Khoom npe: 4-Butylresorcinol hmoov
Specification: 98% min
CAS Nr .: 18979-61-8
English synonyms: N-BUTYLRESEOCINOL.4-N-BUTYLRESORCINOL.4-BUTYLRESORCINOL.4-phenylbutane-1,3-diol.2,4-DIHYDROXY-N-BUTYLBENZEN
Cov mis mos molecular: C10H14O2
Molecular Luj: 166.22
Melting point: 50 ~ 55 ℃
Kub taw tes: 166 ℃ / 7mmHg (lit.)
Tus nqi: 0.1-5%
Pob: 1kg, 25kg
4-Butylresorcinol yog dab tsi
Lub npe tshuaj yog 4-n-butyl resorcinol, tab sis feem ntau, txhua leej txhua tus nyiam kom yooj yim sau butyl resorcinol.Thawj qhov ntxiv rau cov khoom siv ntxuav hniav dawb yog Japanese POLA, um ~ ib qho uas tso siab rau cov tshuaj ntxuav hniav dawb hauv hluav taws hauv tsev.
Nws yog tus cwj pwm los ntawm kev tsis zoo hauv dej thiab soluble hauv ethanol.
Mechanism kev ua ntawm 4-Butylresorcinol
- Tyrosinase plays lub luag haujlwm tseem ceeb hauv kev tsim melanin vim tias nws tswj hwm tus nqi ntawm melanin deposition.
- 4-n-butylresorcinol muaj cov nyhuv inhibitory ntawm melanin ntau lawm los ntawm ncaj qha inhibiting kev ua ntawm tyrosinase thiab B16 dub-ceev qog hlwb inhibiting lub synthesis ntawm tyrosinase yam tsis ua rau tej yam cytotoxicity.
- Hauv qee qhov kev tshawb fawb hauv vitro, 4-n-butylresorcinol tau pom tias inhibit melanin ntau lawm, nrog rau kev ua haujlwm tyrosinase thiab TRP-1.
- Muaj zog inhibitor ntawm tyrosinase thiab peroxidase
- Cov tawv nqaij ua kom tawv nqaij zoo thiab ua kom tawv nqaij toner
- Ib tug zoo whitening neeg sawv cev rau pigmentation ntawm daim tawv nqaij
- Zoo tiv thaiv chloasma (tshwj xeeb hyperpigmented daim tawv nqaij nyob rau hauv lub hnub)
- Nws muaj kev tiv thaiv zoo ntawm DNA kev puas tsuaj los ntawm H2O2.
- Ua pov thawj tias muaj cov nyhuv anti-glycation
Cov txiaj ntsig ntawm 4-Butylresorcinol
Vim li cas koj yuav tsum xaiv 4-Butylresorcinol
Ua ntej, peb yuav tsum paub vim li cas thiaj muaj resorcinol.
Lipofuscin yog ib qho nyuaj rau cuam tshuam nrog melanin.Feem ntau, hydroquinone yog siv rau kev kho mob zoo nkauj.
Hydroquinone yog ib qho tshuaj ntxuav hniav dawb zoo heev.Lub tshuab ntxuav hniav dawb kiag li inhibits cov haujlwm ntawm tyrosinase thiab tiv thaiv kev tsim ntawm melanin, thiab cov nyhuv yog qhov zoo heev.
Txawm li cas los xij, nws cov kev mob tshwm sim zoo sib npaug, thiab cov txiaj ntsig muaj kev phom sij ntau dua li cov txiaj ntsig ntawm kev ntxuav hniav dawb.
- Nws yog oxidizable heev nyob rau hauv cov huab cua, thiab nws yuav tsum tau siv thaum ntxiv rau cov tshuaj pleev ib ce.
- tuaj yeem ua rau liab ntawm daim tawv nqaij;
- Yog hais tias qhov concentration ntau tshaj 5%, nws yuav ua rau rhiab heev, thiab muaj cov piv txwv soj ntsuam ntawm leukoplakia.Tam sim no, US Food and Drug Administration tau teev tseg tias cov khoom siv hydroquinone nrog cov concentration ntau dua 4% yog qib kho mob thiab tsis raug tso cai ua lag luam.
Cov kws tshuaj thiab kws muag tshuaj tau hloov kho cov tshuaj muaj zog hydroquinone kom tau 4-hydroxyphenyl-beta-D-glucopyranoside, uas yog qhov peb tau hnov txog "arbutin".Qhov sib txawv ntawm hydroquinone yog tias arbutin muaj tus Tsov tus tw me me - glycoside dua hydroquinone.Nws yog ib tug pity uas cov nyhuv whitening yog heev txo.
Xyoo tsis ntev los no, cov khoom xyaw nrov tshaj plaws ntawm cov npe loj yog ntau yam derivatives ntawm benzenediol.
Tab sis lub teeb ruaj khov ntawm arbutin tsis zoo thiab tsuas yog siv tau thaum hmo ntuj.
Kev nyab xeeb ntawm 4-n-butyl resorcinol tau dhau los ua qhov tseem ceeb.Yog tsis muaj kev phiv los ntawm hydroquinone, nws muaj cov nyhuv curative zoo dua li lwm cov resorcinol derivatives.
Hauv kev sim tyrosinase kev ua si inhibition, nws cov ntaub ntawv tseem zoo dua li tus tij laug loj phenethyl resorcinol, uas yog 100 ~ 6000 npaug ntawm cov tshuaj ntxuav hniav dawb xws li kojic acid arbutin!
Tom qab ntawd hauv qhov kev sim siab tom ntej melanin B16V, nws kuj tau pom qhov zoo ntawm resorcinol derivatives - inhibition ntawm melanin ntau lawm ntawm cov concentrations uas tsis tsim cytotoxicity.
Tsis tas li ntawd, muaj ntau qhov kev sim tib neeg ntawm 4-n-butyl resorcinol.Hauv qee tus neeg mob 32 tus mob chloasma, 0.3% 4-n-butylresorcinol thiab placebo tau siv rau ntawm ob sab plhu.Ob zaug ib hnub rau 3 lub hlis, qhov tshwm sim yog qhov txo qis ntawm cov xim hauv cov 4-n-butylresorcinol ntau dua li cov placebo.Muaj cov neeg uas ua cov pigmentation inhibition kev sim tom qab dag hnub ci, hmm ~ qhov tshwm sim yog qhov tseeb heev ~
Inhibition ntawm tib neeg tyrosinase los ntawm 4-butylresorcinol
4-butylresorcinol, kojic acid, arbutin thiab hydroquinone qhia txog L-DOPA oxidase kev ua ntawm tyrosinase.Kev txiav txim siab los ntawm ntau qhov ntau ntawm cov inhibitors tso cai rau kev suav ntawm IC50 qhov tseem ceeb.Cov ntaub ntawv no yog qhov nruab nrab ntawm peb qhov kev sim ywj pheej.
Inhibition ntawm melanin tsim nyob rau hauv MelanoDerm daim tawv nqaij qauv los ntawm 4-butylresorcinol
Sib piv nrog 4-butylresorcinol, kojic acid, arbutin thiab hydroquinone hauv melanin ntau lawm.Kev txiav txim siab ntawm melanin cov ntsiab lus ntawm daim tawv nqaij qauv tau pom tom qab 13 hnub ntawm kev cog qoob loo nyob rau hauv muaj ntau yam inhibitor concentrations.Cov ntaub ntawv no yog qhov nruab nrab ntawm tsib qhov kev sim ywj pheej.
Lub hnub nyoog qhov muag pom kev los ntawm 4-butylresorcinol
Sib piv nrog 4-butylresorcinol, kojic acid, arbutin thiab hydroquinone.Kho cov pob khaus ob zaug ib hnub rau 12 lub lis piam nrog cov tshuaj inhibitor.Txheeb xyuas qhov ua tau zoo tom qab 4, 8 thiab 12 lub lis piam.Cov ntaub ntawv sawv cev qhov nruab nrab ntawm 14 yam.* P <0.05: qhov tseem ceeb ntawm cov ntaub ntawv pov thawj piv rau cov hnub nyoog tswj tsis tau kho.
Kev noj tshuaj thiab kev siv ntawm 4-Butylresorcinol
Qhov pom zoo noj yog 0.5% -5%.Txawm hais tias muaj kev tshawb fawb hauv Kaus Lim Kauslim uas muaj qee yam cuam tshuam rau 0.1% qab zib, thiab Is Nrias teb tau tshawb fawb 0.3% qab zib tab sis kev lag luam feem ntau yog 0.5% -5%.Nws yog ntau dua, thiab cov qauv Japanese tseem tsis paub meej, tab sis POLA tau siv.Thiab cov txiaj ntsig thiab kev muag khoom tau zoo heev.
Raws li tau hais los saum no, 4-Butylresorcinol tuaj yeem siv rau hauv cov tshuaj pleev, tab sis nws yog insoluble hauv dej.Lwm yam xws li tshuaj pleev, cream, thiab gels kuj muaj.Ob leeg POLA thiab Eucerin muaj 4-Butylresorcinol cov khoom.
