Inoa mea kūʻai:Lupeol Pauda98%
Puna Botanic: Mango, Acacia visco, Abronia villosa, Kofe Dandelion.
CASNo:545-47-1
kala kala:Keʻokeʻo a keʻokeʻopauda me ke ʻala a me ka ʻono
Hōʻike: ≥98% HPLC
GMOKūlana: GMO Free
Hoʻopili: ma 25kgs fiber drums
Ka mālama ʻana: E mālama i ka pahu i wehe ʻole ʻia ma kahi maloʻo a maloʻo, e haʻalele i ka mālamalama ikaika
Ola Ola: 24 mahina mai ka lā i hana ʻia
Ka hana olaola:
ʻO Lupeol (Clerodol; Monogynol B; Fagarasterol) he triterpenoid pentacyclic ikaika, he anti-oxidant, anti-mutagenic, anti-tumor a me ka hana anti-inflammatory.He ikaika ka Lupeolmea hoʻokipa androgen(AR) inhibitor a hiki ke hoʻohana nomaʻi ʻaʻainoiʻi, ʻoi aku ka prostatemaʻi ʻaʻaio ka androgen-dependent phenotype (ADPC) a me ka castration resistant phenotype (CRPC)[1].
In Vitro Noiʻi:
ʻO Lupeol kahi mea hoʻopaneʻe AR ikaika i hiki ke hoʻomohala ʻia ma ke ʻano he lāʻau lapaʻau no ka mālama ʻana i ka maʻi maʻi prostate kanaka (CaP).Lupeol (10-50 μM) lapaʻau no 48 h i ka hopena i ka hopena o ka ulu ʻana o ka nui o ka androgen-dependent phenotype (ADPC), ʻo ia hoʻi nā pūnae LAPC4 a me LNCaP, me IC50 o 15.9 a me 17.3 μM.Ua kāohi pū ʻo Lupeol i ka ulu ʻana o 22Rν_1 me kahi IC50 o 19.1 μM.Eia hou, ua kāohiʻo Lupeol i ka uluʻana o nā pūnaewele C4-2b me kahi IC50 o 25 μM.Loaʻa iā Lupeol ka mea hiki ke pale i ka ulu ʻana o nā pūnae CaP o nā phenotypes ADPC a me CRPC.ʻIke ʻia nā Androgens e hoʻoulu i ka ulu ʻana o nā pūnae CaP ma o ka hoʻāla ʻana o ka AR[1]
Ma ka ʻimi noiʻi ʻo Vivo:
He lāʻau lapaʻau maikaʻi ʻo Lupeol me ka hiki ke kāohi i ka tumorigenicity o nā cell CaP in vivo.Ua ana ʻia ka nui o nā pae PSA serum e holo nei (i huna ʻia e nā pūnana tumo implanted) ma ka hopena o ke aʻo ʻana i ka lā 56. Ma ka lā 56 ma hope o ka hoʻopili ʻana, ua ʻike ʻia nā pae PSA mai 11.95-12.79 ng / mL i nā holoholona mālama me nā maʻi LNCaP a ʻO nā maʻi maʻi C4-2b, kēlā me kēia.Eia naʻe, ua hōʻike ʻia nā mea i mālama ʻia ʻo Lupeol i ka emi ʻana o nā pae PSA serum mai 4.25-7.09 ng/mL.Ua hōʻike ʻia nā ʻiʻo tumora mai nā holoholona i mālama ʻia me Lupeol i hoʻemi ʻia nā pae PSA serum i hoʻohālikelike ʻia i nā mana [1]
