Khoom npe:Wogonin Bulk Powder

Botanic Source: Scutellaria baicalensis

CAS Nr:632-85-9

Lwm Lub Npe: Vogoni, wagonin, Wogonin hydrate, Vogonin Norwogonin 8-methyl ether

Specification: ≥98% HPLC

Xim: daj hmoov nrog cov yam ntxwv tsw thiab saj

GMO Status: GMO Dawb

Ntim: hauv 25kgs fiber ntau nruas

Cia: Khaws lub thawv tsis qhib hauv qhov chaw txias, qhuav, Khaws kom deb ntawm lub teeb muaj zog

Lub neej txee: 24 lub hlis txij li hnub tsim khoom

Scutellaria baicalensis muaj ntau yam tshuaj lom neeg, xws li ntau yam flavonoids, diterpenoids, polyphenols, amino acids, roj volatile, sterol, benzoic acid, thiab lwm yam.Cov hauv paus hniav qhuav muaj ntau dua 110 hom flavonoids xws li baicalin, baicalein, wogonoside, thiab wogonin, uas yog cov khoom tseem ceeb ntawm Scutellaria baicalensis.Standardized Extract zoo li 80% -90% HPLC Baicalin, 90% -98% HPLC Baicalein, 90% -95% HPLC Wogonoside, thiab 5% -98% HPLC Wogonin

Hauv Vitro Kev Ua Haujlwm: Wogonin inhibits PMA-induced COX-2 noob qhia los ntawm inhibiting c-Jun qhia thiab AP-1 ua kom hauv A549 hlwb [1].Wogonin yog ib qho inhibitor ntawm cyclin-dependent kinase 9 (CDK9) thiab thaiv phosphorylation ntawm carboxy-terminal domain ntawm RNA polymerase II ntawm Ser.Yog li, nws txo qis RNA synthesis thiab tom qab ntawd txo qis ntawm lub neej luv luv los tiv thaiv apoptotic protein myeloid cell leukemia 1 (Mcl-1) ua rau apoptosis induction hauv cov qog nqaij hlav cancer.Wogonin khi ncaj qha rau CDK9, suav tias yog ATP-binding pocketa thiab tsis cuam tshuam CDK2, CDK4 thiab CDK6 ntawm koob tshuaj uas inhibit CDK9 kev ua haujlwm.Wogonin nyiam inhibits CDK9 hauv malignant piv nrog cov lymphocytes li qub.Wogonin kuj tseem muaj zog tiv thaiv oxidant muaj peev xwm tshem tawm ?O2?[2].Wogonin cuam tshuam qhov kev hloov pauv ntawm NFATc1 los ntawm cytoplasm mus rau lub nucleus thiab nws cov kev ua haujlwm ntawm transcriptional activation.Nws kuj tseem cuam tshuam qhov sib txawv ntawm osteoclast thiab txo qhov kev hloov pauv ntawm osteoclast?associated immunoglobulin zoo li receptor, tartrate?resistant acid phosphatase thiab calcitonin receptor[4].Wogonin inhibits N-acetyltransferase kev ua

Hauv Vivo Kev Ua Haujlwm: Wogonin inhibits kev loj hlob ntawm tib neeg mob qog noj ntshav xenografts hauv vivo.Ntawm koob tshuaj tuag rau cov qog hlwb, wogonin qhia tias tsis muaj los yog me ntsis toxicity rau cov hlwb ib txwm thiab kuj tsis muaj qhov pom tseeb toxicity hauv cov tsiaj[2].Wogonin tuaj yeem ua rau apoptosis hauv murine sarcoma S180 yog li inhibiting qog loj hlob ob leeg hauv vitro thiab hauv vivo [3].Kev txhaj tshuaj intraperitoneal ntawm 200 mg / kg Wogonin tuaj yeem cuam tshuam cov kab mob leukemia thiab CEM hlwb.

Kev sim ntawm tes:

A549 hlwb yog kab lis kev cai hauv 24-zoo phaj (1.2 × 105 hlwb / zoo) 1 hnub ua ntej kev kho wogonin.DMSO lossis wogonin tau ntxiv rau hauv A549 hlwb 1 teev ua ntej PMA stimulation, thiab cov hlwb raug incubated rau lwm 6 teev.Cells raug sau los ntawm kev kho trypsin thiab cov xov tooj ntawm tes raug suav los ntawm kev siv hemocytometer thiab trypan xiav cais txoj kev.