Beta-nicotinamide Mononucleotide (NMN), sehlahisoa sa karabelo ea NAMPT le senotlolo sa NAD+ bohareng, se matlafatsa mamello ea tsoekere ka ho khutlisetsa maemo a NAD+ ho litoeba tsa T2D tse hlahisitsoeng ke HFD.NMN e boetse e ntlafatsa kutloisiso ea "insulin" ea sebete 'me e khutlisetsa polelo ea liphatsa tsa lefutso tse amanang le khatello ea oxidative, karabelo ea ho ruruha, le morethetho oa circadian, karolo e 'ngoe ka ts'ebetso ea SIRT1.NMN e sebelisetsoa ho ithuta li-motifs tse tlamang ka har'a li-aptamers tsa RNA le mekhoa ea ts'ebetso ea ribozyme e kenyelletsang likaroloana tsa RNA tse entsoeng ke β-nicotinamide mononucleotide (Beta-NMN).
Nicotinamide mononucleotide (“NMN” le “β-NMN”) ke nucleotide e nkiloeng ho ribose le nicotinamide.Niacinamide (nicotinamide,) ke mofuta oa vithamine B3 (niacin.) Joalo ka selelekela sa biochemical sa NAD +, e ka ba molemo ho thibela pellagra.
Sebopeho sa eona se sa tsitsang, niacin, se fumanoa mehloling e fapaneng ea phepo e nepahetseng: Matokomane, Li-mushroom (portobello, grilled), Avocados, Lierekisi tse Tala (tse ncha), le litlhapi tse itseng le nama ea liphoofolo.
Lithutong [ka litoeba], NMN e bonts'itse ho khutlisa ho se sebetse hantle ha arterial ho amanang le lilemo ka ho fokotsa khatello ea oxidative.
Lebitso: Beta-Nicotinamide Mononucleotide
CAS ＃: 1094-61-7
Lebitso la sehlahisoa: Beta-Nicotinamide Mononucleotide;NMN
Lebitso le leng:β-D-NMN;BETA-NMN;beta-D-NMN;NMN zwitterion;Nicotinamide Ribotide;Nicotinamide nucleotide;Nicotimide mononucleotide;Nicotinamide mononuclotide
CAS: 1094-61-7
Mokhoa oa molek'hule: C11H15N2O8P
Boima ba 'mele: 334.22
Bohloeki: 98%
Mocheso oa polokelo: 2-8°C
Ponahalo: Phofo e tšoeu
Sebelisa: khahlanong le botsofali
Mosebetsi:
1.Nicotinamide mononucleotide liseleng tsa motho e phetha karolo ea bohlokoa ho hlahisa matla, e kenyelelitsoe ho NAD ea intracellular (nicotinamide adenine dinucleotide, phetoho ea bohlokoa ea coenzyme) synthesis, e sebelisoang ho thibela botsofali, ho oa ha tsoekere ea mali le lihlahisoa tse ling tsa tlhokomelo ea bophelo.
2. Nicotinamide Mononucleotide ke vithamine e qhibilihang ka metsing, Sehlahisoa ke phofo e tšoeu ea crystalline, ha e na monko kapa e batla e se na monko, e baba ka tatso, e qhibiliha ka bolokolohi metsing kapa ethanol, e qhibiliha ka glycerin.
3.Nicotinamide Mononucleotide e bonolo ho monya molomo, 'me e ka ajoa haholo' meleng, metabolites e feteletseng kapa prototype e potlakela ho leleka moroto.Nicotinamide ke karolo ea coenzyme I le coenzyme II, e bapala karolo ea phano ea haedrojene ho ketane ea phefumoloho ea bioloji, e ka khothaletsa lits'ebetso tsa bioloji le metabolism ea lisele, ho boloka lisele tse tloaelehileng (haholo-holo letlalo, tšilo ea lijo le tsamaiso ea methapo) botšepehi bo na le karolo ea bohlokoa. .
Ho phaella moo, nicotinamide e na le thibelo le phekolo ea thibelo ea pelo, ts'ebetso ea node ea sinus le li-arrhythmias tsa liteko tse khahlanong le kapele, nicotinamide e ka ntlafatsa haholo lebelo la pelo le "atrioventricular block" e bakoang ke verapamil.
