Hesperidin Methyl ChalconeI-98% yi-UV: Inkcazo yeMveliso eBanzi
1. Intshayelelo ye-Hesperidin Methyl Chalcone (HMC)
I-Hesperidin Methyl Chalcone (HMC) yi-methylated derivative ye-hesperidin, i-flavonoid ngokwemvelo ininzi kwiziqhamo ze-citrus ezifana ne-orenji, i-lemons, kunye ne-grapefruits. Ngokucoceka okugqitywe yi-UV ye-≥98%, le khompawundi yamkelwa ngokubanzi ngezibonelelo zayo ezinamacala amaninzi kwimpilo yemithambo, ukhathalelo lwesikhumba, kunye nokhuseleko lwe-antioxidant. Ifomyula yayo ye-molecular C29H36O15 (ubunzima be-molecular: 624.59 g / mol), kwaye ibonakaliswe nge-yellow yellow to orange crystalline powder ene-hygroscopic kunye ne-soluble emanzini, i-ethanol kunye ne-methanol.
2. IiNkcazo zeMveliso
- Inombolo yeCAS:24292-52-2
- Ubunyulu: ≥98% ngohlalutyo lwe-UV
- Imbonakalo: Umgubo wekristale otyheli ukuya kuorenji
- Ukunyibilika:Ugcino: Gcina kwindawo epholileyo neyomileyo (2–8°C) kude nokukhanya nokufuma. Ubomi beshelufu: iminyaka emi-2.
- Inyibilika simahla emanzini, ethanol, nakwimethanol.
- Inyibilika ngokuyinxenye kwi-ethyl acetate.
- Ukupakishwa: i-25 kg / idrum (iingxowa ze-polyethylene eziphindwe kabini ngaphakathi kwemibhobho yekhadibhodi) .
3. IiNzuzo eziPhambili kunye neendlela zokuSebenza
3.1 I-Vascular and circulatory Health
I-HMC yomeleza ii-capillaries ngokunciphisa ukungeneka kunye nokuphucula ithowuni ye-venous, iyenza isebenze ekunyangeni iimeko ezifana nokungoneli okungapheliyo kwe-venous, i-hemorrhoids, kunye ne-varicose veins. Izifundo zeklinikhi ziqaqambisa intsebenziswano kunyeRuscus aculeatusi-extract kunye ne-ascorbic acid, edibeneyo iphucula i-microcirculation kunye nokunciphisa i-edema.
3.2 Ukhathalelo lwesikhumba kunye nosetyenziso lweDermatological
- I-Anti-Redness kunye nokuNcitshiswa kweSangqa esiMnyama: I-HMC inciphisa ukuvuza kwe-capillary phantsi kwamehlo, ukunciphisa ukugqabhuka kwe-bluish kunye nokukhukhumala. Sisithako esiphambili kwiikhrimu zamehlo zeprimiyamu (umz.,MD Skincare Phakamisa Khanyisa iliso Cream,Provectin Plus Advanced Eye Cream).
- Ukukhuselwa kwe-UV kunye nokuchasana nokuguga: I-HMC inciphisa uxinzelelo lwe-UVB-induced oxidative, inqanda i-MMP-9 (i-collagen-degrading enzyme), kwaye ivuselela ukuveliswa kwe-filaggrin ukunyusa umsebenzi wokuthintela ulusu.
- I-Anti-Inflammatory and Antioxidant Effects: Ngokucinezela iindlela ze-NF-κB kunye ne-IL-6, i-HMC inciphisa ukuvuvukala kunye nomonakalo we-oxidative odibene ne-acne, i-rosacea, kunye ne-photoaging.
3.3 Umsebenzi we-Broad-Spectrum Antioxidant
I-HMC ivula indlela yokubonisa i-Nrf2, yongeza i-antioxidants engapheliyo njenge-glutathione kunye ne-superoxide dismutase. Le ndlela ikhusela kwimitha ye-UV, ungcoliseko, kunye noxinzelelo lwe-metabolic.
4. Izicelo kwiiFormula
4.1 Nutraceuticals
- Umthamo: 30-100 mg / ngosuku kwii-capsules okanye iipilisi zenkxaso ye-venous.
- Iifomula ezidityanisiweyo: Ihlala idityaniswa neI-Diosmin,Ascorbic Acid, okanyeIsicatshulwa seRuscuskuphuculo lwe-bioavailability kunye nokusebenza kakuhle .
4.2 Izinto zokuthambisa kunye nezihloko
- Ugxininiso: 0.5-3% kwiiserum, iikhrimu, kunye neegels.
- Uqulunqo olungundoqo:
- IiSerum ezichasene nokuBomvu: Yehlisa i-erythema ebusweni kunye novakalelo.
- Iimveliso ze-Eye Contour: Ijolise kwizangqa ezimnyama kunye nokukhukhumala (umz.,Kool Eye Gelkunye ne-menthol yeziphumo zokupholisa) .
- Iimveliso zokuKhathalela ilanga: Isebenza njenge-UV filter (i-absorption peak ~ 284 nm) kwaye izinzile i-Avobenzone kwi-sunscreens.
5. UQinisekiso loMgangatho kunye noKhuseleko
- Uvavanyo lokucoceka: Ithobela imigangatho ye-pharmacopeial usebenzisa i-HPLC kunye ne-IR spectroscopy.
- Iprofayili yoKhuseleko:Isimo soLawulo: Idibana nezikhokelo ze-EU kunye ne-US FDA kwizongezo zokutya kunye nezithambiso.
- Ukungacaphuki kwiidosi ezicetyiswayo (LD50> 2000 mg/kg kwiigundane).
- Akukho kuxelwa kokuguquguqukayo okanye ubutyhefu bokuzala .
6. Izinto eziluncedo kwiMarike
- I-Bioavailability ephezulu: Ukufunxa okuphezulu xa kuthelekiswa ne-hesperidin yendalo.
- Ukusebenza kwezinto ezininzi: Iidilesi zezempilo kunye neenkxalabo zobuhle (umzekelo, impilo yemithambo + yokuchasana nokuguga).
- Ukuxhaswa kweKlinikhi: Ngaphezulu kwezifundo ze-20 ezihlaziywe ngontanga ziqinisekisa ukusebenza kwayo ekukhuselweni kwe-vascular, ukuchasana kwe-UV, kunye nokulawulwa kokuvuvukala.
7. Ukuodola kunye nokwenza ngokwezifiso
- I-MOQ: I-25 kg / idrum (ukupakishwa kwesiqhelo kufumaneka).
- Amaxwebhu: I-COA, i-MSDS, kunye nedatha yokuzinza enikwe xa kuceliwe.
- Iinkonzo ze-OEM: Imixube eyenzelwe i-nutraceuticals, izithambiso, okanye amayeza.
8. Isiphelo
I-Hesperidin Methyl Chalcone 98% yi-UV yi-premium, isithako esixhaswa yisayensi kunye neenzuzo eziqinisekisiweyo zokunyaniseka kwemithambo, impilo yesikhumba, kunye nokukhusela i-oxidative. Ukuguquguquka kwayo ekuqulunqeni-ukusuka kwiikhrimu zamehlo ukuya kwizongezelelo ze-venous-yenza ibe lukhetho olucwangcisiweyo kwiimpawu ezijolise kwimpilo kunye neemarike ezigxile kubuhle.
