Product Name:Wogonin Bulk Powder

Botanic Source: Scutellaria baikalensis

Nhamba yeCAS:632-85-9

Rimwe Zita:Vogoni, wagonin, Wogonin hydrate, Vogonin Norwogonin 8-methyl ether

Zvinodiwa:≥98% HPLC

Ruvara: Yellow powder ine unhu hwema uye kuravira

GMO Mamiriro:GMO Yemahara

Kurongedza: mune 25kgs fiber zvigubhu

Kuchengeta: Chengetedza mudziyo usina kuvhurwa munzvimbo inotonhorera, yakaoma, Chengetedza kure nechiedza chakasimba

Sherufu Hupenyu: Mwedzi makumi maviri nemana kubva pazuva rekugadzirwa

Scutellaria baikalensis ine zvakasiyana-siyana zvemakemikari zvikamu, zvakadai seflavonoids dzakasiyana-siyana, diterpenoids, polyphenols, amino acids, mafuta anoputika, sterol, benzoic acid, nezvimwewo.Midzi yakaoma ine marudzi anopfuura zana negumi eflavonoids akadai sebaicalin, baicalein, wogonoside, uye wogonin, inova ndiyo inonyanya kushanda yeScutellaria baikalensis.Yakamisikidzwa inotorwa se80% -90% HPLC Baicalin, 90% -98% HPLC Baicalein, 90% -95% HPLC Wogonoside, uye 5% -98% HPLC Wogonin

MuVitro Chiitiko: Wogonin inhibits PMA-induced COX-2 gene kutaura nekudzivisa c-Jun kutaura uye AP-1 activation muA549 masero[1].Wogonin inhibitor ye cyclin-inotsamira kinase 9 (CDK9) uye inovhara phosphorylation yecarboxy-terminal domain yeRNA polymerase II paSer.Nekudaro, inoderedza RNA synthesis uye nekuzotevera kukurumidza kudzika kweiyo pfupi-yakararama anti-apoptotic protein myeloid cell leukemia 1 (Mcl-1) zvichikonzera apoptosis induction mumasero egomarara.Wogonin inosunga zvakananga kuCDK9, zvichida kune ATP-inosunga pocketa uye haivharidzi CDK2, CDK4 uye CDK6 pamadhora anodzivisa CDK9 chiitiko.Wogonin inonyanya kuvharidzira CDK9 mune yakashata kana ichienzaniswa neyakajairika lymphocytes.Wogonin inorwisa-oxidant ine simba inokwanisa kutsvaira ?O2?[2].Wogonin inodzivirira zvakanyanya kuendeswa kweNFATc1 kubva ku cytoplasm kuenda kunucleus uye yayo transcriptional activation chiitiko.Iyo zvakare inodzivisa zvakanyanya kusiyana kwe osteoclast uye inoderedza kunyorwa kweosteoclast?inobatanidza immunoglobulin?se receptor, tartrate?resistant acid phosphatase uye calcitonin receptor[4].Wogonin Inhibits N-acetyltransferase Chiitiko

MuVivo Chiitiko: Wogonin inodzvinyirira kukura kwekenza yevanhu xenografts mu vivo.Pamadhosi anouraya kumaseru ebundu, wogonin inoratidza hapana kana huturu hudiki hwemasero akajairwa uye yakanga isina huturu huri pachena mumhuka[2].Wogonin inogona kukonzera apoptosis mumurine sarcoma S180 nokudaro ichidzivirira bundu kukura zvese mu vitro uye mu vivo[3].Jekiseni re intraperitoneal re200 mg/kg Wogonin rinogona kuvharisa zvachose leukemia nemasero eCEM.

Miedzo yemasero:

A549 masero itsika mu 24-tsime ndiro (1.2 × 105 masero / zvakanaka) 1 zuva pamberi wogonin kurapwa.DMSO kana wogonin inowedzerwa mumasero eA549 1 h pamberi pePMA stimulation, uye masero anoiswa kune imwe 6 h.Masero anounganidzwa nekurapwa kwetrypsin uye nhamba dzemasero dzinoverengwa nekushandisa hemocytometer uye trypan blue exclusion method.