L-ERGOTHIOONEINE 99% los ntawm HPLC
Hwm Antioxidant rau Nutraceutical & Cosmetic Applications
1. Cov Khoom Muag Khoom
L-Ergothioneine(ERT) yog ib txwm tshwm sim muaj sulfur-muaj amino acid muab tau los ntawm microbial fermentation, feem ntau pom muaj nyob rau hauv nceb xws liTricholoma tshwm simthiabHericium erinaceus yog ib qho ntawm cov kab mob. Peb cov khoom yog high-purity (≥99% los ntawm HPLC) crystalline hmoov nrog CAS No. 497-30-3, validated los ntawm nruj chromatographic tsom xam. Nws nthuav tawm kev ruaj ntseg tshwj xeeb hauv pH 4.0-6.0 formulations, ua rau nws zoo tagnrho rau cov tshuaj pleev ib ce, tshuaj pleev, thiab tshuaj pleev qhov ncauj.
Cov yam ntxwv tseem ceeb:
- Purity: ≥99% (HPLC-certified, batch-specific COA muab)
- Molecular Formula: C₉H₁₅N₃O₂S | Molecular Luj: 229.3 g / mol
- Solubility: 125 mg / mL hauv dej (ultrasonic-pab)
- Daim ntawv pov thawj: Tsis-GMO, Allergen-Free, Vegan-Friendly
2. Kev Tswj Xyuas Zoo & HPLC Txoj Kev
Peb cov txheej txheem analytical sib raug zoo nrog cov phooj ywg tshuaj xyuas raws tu qauv:
- Qauv Npaj: 1 mL kab lis kev cai nruab nrab boiled ntawm 94 ° C rau 10 min, vortexed (1600 rpm / 30 min), centrifuged (10,000 × g / 5 min), thiab khaws cia ntawm -20 ° C yog tias xav tau.
- HPLC System: Dionex Ultimate 3000 nrog Chromeleon software .
- Kem: Cortecs UPLC T3 (2.1 × 150 mm, 1.6 μm hais, 120 Å pore loj).
- Mobile Phase: Gradient elution los ntawm 0.1% formic acid mus rau 70% acetonitrile / 0.1% formic acid, txaus tus nqi 0.3 mL / min.
- Kev kuaj pom: UV absorbance ntawm 254 nm, LOQ 0.15 mmol / L.
Validation Metrics:
- Kev tawm dag zog: 0.3-10 mmol / L (R² > 0.99)
- Precision: ≤6% RSD (intra-/inter-assay)
- Rov qab: ~ 100% raug
3. Cov txiaj ntsig kev noj qab haus huv & kev siv
3.1 Kev siv Nutraceutical
- Kev Tiv Thaiv Mitochondrial: Txo oxidative kev nyuaj siab los ntawm kev tshem tawm hydroxyl radicals (IC₅₀: 2.5 μM) thiab superoxide anions.
- Kev them nyiaj yug Telomere: ncua hnub nyoog txog telomere luv luv hauv vitro .
- Dosage: Cov kev tshawb fawb soj ntsuam pom zoo 5-20 mg / hnub nce qib ERT plasma ntau heev.
Cov khoom pom zoo:
- Capsules: 100 μg–5 mg rau ib qho kev pabcuam (xws li LifeExtension's Essential Youth).
- Synergistic Blends: Ua ke nrog ferulic acid kom txhim kho bioavailability.
3.2 Kev siv tshuaj pleev ib ce
- Anti-Aging: Inhibits tyrosinase (40% txo ntawm 0.5% concentration) thiab tiv thaiv elastin los ntawm UV degradation.
- Formulation Guidelines:
- pH: 4.0-6.0 (zoo stability)
- Concentration: 0.5-2.0% hauv cov tshuaj pleev ib ce
- Compatibility: ruaj khov nrog vitamin C, hyaluronic acid, thiab peptides.
4. Kev qhia tshwj xeeb
| Parameter | Specification | Kev siv |
|---|---|---|
| Qhov tshwm sim | Dawb crystalline hmoov | |
| Purity (HPLC) | ≥99% | |
| Melting Point | 275-280 ° C (decomposes) | |
| Cia | 2-8 ° C nyob rau hauv lub thawv airtight | |
| Txee lub neej | 24 hli |
5. Kev Nyab Xeeb & Kev Tswj Xyuas Kev Ua Raws Cai
- Cov ntaub ntawv kev nyab xeeb: LD₅₀> 2000 mg / kg (qhov ncauj, nas); tsis muaj kev cuam tshuam rau tib neeg kev sim siab.
- Cov ntawv pov thawj: EU Novel Food Approval (Ergoneine®), FDA GRAS .
- Kev tuav: Siv NIOSH-pom zoo ua pa ua pa thiab cov hnab looj tes tshuaj tiv thaiv thaum ua haujlwm.
6. Kev Pabcuam Ntiaj Teb & Ntim
- Ntim Cov Kev Xaiv: 1 kg, 10 kg, 1000 kg (cov hnab aluminium foil nrog desiccant).
- Lub Sijhawm Lead: 3-5 hnub ua haujlwm (kev xa khoom thoob ntiaj teb ntawm DHL / FedEx).
- Kev Lag Luam Kev Lag Luam: Tebchaws Asmeskas, EU, Australia, Nyiv, Brazil.
7. Cov lus tseem ceeb
- Cov ntsiab lus: “L-Ergothioneine 99%HPLC", "Natural Antioxidant Supplier", "Ergothioneine for Skincare".
- suav nrog CAS 497-30-3, purity claims, and application terms.
