Apigenin 98%

Apigenin, e le bioflavonoid e tsebahalang, e bontšitsoe ho bontša mesebetsi e sa tšoaneng ea likokoana-hloko, ho akarelletsa le antioxidant, anti-inflammatory, antitumor, ant-genotoxic, anti-allergic, neuroprotective, cardioprotective, le antimicrobial.Leha ho le joalo, E 'ngoe ea mehloli e mengata ea apigenin ke celery (Apium graveolens), semela sa marsh lelapeng la Apiaceae se 'nileng sa lengoa joalo ka meroho ho tloha khale.Apigenin ke limatlafatsi tse nkiloeng ka ho fetisisa tsa celery, tse nang le 108 mg apigenin ka kilo.E fana ka mesebetsi e fapaneng ea 'mele, joalo ka antioxidant, anti-inflammatory, antiviral, antibacterial le phokotso ea khatello ea mali.

Lebitso la Sehlahisoa:Celery lekhasi le ntšitsoeng Apigenin 98%

Lebitso la Selatine: Apium graveolens L.

Nomoro ea CAS: 520-36-5

Karolo ea Semela e Sebelisitsoeng:Lekhasi

motsoako: Apigenin

Assay:Apigenin 98.0% ka HPLC

Mmala: Phofo e sootho ho isa ho e mosehla e nang le monko le tatso e ikhethang

Boemo ba GMO:GMO Mahala

Ho paka: ka meqomo ea fiber ea 25kgs

Polokelo: Boloka setshelo se sa buloa sebakeng se phodileng, se omileng, Qoba hole le leseli le matla

Shelf Life: Likhoeli tse 24 ho tloha ka letsatsi la tlhahiso

Phello e khahlanong le hlahala

Apigenin e bapala karolo ea bohlokoa thibelong ea mofets'e ka ho kenya apoptosis meleng e fapaneng ea lisele.

Kankere ea mahe a bomme:

Liphuputso tse ling li fumanoe hore apigenin e ka thibela ho hōla, ho ata, le ho fetisoa ha ca-ov3 (sele ea kankere ea mae a motho);e etsa hore ho be le apoptosis ea ca-ov3 ka ho boloka lisele tsa mofetše stasis karolong ea G2/M.Phello e amana le nako le lethal dose.

Kankere ea manyeme:

Apigenin e ka thibela ho ata ha lisele tsa mofetše oa pancreatic.Apigenin e lapisa hlahala ka ho fokotsa mohloli oa tsoekere, e leng lijo tseo lisele tsa kankere li phelang ho tsona.Ntle le moo, Apigenin e ka ntlafatsa katleho ea chemotherapy drug- gemcitabine.

Chemo-sensitization

Ho ile ha fumaneha hore apigenin ka litaba tse tlase e na le phello e tlase ea cytotoxic mme e ne e sa khone ho etsa hore lisele tsa motho tse matla tsa myeloid leukemia (hl-60) li fetohe apoptosis ka nepo.Leha ho le joalo, apigenin e ka ntlafatsa phello ea inhibitory ea cisplatin (DDP) ho hl-60 cell proliferation ha e ntse e kopanya le likarolo tse fapaneng tsa DDP.Kahoo Apigenin e ka ba le phello ea chemotherapy-sensitization ho hl-60;Likarolo tse tlaase tsa apigenin li ka boela tsa fokotsa ho hanyetsa ha lisele tsa hl-60 ho chemotherapy-induced apoptosis, e ka 'nang ea amana le ho theoha-taolo ea NF-κB le BCL-2.(NF-KB ke mofuta oa protheine e rarahaneng e laolang ho ngoloa ha DNA, tlhahiso ea li-cytokine le ho phela ha lisele; BCL-2 e kentsoe 'meleng ka mofuta oa BCL2, ke setho sa pele sa lelapa la liprotheine tsa BCL-2 tse laolang. e ka laola lefu la lisele)

Tšireletso ea sebete

Apigenin e ka fokotsa kotsi ea sebete e bakoang ke ischemia-reperfusion ka ho hanyetsa lipid peroxidation le ho senya li-radicals tsa mahala.

Apigenin e ka fokotsa kotsi ea sebete e bakoang ke khatello ea oxidative ka lebaka la mesebetsi ea eona e matla ea antioxidant le anti-inflammatory.

Liteko tsa meriana li pakile hore apigenin e na le phello e bonahalang ea tšireletso ho kotsi ea sebete / hepatocyte e bakoang ke joala, 'me mokhoa oa eona o ka sehloohong o amana le ho thibela polelo ea CYP2E1 sebeteng / hepatocyte.

Thibela lefu la ho fokola ha masapo

Apigenin e thibela osteoblastogenesis, osteoclastogenesis, hape e thibela tahlehelo ea masapo.

Apigenin e sireletsa lisele tsa masapo ka ho fokotsa tahlehelo ea masapo 'meleng.

Liphuputso tse ling tse amanang le MC3T3-E1, selefouno ea pele ea osteoblast e tsoang ho Mus musculus (mouse) calvaria, e fumane hore apigenin e ka thibela TNF-α, IFN-γ, ebe e etsa hore ho be le secretion ea li-cytokine tse 'maloa tse khothalletsang ho thehoa ha osteoclast.

Apigenin e boetse e thibela ho arohana ha lisele tsa 3T3-L1 tsa pele ho li-adipocyte ka matla, ka hona ho thibela phapano ea mohlokomeli e thibelang phapang ea adipocyte-induced IL-6, MCP-1, sehlahisoa sa lectin.

Apigenin e thibela ho arohana ha li-osteoclasts ho tloha RAW264.7 lisele tsa lisele ebe e thibela ho thehoa ha li-osteoclast tse ngata.E ka boela ea susumetsa osteoclast apoptosis le ho thibela ho tsosolosoa ha masapo.

Ts'ebetso ea anti-inflammatory le anti-oxidant

Apigenin e thibela ts'ebetso ea ho ruruha, e eketsa maemo a IL-10 mme e etsa hore maemo a khatello ea oxidative a tloaelehe.

Apigenin e thibela ho ruruha ha li-cytokine 'me e susumetsa tlhahiso ea li-cytokine tse khahlanong le ho ruruha.

Lingoliloeng tse ling li fana ka maikutlo a hore apigenin e kokobetsa ho ruruha ha lisele tse bakoang ke khatello ea oxidative liseleng ka ho fetola matšoao a fapaneng a oxidative, li-interleukin, matšoao a enzyme ea mali le polelo ea li-enzyme tse ling tse amanang.

Tsamaiso ea tsamaiso ea endocrine

Apigenin e khona ho laola tsoekere ea mali, ho phekola ho haella ha qoqotho le ho laola lipid peroxidation. Ho ile ha fumanoa hore apigenin e ka eketsa maemo a insulin le thyroxine liphoofolong tse nang le lefu la tsoekere, le ho fokotsa khatello ea tsoekere maling le ts'ebetso ea glucose-6-phosphorylase (G- 6-Pase).

Apigenin e khutlisitse litlamorao tsa ho eketseha ha serum cholesterol, ho eketseha ha sebete sa lipid peroxidation (LPO) le ho fokotsa mesebetsi ea li-antioxidants tse kang catalase (CAT) le superoxide dismutase (SOD) liphoofolong tse hlahisoang ke alloxan.

Liphoofolo tse nang le tsoekere e tloaelehileng ea mali, apigenin e ka boela ea fokotsa k'holeseterole ea serum le sebete sa lipid peroxidation, 'me ea eketsa mosebetsi oa li-antioxidants liseleng.

Lintho tsa pharmacological tsa apigenin

Apigenin e 'nile ea nkoa e le ea bohlokoa haholo lilemong tsa morao tjena, e le motšehetsi oa bophelo bo botle ka lebaka la chefo ea eona e tlaase le liphello tsa eona tsa bophelo bo botle ho lisele tsa mofetše le tse tloaelehileng, ha li bapisoa le li-flavonoids tse ling tse amanang le moralo.Ho na le bopaki bo bongata ba lipatlisiso bo bontšitseng hore apigenin e na le monyetla o moholo oa ho phekola mafu a mangata

Mosebetsi:

- Thibela kholo ea lisele tsa mofetše.

-Ho theola khatello ea mali

- E sireletsa tsamaiso ea pelo

-Ho thusa ho robala, ho khutsisa methapo, ho felisa ho teneha

-Hanela ho ruruha

- Thibela lefu la ho fokola ha masapo

- Phello ea diuretic.

- Thibela ho kopana ha platelet.

Kopo:

-Lebala la meriana, Lekala la tlhokomelo ea bophelo