Zita reChigadzirwa: Celastrol yakawanda poda
Botanic Source:Mwari Muzambiringa(Tripterygium wilfordii hook.f)
CASNo:34157-83-0
Ruvara: Reddish orenji crystal poda ine hunhu hwemunhuwi uye kuravira
Tsanangudzo:≥98% HPLC
GMOMamiriro:GMO Yemahara
Kurongedza: mune 25kgs fiber zvigubhu
Kuchengeta: Chengetedza mudziyo usina kuvhurwa munzvimbo inotonhorera, yakaoma, Chengetedza kure nechiedza chakasimba
Sherufu Hupenyu: Mwedzi makumi maviri nemana kubva pazuva rekugadzirwa
Celastrol Powderndicho chinhu chinoshanda muTripterygii Radix, inova mudzi wakaoma uye rhizome yeMuzambiringa waMwari.Kune marudzi mana pamwe chete, anotiTripterygium wilfordii Hook.f, Tripterygium hypoglaucum Hutch, Tripterygium regelii Sprague et Takeda, uye Tripterygium forresti Dicls.
Diterpenoids: triptolide(cas no.38748-32-2), Tripdiolide(cas no.38647-10-8), nezvimwewo.
Triterpenoids: Celastrol(cas no.34157-83-0), Wilforlide A(cas no.84104-71-2), nezvimwewo.
Alkaloids:Wilforgine(cas no.37239-47-7), Wolverine (cas no.11088-09-8), wilforidine, zvichingodaro.
Tripterygium inonzi pentazine triterpene inowanikwa muTripterygium wilfordii.Inoshanda mukurapa rheumatoid arthritis.Triptolide inodzivirira iyo proteasome uye yenyukireya chinhu Kb kubva pakushanda.
Celastrol (Tripterin) inonzi proteasome inhibitor ine anti-inflammatory uye antioxidant mabasa.Iyo inobudirira uye yakasarudzika inodzivisa chymotrypsin-yakafanana nekuita kwe20S proteasome ine IC50 ye2.5 μM.
Tripterine ine simba antioxidant uye anti-inflammatory agent.Itsva HSP90 inhibitor (inokanganisa Hsp90/Cdc37 complex), ine anti-cancer effects (anti-angiogenesis - inhibits vascular endothelial growth factor receptor expression);antioxidant (inhibits lipid peroxidation) uye anti-inflammatory chiitiko (Inodzivisa kugadzirwa kweNOS uye kuputika kwe cytokines)
BiologicalAchiitiko:
Celastrol (Tripterin) pasi-inogadzirisa basal uye DNA-inokuvadza agent-induced FANCD2 monoubiquitination, inoteverwa neprotein degradation.Celastrol kurapwa inobvisa IR-induced G2 cheki uye inowedzera ICL zvinodhaka-induced DNA kukuvara uye inhibitory mhedzisiro pamasero emukenza wemapapu nekupedza FANCD2.Celastrol ine inhibitory yakakosha uye apoptosis-inducing mhedzisiro paDU145 masero akagadzirwa mu vitro mune imwe nguva- uye dosi-inotsamira maitiro.Celastrol's anti-prostate cancer mhedzisiro iri chikamu kuburikidza nekudzika-kudzoreredza mwero wekutaura wehERG chiteshi muDU145 maseru, zvichiratidza kuti Celastrol inogona kunge iri anti-prostate cancer mushonga, uye maitiro ayo anogona kunge ari ekuvhara hERG nzira.Celastrol inovandudza kuedza kwecolitis muIL-10-inoshaya mbeva nekudzivisa PI3K/Akt/mTOR nzira yekusaina uye kusimudzira autophagy.Celastrol ine mukana wekudzivisa cytochrome P450 chiitiko uye inogona kukonzera kusangana kwemishonga.Celastrol induces apoptosis muTNBC masero, zvichiratidza kuti apoptosis inogona kuyananisirwa kuburikidza ne mitochondrial dysfunction uye PI3K/Akt kusaina nzira.Celastrol induces apoptosis uye autophagy kuburikidza neROS/JNK yekusaina nzira.Celastrol inhibits dopaminergic neuron kufa muParkinson's disease nekuita mitochondrial apoptosis.
Basa reCelastrol mukenza chemosensitization:
Chemotherapy inoramba iri nzira huru yekurapa kune varwere vegomarara.Zvisinei, chemotherapy inowanzofanira kusanganiswa nemimwe mishonga kuderedza migumisiro yakaipa uye kudzivisa kuramba zvinodhaka.Zvigadzirwa zvechisikigo zviri kuramba zvichishandiswa seadjuvant kurapa pamwe nearipo chemotherapy regimens kuwedzera kushanda kwekurapa.Mumwe muenzaniso unovimbisa wemushonga wepanyama wakadaro musanganiswa wetriterpene unonzi celastrol, unogona kunge uine mukana mukuru wekushandiswa sekemikari sensitizer.Yakatanga kuzivikanwa kubva kuKutinhira Mwari Muzambiringa, inodzora zvisina kunaka akawanda oncogenic mamorekuru akadai seNF-κB, topoisomerase II, Akt/mTOR, HSP90, STAT3, uye Notch-1.Izvi zvinogona kutungamira kune anti-kuzvimba mhinduro, inhibisa bundu kukura uye kurarama, uye kubvisa angiogenesis.Ichi chitsauko chinopfupisa muchidimbu basa rinogona kuitika recelastrol sechemosensitizer uye ari pasi pemamorekuru masisitimu anoyananisa ayo anonzi chemosensitizing mhedzisiro mumakenza akasiyana siyana.
