NHDC ka sebopeho se hloekileng e fumanoa e le ntho e tšoeu e sa tšoanengtsoekere e phofshoana.
Motsoako o monate ka makhetlo a 1500-1800 ho feta tsoekere e haufi le moeli;hoo e ka bang makhetlo a 340 a monate ho feta boima ba boima ba tsoekere.Matla a eona ka tlhaho a angoa ke lintlha tse kang ts'ebeliso eo e sebelisoang ho eona, lepHea sehlahisoa.
Joalo ka tse ling tse monate hahololi-glycosides, joalo kaglycyrrhizinle ba fumanoang hostevia, Tatso e monate ea NHDC e qala butle ho feta ea tsoekere 'me e lula e le ka hanong nako e itseng.
Ho fapana leaspartame, NHDC e tsitsitse ho mocheso o phahameng le ho maemo a acidic kapa a motheo, 'me kahoo e ka sebelisoa lits'ebetsong tse hlokang nako e telele ea bophelo.NHDC ka boeona e ka lula e bolokehile ho fihlela lilemo tse hlano ha e bolokiloe maemong a nepahetseng.
Sehlahisoa se tsebahala haholo ka ho ba le phello e matla ea synergistic ha e sebelisoa hammoho le tse lingli-sweeteners tsa maiketsetsojoalo kaaspartame, saccharin, potasiamo acesulfame, lecyclamate, hammoho le lino tse tahang tse tsoekere tse kangxylitol.Tšebeliso ea NHDC e eketsa litlamorao tsa linokoane tsena maemong a tlase ho feta kamoo ho neng ho ka hlokahala;ho hlokahala palo e nyane ea li-sweeteners tse ling.Sena se fana ka phaello ea litšenyehelo.
Neohesperidin dihydrochalcone ke eng?
Neohesperidin dihydrochalcone powder, eo hape e tsejoang e le Neohesperidin DC, Neo-DHC le NHDC ka bokhutšoanyane, ke monate o ntlafetseng o hlahisoang ke neohesperidin.NHDC e nkoa e le monate o matla, o se nang phepo o monate o monate;e ka ntlafatsa monate le boleng ba diresepe tse fapaneng tsa lijo.
Neohesperidin dihydrochalcone ke motsoako o monate hoo e ka bang makhetlo a 1500-1800 ho feta tsoekere e haufi le moeli 'me boima ba ona bo monate ka makhetlo a 340 ho feta tsoekere.
Neohesperidin dihydrochalcone hangata e sebelisoa liindastering tsa li-additives tsa lijo le tlatsetso ea lijo.
Fumana le mohloli oa Neohesperidin dihydrochalcone
Neohesperidin dihydrochalcone e ile ya fumanwa ka bo-1960 e le karolo ya Lefapha la US la projeke ya dipatlisiso tsa temo ho fumana ditsela tsa ho fokotsa ho baba ha lero la citrus.Neohesperidin ke motsoako o babang o teng lekhapetleng le makhasi a lamunu e babang le litholoana tse ling tsa lamunu;hape ke motsoako o sebetsang oa flavonoid oa litholoana tsa citrus aurantium.Ha e phekoloa ka hydroxide potassium kapa setsi se seng se matla, ebe hydrogenated, e fetoha Neohesperidin dihydrochalcone (NHDC).
NHDC ha e hlahe ka tlhaho.
Neo-DHC e na le hydrogenated ho tloha neohesperidin ea tlhaho-mohloli oa tlhaho, empa e bile le liphetoho tsa lik'hemik'hale, kahoo ha se sehlahisoa sa tlhaho.
Neohesperidin dihydrochalcone VS tse ling tse monate
Monate le tatso e fapaneng
Ha e bapisoa le sucrose, neohesperidin DC e batla e le monate ka makhetlo a 1500-1800 ho feta tsoekere le makhetlo a 1,000 a monate ho feta sucrose, ha sucralose e le makhetlo a 400-800 le ace-k e monate ho feta tsoekere ka makhetlo a 200.
Neohesperidin DC e latsoa ka mokhoa o hloekileng 'me e na le litakatso tse telele tsa morao-rao.Joalo ka li-glycosides tse ling tse phahameng tsa tsoekere, joalo ka glycyrrhizin e fumanoang ho stevia le tse tsoang motsong oa licorice, monate oa NHDC o lieha ho qala ho feta tsoekere mme o lula ka hanong nako e telele.
Botsitso bo botle le polokeho e phahameng
NHDC e tsitsitse tlas'a mocheso o phahameng, maemo a asiti kapa alkaline 'me ka hona e ka sebelisoa lits'ebetsong tse hlokang nako e telele ea bophelo.NHDC e ka boloka lijo li bolokehile ho fihlela lilemo tse hlano tlas'a maemo a nepahetseng
Li-receptor tse fapaneng
Maikutlo a batho a monate le tatso a kopanngoa ke T1Rs, lelapa la pele la GPCRs, TIRs e hlahisoa ka mokhoa o monate oa mahalapa a bonolo le leleme, ho akarelletsa le TIR1, T1R2, le TIR3, tse atisang ho fumanoa ka mokhoa oa dimers.Dimer T1R1-TIR3 ke receptor ea amino acid, e hlalosang le ho kenya letsoho temohong ea tatso.Dimer T1R2-T1R3 ke mokelikeli o monate, o kenyang letsoho ho lemoha tatso e monate.
Li-sweeteners tse kang sucrose, aspartame, saccharin le cyclamate li sebetsa sebakeng sa extracellular sebopeho sa T1R2.NHDC le cyclamate li sebetsa karolong ea transmembrane ea T1R3 ho hlahisa monate.Neohesperidin DC e sebelisana le masala a itseng a amino acid sebakeng sa transmembrane sa T1R3 ho iketsetsa monate oa eona mme ka nako e ts'oanang, e ka hlahisa phello e monate ea synergistic ea dimer T1R2-T1R3.Joaloka ntho e monate, NHDC e na le phello e monate ea monate ha e kopantsoe le litlolo tse ling tse nang le palo e nyenyane ea metsoako.
Ntle le moo, Neohesperidin DC e fapana le linokoane tsa setso mesebetsing ea eona ea ho natefisa, ho ntlafatsa monko, ho pata ho baba, le ho fetola tatso.
Melemo le lits'ebetso tse ka bang teng tsa neohesperidin dihydrochalcone (NHDC)
Lintho tsa Antioxidant
Lilemong tsa morao tjena, liphuputso tse ngata li bontša hore neohesperidin dihydrochalcone e na le ts'ebetso ea bohlokoa e itšetlehileng ka mahloriso ho li-radicals tsa mahala tse tsitsitseng le mefuta ea oksijene e sebetsang (ROS).Haholo-holo, NHDC e na le phello e matla ka ho fetisisa e thibelang H2O2 le HOCl.(sekhahla sa ho hloekisoa ha HOCl le H2O2 e ne e le 93.5% le 73.5% ka ho latellana)
Ho feta moo, NHDC e ka thibela ho senyeha ha protheine le ho petsoha ha plasmid DNA strand, le ho sireletsa lefu la lisele tsa HIT-T15, HUVEC tlhaselong ea HOCl.
NHDC e na le ts'ebetso e fapaneng ea antioxidant khahlano le li-radicals tsa mahala tse fapaneng.Ts'ebetso ea antioxidant ea NHDC e boetse e kenyelletsa hore e ka thibela karolo e 'ngoe ea phello e sootho ea pigment deposition e bakoang ke polyphenol oxidase, e ka thibelang haholo taolo ea matrix metalloproteinase (MMP-1) e hlahisoang ke mahlaseli a infrared, kahoo e sireletsa letlalo la motho ho tsofala pele ho nako ka baka la ho pepesehela mahlaseli a kotsi.
Kopo: NHDC e ka ba ntho e ka 'nang ea e-ba khahlanong le bosootho le ho etsa bosoeu
Tsoekere e tlase ea mali le k'holeseterole e tlase
NHDC ke setlolo se sebetsang hantle, se seng chefo, se nang le lik'halori tse tlase se khotsofatsang tlhoko ea batho ea monate 'me kahoo se fokotsa ho ja tsoekere.
Liphuputso tsa morao-rao li bontšitse hore NHDC e ka thibela α-amylase ho liphoofolo tse anyesang ka likhato tse sa tšoaneng ebe e fokotsa ho monya ha tsoekere 'meleng, kahoo e fokotsa tsoekere e maling' meleng, e leng ea bohlokoa haholo meriana, haholo-holo ho bakuli ba nang le lefu la tsoekere.
Kopo: NHDC e ka sebelisoa e le sweetener e se nang tsoekere, e se nang lik'halori.Ha e sebelisoa hantle, e ka nkela sucrose sebaka 'me ea fokotsa ho noa ha sucrose.E loketse batho ba batenya le ba se nang botenya.
Sireletsa sebete
Zhang Shuo et al.e fumane hore NHDC e ka fokotsa maemo a ALT, AST ka serum le hydroxyproline ka har'a lisele tsa sebete tsa litoeba tse nang le sebete sa sebete se bakoang ke CCI, hape se fokotsa ho senyeha le necrosis ea lisele le sebete fibrosis ka likhato tse sa tšoaneng.Ho feta moo, ho fokotseha ha ALT le AST ka har'a serum ea mali ho ka ntlafatsa metabolism ea lipid le ts'ebetso ea sebete, ho thibela ho thehoa ha sebete se mafura le endothelial plaque methapong ea mantlha.
Ntle le moo, NHDC e ka fokotsa ts'enyo ea oxidative e bakiloeng ke CC1, ea fokotsa ho ruruha, le apoptosis ea sele.
Kopo: NHDC e na le tšepo ea ho sebelisoa e le hepatoprotective agent.
Thibela seso sa ka mpeng
NHDC e ka thibela secretion ea gastric acid, kahoo e ka sebelisoa e le antacid ho kopanya le Aluminium Hydroxide Gel kapa lisebelisoa tse ling tse tloaelehileng tse etsang asiti ho ntlafatsa ho hanyetsa gastric acid ea ho qetela.
Suhrez et al.e fumane hore NHDC e ka fokotsa haholo index ea seso e bakoang ke khatello ea maikutlo e batang (CRS).Ts'ebetso ea eona e tšoana le ea ranitidine, e ka thibelang ts'ebetso ea histamine mme ea fokotsa haholo secretion ea asiti ea gastric le pepsin.
Kopo: NHDC e kanna ea fetoha sehlahisoa se secha sa moriana oa mala.
Ho laola ho itšireletsa mafung
NHDC e eketsoa ho fepa e le monate, eseng feela ka lebaka la tatso ea eona e monate le ho susumetsa takatso ea liphoofolo, empa hape ka lebaka la phello ea eona ea probiotic e fumanoang ke Daly et al.Ha NHDC e eketsoa ho fepa ea likolobe, Lactobacillus e monyako oa caecum ea likolobe e ile ea eketseha haholo ka keketseho ea lactic acid ka har'a mala a mala.E ka ama limela tsa mala a symbiotic, ea laola tšireletso ea 'mele, le ho fokotsa mafu a mala.
Kopo: Neohesperidin DC e ka sebelisoa e le motsoako oa lijo, NHDC e ntlafatsa tatso ea lijo, e eketsa takatso ea liphoofolo, 'me e ntlafatsa libaktheria tsa mala, ebe e susumetsa kholo ea tsona.
Neohesperidin DC polokeho
NHDC ha e na carious, ha e belise.Patlisiso ea matla mabapi le chefo e entsoeng.Metabolism ea NHDC 'meleng oa motho e tšoana le ea li-flavonoid glycosides tse ling.NHDC e na le metabolism e potlakileng, ha e na tšusumetso 'meleng oa motho, ebile ha e na litla-morao tse chefo.
Neo-DHC e bolokiloe ho European Pharmacopoeia lilemong tse mashome a mabeli tse fetileng mme e amohetsoe joalo ka setlolo se monate ke European Union, empa eseng ke FDA.United States, neo-DHC e lumelletsoe ho sebelisoa feela joalo ka sehlahisoa sa tatso.Ntle le moo, ngoliso ea NHDC bakeng sa boemo ba GRAS ho FDA e ntse e tsoela pele.
Neohesperidin dihydrochalcone (NHDC) e khothalelitsoeng lethal dose le Litla-morao.
Bakeng sa lijo tse theolelang le lihlahisoa tsa lebese, tekanyetso: 10-35 ppm ( sweetener), 1-5 ppm( flavor enhancer)
Bakeng sa Masking ea Bohloko ba Meriana, tekanyo: 10-30 ppm( sweetener), 1-5 ppm(se matlafatsang tatso)
Bakeng sa litlolo tsa phepo, tekanyo e phahameng e khothaletsoang: 30-35 mg NHDC/kg phepo e felletseng, 5 mg NHDC/L metsi;3-8 mg NHDC/L metsi a ho anya le ho khoesoa
Merero e fapaneng e khetholla lethal dose.
Leha ho le joalo, haeba ho nkoa ka ho feteletseng, motsoako ofe kapa ofe o ka baka kotsi 'meleng oa motho.Liphuputso li bontšitse hore neohesperidin dihydrochalcone (NHDC) e ka baka ho nyekeloa ke pelo le migraine ha mahloriso a ka bang 20 ppm kapa ho feta.Ho khothalletsoa ho roala limaske tsa ho buoa ha u sebetsana le NHDC e hloekileng
Setifikeiti sa Tlhahlobo
Tlhahisoleseding ya Sehlahiswa | |
Lebitso la Sehlahisoa: | Neohesperidin Dihydrochalcone 98% |
Lebitso le Leng: | NHDC |
Mohloli oa Limela: | Orange e babang |
Karolo e Sebelisitsoeng: | Motso |
Nomoro ea Batch: | TRB-ND-20190702 |
Letsatsi la MFG: | La 02 Phupu 2019 |
Ntho | Tlhaloso | Mokhoa | Sephetho sa Tlhahlobo |
Metsoako e sebetsang | |||
Assay(%.On Dried Base) | Neohesperidin DC≧98.0% | HPLC | 98.19% |
Taolo ea 'Mele | |||
Ponahalo | Phofo e tšoeu | Organoleptic | E lumellana |
Monko & Tatso | Tatso ea sebopeho | Organoleptic | E lumellana |
Boitsebiso | E tšoana le RSsamples/TLC | Organoleptic | E lumellana |
Psengoloa Boholo | 100% e feta 80mesh | Eur.Ph.<2.9.12> | E lumellana |
Tahlehelo ka ho Omisa | ≦5.0% | Eur.Ph.<2.4.16> | 0.06% |
Metsi | ≦5.0% | Eur.Ph.<2.5.12> | 0.32% |
Boima ba Bongata | 40-60 g / 100mL | Eur.Ph.<2.9.34> | 46g/100mL |
Hlakola Solvent | Ethanol le Metsi | / | E lumellana |
Taolo ea Lik'hemik'hale | |||
Ketapele(Pb) | ≦3.0mg/kg | Eur.Ph.<2.2.58>ICP-MS | E lumellana |
Arsenic(As) | ≦2.0mg/kg | Eur.Ph.<2.2.58>ICP-MS | E lumellana |
Cadmium(Cd) | ≦1.0mg/kg | Eur.Ph.<2.2.58>ICP-MS | E lumellana |
Mercury(Hg) | ≦0.1mg/kg | Eur.Ph.<2.2.58>ICP-MS | E lumellana |
Solvent Residual | Kopano ya USP/Eur.Ph.<5.4> | Eur.Ph.<2.4.24> | E lumellana |
Mesaletsa ea Likokoana-hloko | Kopano ya USP/Eur.Ph.<2.8.13> | Eur.Ph.<2.8.13> | E lumellana |
Taolo ea Likokoana-hloko | |||
Kakaretso ea Plate Count | ≦1,000cfu/g | Eur.Ph.<2.6.12> | E lumellana |
Yeast & Mold | ≦100cfu/g | Eur.Ph.<2.6.12> | E lumellana |
E.Coli | E mpe | Eur.Ph.<2.6.13> | E lumellana |
Salmonella sp. | E mpe | Eur.Ph.<2.6.13> | E lumellana |
Ho paka le ho Boloka | |||
Ho paka | Paka ka har'a meropa ea pampiri.25Kg/Moropa | ||
Polokelo | Boloka ka sejaneng se koetsoeng hantle hole le mongobo le letsatsi le tobileng. | ||
Shelf Life | Lilemo tse 2 haeba li tiisitsoe 'me li bolokiloe hantle. |
Lintlha tse ling tsa TRB | ||
Rsetifikeiti sa egulation | ||
USFDA,CEP,KOSHER HALAL GMP ISO Litifikeiti | ||
Boleng bo Tšepahalang | ||
Hoo e ka bang lilemo tse 20, ho romela linaheng tse 40 le libaka, lihlopha tse fetang 2000 tse hlahisoang ke TRB ha li na mathata leha e le afe a boleng, mokhoa o ikhethileng oa tlhoekiso, ho se hloeke le taolo ea bohloeki li kopana le USP,EP le CP | ||
Comprehensive Quality System | ||
| ▲Sistimi ea Tiisetso ea Boleng | √ |
▲ Taolo ea litokomane | √ | |
▲ Sistimi ea netefatso | √ | |
▲ Sistimi ea Koetliso | √ | |
▲ Protocol ea Internal Audit | √ | |
▲ Sistimi ea Suppler Audit | √ | |
▲ Sistimi ea Lisebelisoa tsa Lisebelisoa | √ | |
▲ Sistimi ea Taolo ea Lintho | √ | |
▲ Sistimi ea Taolo ea Tlhahiso | √ | |
▲ Sistimi ea ho Labela ho paka | √ | |
▲ Sistimi ea taolo ea laboratori | √ | |
▲ Sistimi ea netefatso ea netefatso | √ | |
▲ Tsamaiso ea Litaba tsa Tsamaiso | √ | |
Laola Mehloli Eohle le Mekhoa | ||
E laoloe ka thata, lisebelisoa tsohle tse tala, lisebelisoa le liphutheloana. Lisebelisuoa tse tala tse ratoang le lisebelisoa le thepa ea ho paka ka nomoro ea US DMF. Bafani ba 'maloa ba thepa e tala e le tiisetso ea phepelo. | ||
Mekhatlo e matla ea Cooperative Institutions ho tšehetsa | ||
Setsi sa thuto ea limela/Setheo sa Microbiology/Academy of Science and Technology/University |