Dzina lazogulitsa: Tranexamic Acid 98% ndi HPLC
Nambala ya CAS:1197-18-8
Fomula Yamaselo: C₈H₁₅NO₂
Kulemera kwa Maselo: 157.21 g/mol
Kuyera: ≥98% (HPLC)
Maonekedwe: ufa woyera wa crystalline
Kusungirako: +4 ° C (nthawi yochepa), -20 ° C (nthawi yayitali)
Ntchito: Mankhwala, Zodzoladzola, Kafukufuku
1. Mwachidule cha mankhwala
Tranexamic Acid (TXA), yopangidwa ndi lysine analog, imagwiritsidwa ntchito kwambiri ngati antifibrinolytic agent kuti achepetse magazi m'malo opangira opaleshoni komanso ovulala. Chogulitsachi chimapangidwa mosamalitsa, ndikuwonetsetsa chiyero cha ≥98% monga zatsimikiziridwa ndi High-Performance Liquid Chromatography (HPLC). Kapangidwe kake ka mankhwala (trans-4-(aminomethyl) cyclohexanecarboxylic acid) komanso kukhazikika kwake kumapangitsa kuti ikhale yoyenera kugwiritsidwa ntchito mosiyanasiyana, kuphatikiza:
- Kugwiritsa Ntchito Zachipatala: Kuwongolera magazi, chithandizo chamankhwala owopsa a ubongo (TBI).
- Zodzoladzola: Mafuta oyeretsa khungu omwe amalunjika ku hyperpigmentation.
- Kafukufuku: Kupititsa patsogolo njira zowunikira ndi maphunziro a pharmacokinetic.
2. Chemical and Physical Properties
- Dzina la IUPAC: 4-(Aminomethyl)cyclohexane-1-carboxylic acid
- AKUmwetulira: NC[C@@H]1CCC@HC(=O)O
- InChI Key: InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)/t6-,7
- Malo osungunuka: 386 ° C (dec.)
- Kusungunuka: Kusungunuka m'madzi (1N HCl, pH-adjusted buffers), methanol, ndi acetonitrile.
3. Chitsimikizo cha Ubwino
3.1 Kusanthula kwa HPLC
Njira yathu ya HPLC imatsimikizira kuchuluka kwambiri komanso mbiri yoyipa:
- Mzere: XBridge C18 (4.6 mm × 250 mm, 5 μm) kapena zofanana.
- Gawo Lam'manja: Methanol:acetate buffer (20 mM, pH 4) (75:25 v/v).
- Kuthamanga Kwambiri: 0.8-0.9 mL / min.
- Kuzindikira: UV pa 220 nm kapena 570 nm (post-derivatization ndi 1% ninhydrin).
- Kuyenerera Kwadongosolo:
- Kulondola: ≤2% CV ya malo apamwamba (6 replicates).
- Kuchira: 98-102% (80%, 100%, 120% spiked levels).
3.2 Mbiri Yosayera
- Chidetso A: ≤0.1%.
- Chidetso B: ≤0.2%.
- Zonse Zowonongeka: ≤0.2%.
- Halides (monga Cl⁻): ≤140 ppm.
3.3 Kukhazikika
- pH Kukhazikika: Kugwirizana ndi ma buffers (pH 2-7.4) ndi njira zodziwika bwino za IV (mwachitsanzo, fructose, sodium chloride).
- Kukhazikika kwa Matenthedwe: Kukhazikika pa 37 ° C kwa maola 24 mu matrices achilengedwe.
4. Mapulogalamu
4.1 Kugwiritsa Ntchito Zachipatala
- Care Trauma Care: Imachepetsa kufa kwa odwala TBI ndi 20% (mayesero a CRASH-3).
- Kuchita Opaleshoni: Kumachepetsa kutaya magazi kwapang'onopang'ono (maopaleshoni a mafupa, amtima).
4.2 Zodzoladzola
- Mechanism: Imalepheretsa melanogenesis yopangidwa ndi plasmin mwa kutsekereza malo omangira ma lysine.
- Mapangidwe: 3% TXA zonona za melasma ndi hyperpigmentation.
- Chitetezo: Kugwiritsa ntchito pamutu kumapewa zoopsa zadongosolo (mwachitsanzo, thrombosis).
4.3 Kafukufuku & Chitukuko
- Njira Zowunikira: Kaphatikizidwe: Maphunziro a interconversion a Prodrug pansi pamikhalidwe ya acidic.
- UPLC-MS/MS: Kusanthula kwa plasma (LOD: 0.1 ppm).
- Fluorimetry: Derivatization ndi NDA/CN (5-minute reaction).
5. Kuyika & Kusunga
- Kupaka Kwambiri: Matumba a aluminium osindikizidwa okhala ndi desiccant.
- Alumali Moyo: Miyezi 24 pa -20°C.
- Kutumiza: Kutentha kozungulira (kuvomerezeka kwa maola 72).
6. Chitetezo ndi Kutsata
- Kugwira: Gwiritsani ntchito PPE (magolovesi, magalasi) kuti mupewe kupuma kapena kukhudza.
- Mkhalidwe Wowongolera: Umagwirizana ndi USP, EP, ndi JP pharmacopeias.
- Poizoni: LD₅₀ (mkamwa, makoswe)> 5,000 mg/kg; sanali carcinogenic.
7. Maumboni
- Kutsimikizika kwadongosolo kwa HPLC.
- Ma curve a calibration ndi ma protocol a derivatization.
- UPLC-MS/MS njira yofananira.
- Kutsika mtengo pakusamalira zoopsa.
- Kukhazikika kwa mapangidwe a zodzikongoletsera.
Keywords: Tranexamic Acid 98% HPLC, Antifibrinolytic Agent, Skin Whitening, Trauma Care, UPLC-MS/MS, CRASH-3 Trial, Melasma Treatment
Kufotokozera kwa Meta: High-purity Tranexamic Acid (≥98% yolembedwa ndi HPLC) yachipatala, zodzoladzola, ndi kafukufuku. Njira zovomerezeka za HPLC, chisamaliro chotsika mtengo chovulala, komanso mapangidwe amitu otetezeka. CAS 1197-18-8.
