Ingoa Hua:CMS121
Ētahi atu Ingoa:CMS-121;
1,2-Benzenediol,4-[4-(cyclopentyloxy)-2-quinolinyl]-;
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol(CMS121);
ACC,AcetylCoenzymeACarboxylase,mate,neuroprotective,aukati,anti-inflammatory,mitochondrial,Alzheimer's,antioxidative,acetylation,Inhibitor,H3K9,Acetyl-CoACarboxylase,CMS121,dementia,ACC1,CMS-121
KAUPAPA NO.:1353224-53-9
Te whakamatautau: 98.0%Min
Tae: Te paura kowhai marama
Tapaki: 25kg/DRUMS
Ko te 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol he pūhui e kiia ana ko CMS121. Ko te uauatanga o te hanganga o te puhui e tohu ana tera pea he ahuatanga ahurei me nga whakamahinga pea. Ki te mohio ki tona hiranga, ka awhina i te tautuhi i nga roopu mahi e noho ana me te tātari i o raatau paanga
Ko te CMS121 he quin oline kua whakakapia he neuroprotective, anti-inflammatory, antioxidative, me nga mahi renoprotective. Kei te pupuri i nga taumata glutathione (GSH) i roto i nga pūtau hippocampal kiore HT22 i roto i te vitro i te aroaro o te glutamate, ka whakaawe i te rereketanga o nga pūtau PC12, ka aukati i te LPS-induced N9 microglial activation e 82% i roto i te N9 microglia, me te tarai i nga rauropi kore utu i roto i te Trolox te kukū mahi rite. (TEAC). Ka tiakina e CMS121 te ischemia me te oxytosis i roto i nga mata phenotypic i roto i nga pūtau HT22 in vitro me nga uara EC50 o te 7 me te 200 nM mo te aukati i te mate o te waikawa iodoacetic-, te glutamate-induced cell death ranei. He renoprotective ano, he whakaheke i te mate o te whatukuhu me te whakaheke i te whakaaturanga o te TNF-α, te caspase-1, me te inducible nit ric oxi de synthase (iNOS) i roto i te tauira kiore SAMP8 o te mate whatukuhu mau tonu e pa ana ki te koroheketanga tere i te wa e tukuna ana i te horopeta. o 10 mg/kg ia ra timata i te iwa marama te pakeke.
Ko te 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol he pūhui e kiia ana ko CMS121. Ko te uauatanga o te hanganga o te puhui e tohu ana tera pea he ahuatanga ahurei me nga whakamahinga pea. Ki te mohio ki tona hiranga, ka awhina i te tautuhi i nga roopu mahi e noho ana me te tātari i o raatau paanga. Ko te noho mai o te mowhiti quinoline e tohu ana ka kaha te koiora. Ko nga ngota ngota i ahu mai i te quinoline e mohiotia ana mo o raatau momo momo koiora, tae atu ki nga mahi antibacterial me nga mahi anti-inflammatory. Ko te taapiri o te roopu cyclopentyloxy ka whai waahi ki te memehatanga o te puhui, ki te whakarei ake ranei i tana mahi koiora na roto i nga paanga mate. I roto i nga rangahau mo nga pūtau HT22, kua whakaatuhia e CMS-121 nga paanga neuroprotective nui, he pai te tiaki i enei pūtau mai i te ischemia me te kino o te oxidative. I tua atu, he nui nga taonga anti-inflammatory CMS-121, e tohu ana i tona kaha ki te whakarereke i nga urupare mumura. Ma te mahi pera, ka taea e CMS-121 te whakaiti i te mumura i roto i nga momo kopa me nga whekau. He kaha te mahi rongoa a CMS-121 hei aukati i te acetyl-CoA carboxylase 1 (ACC1). Ko te kaha o te aukati i te ACC1 ka waiho hei puhui whai hua
Taupānga:
