Ingoa Hua:J-147 Paura

Ētahi atu Ingoa:2,2,2-Trifluoroacetic acid 1-(2,4-DiMethylphenyl)-2-[(3-Methoxyphenyl)Methylene]hydrazide],J-147, J147

No CAS:1146963-51-0

Te whakamatautau: 99.0%Min

Tae: Te paura ma

Tapaki: 25kgs Drums

J-147he neuroprotectant tino kaha-waha i ahu mai i te curcumin, te whakauru kaha o te turmeric. Kaore i rite ki te curcumin, ka whiti i te arai toto-roro tino angitu.

Ko te J-147 he tino kaha, he kaha-waha, he kaihoko neuroprotective mo te whakarei hinengaro.
Ka taea e J-147 te whakawhiti i te arai roro toto (BBB). Ka taea e J-147 te aukati i te monoamine oxidase B (MAO B) me te kawe dopamine me nga uara EC50 o 1.88 μM me 0.649 μM, ia. He kaha te J-147 mo te maimoatanga o te mate a Alzheimer

Ko te J-147 he neuroprotectant tino kaha-waha i ahu mai i te curcumin, te whakauru kaha i roto i te turmeric. Kaore i rite ki te curcumin, ka whiti i te arai toto-roro tino angitu. I roto ia ratou, ka mahi a J-147 ma te here ki te ATP synthase. Ko te hanga nui o te ATP e hono ana ki te mahi pakeke. I tua atu i te whakanui ake i nga taumata o nga neurotransmitters NGF me te BDNF, ka taea e J-147 te whakahaere i tenei. I tua atu, ka whakakorehia e J-147 te monoamine oxidase B me te dopamine transporter. Ka whakatairanga i te tipu o te roro ma te whakanui ake i nga taumata o te tauwehe tupu nerve (NGF) me te take neurotrophic i ahu mai i te roro (BDNF). Ko te mea nui, ka taea e J-147 te whakatairanga i te tipu o nga pūtau nerve hou, te whakarei ake i te kaha ako me te mahara o te roro, me te whakapai ake i te mahi hinengaro.

Taumahi:

Ka taea e J-147 te whakawhiti i te arai roro toto (BBB).
Ka taea e J-147 te aukati i te monoamine oxidase B (MAO B) me te kawe dopamine me nga uara EC50 o 1.88 μM me 0.649 μM, ia.
He kaha te J-147 mo te maimoatanga o te mate a Alzheimer (AD).
He kaha te J-147 mo te maimoatanga o te mate a Alzheimer (AD).

Taupānga:

Ko te J-147 he pūhui waihanga ko tana mahi tuatahi ko te whakarei ake i te mitochondrial, na reira ka pai ake te whakaputanga hiko i te taumata pūkoro. I hangaia a J-147 ki te whakarei ake i te kaha o te roro ki te whakatikatika me te tiaki i a ia ano i nga kino e pa ana ki te tau ma te whakapai ake i te mahi mitochondrial. I tua atu, ko te J-147 e whakaatu ana i nga taonga anti-inflammatory me te antioxidant, me te whakanui ake i ona paanga neuroprotective. Ka taea e J-147 te whakatairanga i te tipu o nga pūtau nerve hou, te whakanui i te kaha ako me te mahara o te roro, me te whakapai ake i te mahi hinengaro.