Orukọ ọja:CMS121
Orukọ miiran: CMS-121;
1,2-Benzenediol, 4- [4- (cyclopentyloxy) -2-quinolinyl] -;
4- (4- (cyclopentyloxy) quinolin-2-yl) benzene-1,2-diol (CMS121);
ACC, AcetylCoenzymeACarboxylase, arun, neuroprotective, dojuti, egboogi-iredodo, mitochondrial, Alzheimer's, antioxidative, acetylation, inhibitor, H3K9, Acetyl-CoACarboxylase, CMS121, iyawere, ACC1, CMS-121
CAS RARA.:1353224-53-9
Ayẹwo: 98.0% min
Awọ: Ina ofeefee lulú
Iṣakojọpọ: 25kg/DRUMS
4- (4- (cyclopentyloxy) quinolin-2-yl) benzene-1,2-diol jẹ apopọ ti a npe ni CMS121. Idiju igbekalẹ agbo naa daba pe o le ni awọn ohun-ini alailẹgbẹ ati awọn lilo agbara. Lati loye pataki rẹ, o ṣe iranlọwọ lati ṣe idanimọ awọn ẹgbẹ iṣẹ ṣiṣe ti o wa ati ṣe itupalẹ ipa agbara wọn
CMS121 jẹ aropo quin oline ti o ni neuroprotective, egboogi-iredodo, antioxidative, ati awọn iṣẹ isọdọtun. O ṣetọju awọn ipele glutathione (GSH) ni awọn sẹẹli Hippocampal eku HT22 ni vitro ni iwaju glutamate, nfa iyatọ ti awọn sẹẹli PC12, ṣe idiwọ imuṣiṣẹ N9 microglial LPS ti o fa nipasẹ 82% ni N9 microglia, ati pe o fa awọn ipilẹṣẹ ọfẹ ni ifọkansi iṣẹ deede Trolox. (TEAC) ayẹwo. CMS121 ṣe aabo lodi si ischemia ati oxytosis ninu awọn iboju phenotypic ninu awọn sẹẹli HT22 in vitro pẹlu awọn iye EC50 ti 7 ati 200 nM fun idilọwọ iodoacetic acid- tabi iku sẹẹli ti o fa glutamate, lẹsẹsẹ. O tun jẹ renoprotective, idinku pipadanu iwuwo kidinrin ati idinku ikosile ti TNF-α, caspase-1, ati inducible nit ric oxi de synthase (iNOS) ninu awoṣe asin SAMP8 kan ti arun kidirin onibaje ti o ni nkan ṣe pẹlu ogbologbo iyara nigbati a nṣakoso ni iwọn lilo kan. ti 10 mg / kg fun ọjọ kan ti o bẹrẹ ni osu mẹsan ọjọ ori.
4- (4- (cyclopentyloxy) quinolin-2-yl) benzene-1,2-diol jẹ apopọ ti a npe ni CMS121. Idiju igbekalẹ agbo naa daba pe o le ni awọn ohun-ini alailẹgbẹ ati awọn lilo agbara. Lati loye pataki rẹ, o ṣe iranlọwọ lati ṣe idanimọ awọn ẹgbẹ iṣẹ ṣiṣe ti o wa ati ṣe itupalẹ ipa agbara wọn. Iwaju iwọn quinoline ni imọran pe agbo-ara le ṣiṣẹ ni biologically. Awọn ohun alumọni ti o ni Quinoline ni a mọ fun awọn ohun-ini ti ẹda ti o yatọ, pẹlu awọn iṣẹ ṣiṣe antibacterial ati egboogi-iredodo. Asomọ ti ẹgbẹ cyclopentyloxy le ṣe alabapin si solubility ti yellow tabi mu iṣẹ ṣiṣe ti ibi rẹ pọ si nipasẹ awọn ipa sitẹriiki. Ninu awọn ẹkọ lori awọn sẹẹli HT22, CMS-121 ti ṣe afihan awọn ipa neuroprotective pataki, aabo aabo awọn sẹẹli wọnyi ni imunadoko lati ischemia ati ibajẹ oxidative. Pẹlupẹlu, CMS-121 ni awọn ohun-ini egboogi-egbogi pataki, ti o nfihan agbara rẹ lati ṣe atunṣe awọn idahun iredodo. Nipa ṣiṣe bẹ, CMS-121 ni agbara lati dinku igbona ni orisirisi awọn ara ati awọn ara. CMS-121 ni iṣẹ elegbogi ti o lagbara bi oludena ti acetyl-CoA carboxylase 1 (ACC1). Awọn oniwe-agbara inhibitory ipa lori ACC1 mu ki o kan ni ileri yellow
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