Tom ntej: Neohesperidin Dihydrochalcone (NHDC)

NHDC nyob rau hauv daim ntawv ntshiab yog pom raws li ib yam khoom dawb tsis zoo lihmoov qab zib.

Ib qho kev sib xyaw ua ke kwv yees li 1500-1800 lub sij hawm sweeter dua qab zib ntawm qhov pib concentrations;nyob ib ncig ntawm 340 lub sij hawm sweeter dua qab zib qhov hnyav-rau-qhov hnyav.Nws potency yog ib txwm cuam tshuam los ntawm tej yam xws li daim ntawv thov nyob rau hauv uas nws yog siv, thiab covpHntawm cov khoom.

Zoo li lwm yam qab zib heevglycosides, zoo liglycyrrhizin uathiab cov uas pom hauvstevia, NHDC lub qab zib saj muaj qhov pib qeeb dua li qab zib thiab nyob hauv lub qhov ncauj rau qee lub sijhawm.

Tsis zoo liaspartame, NHDC yog qhov ruaj khov rau qhov kub thiab txias rau cov kua qaub lossis cov kab mob yooj yim, thiab yog li siv tau rau hauv cov ntawv thov uas xav tau lub txee ntev.NHDC nws tus kheej tuaj yeem nyob nyab xeeb txog li tsib xyoos thaum khaws cia rau hauv cov xwm txheej zoo.

Cov khoom no paub zoo tias muaj kev sib koom ua ke muaj zog thaum siv nrog lwm tuskhoom qab zibxws liaspartame, saccharin, acesulfame poov tshuaj, thiabcyclamate, nrog rau qab zib cawv xws lixylitol.Kev siv NHDC txhawb nqa cov txiaj ntsig ntawm cov khoom qab zib no ntawm qhov qis dua li qhov xav tau;tsawg dua lwm cov khoom qab zib yog xav tau.Qhov no muab cov txiaj ntsig zoo.

Neohesperidin dihydrochalcone yog dab tsi?

Neohesperidin dihydrochalcone hmoov, kuj paub tias yog Neohesperidin DC, Neo-DHC thiab NHDC luv luv, yog ib qho khoom qab zib uas tsim los ntawm neohesperidin.NHDC suav hais tias yog lub zog siab, tsis muaj khoom noj qab haus huv nrog lub saj qab ntxiag;nws tuaj yeem txhim kho qhov qab zib thiab zoo ntawm cov zaub mov txawv.

Neohesperidin dihydrochalcone yog ib qho sib xyaw ua ke uas kwv yees li 1500-1800 npaug qab zib dua qab zib ntawm qhov pib qhov siab thiab nws hnyav li 340 npaug qab zib dua qab zib.

Neohesperidin dihydrochalcone feem ntau yog siv rau hauv cov khoom noj khoom haus additives industries thiab kev noj haus ntxiv.

Tshawb nrhiav thiab qhov chaw ntawm Neohesperidin dihydrochalcone

Neohesperidin dihydrochalcone tau pom nyob rau xyoo 1960 uas yog ib feem ntawm US Department of agriculture research project nrhiav txoj hauv kev los txo qhov iab hauv cov kua txiv qaub.Neohesperidin yog xws li ib tug iab tivthaiv uas muaj nyob rau hauv tev thiab pulp ntawm iab txiv kab ntxwv thiab lwm yam citrus txiv hmab txiv ntoo;Nws tseem yog ib qho active flavonoid cov khoom ntawm citrus aurantium txiv hmab txiv ntoo.Thaum kho nrog cov poov tshuaj hydroxide lossis qee lub hauv paus muaj zog, thiab tom qab ntawd hydrogenated, nws dhau los ua Neohesperidin dihydrochalcone (NHDC).

NHDC tsis tshwm sim hauv qhov xwm txheej.

Neo-DHC yog hydrogenated los ntawm tej yam ntuj tso neohesperidin - ib tug natural qhov chaw, tab sis nws underwent tshuaj hloov pauv, yog li nws tsis yog ib yam khoom ntuj.

Neohesperidin dihydrochalcone VS lwm yam sweeteners

Txawv qab zib thiab saj

Piv nrog rau sucrose, neohesperidin DC yog kwv yees li 1500-1800 npaug qab zib dua qab zib thiab 1,000 npaug qab zib dua sucrose, thaum sucralose yog 400-800 npaug thiab ace-k yog 200 npaug sweeter dua qab zib.

Neohesperidin DC saj huv si thiab muaj kev noj qab haus huv ntev.Zoo li lwm cov piam thaj siab glycosides, xws li glycyrrhizin pom hauv stevia thiab cov hauv paus licorice, NHDC lub qab zib pib qeeb dua li qab zib thiab lingers hauv lub qhov ncauj ntev.

Zoo stability thiab kev nyab xeeb siab

NHDC ruaj khov nyob rau hauv qhov kub thiab txias, acidic los yog alkaline tej yam kev mob thiab yog li ntawd yuav siv tau nyob rau hauv daim ntawv thov yuav tsum tau ib tug ntev txee lub neej.NHDC tuaj yeem khaws cov zaub mov kom nyab xeeb txog li tsib xyoos nyob rau hauv cov xwm txheej zoo

Txawv receptors

Tib neeg kev nkag siab ntawm qab zib thiab saj yog kho los ntawm T1Rs, thawj tsev neeg ntawm GPCRs, TIRs tau qhia nyob rau hauv gustatory ntawm lub palate thiab tus nplaig, nrog rau TIR1, T1R2, thiab TIR3, uas feem ntau pom nyob rau hauv daim ntawv ntawm dimers.Lub dimer T1R1-TIR3 yog ib qho amino acid receptor, uas qhia thiab koom nrog kev paub txog saj.Lub dimer T1R2-T1R3 yog cov khoom qab zib, uas koom nrog kev paub qab zib.

Cov khoom qab zib xws li sucrose, aspartame, saccharin, thiab cyclamate ua haujlwm ntawm thaj tsam extracellular qauv ntawm T1R2.NHDC thiab cyclamate ua rau ntawm qhov transmembrane ntawm T1R3 los ua kom qab zib.Neohesperidin DC cuam tshuam nrog qee cov amino acid residues nyob rau hauv cheeb tsam transmembrane ntawm T1R3 kom induce nws tus kheej qab zib thiab nyob rau tib lub sij hawm, nws muaj peev xwm induce lub synergistic sweetening nyhuv ntawm lub dimer T1R2-T1R3.Raws li cov khoom qab zib, NHDC muaj qhov ua kom qab zib tseem ceeb thaum nws sib xyaw nrog lwm cov khoom qab zib nrog cov khoom xyaw me me.

Tsis tas li ntawd, Neohesperidin DC txawv ntawm cov khoom qab zib ib txwm muaj nyob rau hauv nws cov haujlwm ntawm sweetening, aroma li, iab zais, thiab hloov tsw.

Cov txiaj ntsig thiab muaj peev xwm siv tau ntawm neohesperidin dihydrochalcone (NHDC)

Antioxidant Properties

Nyob rau hauv xyoo tas los no, ntau cov kev tshawb fawb qhia tau hais tias neohesperidin dihydrochalcone muaj ib qho tseem ceeb concentration-dependent scavenging kev ua si ntawm ruaj khov dawb radicals thiab reactive oxygen hom (ROS).Tshwj xeeb, NHDC muaj qhov cuam tshuam loj tshaj plaws ntawm H2O2 thiab HOCl.(qhov kev tshem tawm ntawm HOCl thiab H2O2 yog 93.5% thiab 73.5% feem)

Dab tsi ntxiv, NHDC tuaj yeem cuam tshuam cov protein degradation thiab cleavage ntawm plasmid DNA strand, thiab tiv thaiv HIT-T15, HUVEC cell tuag los ntawm HOCl nres.

NHDC muaj ntau yam tshuaj tiv thaiv antioxidant tiv thaiv ntau yam dawb radicals.Kev ua haujlwm antioxidant ntawm NHDC kuj tseem ua rau nws muaj peev xwm cuam tshuam cov xim xim ntawm cov xim deposition los ntawm polyphenol oxidase, uas tseem tuaj yeem cuam tshuam qhov kev tswj hwm ntawm matrix metalloproteinase (MMP-1) cuam tshuam los ntawm hluav taws xob infrared, yog li tiv thaiv tib neeg cov tawv nqaij los ntawm kev laus ntxov ntxov vim raug hluav taws xob infrared.

Daim Ntawv Thov: NHDC tuaj yeem yog qhov muaj peev xwm los tiv thaiv xim av ntxiv thiab ua kom dawb

Txo cov ntshav qab zib thiab Lower Cholesterol

NHDC yog qhov ua tau zoo, tsis muaj tshuaj lom, muaj calories tsawg uas ua rau tib neeg xav tau kev qab zib thiab yog li txo cov piam thaj kom tsawg.

Cov kev tshawb fawb tsis ntev los no tau pom tias NHDC tuaj yeem cuam tshuam α-amylase hauv cov tsiaj txhu hauv ntau qib thiab tom qab ntawd txo lub cev nqus cov suab thaj, yog li txo cov ntshav qab zib hauv lub cev, uas tseem ceeb heev hauv cov tshuaj, tshwj xeeb tshaj yog rau cov neeg mob ntshav qab zib.

Daim ntawv thov: NHDC tuaj yeem siv los ua cov khoom qab zib tsis muaj qab zib, tsis muaj calories.Thaum siv tau zoo, nws tuaj yeem hloov sucrose thiab txo cov neeg siv sucrose.Nws yog tsim rau cov neeg rog thiab tsis rog.

Tiv thaiv lub siab

Zhang Xu et al.pom tias NHDC tuaj yeem txo cov qib ALT, AST hauv cov ntshav thiab hydroxyproline hauv daim siab cov ntaub so ntswg ntawm cov nas uas muaj daim siab fibrosis vim CCI, thiab tseem ua rau cov degeneration thiab necrosis ntawm cov hlwb thiab daim siab fibrosis hauv ntau qib.Tsis tas li ntawd, qhov txo qis ntawm ALT thiab AST hauv cov ntshav tuaj yeem txhim kho lipid metabolism thiab lub siab ua haujlwm, inhibit qhov tsim ntawm daim siab rog thiab endothelial plaque hauv cov hlab ntsha loj.

Tsis tas li ntawd, NHDC tuaj yeem txo cov oxidative puas tsuaj los ntawm CC1, txo qhov mob, thiab cell apoptosis.

Daim Ntawv Thov: NHDC vam tias yuav siv los ua tus neeg sawv cev hepatoprotective.

Tiv thaiv kab mob plab

NHDC tuaj yeem cuam tshuam cov kua qaub hauv lub plab, yog li nws tuaj yeem siv los ua cov tshuaj tiv thaiv kab mob sib xyaw nrog Aluminium Hydroxide Gel lossis lwm cov tshuaj ua kua qaub los txhim kho cov kab mob gastric acid tom kawg.

Suhrez et al.pom tias NHDC tuaj yeem txo qis qhov ua rau lub plab ua rau muaj kev ntxhov siab txias (CRS).Nws cov haujlwm yog piv rau ranitidine, uas tuaj yeem cuam tshuam cov haujlwm ntawm histamine thiab txo qis kev tso tawm ntawm gastric acid thiab pepsin.

Daim Ntawv Thov: NHDC tuaj yeem dhau los ua cov khoom siv tshiab rau cov tshuaj gastric.

Tswj kev tiv thaiv kab mob

NHDC tau ntxiv rau pub ua cov khoom qab zib, tsis yog vim nws saj qab ntxiag thiab ua rau tsiaj qab los, tab sis kuj vim nws cov txiaj ntsig probiotic pom los ntawm Daly li al.Thaum NHDC tau ntxiv rau piglet pub, Lactobacillus hauv caecum nkag ntawm piglets tau nce ntxiv nrog qhov nce ntawm lactic acid concentration hauv plab hnyuv.Nws tuaj yeem cuam tshuam rau symbiotic plab hnyuv flora, tswj kev tiv thaiv ntawm lub cev, thiab txo cov kab mob hauv plab.

Daim ntawv thov: Neohesperidin DC tuaj yeem siv los ua cov khoom noj ntxiv, NHDC txhim kho lub palatability ntawm cov khoom noj, ua kom tsiaj qab los noj mov, thiab txhim kho cov kab mob hauv plab, tom qab ntawd txhawb kev loj hlob.

Neohesperidin DC kev nyab xeeb

NHDC yog cov khoom qab zib uas tsis yog carious, tsis yog fermentative sweetener.Kev tshawb fawb txog toxicity uas tau ua tiav.Cov metabolism ntawm NHDC hauv tib neeg lub cev yog tib yam li lwm cov flavonoid glycosides.NHDC muaj cov metabolism sai, tsis muaj kev txhawb nqa rau tib neeg lub cev, thiab tsis muaj kev phiv tshuaj lom.

Neo-DHC tau khaws cia hauv European Pharmacopoeia ob xyoo dhau los thiab tau pom zoo ua cov khoom qab zib los ntawm European Union, tab sis tsis yog los ntawm FDA.Hauv Tebchaws Meskas, neo-DHC tau pom zoo tsuas yog siv los ua cov tshuaj tsw qab.Tsis tas li ntawd, NHDC kev tso npe rau GRAS txoj cai hauv FDA yog nyob rau hauv txoj kev.

Neohesperidin dihydrochalcone (NHDC) pom zoo koob tshuaj thiab cov kev mob tshwm sim.

Rau cov khoom qab zib thiab khoom noj siv mis, qhov ntau npaum li cas: 10-35 ppm (qab zib), 1-5 ppm (flavor enhancer)

Rau Pharmaceutical Bitterness Masking, qhov ntau npaum li cas: 10-30 ppm (sweetener), 1-5 ppm (ntsuab enhancer)

Rau kev noj zaub mov, qhov siab tshaj plaws pom zoo koob tshuaj: 30-35 mg NHDC / kg tiav pub, 5 mg NHDC / L dej;3-8 mg NHDC / L dej rau nqus thiab weaned

Lub hom phiaj sib txawv txiav txim qhov koob tshuaj.

Txawm li cas los xij, yog tias noj ntau dhau, cov khoom xyaw yuav ua rau muaj kev pheej hmoo rau tib neeg lub cev.Cov kev tshawb fawb tau pom tias neohesperidin dihydrochalcone (NHDC) tuaj yeem ua rau xeev siab thiab mob migraine thaum qhov concentration yog li 20 ppm lossis ntau dua.Nws raug nquahu kom hnav lub ntsej muag phais thaum ua haujlwm nrog NHDC ntshiab

Certificate of Analysis