Celastrol hmoov 98%

Lus piav qhia luv luv:

Celastrol Powder yog cov khoom muaj nyob hauv Tripterygii Radix, uas yog cov cag qhuav thiab rhizome ntawm Vajtswv Vine.Muaj plaub hom nyob rau hauv tag nrho, namelyTripterygium wilfordii Hook.f, Tripterygium hypoglaucum Hutch, Tripterygium regelii Sprague thiab Takeda, thiab Tripterygium forresti Dcls.


  • FOB Nqe:US $0.5 - 2000 / KG
  • Min. Order Quantity:1 KG
  • Muaj peev xwm muab khoom:10000 KG / Ib Hlis
  • Chaw nres nkoj:SHANGHAI / Beijing
  • Cov nqe lus them nqi:L / C, D / A, D / P, T / T
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  • Product Detail

    Khoom cim npe

    Khoom npe: Celastrol bulk hmoov

    Botanic Source: Vajtswv Vine(Tripterygium wilfordii nuv.f)

    CASNo:34157-83-0

    Xim: Reddish txiv kab ntxwv siv lead ua hmoov nrog cov yam ntxwv tsw thiab saj

    Specification: ≥98% HPLC

    GMOStatus: GMO Dawb

    Ntim: hauv 25kgs fiber ntau nruas

    Cia: Khaws lub thawv tsis qhib hauv qhov chaw txias, qhuav, Khaws kom deb ntawm lub teeb muaj zog

    Lub neej txee: 24 lub hlis txij li hnub tsim khoom

     

    Celastrol hmoovyog cov khoom xyaw nquag hauv Tripterygii Radix, uas yog cov cag qhuav thiab rhizome ntawm Vajtswv Vine.Muaj plaub hom nyob rau hauv tag nrho, namelyTripterygium wilfordii Hook.f, Tripterygium hypoglaucum Hutch, Tripterygium regelii Sprague thiab Takeda, thiab Tripterygium forresti Dcls.

     

    Diterpenoids: triptolide (cas no.38748-32-2), Tripdiolide (cas no.38647-10-8), thiab lwm yam.

    Triterpenoids: Celastrol (cas no.34157-83-0), Wilforlide A (cas no.84104-71-2), thiab lwm yam.

    Alkaloids: Wilforgine (cas no.37239-47-7), Wolverine (cas no.11088-09-8), wilforidine, thiab lwm yam.

    Tripterygium yog pentazine triterpene pom nyob rau hauv Tripterygium wilfordii.Nws muaj txiaj ntsig zoo hauv kev kho mob rheumatoid mob caj dab.Triptolide tiv thaiv cov proteasome thiab nuclear factor Kb los ntawm kev ua haujlwm.

     

    Celastrol (Tripterin) yog ib qho proteasome inhibitor nrog kev tiv thaiv kab mob thiab antioxidant.Nws ua tau zoo thiab nyiam inhibits chymotrypsin zoo li kev ua ntawm 20S proteasome nrog IC50 ntawm 2.5 μM.

    Tripterine yog ib tug muaj zog antioxidant thiab anti-inflammatory tus neeg sawv cev.Nws yog ib qho tshiab HSP90 inhibitor ( cuam tshuam rau Hsp90 / Cdc37 complex), muaj kev tiv thaiv kab mob qog noj ntshav (anti-angiogenesis - inhibits vascular endothelial kev loj hlob yam receptor qhia);Antioxidant (inhibits lipid peroxidation) thiab tiv thaiv kev ua haujlwm (Inhibits zus tau tej cov iNOS thiab inflammatory cytokines)

     

    BiologicalActivity:

    Celastrol (Tripterin) down-regulates basal thiab DNA-damaging tus neeg saib xyuas-induced FANCD2 monoubiquitination, ua raws li protein degradation.Celastrol kev kho mob tshem tawm IR-induced G2 checkpoint thiab txhim kho ICL tshuaj-vim DNA puas thiab inhibitory cuam tshuam rau lub ntsws cancer hlwb los ntawm depleting FANCD2.Celastrol muaj qhov tseem ceeb inhibitory thiab apoptosis-inducing teebmeem ntawm DU145 hlwb kab lis kev cai nyob rau hauv vitro nyob rau hauv ib lub sij hawm- thiab koob tshuaj-nyob ntawm seb.Celastrol's anti-prostate cancer nyhuv yog ib feem los ntawm down-regulating theem ntawm hERG channels nyob rau hauv DU145 hlwb, qhia tias Celastrol tej zaum yuav yog ib tug muaj peev xwm los tiv thaiv prostate cancer tshuaj, thiab nws mechanism tej zaum yuav thaiv hERG raws.Celastrol txhim kho kev sim colitis hauv IL-10-tsis muaj nas los ntawm inhibiting PI3K / Akt / mTOR kev taw qhia txoj hauv kev thiab txhim kho autophagy.Celastrol muaj peev xwm inhibit cytochrome P450 kev ua haujlwm thiab tuaj yeem ua rau muaj kev cuam tshuam ntawm cov tshuaj ntsuab.Celastrol induces apoptosis hauv TNBC hlwb, qhia tias apoptosis tuaj yeem kho los ntawm mitochondrial dysfunction thiab PI3K / Akt signaling pathway.Celastrol induces apoptosis thiab autophagy los ntawm ROS / JNK signaling pathway.Celastrol inhibits dopaminergic neuron tuag nyob rau hauv Parkinson tus kab mob los ntawm activating mitochondrial apoptosis.

    Celastrol lub luag haujlwm hauv kev kho mob qog noj ntshav:

    Chemotherapy tseem yog txoj kev kho mob tseem ceeb rau cov neeg mob qog noj ntshav.Txawm li cas los xij, kev siv tshuaj khomob feem ntau yuav tsum tau ua ke nrog lwm cov tshuaj kom txo qis cov kev mob tshwm sim thiab zam cov tshuaj tiv thaiv.Cov khoom siv ntuj tsim tau siv los ua kev kho mob ntxiv nrog rau cov tshuaj kho mob uas twb muaj lawm los txhim kho kev kho mob.Ib qho piv txwv zoo ntawm cov tshuaj zoo li no yog cov tshuaj triterpene hu ua celastrol, uas yuav muaj peev xwm siv tau los ua cov tshuaj loog.Keeb kwm tau txheeb xyuas los ntawm Thunder God Vine, nws tsis zoo tswj ntau yam oncogenic molecules xws li NF-κB, topoisomerase II, Akt/mTOR, HSP90, STAT3, thiab Notch-1.Cov no tuaj yeem ua rau cov tshuaj tiv thaiv kab mob, inhibit qog loj hlob thiab ciaj sia, thiab tshem tawm angiogenesis.Tshooj lus no piav qhia luv luv txog lub luag haujlwm tseem ceeb ntawm celastrol raws li chemosensitizer thiab cov txheej txheem molecular hauv qab kho nws cov kev tshaj tawm chemosensitizing teebmeem hauv ntau yam qog noj ntshav.

     


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