Oleanolic acid e leng pentacyclic triterpenoids tse tharo tse arohaneng le limela tsa Gentianaceae tsa Swertia mileensis joang bohle kapa litholoana tsa privet, tse nang le 'mele o lokolohileng le glycosides limela tse ngata.Oleanolic acid e na le mefuta e mengata ea limela, 'me karolelano ea litaba ke 0.2% - 2%.Cucurbitaceae e phahameng ke 1.5% ~ hunchback bottom 2%, privet fruit content ea 0.6% ~ 0.7%.Oleanolic acid ke mofuta oa motsoako oa pentacyclic triterpenoid o arohaneng le litholoana tsa mofuta oa Asteraceae, Syzygium sylvestris, kapa Ligustrum lucidum.Ke adjuvant ea lefu la sebete 'me e sebelisoa ka bongaka bakeng sa tšoaetso ea phekolo.Acute jaundice hepatitis e na le liphello tse totobetseng ho fokotsa alanine aminotransferase le yellowing.Oolic acid ke pentacyclic triterpenoids e arohaneng le litholoana tsa swertia chinensis kapa fructus ligustris ho tloha semela sa gentianaceae.Oleanolic acid e fumaneha haholo limela, ka kakaretso ea 0.2% ~ 2% [1].Likahare tse tlase tsa calabash e ne e le 1.5% ~ 2%, mme litaba tsa litholoana tsa fructus ligustris e ne e le 0.6% ~ 0.7%.Oleanolic acid ke kristale e tšoeu ea acicular (ethanol), ha e na monko ebile ha e latsoehe.E sa tsitsang ho li-acids le metheo.Melting point of 308 ~ 310 ℃, [alpha] 20 d + 73.3 ° (c = 0.15, chloroform, insolble in water, soluble in methanol, ethanol, ethyl ether, acetone and chloroform.Oleanolic acid is a naturally distributed triterpe lijong le limela tsa meriana, tse amanang le betulinic acid E ka fumanoa Phytolacca americana (American pokeweed), le Syzygium spp, konofolo, joalo-joalo Ha e na chefo e batlang e le chefo, e nang le hepatoprotective, 'me e bontša thepa ea antitumor le antiviral.
Oleanolic acid e ile ea fumanoa e bontša ts'ebetso e matla e khahlanong le HIV, motsoako o amanang le betulinic o ile oa sebelisoa ho theha sethethefatsi sa pele sa khoebo sa maturation inhibitor.E ile ea ithutoa ka lekhetlo la pele 'me ea aroloa ho tsoa ho limela tse' maloa, ho kenyelletsa Rosa woodsii (makhasi), Prosopis glandulosa (makhasi le makala), Phordendron juniperinum (semela kaofela), Syzygium claviflorum (makhasi), Hyptis capitata (semela kaofela), le Ternstromia gymnanthera (ea moea). karolo).Mefuta e meng ea Syzygium e kenyeletsang java apple (Syzygium samarangense) le liapole tsa rose li na le eona.
Lebitso la Sehlahisoa: Oleanolic Acid98%
Tlhaloso: 98% ka HPLC
Mohloli oa Botanic: Olea Europea Extract
Lebitso la Lik'hemik'hale:(3β)-3-Hydroxyolean-12-en-28-oic acid
Nomoro ea CAS:508-02-1
Karolo e Sebelisitsoeng:Lekhasi
'Mala: Phofo e tšoeu e nang le monko le tatso e ikhethang
Boemo ba GMO:GMO Mahala
Ho paka: ka meqomo ea fiber ea 25kgs
Polokelo: Boloka setshelo se sa buloa sebakeng se phodileng, se omileng, Qoba hole le leseli le matla
Shelf Life: Likhoeli tse 24 ho tloha ka letsatsi la tlhahiso
Ke engasiti ea oleanolic?
Oleanolic acid (OA), tlhaho ea hydroxyl pentacyclic triterpenoid acid (HPTA) e tšoanang le betulinic acid, ursolic acid;e na le melemo e kang antibacterial, anti-inflammatory, antitumor activities.
U ka fumana kaeasiti ea oleanolic?
Oleanolic acid e sebelisitsoe ka moetlo bakeng sa kalafo ea mafu a fapaneng, o ka e fumana lijong le limela ka bongata.
Litholoana tse ling tse kang liapole, kharenate, lemon, li-bilberries, mohloaare le tsona li na le oleanolic acid.
| Lebitso la Herb | Lintho tse nang le oleanolic acid | Mokhoa oa teko |
| Ligustrum lucidum Ait | 0.8028% | HPLC |
| Verbena Officinalis L | 0.071%-0.086% | HPLC |
| Prunella vulgaris L | 3.47%-4.46% | HPLC |
| Hemsley Chinensis Cogn. | 1.5%～2% | HPLC |
Hona joale, Sechaena setlamaHemsley Chinensis Cogne ntse e le thepa e tala ka ho fetisisa ea khoebo bakeng sa ho ntša oleanolic acid.
Hemsley Chinensis Cogn.Selelekela
Hemsleya chinensis Cogn.ke setlama sa ho hloa se sa feleng, hape ke moriana oa setso oa Machaena.
Familia: Cucurbitaceae
Tribus: Gomphogyneae
Mofuta: Hemsleya
Mefuta: H. mabilis
Setlama se ajoa liprofinseng tsa Guangxi, Sichuan, Guizhou, Yunnan, Hubei, joalo-joalo. O hlahetse moeling oa meru le lihlahla tsa phula sebakeng se bophahamo ba limithara tse ka bang 2,000.
Lisebelisoa tse sebetsang: e na le Hemslolide Mal, Ma3, H1;Chikusetsaponin-Iva;dihydro cucurbitacin F-25-acetate;dilydrocucurbitacin F;oleanolic acid-beta-Hlucosyloleanolate;Hemsamabilinin A;Cu-curbitacinⅡb-2-beta-D-glucopyranoside.
Boleng ba meriana:
Hemsleya chinensis Cogn.ke haholo-holo bakeng sa detoxification, sterilization, anti-inflammatory, ho matlafatsa mala le ho kokobetsa bohloko.Hona joale, ho na le li-extracts phofo, kapa litokisetso tsa motsoako tse kang li-capsules, matlapa, lipilisi tsa ka mpeng, joalo-joalo, tse sebelisoang haholo litsing tsa bongaka.
Ho ntšoa ha Oleanolic acid ho tlohaHemsleya Chinensis Cogn.
Liforomo tse nang le Oleanolic acid ho li-supplement tsa Lijo
Re fumane hore oleanolic acid e sebelisoang litlatsetsong tsa bophelo bo botle haholo-holo e tsoa mefuteng e meraro ea limela tse qotsitsoeng: Loquat leaf extract, Hemsley Chinensis extract, le Holy Basil extract.
- Phofo e halalelang ea Basil (lekhasi) (0.4% Ursolic acid le Oleanolic acid, 2.0 mg)
- Holy Basil supercritical CO2 extract (lekhasi) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid le Oleanolic acid, 1.5 mg)
- Loquat Extract (tholoana) (e fanang ka Ursolic acid, Oleanolic Acid) (E Eketsehileng ho Ursolic Acid Ka Ho Sebelisa 125mg)
Oleanolic acid VS Ursolic acid
Oleanolic acid (OA) le ursolic acid (UA) ke li-triterpenoids tsa tlhaho tse nang le sebopeho sa lik'hemik'hale tse tšoanang.
Metsoako ena ea triterpenoids e tsejoa hore e teng litlamang tsa meriana le lijong.
Li na le lintho tse ngata tse tloaelehileng tsa meriana: hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV activity, antioxidant, le antifertility.
Phapang ea OA le UA:
| Lebitso la Sehlahiswa | Oleanolic acid | Ursolic acid |
| CAS NO. | 508-02-1 | 77-52-1 |
| Pentacyclic triterpenes | β-Amyrin | α-Amyrin |
| Mehloli ea litlama | Lekhasi la Loquat, Basil e Halalelang, Rosemary, lekhasi la Mohloaare.etc. | |
| Litlhaloso | 40%,98% phofo | 15%,25%,50%,98%phofo |
| Ponahalo(mmala le monko) | 40% e mosehla o khanyang98%phofo e tšoeu e sa nkheng | 15% -50% sootho-mosehla kapa mosehla98%phofo e tšoeuTlhahiso |
| Ho khetholla | IR:(1355~1392cm-1) litlhōrō tse peli(1245~1330cm-1) litlhōrō tse tharoNMR:δ(C12)122.1,δ(C13)143.4 | (1355-1392cm).-1litlhōrō tse tharo (1245 ~ 1330cm-1) litlhōrō tse tharoδ(C12)125.5,δ(C13)138.0 |
| Litlhahiso | Oleanolic sodium letsoaiOleanolic acid phosphate disodium letsoai3-oxo oleanolic acid bardoxolone methyl (CDDO-Me) | Ursolic sodium letsoai le dicarboxylic acid e tsoang halofo ea ester Ursolic acid ketene derivatives3-carbon ursolic acid 3-acetoxyursolic acid |
| Anticancer e ka bang teng | UA e tumme ho feta OA. | |
Mesebetsi ea Biological ea Oleanolic Acid
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Liphello tsa Anti-Tumor/Anti-Cancer
Tšusumetso e thibelang ea oleanolic acid ho hepatocellular carcinoma ka ERK-p53-mediated cell cycle ho tšoaroa le apoptosis e itšetlehileng ka mitochondrial.
– ka Xin Wang, Hua Bai, joalo-joalo Bafuputsi
OA e bonts'itse phello ea inhibitory ho HCC ka ho kenngoa ha apoptosis le ho ts'oaroa ha cell cycle ho lihlahala tse fetisitsoeng le liseleng tsa HepG2.
OA e hlahisitse apoptosis ka tsela ea mitochondrial, e pakoang ke ho thibela sepheo sa Akt/mammalian sa tsela ea rapamycin.
OA e ile ea etsa hore G2/M e ts'oaroe ka li-cell cycle ka p21-mediated down-regulation ea cyclin B1/cdc2.
OA e bonts'itse mesebetsi ea bohlokoa ea antitumor ho HCC in vivo le in vitro models.Lintlha tsena li fana ka temohisiso e ncha mabapi le mekhoa e thehiloeng ho phello ea antitumor ea OA.
Ntle le moo, lipatlisiso li bonts'a hore OA le motsoako oa eona oa Oleanolic acid methyl ester le tsona li na le litlamorao ho mofetše oa matsoele, mofets'e oa matšoafo, mofetše oa senya, mofets'e oa popelo, lisele tsa mofetše oa pancreatic ...
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Mosebetsi oa Antimicrobial
OA e lebelletsoe ho ba le tšebetso ea antimicrobial khahlano le mefuta e mengata ea likokoana-hloko hobane e bapala karolo ea bohlokoa ho sireletseng khahlanong le likokoana-hloko tse limela.
OA e bontšitse ts'ebetso e itekanetseng khahlano le Staphylococcus aureus le Bacillus Thuringiensis ka 62.5 µg/mL le Escherichia coli, Salmonella Enterica, le Shigella dysenteriae ho 31.2 µg/mL minimum inhibitory concentration (MIC).
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Matla a Hepatoprotective
E 'ngoe ea li-bioactivities tse hlokomelehang tsa OA ke ts'ireletso ea sebete khahlano le chefo 'me hajoale e ntse e sebelisoa e le setlhare sa antihepatic counter China.
Ho likhoto tsa Wistar albino, OA e tsoang Flaveria Trinervia e ile ea sebelisoa 'me ea e-ba le phello e kholo ea tšireletso ho chefo ea sebete e bakoang ke ethanol ka ho tsosolosa litekanyetso tsa enzyme ea serum ea hepatotoxic.Boithuto bona bo khothalelitse bokhoni ba antioxidant ba OA joalo ka mokhoa o mong o ka khonehang oa bokhoni ba eona ba hepatoprotective.
Oleanolic acid le lihlahisoa tsa eona
Liteko tsa Oleanolic Acid Clinical
Oleanolic acid (e tsoang mohloaare), ho na le liteko tse ka bang 500 tse ngolisitsoeng tsa bongaka, li bontšitse hore e na le liphello tse molemo litekong tsa bongaka tse amanang le lefu la liphio le sa foleng, lefu la tsoekere la mofuta oa 2, le maemo a mang a ho ruruha a kang ramatiki.
Li-derivatives tse tummeng ka ho fetisisa litekong tsa meriana ke bardoxolone methyl (CDDO-Me).CDDO-Me e ile ea hlahlojoa ka tumor biopsies, 'me e ka khona ho bapala karolo ea phekolo ea lefu la liphio le sa foleng, hajoale e ntse e hlahlojoa ka litlamorao tsa khatello ea mali.
Sechaena Pharmacopoeia Tekanyetso ea Oleanolic Acid
| Lebitso la sehlahisoa | Oleanolic acid |
| Boitsebiso | (1) Nka 30mg ea sehlahisoa sena, e behe ka har'a tube ea teko, eketsa 3ml ea chloroform ho qhibiliha, eketsa marotholi a mabeli a sulfuric acid, sisinya metsotso e 5, lesela la chloroform le pherese-e khubelu. |
| (2) Nka hoo e ka bang 20mg ea sehlahisoa sena, eketsa 1ml ea acetic anhydride, e qhibilihe ka mocheso o fokolang, eketsa sulfuric acid ho 'mala o pherese,' me u fifale ka mor'a ho beha. | |
| (3)Nka hoo e ka bang 10mg ea sehlahisoa sena, eketsa vanillin glacial acetic acid solution (nka vanillin 0.5g, eketsa 10ml ea glacial acetic acid ho qhibiliha, ke hore) 0.2ml, eketsa 0.8ml ea perchloric acid, 'me ue chese metsotso e mengata. ka bateng ea metsi.Fuchsia, eketsa 2ml ea ethyl acetate, e pherese-e khubelu e qhibilihisitsoeng ka ethyl acetate, e behiloeng ntle le ho fetoha ha mebala. | |
| (4) Maqhubu a ho monya a infrared a sehlahisoa sena a lokela ho lumellana le taolo ea taolo. | |
| Boikemisetso ba tlhahiso | Nka 0.15g ea sehlahisoa sena, se lekanya ka nepo, eketsa 30ml ea ethanol, e sisinye, e chese ka bateng ea metsi a futhumetseng ho qhibiliha, tlohela ho pholile mocheso oa kamore, eketsa marotholi a 3 a phenolphthalein indicator solution, etsa tharollo ea potassium hydroxide ka ethanol ( 0.05mol / L) Titrate hang-hang 'me u lokise tlhahlobo e se nang letho.Tharollo ea potasiamo hydroxide (0.05 mol/L) ka 1 ml ea ethanol e lumellana le 22.84 mg ea C.30H48O3. |
Oleanolic acid e khothaletsa litekanyetso
Ho ea ka Chinese Pharmacopoeia Standard, Oleanolic acid Oral dose ke 20 ~ 80mg ka nako, 60 ~ 240mg ka letsatsi.
Litla-morao tsa Oleanolic acid
Oleanolic acid e sebelisitsoe e le setlhare sa hepatoprotective ka lilemo tse mashome China.
Haeba ho feta tekano kapa ho fosahetse, palo e nyenyane ea bakuli e na le molomo o omileng, letšollo, ho se utloise bohloko ka mpeng e ka holimo, 'me e ka nyamela ka mor'a phekolo ea matšoao.
Ka kopo, buisana le ngaka ea hau kapa setsebi sa meriana pele u sebelisa sehlahisoa sena.
Mosebetsi:
1.Oleanolic acid e batla e se chefo, antitumor, le hepatoprotective, hammoho le ho bontša thepa ea antiviral.
2.Oleanolic acid e fumanoe e bontša mosebetsi o matla o khahlanong le HIV.
3.Oleanolic acid ke mosireletsi ea ka sehloohong oa lisele tse khahlanong le khatello ea oxidative le electrophile.
4.Oleanolic acid e na le phello e kholo ho trating kokoana-hloko ea lefu la sebete, lefu la sebete la icteric le lefu la sebete le sa foleng.
Kopo:
1. E sebelisoa tšimong ea lijo, e ka sebetsa e le lisebelisoa tse tala tsa tee ho fokotsa phlegm;
2. E sebelisoa tšimong ea meriana, e fetoha lithethefatsi tse ncha tse khahlanong le mofetše tse nang le chefo e tlaase;
3. E sebelisoa tšimong ea litlolo, e ka matlafatsa phallo ea mali le ho tlosa seno.
| Lintlha tse ling tsa TRB | ||
| Setifikeiti sa taolo | ||
| USFDA,CEP,KOSHER HALAL GMP ISO Litifikeiti | ||
| Boleng bo Tšepahalang | ||
| Hoo e ka bang lilemo tse 20, ho romela linaheng tse 40 le libaka, lihlopha tse fetang 2000 tse hlahisoang ke TRB ha li na mathata leha e le afe a boleng, mokhoa o ikhethileng oa tlhoekiso, ho se hloeke le taolo ea bohloeki li kopana le USP,EP le CP | ||
| Comprehensive Quality System | ||
|
| ▲Sistimi ea Tiisetso ea Boleng | √ |
| ▲ Taolo ea litokomane | √ | |
| ▲ Sistimi ea netefatso | √ | |
| ▲ Sistimi ea Koetliso | √ | |
| ▲ Protocol ea Internal Audit | √ | |
| ▲ Sistimi ea Suppler Audit | √ | |
| ▲ Sistimi ea Lisebelisoa tsa Lisebelisoa | √ | |
| ▲ Sistimi ea Taolo ea Lintho | √ | |
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| ▲ Tsamaiso ea Litaba tsa Tsamaiso | √ | |
| Laola Mehloli Eohle le Mekhoa | ||
| E laoloe ka thata, lisebelisoa tsohle tse tala, lisebelisoa le liphutheloana. Lisebelisuoa tse tala tse ratoang le lisebelisoa le thepa ea ho paka ka nomoro ea US DMF. Bafani ba 'maloa ba thepa e tala e le tiisetso ea phepelo. | ||
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| Setsi sa thuto ea limela/Setheo sa Microbiology/Academy of Science and Technology/University | ||
