Sialic Acid hmoov

Sialic acid (SA), kev tshawb fawb hu ua "N-acetylneuraminic acid," yog ib qho tshwm sim ntawm cov carbohydrates.Nws yog Ameslikas cais tawm ntawm lub caj pas submandibular mucin, li no lub npe.Sialic acid feem ntau muaj nyob rau hauv daim ntawv ntawm oligosaccharides, glycolipids los yog glycoproteins.Hauv tib neeg lub cev, lub hlwb muaj sialic acid ntau tshaj plaws.Cov ntsiab lus sialic acid nyob rau hauv cov teeb meem grey yog 15 npaug ntawm cov kab mob hauv nruab nrog cev xws li daim siab thiab lub ntsws.Cov zaub mov tseem ceeb ntawm sialic acid yog cov kua mis, uas tseem muaj nyob hauv cov mis nyuj, qe thiab cheese.

Hauv cov tshuaj, glycolipids uas muaj sialic acid yog hu ua gangliosides, uas ua lub luag haujlwm tseem ceeb hauv kev tsim thiab kev loj hlob ntawm lub hlwb thiab lub paj hlwb.Nyob rau tib lub sijhawm, kev tshawb fawb tsiaj tau pom tias qhov txo qis ntawm qib ganglioside cuam tshuam nrog kev noj zaub mov tsis zoo thaum ntxov thiab txo qis kev kawm, thaum ntxiv nrog sialic acid tuaj yeem txhim kho tus cwj pwm kev kawm tsiaj.Kev txaus siab ntawm sialic acid yuav yog qhov tseem ceeb tshwj xeeb rau kev loj hlob ntawm lub hlwb ua haujlwm hauv cov menyuam yaus uas tsis muaj qhov hnyav.Tom qab tus me nyuam yug los, sialic acid nyob rau hauv cov kua mis yog qhov tseem ceeb los xyuas kom meej lawv txoj kev loj hlob.Kev tshawb nrhiav tau pom tias qib sialic acid hauv cov niam tom qab yug menyuam poob qis dhau sijhawm.Yog li ntawd, kev noj ntau txaus ntawm sialic acid thaum cev xeeb tub thiab tom qab cev xeeb tub tuaj yeem pab tswj qib sialic acid hauv lub cev.Ntxiv mus, cov ntsiab lus ntawm sialic acid kuj tseem cuam tshuam nrog cov ntsiab lus ntawm DHA, qhia tias nws muaj feem cuam tshuam nrog lub paj hlwb thiab kev loj hlob ntawm lub hlwb hauv cov menyuam mos, ob qho tib si yuav muaj txiaj ntsig zoo rau lub hlwb thaum ntxov.

Cov kev tshawb fawb tau pom tias lub sijhawm kub ntawm tib neeg lub hlwb kev loj hlob yog nyob nruab nrab ntawm cov hnub nyoog ntawm 2 thiab 2 xyoos.Cov theem no yog lub sijhawm tseem ceeb rau kev hloov pauv ntawm lub hlwb ntawm lub hlwb, qhov ntim nce, kev ua haujlwm zoo, thiab tsim cov neural network.Yog li ntawd, cov niam txiv ntse yuav ua tib zoo saib xyuas kom txaus ntawm sialic acid thaum cev xeeb tub.Tom qab tus menyuam yug los, cov kua mis yog ib txoj hauv kev zoo los ntxiv sialic acid rau tus menyuam, vim hais tias txog 0.3-1.5 mg ntawm sialic acid ib milliliter ntawm cov kua mis.Qhov tseeb, tag nrho cov tsiaj txhu, suav nrog tib neeg, muaj peev xwm ua rau sialic acid los ntawm lub siab los ntawm lawv tus kheej.Txawm li cas los xij, lub siab txoj kev loj hlob ntawm cov me nyuam mos tseem tsis tau paub tab, thiab qhov kev xav tau ntawm kev loj hlob sai thiab kev loj hlob ntawm lub hlwb yuav txwv tsis pub cov synthesis ntawm sialic acid, tshwj xeeb tshaj yog rau cov me nyuam mos ntxov ntxov.Yog li ntawd, sialic acid nyob rau hauv cov kua mis yog qhov tseem ceeb rau kev ua kom lub cev loj hlob thiab kev loj hlob ntawm tus me nyuam.
Cov kws tshawb fawb Australian tau pom tias cov menyuam mos uas pub mis niam muaj ntau dua ntawm sialic acid nyob rau hauv frontal cortex dua li cov menyuam mos noj mis.Qhov no tuaj yeem txhawb kev tsim cov synapses, pab tus menyuam lub cim xeeb los tsim kom muaj lub hauv paus ruaj khov, thiab ntxiv dag zog rau txoj kev loj hlob ntawm lub paj hlwb.

Dab tsi yog Sialic acid

Sialic Acidyog ib pawg derivatives ntawm neuraminic acid (N- los yog O-substituted derivatives neuraminic acid).Feem ntau nyob rau hauv daim ntawv ntawm oligosaccharides, glycolipids los yog glycoproteins.

Sialic Acidkuj yog lub npe rau pawg neeg no feem ntau - N-acetylneuraminic acid (Neu5Ac los yog NANA).

Sialic acid tsev neeg

Nws tau paub txog ze li ntawm 50 tus tswv cuab, tag nrho cov derivatives ntawm qhov tsis zoo 9-carbon qab zib neuraminic acid.

N-acetylneuraminic acid (Neu5Ac), N-glycolylneuraminic

acid (Neu5Gc) thiab deaminoneuraminic acid (KDN) yog nws cov core monomer.

N-acetylneuraminic acid yog tib hom Sialic Acid hauv peb lub cev.

Sialic Acid thiab noog lub zes

Vim tias Sialic acid yog nplua nuj nyob rau hauv noog lub zes, nws tseem hu ua noog lub zes acid, uas yog ib qho tseem ceeb qhia txog kev txheeb xyuas noog lub zes.

Sialic Acid yog cov khoom xyaw tseem ceeb hauv cov noog lub zes, nyob ib ncig ntawm 3% -15% los ntawm qhov hnyav.

Ntawm tag nrho cov khoom noj uas paub, noog lub zes muaj cov ntsiab lus siab tshaj plaws ntawm Sialid acid, nyob ib ncig ntawm 50 npaug siab dua lwm yam khoom noj.

1g noog lub zes sib npaug 40 qe yog tias peb tau txais tib qhov ntau ntawm Sialic Acid.

Sialic Acid cov khoom noj

Feem ntau, cov nroj tsuag tsis muaj Sialic acid.Cov khoom tseem ceeb ntawm Sialic acid yog tib neeg cov mis nyuj, nqaij, qe, thiab cheese.

Cov ntsiab lus ntawm tag nrho Sialic acid nyob rau hauv cov zaub mov ib txwm (µg / g lossis µg / ml).

Peb tuaj yeem pom tias Sialic acid nyob rau hauv Tib neeg cov kua mis yog siab, uas yog cov khoom tseem ceeb rau tus menyuam lub hlwb kev loj hlob.

Tab sis Sialic Acid cov ntsiab lus sib txawv nyob rau lub sijhawm sib txawv Tib neeg cov kua mis

Mis nyuj colostrum 1300 +/- 322 mg/l

10 hnub tom qab 983 +/- 455 mg / l

197 +/- 31 mg/l

Cov mis hloov pauv 190 +/- 31 mg / l

Ib feem ntawm cov mis hloov pauv 100 +/- 33 mg / l

Cov kua mis tom qab 100 +/- 33 mg / l

Soy-based mis nyuj cov mis 34 +/- 9 mg / l

Piv nrog rau cov mis nyuj mis, Cov mis mos mis nyuj muaj nyob ib ncig ntawm 20% Sialic acid los ntawm Tib neeg cov mis nyuj, thaum tus menyuam tsuas tuaj yeem tau 25% Sialic acid los ntawm Mis Mis.

Rau cov menyuam mos uas tsis muaj menyuam, Sialic acid yog qhov tseem ceeb tshaj li tus menyuam noj qab nyob zoo hauv lub hlwb.

Sialic Acid Study on Mis hmoov

"Cov txiaj ntsig tau qhia tias lub paj hlwb sialic acid cov ntsiab lus ua lub luag haujlwm tseem ceeb hauv kev txiav txim siab tus cwj pwm.Lwm pab pawg tau pom kev txhim kho kev kawm nrog kev kho mob sialic acid dawb hauv cov nas. "

CAB Tshuaj Xyuas: Kev Pom Zoo hauv Kev Ua Liaj Ua Teb, Veterinary Science, Khoom Noj, thiab Ntuj

Resources 2006 1, No. 018, Puas yog sialic acid nyob rau hauv cov mis nyuj noj rau lub hlwb?, Bing Wang

"Lub ntsiab lus yog siab dua lub hlwb ganglioside thiab glycoprotein sialic acid concentrations nyob rau hauv cov me nyuam mos noj cov mis nyuj uas muaj zog synaptogenesis thiab qhov sib txawv ntawm neurodevelopment."

Am J Clin Nutr 2003; 78:1024–9.Luam tawm hauv Tebchaws Meskas.© 2003 American Society for Clinical Nutrition, Brain ganglioside, thiab glycoprotein sialic acid hauv kev pub niam mis piv nrog cov menyuam mos noj mis, Bing Wang

"Neural cell membranes muaj 20 npaug ntau sialic acid dua li lwm hom membranes, qhia tias sialic acid muaj lub luag haujlwm meej hauv cov qauv neural."

European Journal of Clinical Nutrition, (2003) 57, 1351–1369, Lub luag haujlwm thiab lub peev xwm ntawm sialic acid hauv tib neeg noj zaub mov, Bing Wang

Daim ntawv thov N-Acetylneuraminic acid

Mis Hmoov

Tam sim no, Ntau thiab ntau tus niam txiv pub mis niam mis hmoov, Me nyuam mos mis hmoov, thiab cov khoom noj khoom haus muaj Sialic Acid ntawm Kev Ua Lag Luam.

Rau cov niam txiv pub niam mis

Rau Me Nyuam Mis Hmoov 0-12 lub hlis

Rau Healthcare khoom

Rau haus

Txij li thaum Sialic acid muaj peev xwm ua tau dej-soluble zoo, ntau lub tuam txhab tab tom sim txhim kho Sialic acid dej haus rau lub hlwb noj qab haus huv los yog ntxiv rau hauv cov khoom siv mis nyuj.

N-Acetylneuraminic acid Kev nyab xeeb

N-Acetylneuraminic acid muaj kev nyab xeeb heev.Tam sim no, tsis muaj xov xwm tsis zoo qhia txog Sialic acid.

Tsoomfwv Meskas, Tuam Tshoj, thiab EU tsoomfwv pom zoo Sialic acid los siv rau hauv cov khoom noj khoom haus thiab kev noj qab haus huv.

Teb chaws USA

Hauv xyoo 2015, N-Acetyl-D-neuraminic acid (Sialic acid) tau txiav txim siab Feem ntau Pom tau tias muaj kev nyab xeeb (GRAS)

Tuam Tshoj

Xyoo 2017, Tuam Tshoj Tsoomfwv tau pom zoo N-Acetylneuraminic acid ua Cov Khoom Noj Khoom Noj Tshiab.

EU

Kev nyab xeeb ntawm hluavtaws N-acetyl-d-neuraminic acid ua cov khoom noj tshiab raws li Txoj Cai (EC) Tsis muaj 258/97

Thaum Lub Kaum Hli 16, 2015, kev xaiv tus menyuam ntsuag (EU/3/12/972) tau tso cai los ntawm European Commission rau Ultragenyx UK Limited, United Kingdom, rau sialic acid (tseem hu ua aceneuramic acid) rau kev kho mob ntawm GNE myopathy.

Kev xav txog kev tshawb fawb txog kev lees paub txog kev noj qab haus huv ntsig txog sialic acid thiab kev kawm thiab kev nco (ID 1594) raws li Tshooj 13(1) ntawm Txoj Cai (EC) No 1924/2006

Kev noj tshuaj

CFDA qhia 500mg / hnub

Novel zaub mov qhia 55mg / hnub rau Me Nyuam mos thiab 220mg / hnub rau cov poj niam hluas thiab hnub nyoog nruab nrab

N-acetylneuraminic acid muaj nuj nqi

Kev nco thiab kev txawj ntse txhim kho

Los ntawm kev cuam tshuam nrog lub hlwb cell membranes thiab synapses, Sialic acid nce cov lus teb ntawm synapses hauv lub hlwb cov paj hlwb, yog li txhawb kev loj hlob ntawm kev nco thiab kev txawj ntse.

Cov kws tshawb fawb New Zealand tau ua ntau qhov kev sim kom paub meej tias lub luag haujlwm tseem ceeb ntawm noog lub zes acid nyob rau hauv cov me nyuam txoj kev loj hlob ntawm kev txawj ntse.Thaum kawg, cov kws tshawb fawb tau xaus lus tias kev ntxiv cov noog lub zes acid hauv cov me nyuam mos tuaj yeem ua rau kom cov noog lub zes acid nyob rau hauv lub hlwb, yog li txhim kho lub hlwb kev kawm.

Txhim kho plab hnyuv muaj peev xwm nqus

Raws li qhov yooj yim lub cev tshwm sim ntawm tus poj niam cev xeeb tub, qhov txiaj ntsig zoo ntawm cov zaub mov thiab qee cov vitamins uas nkag mus rau hauv txoj hnyuv tau yooj yim ua ke nrog lub zog tsis zoo ntawm cov noog zes acid, yog li txoj hnyuv nqus ntawm cov vitamins thiab minerals.Lub peev xwm tau txhim kho los ntawm nws.

Txhawb plab hnyuv antibacterial detoxification

Sialic Acid ntawm cov cell membrane protein ua lub luag haujlwm tseem ceeb hauv kev txhim kho lub peev xwm ntawm tes, detoxification ntawm tus kab mob cholera toxin, tiv thaiv kab mob Escherichia coli, thiab kev tswj hwm cov ntshav protein ib nrab-lub neej.

Lub neej ntev

Sialic acid muaj kev tiv thaiv thiab ruaj khov ntawm cov hlwb, thiab qhov tsis muaj sialic acid tuaj yeem ua rau txo qis hauv cov ntshav cell lub neej thiab txo qis hauv glycoprotein metabolism.

Tsim cov tshuaj tshiab rau Sialic Acid

Cov kws tshawb fawb sim kho cov kab mob hauv plab nrog sialic acid anti-adhesion tshuaj.Sialic acid anti-adhesive tshuaj tuaj yeem kho Helicobacter pylori los kho mob plab thiab duodenal ulcers.

Sialic acid yog glycoprotein.Nws txiav txim siab kev sib nrig sib paub thiab kev khi ntawm cov hlwb thiab muaj cov tshuaj tiv thaiv zoo li tshuaj aspirin.

Sialic acid yog ib qho tshuaj rau cov kab mob hauv nruab nrab lossis cov kab mob hauv lub paj hlwb thiab cov kab mob demyelinating;sialic acid kuj yog ib qho hnoos expectorant.

Sialic acid ua cov khoom siv raw tuaj yeem tsim cov tshuaj qab zib tseem ceeb, tshuaj tiv thaiv kab mob, tiv thaiv qog, tiv thaiv kab mob, thiab kev kho mob ntawm senile dementia muaj txiaj ntsig zoo.

Kev tsim cov txheej txheem ntawm Sialic Acid

Cov khoom siv pib yog cov piam thaj, pob kws khov cawv, glycerinum, thiab magnesium sulfate.Thiab peb siv fermented technology.Thaum lub sijhawm txheej txheem no, peb siv txoj kev ua kom tsis muaj menyuam kom cov khoom huv si.Tom qab ntawd los ntawm hydrolysis, concentration, ziab, thiab smashing.Tom qab tag nrho cov txheej txheem, peb tau txais cov khoom kawg.Thiab peb QC yuav siv HPLC los kuaj cov khoom zoo rau txhua pawg ua ntej peb xa mus rau cov neeg siv khoom.

Khoom npe: Sialic acid;N-Acetylneuraminic acid

Lwm Lub Npe: 5-Acetamido-3,5-dideoxy-D-glycero-D-galactonulosonic acid o-Sialic acid Galactonulosonic acid Lactaminic acid NANA N-Acetylsialic acid

Keeb kwm: Edible noog lub zes
Cov ntsiab lus: 20% - 98%
Qhov tsos: dawb hmoov zoo
CAS Nr .: 131-48-6
PIB: 309.27
Qauv TSIS MUAJ: C11H19NO9

Qhov chaw ntawm Keeb Kwm: Suav teb

Cia: Khaws rau hauv qhov chaw txias & qhuav, kom deb ntawm lub teeb ncaj qha thiab cua sov.
Siv tau: Ob xyoos yog tias khaws cia zoo.

FUNCTION:

1. Anti-virus muaj nuj nqi.
2. Anti-cancer muaj nuj nqi.
3. Kev tiv thaiv kab mob ua haujlwm.
4. Kev tiv thaiv muaj nuj nqi tiv thaiv kab mob bacteriological.
5. Tswj kev muaj peev xwm ntawm kev tiv thaiv kab mob.
6. Restraining muaj peev xwm tiv thaiv pigmentation.
7. Kev hloov pauv hauv cov paj hlwb.
8. Ua lub luag haujlwm tseem ceeb hauv kev loj hlob ntawm hlwb thiab kev kawm.
9. Raws li precursor rau kev tsim khoom ntawm ntau yam tshuaj.