Neohesperidin Dihydrochalcone (NHDC)

NHDC in pure form inowanikwa sechinhu chichena chisina kusiyanashuga yehupfu.

Mushonga ungaita 1500-1800 nguva dzinotapira kupfuura shuga pazvikumbaridzo zvekuisa;zvakapoteredza 340 nguva dzinotapira kupfuura shuga kurema-kurema.Simba rayo rinowanzobatwa nezvinhu zvakadai sekushandiswa kwairi kushandiswa, uyepHzvechigadzirwa.

Sezvimwe zvinotapira zvakanyanyaglycosides, zvakaita seglycyrrhizinnevanowanikwa mukatistevia, kutapira kweNHDC kunotanga zvishoma kudarika shuga uye kunogara mumuromo kwenguva yakati.

Kusiyanaaspartame, NHDC yakagadzikana kune yakakwirira tembiricha uye kune acidic kana mamiriro ekutanga, uye saka inogona kushandiswa muzvikumbiro zvinoda hupenyu hurefu hwesherufu.NHDC pachayo inogona kugara yakachengetedzeka kwechikafu kweanosvika makore mashanu kana ichinge yachengetwa mumamiriro ekunze.

Chigadzirwa chacho chinozivikanwa nekuve nechakasimba che synergistic mhedzisiro kana ichishandiswa pamwe chete nezvimweartificial sweetenerszvakaita seaspartame, saccharin, acesulfame potassium,uyecyclamate, pamwe chete nedoro reshuga sexylitol.Kushandiswa kweNHDC kunowedzera mhedzisiro yezvinotapira izvi munzvimbo dzakaderera pane zvaizodiwa neimwe nzira;huwandu hudiki hwezvimwe zvinotapira hunodiwa.Izvi zvinopa mari inobatsira.

Chii chinonzi Neohesperidin dihydrochalcone?

Neohesperidin dihydrochalcone powder, inozivikanwawo seNeohesperidin DC, Neo-DHC uye NHDC kwenguva pfupi, inotapira inogadzirwa neohesperidin.NHDC inoonekwa seyakanyanya-simba, isina-inovaka inotapira inonaka inonaka;inogona kuvandudza kutapira uye kunaka kwezvokudya zvakasiyana-siyana zvekubika.

Neohesperidin dihydrochalcone ikamu rinoita 1500-1800 nguva kutapira pane shuga iri pachikumbaridzo uye inorema kanosvika 340 kutapira kupfuura shuga.

Neohesperidin dihydrochalcone inowanzoshandiswa mumaindasitiri ezvekuwedzera ezvekudya uye chikafu chekuwedzera.

Tsvaga uye kunobva Neohesperidin dihydrochalcone

Neohesperidin dihydrochalcone yakawanikwa muna 1960s sechikamu cheDhipatimendi reUnited States repurojekiti yekutsvagisa zvekurima kutsvaga nzira dzekudzikisa kuvava kwemuto wecitrus.Neohesperidin chinhu chinovava chakadaro chinowanikwa musvuura uye pulp yeorenji inovava nemimwe michero yecitrus;iyo zvakare inoshanda flavonoid ingredient yemuchero wecitrus aurantium.Kana yakabatwa ne potassium hydroxide kana imwe nheyo yakasimba, uyezve hydrogenated, inova Neohesperidin dihydrochalcone (NHDC).

NHDC haiitike mumasikirwo.

Neo-DHC is hydrogenated kubva kune yakasikwa neohesperidin-yakasikwa sosi, asi yakave nekemikari shanduko, saka haisi yechisikigo chigadzirwa.

Neohesperidin dihydrochalcone VS zvimwe zvinotapira

Kusiyana kutapira uye kuravira

Kana ichienzaniswa ne sucrose, neohesperidin DC inoda kusvika 1500-1800 nguva inotapira kupfuura shuga uye ka1,000 inotapira kupfuura sucrose, nepo sucralose iri 400-800 nguva uye ace-k inotapira ka200 kupfuura shuga.

Neohesperidin DC inoravira zvakachena uye ine nguva refu yekuravira.Kufanana nemamwe mashuga akakwirira glycosides, akadai se glycyrrhizin inowanikwa mu stevia uye iyo inobva kumudzi we licorice, NHDC inotapira inononoka kutanga kupfuura shuga uye inogara mumuromo kwenguva yakareba.

Kugadzikana kwakanaka uye kuchengetedzwa kwepamusoro

NHDC yakagadzikana pasi pekushisa kwepamusoro, acidic kana alkaline mamiriro uye saka inogona kushandiswa mumashandisirwo anoda hupenyu hurefu hwesherufu.NHDC inokwanisa kuchengetedza chikafu chakachengeteka kweanosvika makore mashanu pasi pemamiriro akakwana

Ma receptors akasiyana

Maonero evanhu ekutapira uye kuravira anopindirana neT1Rs, mhuri yekutanga yeGPCRs, TIRs inoratidzwa mugustatory yekanyoro nyoro uye rurimi, kusanganisira TIR1, T1R2, uye TIR3, iyo inowanzowanikwa mumhando ye dimers.Iyo dimer T1R1-TIR3 ndeye amino acid receptor, iyo inoratidzira uye inotora chikamu mukuzivikanwa kuravira.Iyo dimer T1R2-T1R3 inotapira inogamuchira, iyo inotora chikamu mukuzivikanwa kuravira kutapira.

Sweeteners senge sucrose, aspartame, saccharin, uye cyclamate inoshanda pane extracellular chimiro dunhu reT1R2.NHDC uye cyclamate inobata pane transmembrane chikamu cheT1R3 kuburitsa kutapira.Neohesperidin DC inodyidzana nemasara eamino acid munharaunda yeT1R3 kuunza kutapira kwayo uye panguva imwe chete, inogona kukonzera synergistic kutapira mhedzisiro ye dimer T1R2-T1R3.Sezvinonhuhwira, NHDC ine kutapira kwakakosha kana yakasanganiswa nezvimwe zvinotapira zvine nhamba diki yezvinwiwa.

Kunze kwezvo, Neohesperidin DC inosiyana kubva kune zvechinyakare zvinotapira mumabasa ayo ekutapira, kuwedzera hwema, kuvanza kuvava, uye kugadzirisa flavour.

Mabhenefiti uye zvinogona kushandiswa neohesperidin dihydrochalcone (NHDC)

Antioxidant Properties

Mumakore achangopfuura, zvidzidzo zvakawanda zvinoratidza kuti neohesperidin dihydrochalcone ine yakakosha-inotsamira-inotsamira scavenging chiitiko pane yakagadzikana mahara radicals uye reactive oxygen marudzi (ROS).Kunyanya, NHDC ine yakanyanya inhibitory mhedzisiro paH2O2 uye HOCl.(yero yekutsvaira yeHOCl neH2O2 yaive 93.5% uye 73.5% zvichiteerana)

Zvakare, NHDC inogona kutadzisa kuparara kweprotein uye kutsemuka kweplasmid DNA strand, uye kudzivirira iyo HIT-T15, HUVEC sero kufa kubva kuHOCl kurwiswa.

NHDC ine akasiyana antioxidant chiitiko kurwisa akasiyana emahara radicals.Iyo antioxidant chiitiko cheNHDC inosanganisirawo kuti inogona kuvharidzira kubrown mhedzisiro yepigment deposition inokonzerwa ne polyphenol oxidase, iyo inogona zvakare kumisa zvakanyanya kukwira-regulation yematrix metalloproteinase (MMP-1) inokonzerwa neradio infrared, nokudaro kudzivirira ganda remunhu kubva. kuchembera nguva isati yakwana nekuda kwekuratidzwa kune infrared radiation.

Chishandiso: NHDC inogona kuve inogona kunge inopesana-browning yekuwedzera uye chena mumiriri

Shuga yepasi uye Lower Cholesterol

NHDC inotapira, isina chepfu, ine macalorie mashoma inogutsa zvinodiwa nevanhu zvekutapira nekudaro inoderedza kudyiwa kweshuga.

Zvidzidzo zvenguva pfupi yapfuura zvakaratidza kuti NHDC inogona kuvharidzira α-amylase mumhuka dzinoyamwisa mune madhigirii akasiyana-siyana uyezve kuderedza kutorwa kwemuviri kweshuga, nokudaro kuderedza shuga yeropa mumuviri, iyo inokosha zvikuru mumishonga, kunyanya kuvarwere vane chirwere cheshuga.

Kushandisa: NHDC inogona kushandiswa seisina shuga, calorie-isina sweetener.Kana ikashandiswa nemazvo, inogona kutsiva sucrose uye kuderedza kudya kwevanhu sucrose.Inokodzera vanhu vakafutisa uye vasina kufutisa.

Chengetedza chiropa

Zhang Shuo et al.akawana kuti NHDC inogona kuderedza mazinga eALT, AST mu serum uye hydroxyproline mumakumbo echiropa emakonzo ane chiropa fibrosis inokonzerwa neCCI, uye inoderedzawo kuderera uye necrosis yemasero uye chiropa fibrosis mumadhigirii akasiyana.Uyezve, kudzikira kweALT uye AST muserum kunogona kuvandudza lipid metabolism uye kushanda kwechiropa, kurambidza kuumbwa kwechiropa chemafuta uye endothelial plaque mutsinga huru.

Kunze kwezvo, NHDC inogona kunyatso kudzikisa kukuvadzwa kweoxidative kunokonzerwa neCC1, kuderedza kuzvimba, uye sero apoptosis.

Application: NHDC inotarisira kushandiswa sehepatoprotective agent.

Kudzivirira gastric ulcer

NHDC inogona kuvharidzira gastric acid secretion, saka inogona kushandiswa seantacid kusanganisa neAluminium Hydroxide Gel kana zvimwe zvinojairika kugadzira asidhi kuvandudza gastric acid kuramba kweyekupedzisira.

Suhrez et al.akawana kuti NHDC inogona kuderedza zvakanyanya iyo ulcer index inokonzerwa nekutonhora kuzvidzora kusagadzikana (CRS).Basa rayo rinofananidzwa neranitidine, iyo inogona kudzivisa basa re histamine uye kuderedza zvakanyanya kubudiswa kwegastric acid uye pepsin.

Chikumbiro: NHDC inogona kuve nyowani nyowani yemushonga yemudumbu.

Regulating immunity

NHDC inowedzerwa kudyisa sekutapira, kwete chete nekuda kwekunakidza kwayo uye inducing mhuka kudya, asiwo nekuda kweiyo probiotic maitiro akawanikwa naDaly et al.Apo NHDC yakawedzerwa kune kudya kwenguruve, Lactobacillus mumusuo wecaecum yenguruve yakawedzera zvakanyanya nekuwedzera kwelactic acid concentration mumatumbo emukati.Inogona kukanganisa symbiotic intestinal flora, kugadzirisa kusadzivirirwa kwemuviri, uye kuderedza zvirwere zvemukati.

Kushandisa: Neohesperidin DC inogona kushandiswa sekuwedzera kwekudya, NHDC inovandudza kunaka kwekudya kwezvinhu, inowedzera chido chemhuka, uye inovandudza mabhakitiriya emukati, zvino inomutsa kukura kwavo.

Neohesperidin DC kuchengetedza

NHDC chinhu chisina carious, chisingavirise zvinotapira.Empical research pamusoro pechepfu yakaitwa.Iyo metabolism yeNHDC mumuviri wemunhu yakafanana neiyo yemamwe echisikigo flavonoid glycosides.NHDC ine kukurumidza metabolism, haina kukurudzira kumuviri wemunhu, uye haina chepfu mhedzisiro.

Neo-DHC yakachengetwa muEuropean Pharmacopoeia makumi maviri emakore apfuura uye yakabvumidzwa sechinhu chinotapira neEuropean Union, asi kwete neFDA.MuUnited States, neo-DHC inotenderwa chete kushandiswa sechinhu chinonatsa kunaka.Kunze kwezvo, kunyoreswa kweNHDC kwechimiro cheGRAS muFDA kuri munzira.

Neohesperidin dihydrochalcone (NHDC) yakakurudzirwa dose uye Side effects.

Pamadhiri uye zvigadzirwa zvemukaka, iyo dosage: 10-35 ppm ( sweetener), 1-5 ppm ( flavour enhancer)

Kune Pharmaceutical Bitterness Masking, iwo dosi: 10-30 ppm( sweetener), 1-5 ppm (flavour enhancer)

Pakunhuhwirira kwekudya, chiyero chepamusoro chinokurudzirwa: 30-35 mg NHDC / kg chikafu chakakwana, 5 mg NHDC / L mvura;3-8 mg NHDC/L mvura yekuyamwa nekurumurwa

Zvinangwa zvakasiyana zvinosarudza dose.

Nekudaro, kana ikatorwa zvakawandisa, chero chinhu chinogona kuisa njodzi kumuviri wemunhu.Zvidzidzo zvakaratidza kuti neohesperidin dihydrochalcone (NHDC) inogona kukonzera kusvotwa uye migraine apo iyo yekumisikidza inenge 20 ppm kana kupfuura.Zvinokurudzirwa kupfeka masiki ekuvhiya kana uchibata neNHDC yakachena

Chitupa chekuongorora