Ingoa Hua:YDL223C (HBT1) Paura

Ētahi atu Ingoa:HBT1,YDL223C

CASNo:489408-02-8

Whakatakotoranga:99.0%

Tae:Kowhai marama totokame te kakara me te reka

GMOTūnga: GMO Free

Tapeke: i roto i te 25kgs pahū muka

Rokiroki: Puritia te ipu kia kore e tuwhera ki te waahi makariri, maroke, mawehe atu i te marama kaha

Te Ora: 24 marama mai i te ra o te whakaputanga

Ko te HBT1 he ngota ngota ka taea anake te here ki tetahi waahi motuhake i runga i te pūmua AMPA-R i te wa e noho ana te glutamate, a ka awhina tenei here ki te whakahaere i te mahi o te pūmua. Ko nga kaiwhakawhiwhi AMPA e whakaatuhia ana puta noa i te punaha nerve matua me te whai waahi nui ki te whakawhitiwhiti korero neuronal, te tukatuka tairongo, te ako, te mahara, me te kirihou synaptic. Ko nga kaiwhakawhiwhi AMPA he kaikoha nui ki te neurotransmission whakahihiri, te takawaenga tere, te whakaheke tere i te whakaihiihi i te maha o nga synapses, ka uru ki nga urupare wawe ki te glutamate i nga rohe synaptic. Ko nga kaiwhakawhiwhi AMPA he maha nga wa e whakaatuhia ana me nga kaiwhakawhiwhi NMDA i nga synapses, a ka whakatairanga tahi ratou i nga tukanga kirihou synaptic e whai waahi ana ki te ako, te mahara, te excitotoxicity, me te neuroprotection. Ko te tauwehe neurotrophic i ahu mai i te roro (BDNF) he kaupapa neurotrophic e whai waahi nui ana ki te tiaki me te whakawhänui i nga neurons me te kaha me te maha o nga paanga ki te whakatipuranga, te rerekeetanga, te oranga me te mate o nga pūtau neuronal me te kore-neuronal. , he modulator neurotransmitter e whai wāhi ana ki te kirihou neuronal i roto i te ako me te mahara. Na reira, he mea nui mo te hauora me te oranga o te punaha nerve.

Nga Mahi:

1. He rewharewha whakaraerae ira tangata
   2. Shmoo matamata pūmua, tïpako o Hub1p ubiquitin-rite pūmua; Ko nga mutants he koha mo te whakahiatotanga matapae, na reira
   te whakauru i te Hbt1p ki te morphogenesis pūtau polarized; He paraloga ta HBT1, YNL195C, i puta mai i te katoa o te taarua ira
   3. Ka whakamahia i roto i te mara rongoa.
   4. Whakanuia te matauranga hinengaro.
   5. Whakanuia te mahara me te kaha okioki.
   6. Whakanuia te taumata hihiri.
   7. Whakanuia te mana o te mahi roro cortical/subcortical.
   8. Whakapai ake i te tirohanga tairongo.
   9. Whakapai ake i te kaha o te roro ki te whakaoti rapanga me te tiaki mai i nga matū, tinana ranei.

Nga tono:

Ko te HBT1 he kaha hou AMPA-R [alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor] potentiator me te iti o te agonistic agonistic ka whakaritea ki te LY451395 me OXP1, ka whakaawe i te hanga o te roro. te tauwehe neurotrophic (BDNF) me te whakaatu i te paanga agonistic iti i roto i nga neurons tuatahi. Ka herea te HBT1 ki te rohe here-ligan o AMPA-R i roto i te glutamate dependent manner