (Nomoro ea Registry ea CAS).Kaha AEA ke nako e khuts'oane ea anandamide, re ka sebelisa AEA khafetsa ho bua ka anandamide litemaneng le litšoantšong tse latelang.
Lebitso la Sehlahiswa:BongataAnandamide phofo
Synonyms:Arachidonoyl Ethanolamide, AEA phofo, arachidonoylethanolamide, (5Z,8Z,11Z,14Z)-N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide, N-arachidonoylethanolamine
Nomoro ea CAS: 94421-68-8
Karolo ea Semela e Sebelisitsoeng:Lekhasi
motsoako: Apigenin
Assay: Oli ea AEA: 90%
AEA phofo: 50%
'Mala: phofo e tšehla
oli e bosehla bo sootho
Ho paka: ka meqomo ea fiber ea 25kgs
Polokelo: Boloka setshelo se sa buloa sebakeng se phodileng, se omileng, Qoba hole le leseli le matla
Shelf Life: Likhoeli tse 24 ho tloha ka letsatsi la tlhahiso
Ho latela Wikipedia, anandamide ke ntho ea tlhaho e etsahalang cannabinoid neurotransmitter bokong, ho bolelang hore boko ba motho bo khona ho hlahisa anandamide ntle le ho ja lijo tse nang le AEA.Boko ba liphoofolo tse anyesang le cacao e tala li netefalitsoe hore li na le palo e itseng ea anandamide.
Mehloli ea lijo ea anandamide
Ha ho na mehloli e mengata ea tlhaho e tobileng ea anandamide, 'me chokolete le li-truffle li ka holim'a tsona.Truffle e theko e boima haholo ho e fumana bakeng sa anandamide, 'me chokolete e bonahala e le mohloli o ka tšeptjoang ka ho fetisisa oa lijo tse ngata tse tsitsitseng.
Anandamidele lichokolete
Linaoa tsa cacao, mohloli oa chokolete, le tsona ke mohloli o ruileng oa anandamide.Ho na le likarolo tse fetang 300 tsa lik'hemik'hale ka chokolete.Caffeine, theobromine, le phenylethylamine ke metsoako e tsebahalang e phahamisang maikutlo a rona.Theobromine e hlile e thusa ho susumetsa boko ho lokolla anandamide e eketsehileng ho etsa hore re ikutloe re thabile haholoanyane.
Hobaneng ha anandamide e ntse e tsebahala haholo lilemong tsa morao tjena?
Pele re araba potso ena, re hloka ho bua ka cannabis, THC & CBD (Cannabidiol) pele.
Cannabis, eo hape e tsejoang e le matekoane, ke semela se thunyang, 'me batho ba se sebelisa e le sethethefatsi sa mokete kapa ba se tsuba ho hlahisa maikutlo a "phahameng" kapa "majoe".
Sejo se sebetsang ho cannabis se etsang hore u be holimo ke THC, e nang le lebitso le felletseng e le delta 9-Tetrahydrocannabinol.Ha batho ba tsuba matekoane, tetrahydrocannabinol e ka har'a cannabis e susumetsa mokelikeli oa cannabis, e etsa hore batho ba ikutloe ba thabile le ho phela hantle kelellong.
Cannabis ha e molaong linaheng tse ngata kaha batho ba bangata ba tla lemalla eona.
Leha ho le joalo, Uruguay ke naha ea pele ea ho ngolisa cannabis ka molao ka selemo sa 2013.
Ka la 17 Mphalane 2018, mmuso oa Canada o phatlalalitse hore cannabis e ba molao naheng eohle ea Canada.
United States, linaha tse 10 le Setereke sa Columbia li ngolisitse ka molao tšebeliso ea boithabiso ea cannabis leha e ntse e le molaong.
Anandamide vs THC
Cannabis ke mohloli oa semela oa THC.
Anandamide ke mofuta oa batho oa THC.
Scientist e fumane AEA ka 1992 le THC ka 1964.
Anandamide e lokolla lik'hemik'hale tse matlafatsang maikutlo bokong, 'me mokhoa oa eona oa tlhaho o tšoana le oa tetrahydrocannabinol ho cannabis.
Ee, ba shebile li-cannabis receptor tse tšoanang, 'me re tla bua ka mochini oa AEA haufinyane.
Leha ho le joalo, matla a THC a matla ho feta AEA.Boikutlo ba ho nka AEA ha bo monate ho feta ba ho tsuba cannabis kaha anandamide e kenella kapele 'meleng, mohlomong nakong ea metsotso e 30.
Kaha cannabis e thibetsoe linaheng tse ngata, li-supplement, lijo, lino kapa litlolo tse nang le THC ha li molaong.Ka kutloisiso ena, anandamide ke bokamoso.
Anandamide vs CBD
Semela sa matekoane se na le metsoako ea 400+, 'me li-cannabinoids tse fetang 60 tse fapaneng li tlama ho li-receptor' meleng ea rona.
CBD ke mofuta o mokhuts'oane oa cannabidiol mme ke e 'ngoe ea li-cannabinoids tse 60.CBD ke phytocannabinoid ho cannabis.Ho feta 40% ea tlhahiso ea cannabis ke CBD.
Bo-rasaense le lingaka ba fumane hore CBD e khona ho ntlafatsa boemo ba anandamide ka har'a li-synapses tsa boko e le "anandamide reuptake" le "breakdown inhibitor".Mafura a mafura a amide hydrolase, a tsejoang hape e le FAAH ka bokhutšoanyane, ke enzyme e senyang AEA.Ke kamoo CBD e thibelang FAAH le ho ntlafatsa AEA ka tlhaho.
CBD e ka etsa ho feta moo.CBD e ka ba molemo ho Sisteme eohle ea Endocannabinoid
Mokhoa oa ts'ebetso oa anandamide
Anandamide e sebetsa joang?E rarahane ruri.U kanna ua hloka ho tseba pele ka sistimi ea endocannabinoid, receptor ea CB1, le CB2 receptor.
CB1
THC e na le kamano e phahameng bakeng sa receptor ea CB1, e tlamahanang ka matla ho receptor.
Ntle le moo, anandamide e ama maikutlo a "phahameng" ka ho ama receptor ea CB1, ho kenya tšebetsong sistimi ea moputso oa boko le ho hlahisa lik'hemik'hale tse monate joalo ka dopamine Hormone.
CB2
U ka fumana li-receptor tsa CB2 liseleng tsa 'mele oa hau.Mokelikeli oa CB2 o laola likarabo tsa neuroprotective le ho loantša ho ruruha.Bo-rasaense ba lumela hore CB2 receptor e molemo ho kokobetsa bohloko.
Li-receptor tsa CB1 li tsepamisitsoe haholo bokong le tsamaisong ea CNS, athe li-receptor tsa CB2 li fumaneha haholo sesoleng sa 'mele.
Sistimi ea Endocannabinoid (ECS)
Pele o bua ka mesebetsi ea sistimi ea endocannabinoid (ECS), ho bohlokoa ho utloisisa likarolo tsa eona.ECS e entsoe ka li-cannabinoid receptors, li-ligand tse sa feleng (limolek'hule tse tlamang) bakeng sa li-receptor tseo, le li-enzyme tse kopanyang le ho theola li-ligands.
| ECS ea khale | Eketsehile ECS | |
| li-receptor tsa cannabinoid | CB1, CB2 | PPAR, GPR, TRPV, FLAT, FABP |
| endogenous ligands | AEA, 2-AG | OEA,PEA,2-AGE,NADA,VA,EPEA,SEA,OA,DHEA |
| Li-enzyme tse senyang li-ligands | FAAH, MAGL | ABHD6,COX-2,ABHD12 |
| Li-enzyme tse kopanyang li-ligands | DAGL,NAT,NAPE-PLD | SHIP1,PTPN22,PLC,GDEI,ABHD4 |
selikalikoe se ka hare (bohlooho bo bobebe) se emela "classical" endocannabinoid system.Selika-likoe se ka ntle (bohlooho bo lefifi) se kenyelletsa likarolo tsa sistimi e atolositsoeng ea endocannabinoid.Joalokaha u ka bona, PEA, SEA, le OEA le tsona li kenyelelitsoe tsamaisong ea endocannabinoid.
Li-EC li na le tšimoloho ea tsamaiso ea methapo ea bohareng (CNS) 'me e kenyelletsa anandamide (AEA), 2-arachidonoylglycerol (2-AG), noladin ether, virodhamine le N-arachidonylodopamine (NADA).'Me anandamide ke eona ea pele hape e bohlokoa ka ho fetisisa tsamaisong ea endocannabinoid.
Anandamide le 2-AG
Joalokaha ho boletsoe ka holimo, anandamide (AEA) le 2-arachidonoylglycerol (2-AG) ke li-ligand tse peli tse ka sehloohong tsamaisong ea ECS.ECS e thusa ho laola mesebetsi e kang ho robala, tsamaiso ea 'mele ea ho itšireletsa mafung, le ho feto-fetoha ha bohloko.
Bo-rasaense ba ile ba sibolla Anandamide ka selemo sa 1992 le 2-AG lilemo tse 3 hamorao.AEA le 2-AG li na le sebopeho sa limolek'hule tse ts'oanang haholo mme ka hona li na le thepa ea 'mele le ea lik'hemik'hale.
Anandamide e shebisisa haholo receptor CB1 bokong, athe 2-AG e shebile ka bobeli li-receptor tsa CB1 le CB2 (mokhoeng oa ho itšireletsa mafung).
Ka bobeli Anandamide le 2-AG li entsoe ho tsoa ho arachidonic acid, e leng Omega-6 fatty acid, e nang le litsela tse fapaneng le li-enzyme tsa synthesizing.Enzyme e senyang FAAH (Fatty Acid Amide Hydrolase) bakeng sa AEA le 2-AG ka enzyme ea MAGL (Monoacylglycerol Lipase).
Melemo ea Anandamide
Bopaki ba saense bo fana ka maikutlo a hore anandamide e ka ba molemo bakeng sa ho thibela ho tšoenyeha, bophelo bo botle ba kelello, ts'ebetso ea memori, taolo ea takatso ea lijo, ho imolla bohloko, neuroprotection, le tse ling.
Anandamide le matšoenyeho
Batho ba reha Anandamide "molek'hule ea thabo" hobane AEA e khona ho etsa hore u ikutloe u thabile.
Bopaki bo feto-fetohang bo fana ka maikutlo a hore sistimi ea endocannabinoid ke karolo ea bohlokoa ea li-neuronal substrates tse amehang lits'ebetsong tsa moputso oa boko le karabelo ea maikutlo khatellong ea maikutlo.
Pharmacological blockade ea enzyme fatty acid amide hydrolase (FAAH), e ikarabellang bakeng sa ho senyeha ha intracellular anandamide, e hlahisa liphello tse kang anxiolytic ho likhoto ntle le ho baka mefuta e mengata ea likarabo tsa boitšoaro tse tloaelehileng tsa li-agonists tsa cannabinoid tse sebetsang ka ho toba.
Liphuputso tsena li fana ka maikutlo a hore anandamide e kenya letsoho taolong ea maikutlo le matšoenyeho le hore FAAH e kanna ea ba sepheo sa sehlopha se secha sa lithethefatsi tse tšoenyang maikutlo.
Bakeng sa tlhaiso-leseling e batsi mabapi le litlamorao tsa anandamide mabapi le matšoenyeho, ka kopo bala lingoliloeng tse ka tlase:
- Endogenous cannabinoid anandamide e na le litlamorao ho khothatso le matšoenyeho tse senotsoeng ke inhibition ea mafura a acid amide hydrolase (FAAH).
- Anandamide hydrolysis: sepheo se secha sa lithethefatsi tse thibelang ho tšoenyeha?
- Boitšoaro bo fokotsehileng bo kang ba ho tšoenyeha bo bakoang ke thibelo ea liphatsa tsa lefutso le ea meriana ea endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) e tsamaisoa ke li-receptor tsa CB1.
Anandamide le ho imolla bohloko
bopaki ba saense bo bontša hore ho thibela FAAH (enzyme e senyang anandamide bokong) e fokolitse haholo likarabo tsa nociceptive mefuteng e mengata ea bohloko.
Li-inhibitors tsa FAAH li ntlafatsa haholo maemo a anandamide bokong mme haholo-holo li susumetsoa ke CB1receptor-mediated antinociception, e fanang ka maikutlo a hore anandamide ea endogenous, ha e sirelelitsoe ho senyeha, e ka hlahisa antinociception ka CB.1li-receptors.
Palmitoylethanolamide (PEA) ke motsoako oa tlhaho o matlafatsang ts'ebetso ea anandamide.'Mele oa motho ka tlhaho o fana ka PEA ho loantša ho ruruha le bohloko.Bakuli ba fetang 800,000 e bile lipilisi tsa PEA le li-supplement tsa lijo ho phekola bohloko lefatšeng.
Ho ithuta haholoanyane ka PEA, ka kopo etela ronaLeqephe la PEA.
Anandamide le semathi se phahameng
A re qaleng ka ho sheba tlhaloso ea hore na semathi se phahameng ke eng: maikutlo a nyakallo le matšoenyeho a fokotsehileng le bokhoni bo fokolang ba ho utloa bohloko.Ka mor'a ho ikoetlisa ka nako e telele, u tla ba le ketsahalo e monate ha u ntse u matha nako e telele.
Lilemong tse mashome tse fetileng, bafuputsi ba ne ba nahana hore endorphin ke eona feela ntho e ikarabellang bakeng sa limathi tse phahameng kaha maemo a ntseng a eketseha a β-endorphin a fumaneha habonolo maling.Joalo ka ha o se o ntse o tseba, endorphin e na le bokhoni ba ho ntlafatsa maikutlo a rona le ho etsa hore re be le maikutlo a nyakallo.
Leha ho le joalo, bo-ramahlale joale ba lumela hore ke sistimi ea endocannabinoid (ECS) le anandamide tse etsang hore semathi se phahame.Anandamide e khona ho tšela mokoallo oa boko ba mali mme e fana ka litlamorao tse bohareng tsa li-opioid tsa peripheral.Empa endorphin ha e khone.
Haeba u batla ho ithuta ka teko e mabapi le semathi se phahameng, bala lingoliloeng tsena:Bophahamo ba semathi bo ipapisitse le li-receptor tsa cannabinoid ho litoeba
Litsebi tsa phepo e nepahetseng li fumana hore anandamide le eona e ka ba taolo e ntle ea takatso ea lijo.Anandamide e ka tsosa tlala ea hau le takatso ea ho ja ho feta.Haeba u le tseleng ea ho theola boima ba 'mele, nahana ka hloko pele u nka AEA.
Lisebelisoa tse nang le anandamide
Na u batla li-supplement tsa anandamide kapa lipilisi tsa anandamide?
Ka bomalimabe, ha ho na nako ea hona joale.Anandamide ke motsoako o mocha hoo ho seng mefuta ea tlatsetso ea lijo e kileng ea e leka ka liforomo tsa bona tsa hajoale.
U ka fumana k'hamphani e bitsoang Sun Potion e rekisa phofo ea anandamide ho Amazon.Leha ho le joalo, seo hase ’nete.Ke phofo ea cacao e tala feela, empa ha se tlhahiso e tloaelehileng ea anandamide.'Me litaba tse sebetsang ka foromo ea phofo li tlaase haholo,' me u ka 'na ua se ke ua ba le katleho ea AEA.
Ehlile, o ka fumana hore barekisi ba bang ba rekisa litekanyetso tsa litšupiso tsa anandamide kapa li-reagents.Ntho e mpe ke hore ba rekisa feela ka 5mg, 25mg, le bakeng sa lipatlisiso feela.Ha ho na tlhaiso-leseling e ngata ea oli ea AEA e fumanehang ho hang.
Litaba tse monate ke hore baetsi ba li-supplement United States le linaheng tsa Europe tse kang Jeremane, France, Netherland, UK, Spain, Italy, joalo-joalo ba ntse ba odara lisampole tsa AEA ho tsoa ho Wuxi Cima Science Co., Ltd, 'me tlhahiso e ngata ea khoebo e ntse e tsoela pele. .
Litlhaloso tsa Anandamide
Bongata ba oli ea anandamide le phofo ea anandamide ka bobeli li fumaneha ho Cima Science.
Oli ea Anandamide: 70%, 90%
