Igoa o oloa:Celastrol bulk powder
Punavai Botanic:Le Atua Vine(Tripterygium wilfordii hook.f)
CASNo:34157-83-0
Lanu: Pa'u tioata moli moli mumu e iai le manogi ma le tofo
Faʻamatalaga: ≥98% HPLC
GMOTulaga: GMO Free
afifiina: i 25kgs fibre talipalau
Teuina: Taofi le atigipusa e le tatalaina i se nofoaga malulu, matutu, Taofi ese mai le malamalama malosi
Ola Faʻamau: 24 masina mai le aso na gaosia ai
Celastrol Powdero le vaega malosi i Tripterygii Radix, o le aʻa mago ma rhizome o le Atua Vine.E fa ituaiga i le aofaʻi, e taʻuaTripterygium wilfordii Hook.f, Tripterygium hypoglaucum Hutch, Tripterygium regelii Sprague ma Takeda, ma Tripterygium forresti Dicls.
Diterpenoids: triptolide(cas no.38748-32-2), Tripdiolide(cas no.38647-10-8), ma isi.
Triterpenoids: Celastrol(cas no.34157-83-0), Wilforlide A(cas no.84104-71-2), ma isi.
Alkaloids:Wilforgine(cas no.37239-47-7), Wolverine (cas no.11088-09-8), wilforidine, etc.
Tripterygium o se pentazine triterpene e maua faanatura i Tripterygium wilfordii.E aoga i le togafitia o le ma'i rumatika.Triptolide e taofia le proteasome ma le faaniukilia Kb mai le galue.
Celastrol (Tripterin) o se fa'aininisi fa'apolofesa fa'atasi ai ma gaioiga fa'atosina ma fa'ama'i.E lelei ma sili ona faʻalavelaveina le gaioiga e pei o le chymotrypsin o le 20S proteasome ma le IC50 o le 2.5 μM.
Tripterine o se antioxidant mamana ma anti-inflammatory agent.O se inhibitor HSP90 fou (faʻalavelaveina le faʻalavelave Hsp90 / Cdc37), e iai aʻafiaga o le kanesa (anti-angiogenesis - faʻalavelaveina le faʻaalia o le talitaliga o le endothelial growth factor receptor);antioxidant (taofia le lipid peroxidation) ma le anti-inflammatory activity (Fa'asa le gaosiga o le iNOS ma cytokines inflammatory)
Bfa'aletinoAgaioiga:
Celastrol (Tripterin) lalo-faʻatonutonu le basal ma le DNA-faʻaleagaina sui faʻaoso FANCD2 monoubiquitination, sosoo ai ma le faʻaleagaina o porotini.O togafitiga Celastrol e faʻaumatia ai le siaki G2 faʻaosoina IR ma faʻaleleia le faʻaleagaina ole DNA faʻaleagaina ole vailaʻau ole ICL ma aʻafiaga faʻalavelave i sela o le kanesa mama e ala ile faʻaumatia FANCD2.O le Celastrol o loʻo i ai ni aʻafiaga faʻalavelave ma apoptosis i luga o sela DU145 na faʻatupuina i totonu o le vitro i se taimi-ma faʻatatau-faʻalagolago.O le a'afiaga o le kanesa o le prostate a Celastrol o se vaega e ala i lalo-faʻatonutonu le maualuga o le faʻaaliga o alalaupapa hERG i sela DU145, e faʻaalia ai o le Celastrol atonu o se vailaʻau faʻamaʻi faʻamaʻi faʻamaʻi, ma o lona faiga e ono poloka ai ala o le hERG.Celastrol faʻaleleia le faʻataʻitaʻiga colitis i isumu IL-10-deficient e ala i le faʻalavelaveina o le ala faʻailoga PI3K / Akt / mTOR ma le faʻaleleia o le autophagy.E iai le malosi o le Celastrol e fa'alavelave ai le gaioiga o le cytochrome P450 ma e ono mafua ai fegalegaleaiga o la'au.Celastrol fa'aoso apoptosis i sela TNBC, fa'ailoa mai e mafai ona fa'atalanoaina apoptosis e ala i le mitochondrial dysfunction ma le ala fa'ailoga PI3K/Akt.O le Celastrol e faʻaosofia ai le apoptosis ma le autophagy e ala i le ala faʻailoga ROS / JNK.O le Celastrol e taofia le oti o le neuron dopaminergic i le maʻi o Parkinson e ala i le faʻagaoioia o apoptosis mitochondrial.
Ole matafaioi a Celastrol ile chemosensitization ole kanesa:
Chemotherapy o loʻo tumau pea le togafitiga autu mo tagata mamaʻi kanesa.Ae ui i lea, o le chemotherapy e masani ona tatau ona tuʻufaʻatasia ma isi vailaʻau e faʻaitiitia ai aʻafiaga leaga ma aloese mai le teteʻe i vailaʻau.O oloa fa'anatura ua fa'ateleina le fa'aogaina e fai ma togafitiga fa'aopoopo fa'atasi ai ma faiga fa'a-chemoaga o lo'o iai e fa'aleleia atili ai le lelei o togafitiga.O se tasi o faʻataʻitaʻiga faʻamaonia o sea vailaʻau faʻanatura o se triterpene compound e taʻua o le celastrol, lea e mafai ona tele le gafatia e faʻaaogaina e avea o se vailaʻau faʻamaʻi.Muamua na faailoa mai le Thunder God Vine, e le lelei le faatonutonuina o le tele o mole oncogenic e pei ole NF-κB, topoisomerase II, Akt/mTOR, HSP90, STAT3, ma Notch-1.O nei mea e mafai ona taʻitaʻia ai se tali faʻamaʻi, faʻalavelave le tuputupu aʻe o le tuma ma le ola, ma faʻaumatia le angiogenesis.O lenei mataupu o loʻo faʻapuʻupuʻu faʻapuupuuga le matafaioi a le celastrol e avea o se chemosensitizer ma le faʻavae mole mole masini faʻasalalau ona lipotia chemosensitizing aafiaga i kanesa eseese.
