Oleoylethanolamide (OEA)

Product name:Oleoylethanolamide, N-Oleoylethanolamide, OEA
Rimwe zita:N-(2-Hydroxyethyl)-9-Z-octadecenamide, N-oleoyl ethanolamide, Oleoyl monoethanolamide, 9-Octadecenamide , N-(2-Hydroxyethyl)oleamide
Nhamba yeCAS:111-58-0
Molecular Formula:C₂₀H₃₉NO₂
Molecular Weight:325.5
Assay:90%, 95%, 85% min
Chitarisiko :cream-ruvara poda

Oleoylethanolamidechimwe chinhu chitsva kumusika wezvekudya sechinhu chakakurumbira chekudya chekuwedzera chinoshandiswa muhuremu mafomula.Vazhinji vateveri vekuvaka muviri vari kukurukura nezve oleoylethanolamide pa reddit uye mamwe masocial network mapuratifomu.

Oleoylethanolamide ndeye yakasikwa metabolite yeoleic acid yakagadzirwa mudumbu diki mukati memuviri wemunhu.Zviri kungoitika, uye nyanzvi dzinozvidaidza kuti "endogenous".

OEA inodzora chisikigo chekudya, uremu uye cholesterol.Iyo yakasikwa metabolite inogadzirwa mudiki mudumbu mako.OEA inobatsira kudzora nzara, uremu, mafuta emuviri uye cholesterol nekusunga kune receptor inozivikanwa sePPAR-Alpha (Peroxisome proliferator-activated receptor alpha).Muchidimbu, OEA inowedzera metabolism yemafuta emuviri uye inoudza uropi hwako kuti wakaguta uye yave nguva yekumira kudya.OEA inozivikanwa zvakare kuwedzera isiri-exercise inoenderana necalorie mari.

Oleylethanolamide Nhoroondo

Oleoylethanolamide's biological function yakawanikwa kare semakore makumi mashanu apfuura.Gore ra2001 risati rasvika, pakanga pasina tsvakiridzo yakawanda paOEA.Zvisinei, gore iroro, vatsvakurudzi veSpain vakaputsa lipid uye vakadzidza kuti inogadzirwa sei, painoshandiswa uye chii chainoita.Vakaedza kuita kweOEA pahuropi (hwemakonzo) nekuibaya yakananga muuropi ventricles.Havana kuwana mhedzisiro pakudya uye vakasimbisa kuti OEA haiite muuropi, asi panzvimbo pezvo, inokonzeresa chiratidzo chakasiyana chinokanganisa nzara uye maitiro ekudya.

Oleylethanolamide VS cannabinoid anandamide

Mhedzisiro yeOEA yakatanga kudzidzwa nekuti inogovana zvakafanana neimwe kemikari, cannabinoid inozivikanwa seanandamide.Cannabinoids ine hukama nechirimwa Cannabis, uye anandamides aripo muchirimwa (uye mbanje) anogona kuwedzera chishuwo chemunhu chekudya nekukonzera mhinduro yekudyisa.Maererano neWikipedia, Oleoylethanolamide ndiyo monounsaturated analogue ye endocannabinoid anandamide.Kunyangwe OEA iine chimiro chemakemikari chakafanana neanandamide, mhedzisiro yayo pakudya uye uremu manejimendi akasiyana.Kusiyana neanandamide, OEA inoshanda yakazvimiririra ye cannabinoid nzira, inoronga PPAR-α chiitiko kukurudzira lipolysis.

Zvimiro zveakasiyana mafuta-asidhi ethanolamides: oleoylethanolamide (OEA), palmitoylethanolamide (PEA) uye anandamide (arachidonoylethanolamide, AEA).(Cima Science Co., Ltd ndiyo yega inogadzira zvinhu zvakawanda zveOEA, PEA neAEA kuChina, kana iwe uchida sampuli uye mutengo quote, tapota tidonhedze email mune iyo inotibata peji.)

OEA inosunga nehukama hwepamusoro kune peroxisome-proliferator-activated receptor-a (PPAR-a), nyukireya receptor inogadzirisa akati wandei emafuta metabolism.

Zvisikwa zviwanikwa zve oleoylethanolamide

Oleoylethanolamide ndeye yakasikwa metabolite yeoleic acid.Naizvozvo, zvikafu zvine oleic acid ndiyo yakananga sosi yeOEA.

Oleic acid ndiyo mafuta ekutanga mumafuta emiriwo akadai semuorivhi, canola uye sunflower.Oleic acid inogonawo kuwanikwa mumafuta enzungu, nyama, huku, chizi, nezvimwe.

Zvokudya zvakapfuma muoleic acid zvinosanganisira: Canola Oil, Oil Oil, Avocado Oil, Almond Oil, Avocados, High Oleic Safflower Oil.

Zvimwe pamusoro peOleic Acid:

Imwe yemafuta akajairika mumukaka wevanhu

Inoita 25% yemafuta mumukaka wemhou

Monounsaturated

Omega-9 fatty acid

Kemikari formula ndeye C18H34O2(CAS 112-80-1)

Inosanganisira triglycerides

Inoshandiswa mumakosmeti emutengo wepamusoro seyakanyanya kushanda moisturizer

Inowanikwa mumafuta emukaka, cheese, mafuta omuorivhi, mafuta emuorivhi, nzungu, avocados, mazai uye nyama.

Ive ine mutoro kune mazhinji ehutano mabhenefiti emafuta omuorivhi!

Inogadzira super hero complexes nemamwe mapuroteni emukaka kurwisa cancer maseru

Oleoylethanolamide Benefits

Oleoylethanolamide (OEA) yakanaka kuderedza uremu seyekudzora kudya uye inotsigira hutano hwecholesterol mazinga muvakuru.

OEA seanodzvinyirira kudya

Kudzvinyirirwa kwechido inzvimbo huru yekudzora simba (chikafu) kutora, kutonga kudya kwakakosha mukudzora huremu hwemuviri hune hutano.OEA inodzora sei chido chako?Unogona kutarisa maitiro ekuita pazasi.

OEA uye cholesterol

Mafuta omuorivhi inyanzvi yehutano, uye anobatsira kuderedza "yakaipa" LDL cholesterol uye kuwedzera "yakanaka" HDL.Sei?Kusvika ku85% yemafuta emuorivhi oleic acid, uye iyo huru ine hutano metabolite yeoleic acid ndeye OEA (Oleoylethanolamide ndiro zita rizere).Naizvozvo, hapana kupokana kuti OEA inobatsira hutano cholesterol.

Imwe rereearch inoratidza kuti oleoylethanolamide ine mhedzisiro yekushushikana, uye mamwe makwara nehumbowo hunodiwa kutsigira.

Kugadzira maitiro eOleoylethanolamide

Iyo inoyerera char yeOleoylethanolamide iri pazasi:

Matanho echikuru ndeichi: kuita → Kucheneswa → kusefa → Kunyungudika zvakare mu ethanol → hydrogenation → Sefa Yakajeka Mvura → crystallization → Kusefa → Kuedza → Kurongedza → Kupedzisa Chigadzirwa

Mechanism yekuita oleoylethanolamide

Kuzvitaura zviri nyore, oleoylethanolamide inoshanda senge nzara regulator.OEA inokwanisa kudzora madyiro ako ekudya nekuudza uropi kuti muviri wakazara, uye hapachadiwi chikafu.Iwe unodya zvishoma zuva rega rega, uye muviri wako unogona kunge usina kuwandisa mukufamba kwenguva.

Iyo anti-obesity zviito zve oleoylethanolamide (OEA) inoratidzwa pamufananidzo.OEA inogadzirwa uye inounganidzwa mukati mehuku hudiki kubva mukudya-inotorwa oleic acid, semafuta emuorivhi.Kudya kwakawanda-mafuta kunogona kutadzisa kugadzirwa kweOEA muura.OEA inoderedza kudya nekuita homeostatic oxytocin uye histamine brain circuitry pamwe nehedonic dopamine nzira.Pane humbowo hwekuti OEA inogonawo kudzikisa hedonic cannabinoid receptor 1 (CB1R) chiratidzo, iyo activation inosanganiswa nekuwedzera kwekudya.OEA inoderedza kutakura lipid kuita adipocytes kuderedza mafuta akawanda.Kuwedzera kujekeswa kwemhedzisiro yeOEA pakudya kwekudya uye lipid metabolism ichabatsira mukugadzwa kwemaitiro emuviri anogona kunangana nekugadzira anonyanya kushanda ekurapa kufutisa.

OEA inoshanda kumisa chimwe chinhu chinodaidzwa kuti PPAR uye panguva imwe chete inokwidza kupisa-mafuta uye inoderedza kuchengetwa kwemafuta.Paunodya, mazinga eOEA anowedzera uye havi yako yekudya inodzikira apo tsinga dzekunzwa dzinobatana nehuropi hwako dzinozviudza kuti wakaguta.PPAR-α iboka re ligand-activated nuclear receptor iyo inobatanidzwa mune gene expression ye lipid metabolism uye energyhomeostasis nzira.

OEA inoratidza ese anotsanangura maitiro e satiety factor:

(1) Inodzivisa kudya nekuwedzera nguva yekudya kunotevera;

(2) Kuumbwa kwayo kunodzorwa nekuwanikwa kwekudya uye

(3) Matanho ayo anochinja-chinja.

Oleoylethanolamide side effects

Oleoylethanolamide chengetedzo inyaya hombe pakati pemhando dzekuwedzera dzinoda kuyedza inoveli inongedzo mune yavo yekurasikirwa uremu mafomula.

Mushure mekuongorora kwakadzama kwemabhuku ese aripo uye data, iyo US Chikafu neDrug Administration (FDA) yakanga isina hanya nezvekuchengetedzwa kweOEA.RiduZone ndiyo yekutanga yakanzi oleoylethanolamide poda yezvigadzirwa kubvira 2015.

Oleoylethanolamide is metabolite yeoleic acid, inova chikamu chekudya kwezuva nezuva kune hutano.Zvakachengeteka kuyedza OEA supplements, uye hapana yakakomba mhedzisiro yakataurwa.

migumisiro yakashumwa.

Oleoylethanolamide miedzo yevanhu

Mune imwe ongororo, makumi mashanu (n = 50) vanhu vanofarira kuderedza uremu vakarayirwa kutora OEA 2-3 nguva / zuva, 15-30 maminetsi vasati vadya kwemavhiki 4-12.Zvidzidzo zvaisanganisira avo vakanga vasati vamboshandisa zvigadzirwa zvekuderedza uremu, avo vakawana zviitiko zvakashata nezvimwe zvigadzirwa zvekurasikirwa nehuremu, avo vane uremu hwakakwira pane mamwe maajenti ekurasikirwa uremu akadai se phentermine, avo vanoedza kuita shanduko yemararamiro (chikamu chekudzora uye kugara uchirovedza muviri. ), uye avo vari kushingaira kutungamirirwa nokuda kwehutano hwehutano hunosanganisira kusagadzikana kweglucose kushivirira, dyslipidemia, hypertension uye zvirwere zvemwoyo.

Muchidzidzo chechipiri, zvidzidzo zve4 zvine huremu hwekutanga hwe229, 242, 375 uye 193 lbs zvakateerana, vakarayirwa kutora Oleoylethanolamide capsules (imwe capsule ine 200mg 90% OEA).Vatungamiri vakatora 4 capsules (1 capsule 15-30 maminetsi vasati vadya uye vaifanira kutora imwe capsule vasati vapedza kudya kwavo kukuru kwezuva) zuva nezuva kwemazuva makumi maviri nemasere.Nyaya yekupedzisira yakanga yamboitwa lap band kuiswa.Zvidzidzo zvakarayirwa kuti zvisachinja pakudya kwavo uye tsika dzekurovedza muviri.

Results

Muchidzidzo chekutanga, zvidzidzo zvakarasikirwa neavhareji ye1-2 lbs / vhiki.Pakange pasina mhedzisiro kunze kwemurwere mumwe chete ainzwa kusvotwa kwenguva pfupi kwakagadziriswa mukati meisingasviki svondo.Muchidzidzo chechipiri, 3 kunze kwe4 zvidzidzo zvakashuma kurasikirwa (3, 7, 15 uye 0 lbs maererano).Zvose zvidzidzo zve4 zvakashuma kuderera kwe10-15% muhukuru hwechikamu, nguva yakareba yepakati-yekudya, uye pasina migumisiro.

Kana iwe uchifarira mamwe mabhuku ezviyedzo zvevanhu neOEA, ndapota shanyira zvinodhaunirodha PDF zvinongedzo.

Oleoylethanolamide dosage

Pane ruzivo rushoma rwekutsvagisa nezve yazvino OEA yekuwedzera muvanhu, uye kunyangwe ichionekwa seyakachengeteka, hapana dosi inokurudzirwa.Nekudaro, pane zvimwe zvekuwedzera pamusika, uye iwe unogona kuwana zvimwe zvereferensi yako.

Iyo dosing pazuva reRiduZone (yakanzi OEA/Oleoylethanolamide 90%) ndeye 200mg (1capsule ine OEA chete mairi).Kana yakasanganiswa pamwe chete nezvimwe zvinongedzo zvekurasikirwa nehuremu, iyo dosing yezuva nezuva inoita kunge ishoma, taura 100mg kana 150mg.Zvimwe zvekuwedzera

Zvinokurudzirwa kutora oleoylethanolamide supplements 30 maminetsi usati wamangwanani uye kudya kwemanheru, iwe unozonzwa wakaguta panguva yekudya uye semhedzisiro ungangodya zvishoma.

Tsvagiridzo mabhuku eoleoylethanolamide

Oleoylethanolamide: mutambi mutsva mune simba metabolism control.Basa mukutora chikafu

Oleoylethanolamide inowedzera kutaura kwePPAR-Α uye inoderedza kudya uye uremu hwemuviri muvanhu vakafuta: Chiyedzo chekiriniki.

Brain Molecules uye Appetite: Nyaya yeOleoylethanolamide

Oleylethanolamide inodzora kudya uye uremu hwemuviri kuburikidza nekuita kweiyo nyukireya receptor PPAR-a

Kuitwa kweTRPV1 neiyo Satiety Factor Oleoylethanolamide

Kudzora kwekudya kwekudya neoleoylethanolamide

Mechanism ye oleoylethanolamide pane fatty acid inotorwa mudumbu diki mushure mekudya kwekudya uye kuderedzwa kwehuremu.

Oleoylethanolamide: Basa rebioactive lipid amidein modulating kudya maitiro

Oleoylethanolamide: Mubatsiri ane mafuta mukurwisa kufutisa

Oleoylethanolamide: A Novel Inogona Pharmacological Alternative kune Cannabinoid Antagonists yeKudzora Kwekudya.