I-10-Deacetylbaccatin III (10-DAB)

Inkcazelo emfutshane:

I-10-Deacetylbaccatin III (C29H36O10) yi-bioactive diterpenoid ngokwemvelo ekhutshwe kwiinaliti kunye nexolo leIrhafuiintlobo (yew trees). Njengomanduleli ophambili kwi-semi-synthesis ye-paclitaxel, i-docetaxel, kunye nezinye ii-agent ze-chemotherapeutic ezisekelwe kwi-taxane, i-10-DAB isetyenziswa ngokubanzi kwi-R&D yamayeza kunye nokuveliswa kweziyobisi ze-oncology.

I-10-Deacetylbaccatin III, eyaziwa ngokuba yi-10-DAB okanye i-10-DAB III, i-organic compounds yendalo ehambelana ngokusondeleyo ehlukanisiwe kwiinaliti ezomileyo kunye namasebe amancinci omthi we-yew waseYurophu (i-Taxus baccata) . pacitaxel (taxol); cabazitaxel. I-10-10-deacetylbaccatin III ifunyenwe ukuba inqande ngokukhetha ukukhula kwe-L. DONOVANI intracellular amastigotes ngaphakathi kwe-J774 murine macrophages in vitro kwi-nanomolar concentrations kunye ne-IC (50) ixabiso le-70 nM.

FOB ixabiso:US 5 - 2000 / KG

Min.Ubungakanani boMyalelo:1KG

Ukubonelela ngezakhono:I-10000 KG / ngenyanga

Izibuko:eShanghai / eBeijing

Immimiselo yokuhlawula:L/C,D/A,D/P,T/T,O/A

Imigaqo yokuthumela ngenqanawe:Ngolwandle/Ngomoya/ngeCourier

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Igama lomchiza:	I-10-Deacetylbaccatin III
Inombolo yeCAS:	32981-86-5
Izithethantonye:	10-Desacetylbaccatin III; I-10β-Deacetylbaccatin III; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dod ecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-enye; 7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-enye, 12b-(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-; (Docetaxel USP Ukungcola);I-10-Deacetylbaccatin III; 10-Deacetyl baccatin; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-1,2a,3,4,4a,6,9,10,11,12,12a, 12b-Dodecahydro-4,6,9,11,12,12b-hexahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-enye 12b-acetate, 12-acetate (USP-benzo);
Imo yemolekyuli:	C29H36O10
Imbonakalo:	Okumhlophe Okuqinileyo
Mol. Ubunzima:	544.6
Ugcino:	2-8 ° C efrijini

Isihlokwana: I-API ye-Plant-Derived Intermediate, CAS32981-86-5| Isiqinisekiso se-GMP, i-COA ibonelelwe

Yintoni i-10-Deacetylbaccatin III?10-DAB)?

IiNgcaciso eziPhambili kunye neMiba

Ubunyulu: ≥98% (i-HPLC-UV iqinisekisiwe, i-COA ikhona)
Imbonakalo: Emhlophe ukuya kumhlophe-umgubo wekristale
Ukunyibilika: Inyibilika kwi-methanol, i-ethanol, i-DMSO; Inyibilika kancinane emanzini
Ugcino: Izinzile kwi -20°C kwizikhongozeli ezingangeni moya, zikhuselwe ekukhanyeni
Umthombo wezityalo: Zivunwe ngokuzinzileyoTaxus wallichiana(Yew Himalayan)

Usetyenziso lwe-10-DAB

I-Anticancer Drug Synthesis
- I-intermediate ebalulekileyo kwimveliso ye-semi-synthetic ye-paclitaxel (i-Taxol®) kunye ne-docetaxel (i-Taxotere®).
- Isetyenziswa kwi-R&D kwizinto ezintsha ze-taxane ezijolise kumhlaza onganyangekiyo ngamachiza.
Uphando lweBiochemical
- Uphononongo lweendlela ze-tubulin polymerization kunye ne-apoptosis induction.
- Umgangatho wereferensi yekhemistri yohlalutyo kunye nolawulo lomgangatho.
Ukutsalwa kweMveliso yeNdalo
- Inkqubo yokukhutshwa kwesivuno esiphezulu ihambelana nemigaqo ye-chemistry eluhlaza.

Kutheni uMthombo we-10-DAB uvela kuthi?

✅ Umgangatho oqinisekisiweyo:

IBatch-specific Certificate of Analysis (COA) kunye ne-HPLC, MS, idatha ye-NMR.
Iyahambelana nezikhokelo ze-USP, EP, kunye ne-ICH Q7 GMP.

✅ Ubonelelo oluZinzileyo:

Kuvunwa ngokusesikweni kumasimi alinywayo eTaxus (i-CITES Appendix II iyahambelana).

✅ ULungiselelo lweHlabathi:

Ukuhambisa ngenqanawa ngekhonkco ebandayo ukuya e-USA, EU, nakwimimandla ye-APAC.
Ukupakishwa okwenziwe ngokwezifiso (i-1g ukuya kwi-1kg, i-amber glass vials kunye ne-desiccant).

Inkxaso yobuGcisa kunye noXwebhu

I-MSDS yasimahla (iPhepha leDatha loKhuseleko lweMathiriyeli) kunye nedatha yokuzinza xa uceliwe.
Udibaniso lwesiko kunye namaxabiso amaninzi akhoyo kumaqabane e-OEM.
Inkxaso yolawulo ezinikeleyo yokungeniswa kwe-IND/NDA.

Ukhuseleko kunye nokuThobela

Inombolo yeCAS: 32981-86-5
Iikhowudi zeHazard: Bamba ngePPE (iiglavu, iiglasi) - engeyongozi kusetyenziso lobungcali.
Ubume boLawulo: REACH ebhalisiweyo; I-DMF iyafumaneka kubathengi bamayeza.

Ii-FAQ ze-10-DAB

Umbuzo: Ngaba i-10-DAB ingasetyenziswa ngokuthe ngqo kwizifundo zenkcubeko yeeseli?
A: Hayi. Ifuna ukuguqulwa kweekhemikhali (umzekelo, ukongezwa kwe-side-chain) ukuze ibe yi-bioactive taxanes.

Umbuzo: Liliphi ixesha elikhokelayo kwii-odolo ze-500g?
A: Ixesha eliqhelekileyo lokuvelisa: iiveki ze-2-3. Ukuhanjiswa ngenqanawe kuyafumaneka.

Umbuzo: Ngaba uyabonelela ngeeprothokholi ze-taxane synthesis?
A: Ewe! Amaphepha amhlophe obugcisa afumanekayo kubathengi abafanelekileyo.

Inkcazo:
Umthombo we-98% we-HPLC-grade 10-Deacetylbaccatin III (CAS 32981-86-5) - Isicatshulwa se-Taxus esiqinisekisiweyo se-GMP se-paclitaxel synthesis. Ii-odolo ezininzi, i-COA/MSDS, kunye nenkxaso yolawulo ibandakanyiwe.

Amagama angundoqo:
- Okuphambili: "10-Deacetylbaccatin III umthengisi", "Ucoceko oluphezulu 10-DAB", "i-Paclitaxel precursor"
- Umsila omde: "ixabiso le-CAS 32981-86-5", "isicatshulwa se-Taxus sophando lomhlaza", "GMP 10-DAB"
Amagama angundoqo:
- “Taxane intermediate”, “semi-synthetic paclitaxel”, “C29H36O10″, “yew tree compound”