Lebitso la Sehlahisoa:Phofo ea Lupeol98%
Mohloli oa Botanic:Mango, Acacia visco, Abronia villosa, kofi ea Dandelion.
CASNo:545-47-1
Mmala:Bosoeu ho isa bosoeuphofo e nang le monko le tatso e ikhethang
Tlhaloso:≥98% HPLC
GMOBoemo: GMO Mahala
Ho paka: ka meqomo ea fiber ea 25kgs
Polokelo: Boloka setshelo se sa buloa sebakeng se phodileng, se omileng, Qoba hole le leseli le matla
Shelf Life: Likhoeli tse 24 ho tloha ka letsatsi la tlhahiso
Ts'ebetso ea Baeloji:
Lupeol (Clerodol; Monogynol B; Fagarasterol) ke pentacyclic triterpenoid e sebetsang, e na le anti-oxidant, anti-mutagenic, anti-tumor le anti-inflammatory.Lupeol e matlali-receptor tsa androgen(AR) inhibitor mme e ka sebelisoa bakeng sakankerelipatlisiso, haholo-holo prostatekankereea phenotype e itšetlehileng ka androgen (ADPC) le phenotype e hanyetsanang le "castration" (CRPC)[1].
Ka Vitro Patlisiso:
Lupeol ke inhibitor e matla ea AR e ka hlahisoang e le moriana o ka sebelisoang ho phekola mofetše oa tšoelesa ea senya ea motho (CaP).Kalafo ea Lupeol (10-50 μM) bakeng sa 48 h e entse hore ho be le thibelo ea kholo e itšetlehileng ka tekanyo ea lisele tse itšetlehileng ka androgen-phenotype (ADPC), e leng lisele tsa LAPC4 le LNCaP, tse nang le IC50 ea 15.9 le 17.3 μM, ka ho latellana.Lupeol e boetse e thibetse kholo ea 22Rν_1 ka IC50 ea 19.1 μM.Ho phaella moo, Lupeol e ile ea thibela kholo ea lisele tsa C4-2b tse nang le IC50 ea 25 μM.Lupeol e na le monyetla oa ho thibela kholo ea lisele tsa CaP tsa ADPC le CRPC phenotypes.Li-Androgens li tsejoa ka ho tsamaisa kholo ea lisele tsa CaP ka ho kenya tšebetsong AR[1]
Phuputsong ea Vivo:
Lupeol ke moriana o sebetsang o nang le bokhoni ba ho thibela tumorigenicity ea lisele tsa CaP ka har'a vivo.Kakaretso ea potoloho ea serum ea PSA (e patiloe ke lisele tsa hlahala tse kentsoeng) li ile tsa lekanyetsoa qetellong ea thuto ka letsatsi la 56. Letsatsing la 56 ka mor'a ho kenngoa, litekanyetso tsa PSA ho tloha 11.95-12.79 ng / mL li ne li hlokomeloa liphoofolong tse laolang tse nang le lihlahala tsa LNCaP le Lihlahala tsa C4-2b, ka ho latellana.Leha ho le joalo, balekane ba phekoloang ke Lupeol ba bontšitse maemo a fokotsehileng a PSA ea serum ho tloha ho 4.25-7.09 ng/mL.Li-tissue tsa hlahala tse tsoang liphoofolong tse tšoaroang ka Lupeol li bonts'itse maemo a fokotsehileng a serum ea PSA ha a bapisoa le taolo[1]
