Magaca Alaabta:Isku dhafka 7P

Magaca kale: Compound7P; 2- [(2-methoxyphenyl) [(4-methylphenyl) sulfonyl] amino]-N- (4-methoxy-3-pyridinyl) acetamide; 2- (N- (2-methoxyphenyl) -4- methylphenylsulfonamido -N- (4-methoxypyridin-3-yl) acetamide

CAS Maya:1890208-58-8

Tilmaamaha: 99.0%

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Xaalada GMO:GMO Bilaash

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Isku-dhafka 7p ayaa lagu muujiyay in uu kiciyo kobaca GAP-43-positive axon ee qaabka xayawaanka ee dhaawaca dareemayaasha indhaha, taas oo soo jeedinaysa in waxqabadka neurite ee ka soo baxa xarunta 7p ee vitro ay u tarjumayso kicinta dib u soo kabashada axon ee Vivo.

Qaabka xayawaanka ee dhaawaca dareemayaasha indhaha, xarunta 7p ayaa lagu muujiyay in ay kiciso koritaanka farqiga-43 axon togan, taas oo muujinaysa in in vitro neurite dhaqdhaqaaqa ka soo baxa xarunta 7p ay u tarjumayso kicinta dib u soo kabashada axon ee vivo. hababka ay ku soo saarto dib u soo kabashada axon ee vivo waxay siin doontaa saldhig macquul ah dadaalka mustaqbalka si kor loogu qaado xeeladaha daaweynta.

Isku dhafka 7P waxaa loola jeedaa isku dhis dabiici ah oo gaar ah oo ka kooban todoba atamka kaarboon. Kiimikada dabiiciga ah, kaarboonku waa curiye muhiim ah sababtoo ah waxay samayn kartaa curaarta xasilloon ee atamka kale, oo ay ku jiraan atamka kaarboonka, si ay u sameeyaan unugyo isku dhafan. Unugyadani waxay yeelan karaan hanti iyo shaqooyin kala duwan, iyagoo ka dhigaya isku-dhisyada kaarboon-ku-salaysan ee dhismaha nolosha. Noocyada xayawaanka ee dhaawaca dareemaha indhaha, xarunta 7p ayaa lagu muujiyay in ay kiciso kobaca GAP-43-positive axon, taas oo soo jeedinaysa in dhaqdhaqaaqa koritaanka neurite ee xarunta 7p in vitro ay u tarjumayso kicinta dib u soo kabashada axonal ee vivo. Isku-dhafka 7P budada waa caddaan ama budo cad-cad oo loo soo saaray sidii isku-darka tandem si loo aqoonsado laba-qabta tromboxane antagonist antagonist. Dhab ahaantii, xarunta 7p waxay muujisay xulashada prostaglandin I2 synthase (PTGIS, CYP8A1) marka loo eego thromboxane synthase (CYP5A1). Xarunta nootropic 7P budada waxay kor u qaadaa korriinka Gap-43-positive axon, taas oo kicinaysa dib u soo kabashada axonal ee jirka. Complex 7p oo tayo sare leh waxaa loogu talagalay in lagu wanaajiyo isuduwidda, wanaajiso niyadda iyo caawinta la dagaalanka daalka. Waxa kale oo ay ka hortagtaa oksaydheynta maskaxda waxayna ka caawisaa la dagaalanka dhaawaca maskaxda ee ay keento cabbitaanka khamriga.

Shaqada:

Dib-u-soo-nooleynta Axon ka dib dhaawaca habka dhexe ee neerfayaasha ayaa caqabad ku ah qayb ahaan sababtoo ah haddii hoos u dhac ku yimaada da'da ku-tiirsanaanta awoodda kobaca axon ee gudaha, iyo mid ka mid ah xeeladaha lagu kicinayo koritaanka axon ee neerfaha dhaawacan waxay ku lug leedahay farmashiolojiyeed ee waddooyinka calaamadaynta. Shaashada unugyada phenotypic ee maktabadaha kiimikaad iyo qaab-dhismeed-hagaajinta waxqabadka-hagaya taas oo keentay aqoonsiga xarunta 7p taas oo kor u qaadaysa koritaanka neurite ee neerfayaasha asaasiga ah ee dhaqameed ee ka soo jeeda hippocampus, kiliyaha maskaxda, iyo retina. qaabka xayawaanka ee dhaawaca dareemaha indhaha, xarunta 7p ayaa lagu muujiyay in ay kiciso koritaanka farqiga-43 axon togan, taas oo muujinaysa in in vitro neurite dhaqdhaqaaqa ka soo baxa xarunta 7p ay u tarjumayso kicinta dib u soo kabashada axon ee vivo. hababka ay ku soo saarto dib u soo kabashada axon ee vivo waxay siin doontaa saldhig macquul ah dadaalka mustaqbalka si kor loogu qaado xeeladaha daaweynta.
Codsiga:

Hadda waa daroogo caqli badan oo nootropic ah oo isu muujisa mid ka mid ah racetams-ka ugu awoodda badan caalamka nootropic. Waxaa laga sameeyay fasalka xeryahooda loo yaqaan 'racetams', oo ku shaqeeya ma aha oo kaliya acetylcholine, laakiin sidoo kale GABA reseptors ee maskaxda, tani waxay awood u leedahay inay dhaqaajiso labadaba cholinergic iyo glutamate reseptors ee kiliyaha maskaxda, waana daroogada racetam kacaanka sababtoo ah aadka u daran. habka gaarka ah ee ficilka. Fasoracetam hadda waxay sidoo kale muujinaysaa faa'iidooyinka sida ka-hortagga niyad-jabka, kicinta ADHD, iyo anxiolytic, sidoo kale, sida lagu caddeeyey shaybaarrada qaranka oo dhan, waxay ka caawisaa sameynta iyo xajinta xusuusta cusub.