Zita rechigadzirwa: 4-Butylresorcinol poda
Tsanangudzo: 98% min
Nhamba yeCAS: 18979-61-8
Mazwi anoreva Chirungu: N-BUTYLRESEOCINOL;4-N-BUTYLRESORCINOL;4-BUTYLRESORCINOL;4-phenylbutane-1,3-diol;2,4-DIHYDROXY-N-BUTYLBENZEN
Molecular formula: C10H14O2
Molecular uremu: 166.22
Kunyungudika: 50 ~ 55 ℃
Poindi yekubikira: 166℃/7mmHg(lit.)
Dosage: 0.1-5%
Package: 1kg, 25kg
Chii chinonzi 4-Butylresorcinol
Iyo yepamutemo zita remakemikari ndeye 4-n-butyl resorcinol, asi kazhinji, munhu wese anofarira kurerutsa kunyora butyl resorcinol.Yekutanga kuiwedzera kune chena chigadzirwa ndeyeJapan POLA, um~ iyo inovimba nepiritsi rekuchena mumoto wepamba.
Iyo inoratidzirwa nekusagadzikana kunyungudika mumvura uye kunyungudika mu ethanol.
Mechanism chiito che4-Butylresorcinol
- Tyrosinase inoita basa rakakosha mukugadzirwa kwe melanin nekuti inodzora mwero we melanin deposition.
- 4-n-butylresorcinol ine inhibitory effect pakugadzirwa kwe melanin nekudzivisa zvakananga basa re tyrosinase uye B16 dema-speed tumor cell inhibiting synthesis ye tyrosinase pasina kukonzera chero cytotoxicity.
- Mune zvimwe zvidzidzo zve in vitro, 4-n-butylresorcinol yakaratidzwa kudzivisa kugadzirwa kwe melanin, pamwe chete nebasa re tyrosinase uye TRP-1.
- Inhibitor yakasimba ye tyrosinase uye peroxidase
- Inoshanda ganda whitening agent uye yakajairika ganda toner
- Inoshanda whitening agent ye pigmentation yeganda
- Inoshanda kurwisa chloasma (yakafumurwa hyperpigmented ganda muzuva)
- Iyo ine simba rakasimba rekudzivirira pakukuvara kweDNA kunokonzerwa neH2O2.
- Yakaratidza kuti ine anti-glycation effect
Benefits ye4-Butylresorcinol
Nei uchifanira kusarudza 4-Butylresorcinol
Kutanga, tinofanira kuziva kuti nei kune resorcinol.
Lipofuscin ndeimwe yezvakanyanya kuoma kubata nayo mu melanin.Kazhinji, hydroquinone inoshandiswa mukunaka kwekurapa.
Hydroquinone inoshanda kwazvo yekuchena mumiriri.Iyo yekuchenesa nzira inodzivisa zvachose basa re tyrosinase uye inodzivirira kuumbwa kwe melanin, uye mhedzisiro yacho inoshamisa kwazvo.
Zvisinei, migumisiro yaro inoratidzika zvakaenzana, uye zvikomborero zvakanyanya kukuvadza kupfuura zvinobatsira zvekuchenesa.
- Iyo yakanyanya oxidizable mumhepo, uye inofanirwa kushandiswa pakuiwedzera kune zvizorwa.
- inogona kukonzera kutsvuka kweganda;
- Kana iyo yakasungwa ichipfuura 5%, inokonzeresa sensitization, uye kune mienzaniso yekiriniki yeleukoplakia.Parizvino, US Food and Drug Administration inotaura kuti zvigadzirwa zvehydroquinone zvine huwandu hunodarika 4% igiredhi rekurapa uye hazvitenderwe kutengeswa.
Vemakemikari nevemishonga vakashandura mushonga une simba wehydroquinone kuti uwane 4-hydroxyphenyl-beta-D-glucopyranoside, izvo zvatinowanzonzwa nezve "arbutin".Musiyano uripo pakati pehydroquinone ndewekuti arbutin ine muswe mudiki - glycoside pane hydroquinone.Zvinonzwisa urombo kuti kuchena kwekuita kwakaderedzwa zvakanyanya.
Makore achangopfuura, izvo zvinonyanya kufarirwa zvinongedzo zvemhando huru zvakasiyana-siyana zvinobva kune benzenediol.
Asi kugadzikana kwechiedza che arbutin kwakashata uye kunoshanda chete husiku.
Kuchengetedzeka kwe4-n-butyl resorcinol kwave kutarisisa.Pasina mhedzisiro yehydroquinone, ine zvirinani kurapa mhedzisiro pane zvimwe zvinobuda resorcinol.
Muchiyedzo che tyrosinase inhibition test, data rayo rakatonaka kudarika mukoma mukuru phenethyl resorcinol, inova 100~6000 nguva dzechinyakare chekuchenesa agent senge kojic acid arbutin!
Zvino mune yakatevera yakatevera yekuyedza kuyedza melanin B16V, yakaratidzawo mukana wakajairwa weresorcinol derivatives - inhibition yekugadzirwa kwemelanin pamisumbu isina kuburitsa cytotoxicity.
Pamusoro pezvo, kune zvakawanda zvekuedza kwevanhu pa4-n-butyl resorcinol.Mune vamwe varwere makumi matatu nevaviri vane chloasma, 0.3% 4-n-butylresorcinol uye placebo zvakashandiswa pamatama ose.Kaviri pazuva kwemwedzi ye3, mhedzisiro yaive yakaderera zvakanyanya pigment kuderedzwa muboka re4-n-butylresorcinol kupfuura muboka re placebo.Kune vanhu vanoita artificial pigmentation inhibition kuyedza mushure mekupisa kwezuva, hmm~ mhedzisiro yacho yakanaka ~
Kuvharirwa kwevanhu tyrosinase ne4-butylresorcinol
4-butylresorcinol, kojic acid, arbutin uye hydroquinone inoratidza paL-DOPA oxidase chiitiko chetyrosinase.Yakatemerwa nehuwandu hwakasiyana-siyana hweiyo inhibitors kubvumira kuverengerwa kweIC50 kukosha.Iyi data ndeyeavhareji yezviedzo zvitatu zvakazvimirira.
Kudzivirirwa kwekugadzirwa kwe melanin muMelanoDerm mhando dzeganda ne4-butylresorcinol.
Enzanisa ne4-butylresorcinol, kojic acid, arbutin uye hydroquinone mukugadzirwa kwemelanin.Kutsunga kwehuwandu hwe melanin yemhando dzeganda kwakaratidzwa mushure memazuva gumi nematatu ekurima pamberi peakasiyana inhibitor concentrations.Iyi data iavhareji yezviyedzo zvishanu zvakazvimirira.
Zera nzvimbo kupenya ne4-butylresorcinol
Enzanisa ne4-butylresorcinol, kojic acid, arbutin uye hydroquinone.Rapa makwapa kaviri pazuva kwemavhiki gumi nemaviri ane inhibitor.Ongorora kushanda mushure me4, 8 uye 12 mavhiki.Data inomiririra zvinoreva 14 zvidzidzo.*P <0.05: statistically akakosha maringe neasina kurapwa anodzora zera mavara.
Chiyero uye kushandiswa kwe4-Butylresorcinol
Iyo inokurudzirwa dosage ndeye 0.5% -5%.Kunyangwe paine zvidzidzo muKorea zvine imwe mhedzisiro pa 0.1% cream, uye India ine tsvakurudzo 0.3% cream asi musika unonyanya 0.5% -5%.Iyo yakajairika, uye fomula yeJapan haisati yanyatsojeka, asi POLA yakashandiswa.Uye mhedzisiro uye kutengesa zvinokatyamadza.
Sezvambotaurwa pamusoro, 4-Butylresorcinol inogona kushandiswa mumakirimu, asi isinganyunguriki mumvura.Mamwe akadai semafuta ekuzora, makirimu, uye gerosi aripowo.Vese POLA neEucerin vane 4-Butylresorcinol zvigadzirwa.
