Lebitso la Sehlahisoa: Celastrol phofo e ngata
Mohloli oa Botanic:The God Vine(Tripterygium wilfordii hook.f)
CASNo:34157-83-0
'Mala: Phofo ea kristale e khubelu e nang le monko le tatso e ikhethang
Tlhaloso:≥98% HPLC
GMOBoemo: GMO Mahala
Ho paka: ka meqomo ea fiber ea 25kgs
Polokelo: Boloka setshelo se sa buloa sebakeng se phodileng, se omileng, Qoba hole le leseli le matla
Shelf Life: Likhoeli tse 24 ho tloha ka letsatsi la tlhahiso
Phofo ea Celastrolke motsoako o sebetsang ho Tripterygii Radix, e leng motso o omileng le rhizome ea God Vine.Ho na le mefuta e mene ka kakaretso, e lengTripterygium wilfordii Hook.f, Tripterygium hypoglaucum Hutch, Tripterygium regelii Sprague et Takeda, le Tripterygium forresti Dicls.
Diterpenoids: triptolide(cas no.38748-32-2), Tripdiolide( cas no.38647-10-8), joalo-joalo.
Triterpenoids: Celastrol(cas no.34157-83-0), Wilforlide A(cas no.84104-71-2), joalo-joalo.
Alkaloids:Wilforgine(cas no.37239-47-7), Wolverine (cas no.11088-09-8), wilforidine, joalo-joalo.
Tripterygium ke pentazine triterpene e fumanehang ka tlhaho ho Tripterygium wilfordii.E sebetsa hantle ho alafa lefu la ramatiki.Triptolide e thibela proteasome le nuclear factor Kb ho sebetsa.
Celastrol (Tripterin) ke proteasome inhibitor e nang le mesebetsi e khahlanong le ho ruruha le antioxidant.E thibela ka katleho le ka mokhoa o ikhethileng mosebetsi o kang oa chymotrypsin oa 20S proteasome e nang le IC50 ea 2.5 μM.
Tripterine ke antioxidant e matla le e khahlanong le ho ruruha.Ke HSP90 inhibitor e ncha (e senya Hsp90 / Cdc37 e rarahaneng), e na le liphello tse khahlanong le kankere (anti-angiogenesis - e thibela vascular endothelial growth factor receptor expression);antioxidant (e thibela peroxidation ea lipid) le ts'ebetso e khahlanong le ho ruruha (E thibela tlhahiso ea iNOS le li-cytokine tsa ho ruruha)
Bthuto-thutoAmosebetsi:
Celastrol (Tripterin) e theola fatše-e laola basal le DNA-e senyang moemeli e bakoang ke FANCD2 monoubiquitination, e lateloa ke ho senyeha ha protheine.Kalafo ea Celastrol e felisa tlhahlobo ea G2 e entsoeng ke IR mme e ntlafatsa tšenyo ea DNA e bakoang ke lithethefatsi ea ICL le liphello tse thibelang lisele tsa kankere ea matšoafo ka ho senya FANCD2.Celastrol e na le litlamorao tse kholo tsa inhibitory le apoptosis ho lisele tsa DU145 tse hlahisitsoeng ka har'a vitro ka mokhoa o itšetlehileng ka nako le tekanyetso.Phello ea Celastrol e khahlanong le tšoelesa ea senya ke karolo e 'ngoe ea ho theola boemo ba polelo ea liteishene tsa hERG liseleng tsa DU145, ho fana ka maikutlo a hore Celastrol e kanna ea ba setlhare se ka bang teng sa mofetše oa tšoelesa ea senya, mme mokhoa oa eona e ka ba ho thibela liteishene tsa hERG.Celastrol e ntlafatsa colitis ea liteko ho litoeba tse haelloang ke IL-10 ka ho thibela tsela ea pontšo ea PI3K/Akt/mTOR le ho laola autophagy.Celastrol e na le monyetla oa ho thibela ts'ebetso ea cytochrome P450 mme e ka baka likamano tsa litlama.Celastrol e kenya apoptosis liseleng tsa TNBC, e fana ka maikutlo a hore apoptosis e ka 'na ea kopanngoa ka ho se sebetse ha mitochondrial le tsela ea pontšo ea PI3K/Akt.Celastrol e kenya apoptosis le autophagy ka tsela ea pontšo ea ROS / JNK.Celastrol e thibela lefu la dopaminergic neuron lefung la Parkinson ka ho kenya apoptosis ea mitochondrial.
Karolo ea Celastrol ho chemosensitization ea mofetše:
Chemotherapy e ntse e le khetho ea mantlha ea kalafo bakeng sa bakuli ba mofetše.Leha ho le joalo, chemotherapy hangata e tlameha ho kopanngoa le lithethefatsi tse ling ho fokotsa litla-morao le ho qoba ho hanyetsa lithethefatsi.Lihlahisoa tsa tlhaho li ntse li sebelisoa haholo e le liphekolo tsa adjuvant hammoho le li-regimens tse teng tsa chemotherapy ho ntlafatsa katleho ea kalafo.Mohlala o mong o tšepisang oa moriana o joalo oa tlhaho ke motsoako oa triterpene o bitsoang celastrol, o ka ’nang oa e-ba le monyetla o moholo oa ho sebelisoa e le sesebelisuoa sa lik’hemik’hale.E khethiloe qalong ho tloha ho Thunder God Vine, e laola hampe limolek'hule tse ngata tsa oncogenic tse kang NF-κB, topoisomerase II, Akt/mTOR, HSP90, STAT3, le Notch-1.Tsena li ka lebisa ho karabelo e khahlanong le ho ruruha, ho thibela ho hōla ha hlahala le ho phela, le ho felisa angiogenesis.Khaolo ena e akaretsa ka bokhutšoanyane karolo e ka bang teng ea celastrol e le chemosensitizer le mekhoa ea limolek'hule e hokahanyang litlamorao tse tlalehiloeng tsa chemosensitizing mefuteng e fapaneng ea mofetše.
