Khoom npe:Lupeol hmoov98%
Botanic Source: Mango, Acacia visco, Abronia villosa, Dandelion kas fes.
CASNo:545-47-1 : kuv
Xim:Dawb mus rau dawbhmoov nrog cov yam ntxwv tsw thiab saj
Specification: ≥98% HPLC
GMOStatus: GMO Dawb
Ntim: hauv 25kgs fiber ntau nruas
Cia: Khaws lub thawv tsis qhib hauv qhov chaw txias, qhuav, Khaws kom deb ntawm lub teeb muaj zog
Lub neej txee: 24 lub hlis txij li hnub tsim khoom
Kev Ua Txhaum Cai:
Lupeol (Clerodol; Monogynol B; Fagarasterol) yog ib qho nquag pentacyclic triterpenoid, muaj cov tshuaj tiv thaiv oxidant, tiv thaiv mutagenic, tiv thaiv qog thiab tiv thaiv kev ua haujlwm.Lupeol yog ib tug muaj zogandrogen receptor(AR) inhibitor thiab tuaj yeem siv raumob qog noj ntshavkev tshawb fawb, tshwj xeeb tshaj yog prostatemob qog noj ntshavntawm androgen-dependent phenotype (ADPC) thiab castration resistant phenotype (CRPC)[1].
Hauv Vitro Kev tshawb fawb:
Lupeol yog ib qho muaj zog AR inhibitor uas tuaj yeem tsim los ua cov tshuaj muaj peev xwm rau kev kho mob qog noj ntshav tib neeg prostate (CaP).Lupeol (10-50 μM) kev kho mob rau 48 h ua rau muaj kev loj hlob ntawm koob tshuaj tiv thaiv ntawm androgen-dependent phenotype (ADPC) hlwb, uas yog LAPC4 thiab LNCaP hlwb, nrog IC50 ntawm 15.9 thiab 17.3 μM, feem.Lupeol kuj inhibited kev loj hlob ntawm 22Rν_1 nrog IC50 ntawm 19.1 μM.Tsis tas li ntawd, Lupeol inhibited kev loj hlob ntawm C4-2b hlwb nrog IC50 ntawm 25 μM.Lupeol muaj peev xwm inhibit qhov kev loj hlob ntawm CaP hlwb ntawm ADPC thiab CRPC phenotypes.Androgens paub tias yuav tsav kev loj hlob ntawm CaP hlwb los ntawm kev ua kom AR[1]
Hauv Vivo Research:
Lupeol yog ib qho tshuaj zoo nrog lub peev xwm los cuam tshuam cov qog nqaij hlav ntawm CaP hlwb hauv vivo.Tag nrho cov circulating serum PSA qib (tso tseg los ntawm cov qog nqaij hlav qog) tau ntsuas thaum kawg ntawm txoj kev tshawb no nyob rau hnub 56. Hnub 56 tom qab cog, PSA qib li ntawm 11.95-12.79 ng / mL tau pom nyob rau hauv cov tsiaj tswj nrog LNCaP qog thiab C4-2b qog, feem.Txawm li cas los xij, Lupeol-kho cov neeg ua haujlwm tau pom tias txo cov ntshav PSA qib ntawm 4.25-7.09 ng / mL.Cov qog nqaij hlav los ntawm cov tsiaj kho nrog Lupeol nthuav tawm txo cov ntshav PSA qib piv rau kev tswj hwm[1]
