Orukọ ọja: Celastrol olopobobo lulú
Botanic Orisun:Olorun Ajara(Tripterygium wilfordii hook.f)
CASNo:34157-83-0
Awọ: Pupa osan gara lulú pẹlu õrùn abuda ati itọwo
Ni pato: ≥98% HPLC
GMOIpo: GMO Ọfẹ
Iṣakojọpọ: ni 25kgs okun ilu
Ibi ipamọ: Jeki apoti ti a ko ṣii ni itura, aye gbigbẹ, Jeki kuro ni ina to lagbara
Igbesi aye selifu: awọn oṣu 24 lati ọjọ iṣelọpọ
Celasttrol Powderjẹ eroja ti nṣiṣe lọwọ ni Tripterygii Radix, eyi ti o jẹ gbigbẹ gbigbẹ ati rhizome ti Ajara Ọlọrun.Nibẹ ni o wa mẹrin eya ni lapapọ, eyunTripterygium wilfordii Hook.f, Tripterygium hypoglaucum Hutch, Tripterygium regelii Sprague et Takeda, ati Tripterygium forresti Dicls.
Diterpenoids: triptolide (cas no.38748-32-2), Tripdiolide (cas no.38647-10-8), ati be be lo.
Triterpenoids: Celastrol (cas no.34157-83-0), Wilforlide A (cas no.84104-71-2), ati be be lo.
Awọn alkaloids: Wilforgine (cas no.37239-47-7), Wolverine (cas no.11088-09-8), wilforidine, ati bẹbẹ lọ.
Tripterygium jẹ pentazine triterpene ti a rii ni ti ara ni Tripterygium wilfordii.O ti wa ni munadoko ninu atọju rheumatoid Àgì.Triptolide ṣe idiwọ proteasome ati ifosiwewe iparun Kb lati ṣiṣẹ.
Celastrol (Tripterin) jẹ onidalẹkun proteasome pẹlu egboogi-iredodo ati awọn iṣẹ antioxidant.O ni imunadoko ati ni pataki ṣe idiwọ iṣẹ ṣiṣe bi chymotrypsin ti 20S proteasome pẹlu IC50 ti 2.5 μM.
Tripterine jẹ antioxidant ti o lagbara ati oluranlowo egboogi-iredodo.O jẹ onidalẹkun HSP90 tuntun kan (idiwọ eka Hsp90 / Cdc37), ni awọn ipa-egboogi-akàn (egboogi-angiogenesis - n ṣe idiwọ ikosile ifọrọhan idagbasoke endothelial ti iṣan ti iṣan);antioxidant (idiwọ fun peroxidation ọra) ati iṣẹ-ṣiṣe egboogi-iredodo (Dina iṣelọpọ ti iNOS ati awọn cytokines iredodo)
BimoolojiAakitiyan:
Celastrol (Tripterin) ni isalẹ-ṣe ilana basal ati DNA-bibajẹ oluranlowo FANCD2 monoubiquitation, atẹle nipa ibajẹ amuaradagba.Itọju Celastrol ṣe imukuro IR-induced G2 checkpoint ati ki o mu ICL oògùn-induced DNA bibajẹ ati awọn ipa inhibitory lori ẹdọfóró akàn ẹyin nipa idinku FANCD2.Celastrol ni idinamọ pataki ati awọn ipa idawọle apoptosis lori awọn sẹẹli DU145 ti o gbin ni vitro ni akoko- ati iwọn-igbẹkẹle ọna.Ipa akàn egboogi-prostate ti Celastrol jẹ apakan nipasẹ sisalẹ-iṣakoso ipele ikosile ti awọn ikanni hERG ni awọn sẹẹli DU145, ni iyanju pe Celastrol le jẹ oogun akàn pirositeti ti o pọju, ati pe ẹrọ rẹ le jẹ lati dènà awọn ikanni hERG.Celastrol ṣe ilọsiwaju colitis esiperimenta ni awọn eku aipe IL-10 nipasẹ didi ọna ami ifihan PI3K/Akt/mTOR ati iṣagbega autophagy.Celastrol ni agbara lati ṣe idiwọ iṣẹ ṣiṣe cytochrome P450 ati pe o le fa awọn ibaraẹnisọrọ egboigi.Celastrol nfa apoptosis ni awọn sẹẹli TNBC, ni iyanju pe apoptosis le jẹ laja nipasẹ aiṣedeede mitochondrial ati ipa ọna ifihan PI3K/Akt.Celastrol ṣe agbejade apoptosis ati autophagy nipasẹ ọna ifihan ROS/JNK.Celastrol ṣe idiwọ iku neuron dopaminergic ni arun Pakinsini nipasẹ mimu apoptosis mitochondrial ṣiṣẹ.
Ipa Celasttrol ni kemosensitization akàn:
Kimoterapi jẹ aṣayan itọju akọkọ fun awọn alaisan alakan.Sibẹsibẹ, kimoterapi nigbagbogbo gbọdọ ni idapo pelu awọn oogun miiran lati dinku awọn ipa ẹgbẹ ti ko dara ati yago fun ilodisi oogun.Awọn ọja adayeba ti wa ni lilo siwaju sii bi awọn itọju alaranlọwọ ni apapo pẹlu awọn ilana chemotherapy ti o wa tẹlẹ lati jẹki ipa itọju.Àpẹẹrẹ kan tí ń ṣèlérí ti irú oògùn àdánidá bẹ́ẹ̀ jẹ́ èròjà triterpene tí a ń pè ní celastrol, èyí tí ó lè ní agbára ńlá fún lílò gẹ́gẹ́ bí onímọ̀lára kẹ́míkà.Ni akọkọ ti a mọ lati Thunder God Vine, o ṣe atunṣe awọn ohun elo oncogenic pupọ gẹgẹbi NF-κB, topoisomerase II, Akt/mTOR, HSP90, STAT3, ati Notch-1.Awọn wọnyi le ja si idahun egboogi-iredodo, dẹkun idagbasoke tumo ati iwalaaye, ati imukuro angiogenesis.Ipin yii ni ṣoki ni ṣoki ipa agbara ti celastrol gẹgẹbi chemosensitizer ati awọn ọna ṣiṣe molikula ti o wa ni ipilẹ ti o ṣe agbero awọn ipa chemosensitizing ti o royin ni ọpọlọpọ awọn alakan.
