Beta-nicotinamide Mononucleotide (NMN), ọja ti iṣesi NAMPT ati aarin NAD + bọtini kan, ṣe imudara ailagbara glukosi nipasẹ mimu-pada sipo awọn ipele NAD + ninu awọn eku T2D ti o fa HFD.NMN tun ṣe alekun ifamọ hisulini ẹdọ ati mimu-pada sipo ikosile jiini ti o ni ibatan si aapọn oxidative, idahun iredodo, ati rhythm ti circadian, ni apakan nipasẹ imuṣiṣẹ SIRT1.NMN ni a lo fun kikọ ẹkọ awọn idii abuda laarin awọn aptamers RNA ati awọn ilana imuṣiṣẹ ribozyme ti o kan β-nicotinamide mononucleotide (Beta-NMN) -awọn ajẹkù RNA ti mu ṣiṣẹ.
Nicotinamide mononucleotide ("NMN" ati "β-NMN") jẹ nucleotide ti o wa lati ribose ati nicotinamide.Niacinamide (nicotinamide,) jẹ fọọmu ti Vitamin B3 (niacin.) Gẹgẹbi ipilẹṣẹ biochemical ti NAD +, o le wulo ni idena ti pellagra.
Fọọmu ti ko ni idojukọ, niacin, ni a rii ni ọpọlọpọ awọn orisun ijẹẹmu: Epa, Olu (portobello, ti ibeere), Avocados, Ewa alawọ ewe (tuntun), ati diẹ ninu awọn ẹja ati ẹran ẹran.
Ninu awọn ẹkọ [lori awọn eku], NMN ti han lati yiyipada aiṣedeede iṣọn-ẹjẹ ti ọjọ-ori nipasẹ idinku aapọn oxidative.
Orukọ: Beta-Nicotinamide Mononucleotide
CAS : 1094-61-7
Orukọ ọja: Beta-Nicotinamide Mononucleotide;NMN
Orukọ miiran: β-D-NMN; BETA-NMN; beta-D-NMN; NMN zwitterion; Nicotinamide Ribotide; Nicotinamide nucleotide; Nicotimide mononucleotide; Nicotinamide mononuclotide
CAS: 1094-61-7
Ilana molikula: C11H15N2O8P
Iwọn Molikula: 334.22
Mimọ: 98%
Ibi ipamọ otutu: 2-8°C
Irisi: funfun lulú
Lo: egboogi-ti ogbo
Iṣẹ:
1.Nicotinamide mononucleotide ninu awọn sẹẹli eniyan ṣe ipa pataki ninu iran agbara, o ni ipa ninu NAD intracellular (nicotinamide adenine dinucleotide, iyipada agbara sẹẹli pataki coenzyme) iṣelọpọ, ti a lo ninu egboogi-ti ogbo, isubu suga ẹjẹ ati awọn ọja itọju ilera miiran.
2. Nicotinamide Mononucleotide jẹ Vitamin ti o ni omi-omi, Ọja naa jẹ funfun crystalline lulú, odorless tabi fere olfato, kikorò ni itọwo, larọwọto tiotuka ninu omi tabi ethanol, tituka ni glycerin.
3.Nicotinamide Mononucleotide jẹ rọrun lati fa ẹnu, ati pe o le pin kaakiri ninu ara, awọn metabolites ti o pọju tabi Afọwọkọ ni kiakia yọ jade lati ito.Nicotinamide jẹ apakan ti coenzyme I ati coenzyme II, ṣe ipa ti ifijiṣẹ hydrogen ni pq atẹgun oxidation ti ibi, le ṣe igbelaruge awọn ilana ifoyina ti ibi ati iṣelọpọ ti ara, ṣetọju awọ ara deede (paapaa awọ ara, apa ounjẹ ati eto aifọkanbalẹ) iduroṣinṣin ni ipa pataki .
Ni afikun, nicotinamide ni o ni idena ati itoju ti okan Àkọsílẹ, sinus ipade iṣẹ ati egboogi-sare esiperimenta arrhythmias, nicotinamide le significantly mu awọn okan oṣuwọn ati atrioventricular block ṣẹlẹ nipasẹ verapamil.
