Product Name:Lupeol Powder98%
Botanic Source:Mango, Acacia visco, Abronia villosa, Dandelion kofi.
CASNo:545-47-1
Color:Muchena kusvika kure-chenahupfu nehunhu hwema uye kuravira
Tsanangudzo:≥98% HPLC
GMOMamiriro:GMO Yemahara
Kurongedza: mune 25kgs fiber zvigubhu
Kuchengeta: Chengetedza mudziyo usina kuvhurwa munzvimbo inotonhorera, yakaoma, Chengetedza kure nechiedza chakasimba
Sherufu Hupenyu: Mwedzi makumi maviri nemana kubva pazuva rekugadzirwa
Biological Activity:
Lupeol (Clerodol; Monogynol B; Fagarasterol) inoshingaira pentacyclic triterpenoid, ine anti-oxidant, anti-mutagenic, anti-tumor uye anti-inflammatory activity.Lupeol ine simbaandrogen receptor(AR) inhibitor uye inogona kushandiswakenzatsvakurudzo, kunyanya prostatekenzaye androgen-inotsamira phenotype (ADPC) uye castration resistant phenotype (CRPC) [1].
In Vitro Tsvagiridzo:
Lupeol ine simba AR inhibitor inogona kugadzirwa semushonga unogona kurapa kenza yeprostate yemunhu (CaP).Lupeol (10-50 μM) kurapwa kwe48 h kwakaguma nedosi-inotsamira kukura inhibition ye androgen-inotsamira phenotype (ADPC) masero, anoti LAPC4 uye LNCaP masero, ane IC50 ye15.9 uye 17.3 μM, zvichiteerana.Lupeol yakamisawo kukura kwe22Rν_1 neIC50 ye19.1 μM.Mukuwedzera, Lupeol yakadzivisa kukura kweC4-2b masero ane IC50 ye25 μM.Lupeol ine mukana wekudzivisa kukura kweCaP masero eADPC uye CRPC phenotypes.Androgens anozivikanwa kufambisa kukura kweCaP masero kuburikidza nekushandiswa kweAR[1]
MuVivo Tsvagiridzo:
Lupeol mushonga unoshanda une mukana wekudzivisa tumorigenicity yeCaP cell in vivo.Total circulating serum PSA mazinga (akavanzwa neakaiswa tumarara masero) akayerwa pakupera kwechidzidzo pazuva 56. Pazuva 56 post-implantation, PSA mazinga kubva 11.95-12.79 ng / mL akaonekwa mukudzora mhuka dzine LNCaP mapundu uye C4-2b tumors, zvichiteerana.Nekudaro, vamwe vakabatwa neLupeol vakaratidza kuderedzwa kweserum PSA mazinga kubva ku4.25-7.09 ng/mL.Tumor tishu kubva kumhuka dzakabatwa neLupeol dzakaratidza dzakaderedzwa serum PSA mazinga achienzaniswa nekutonga[1]
