Sunan samfur:Saukewa: CMS121
Wani Suna: CMS-121;
1,2-Benzenediol,4-[4- (cyclopentyloxy) -2-quinolinyl] -;
4- (4- (cyclopentyloxy) quinolin-2-yl) benzene-1,2-diol (CMS121);
ACC, AcetylCoenzymeACarboxylase, Cuta, Neuroprotective, hanawa, anti-mai kumburi, mitochondrial, Alzheimer ta, Antioxidative, acetylation, Inhibitor, H3K9, Acetyl-CoACarboxylase, CMS121, Dementia, ACC1, CMS-121
CAS NO.:1353224-53-9
Matsakaicin: 98.0% Min
Launi: Hasken rawaya foda
Shiryawa:25kg/DRUMS
4- (4- (cyclopentyloxy) quinolin-2-yl) benzene-1,2-diol wani fili ne wanda ake kira CMS121. Rukunin tsarin mahallin yana nuna yana iya samun kaddarori na musamman da yuwuwar amfani. Don fahimtar mahimmancinsa, yana taimakawa wajen gano ƙungiyoyi masu aiki da suke gabatarwa da kuma nazarin tasirin su
CMS121 shine quin oline wanda aka maye gurbinsa wanda ke da neuroprotective, anti-inflammatory, antioxidative, da ayyukan renoprotective. Yana kula da matakan glutathione (GSH) a cikin HT22 linzamin kwamfuta hippocampal Kwayoyin in vitro a gaban glutamate, haifar da bambance-bambancen na PC12 Kwayoyin, hana LPS-jawo N9 microglial kunnawa da 82% a cikin N9 microglia, kuma scavenges free radicals a cikin wani Trolox daidai taro taro. (TEAC) bincike. CMS121 yana kare kariya daga ischemia da oxytosis a cikin phenotypic fuska a cikin kwayoyin HT22 a cikin vitro tare da ƙimar EC50 na 7 da 200 nM don hana iodoacetic acid- ko glutamate-induced cell mutuwar, bi da bi. Har ila yau, ba shi da kariya, rage yawan asarar koda da kuma rage bayyanar TNF-α, caspase-1, da inducible nit ric oxi de synthase (iNOS) a cikin samfurin linzamin kwamfuta na SAMP8 na cututtukan koda na yau da kullum da ke hade da saurin tsufa lokacin da aka gudanar a wani kashi. na 10 mg / kg kowace rana farawa daga watanni tara.
4- (4- (cyclopentyloxy) quinolin-2-yl) benzene-1,2-diol wani fili ne wanda ake kira CMS121. Rukunin tsarin mahallin yana nuna yana iya samun kaddarori na musamman da yuwuwar amfani. Don fahimtar mahimmancinsa, yana taimakawa wajen gano ƙungiyoyi masu aiki da suke gabatarwa da kuma nazarin tasirin su. Kasancewar zoben quinoline yana nuna cewa fili yana iya aiki da ilimin halitta. Kwayoyin da aka samu Quinoline an san su don nau'ikan abubuwan halitta na halitta, gami da ayyukan ƙwayoyin cuta da ƙwayoyin cuta. Haɗe-haɗe na ƙungiyar cyclopentyloxy na iya ba da gudummawa ga solubility na fili ko haɓaka ayyukan nazarin halittu ta hanyar sakamako masu illa. A cikin nazarin kan kwayoyin HT22, CMS-121 ya nuna muhimmancin tasirin neuroprotective, yana kare lafiyar waɗannan kwayoyin halitta daga ischemia da lalacewar oxidative. Bugu da ƙari kuma, CMS-121 yana da mahimman kaddarorin anti-mai kumburi, yana nuna ikonsa don daidaita martanin kumburi. Ta yin haka, CMS-121 yana da damar rage kumburi a cikin kyallen takarda da gabobin daban-daban. CMS-121 yana da aiki mai ƙarfi na pharmacological azaman mai hana acetyl-CoA carboxylase 1 (ACC1). Babban tasirin hanawa akan ACC1 ya sa ya zama fili mai ban sha'awa
Aikace-aikace:
