Lebitso la sehlahisoa:Nicotinamide riboside chloride phofo
Lebitso le leng:3-(Aminocarbonyl) -1-PD-ribofuranosyl-pyridinium chloride(1 :1);Nicotinamide
Riboside.Cl;3-Carbamoyl-1-beta-D-ribofuranosyl-pyridinium chloride;NR, vithamine NR; Niagen, TRU NIAGEN
CASNO:23111-00-4
Mokhoa oa molek'hule: C11H15N2O5.Cl
Boima ba 'mele: 90.70 g / mol
Bohloeki: 98%
Sebaka se qhibilihang: 115 ℃-125 ℃
Ponahalo: E Tlohile Bosoeu ho ea Bofuteng bo Bosehla
Tšebeliso: E matlafatsa maemo a NAD+, E tšehetsa botsofali bo botle le boko / kelello
Likopo: joalo ka tlatsetso ea lijo, lijo tse sebetsang, le lino tse tahang
Tekanyetso e khothalletsoang: eseng ho feta 180 mg / letsatsi
Nicotinamide riboside ke mofuta o sa tsoa ananeloa oa Vithamine B3, e nang le thepa e ikhethang;ke selelekela sa semmuso sa NAD +.
Nicotinamide riboside (NR), e qalileng ho hlalosoa ka 1944 e le sesosa sa kholo (Factor V) bakeng sa ntaramane ea Haemophilus, 'me ka 1951, NR, e ile ea qala ho fuputsoa e le qetello ea metabolic liseleng tsa mammalian.
Joalokaha u ka hlokomela hore, ho na le mefuta e 'meli ea NR e fumanehang, e' ngoe ke Nicotinamide Riboside, 'me e' ngoe ke Nicotinamide Riboside chloride.
Ha re bua ka lik'hemik'hale, ke metsoako e 'meli e fapaneng ka ho feletseng kaha e na le linomoro tse fapaneng tsa CAS, NR e nang le 1341-23-7 ha NR chloride e nang le 23111-00-4.NR ha e tsitse mocheso oa kamore, ha NR chloride e tsitsitse.Brand e tsebahalang e nang le tokelo ea molao e bitsoang NIAGEN®, e lokollotsoeng ke Chromadex Inc ka 2013, ke mofuta oa Nicotinamide riboside chloride, e ikemiselitseng ho khutlisa matšoao a botsofali ka hare ho 'mele oa hau.Nicotinamide Riboside e entsoeng ho tloha Cima Science e boetse e le ka foromo ea phofo ea chloride.Haeba e sa hlalosoa, NR e tla bua ka foromo ea NR chloride sengolong se ka tlase.
Mehloli ea lijo tsa Nicotinamide riboside
Palo ea NR lijong ke motsotso, ha e bapisoa le ea li-supplement tsa phepo.Leha ho le joalo, mehloli ea mantlha ea lijo e nang le nicotinamide riboside (NR) ke efe?
Lebese la khomo
Hangata lebese la khomo le na le ~12 μmol NAD(+) precursor vitamin/L, eo 60% ea eona e neng e le teng e le nicotinamide, mme 40% e ne e le ea hajoale joalo ka NR.(Lebese le tloaelehileng le ne le e-na le NR e ngata ho feta lebese la tlhaho), thuto e hatisitsoeng ke Univesithi ea Iowa, ka 2016.
Tomoso
Boithuto ba khale bo boletse, "Sesebelisoa se le seng se thibelang tomoso se ile sa qheleloa ka thoko ho tomoso 'me sa fumanoa e le nicotinamide riboside, e kanna ea ba le NAD (P) nakong ea ho lokisoa ha lihlahisoa tsa tomoso, kapa ho tsoa ho tlatsetso ea tomoso ea lijo nakong ea tšilo ea lijo ka vivo."Le hoja ho se na data ea palo ea tomoso
Biri
Biri e na le palo e lekaneng ea lik'habohaedreite 'me ho noa tse nang le mokelikeli o joalo ho tla ba le phello ea glycemic;lipampiri tse fapaneng tsa lipatlisiso li boletse biri e le mohloli oa lijo oa nicotinamide riboside.
Hape, ho ka 'na ha e-ba le palo e fokolang ea NR joalo ka protheine ea whey, li-mushroom, joalo-joalo.
Bakeng sa batho ba bangata, lebese le khaotsoe ka mabaka a mang.Mehloli ea lijo ea nicotinamide riboside e kanna ea ba molemo, empa ha e sebetse hantle ho feta tlatsetso ea NR.
Hobaneng ha Nicotinamide Riboside (NR) e khetha e le li-invertebrates tsa vithamine tsa 'nete tsa NAD +?
Ho na le mabaka a mahlano a tšehetsang taba ena:
Haemophilus influenza, baktheria e bakang ntaramane, e se nang tsela ea de novo mme e sa khone ho sebelisa Na kapa Nam, e itšetlehile haholo ka NR, NMN, kapa NAD+ bakeng sa kholo ea mali a amohelang.
Lebese ke mohloli oa NR.
NR e sireletsa li-neuron tsa murine tsa DRG ka tlhahlobo ea ex vivo axonopathy ka ho kenngoa ha transcriptional ea nicotinamide riboside kinase (NRK) 2 gene.
NR e kenyellelitsoeng ka mokhoa o makatsang le tse tsoang ho tse ling li eketsa pokello ea NAD + ka mokhoa o itšetlehileng ka tekanyetso meleng ea lisele tsa motho.
Candida glabrata, fungus e nkang monyetla e itšetlehileng ka livithamini tsa NAD + bakeng sa kholo, e sebelisa NR nakong ea ts'oaetso e hasaneng.
Nicotinamide Riboside VS Nicotinamide VS Niacin
Niacin (kapa nicotinic acid), ke motsoako oa tlhaho le mofuta oa vithamine B3, limatlafatsi tsa bohlokoa tsa motho.E na le foromo ea C6H5NO2.
Nicotinamide kapa e bitsoang niacinamide ke mofuta oa vithamine B3 e fumanoang lijong 'me e sebelisoa e le tlatsetso ea lijo le meriana.E na le foromo ea C6H6N2O.
Nicotinamide riboside ke mofuta oa pyridine-nucleoside oa vithamine B3 e sebetsang e le selelekela sa nicotinamide adenine dinucleotide kapa NAD+.E na le foromo ea C11H15N2O5+.
Nicotinamide Riboside Melemo ea Bophelo bo Botle
Nicotinamide Riboside e thusa ho hlahisa matla
Liphoofolo, tlatsetso ea NR e fokolitse tšebeliso ea NAD, e ntlafalitseng ts'ebetso ea mitochondrial, boima ba mesifa bo tsosolositsoeng ka potlako, le ho boloka matla a NAD le ho ikoetlisa ka bongata litoeba tsa khale, ho thusa ho boloka mesifa le ts'ebetso, ho ts'ehetsa tlhahiso ea matla a mangata.
Nicotinamide Riboside e ntlafatsa ts'ebetso ea kelello
NR e boloka lisele tsa methapo bokong ka ho kenya tšebetsong SIRT3, Supplementation e susumetsa litsela tsa NAD mme e thusa ho thibela ho senyeha kelellong.
NR e matlafalitse ts'ebetso ea kelello 'me ea fokotsa tsoelo-pele ea lefu la Alzheimer ho litoeba tse fuoeng NR ka likhoeli tse tharo.
Nicotinamide Riboside e thibela tahlehelo ea kutlo
Ka ho kenya tšebetsong tsela ea SIRT3, boithuto ba UNC bo fumane hore bo thusitse ho sireletsa litoeba khahlano le tahlehelo ea kutlo e bakoang ke lerata.
Nicotinamide Riboside e sireletsa sebete
NR e nkiloeng ka molomo e eketsa NAD 'meleng, e thusang ho sireletsa sebete.NR e ile ea emisa ho bokellana ha mafura, ea theola khatello ea oxidative, ea thibela ho ruruha, le ho ntlafatsa kutloisiso ea insulin sebeteng sa litoeba.
Ho feta moo, NR e ka lelefatsa bophelo bo bolelele, E eketsa metabolism, e tšehetsa ntoa khahlanong le mofetše, ea fokotsa matšoao a lefu la tsoekere, ea eketsa metabolism, e ka thusa ka ho theola boima ba 'mele.
Na Nicotinamide Riboside e Sireletsehile?
E, NR e bolokehile.
NR e na le liteko tse tharo tse hatisitsoeng tsa bongaka tse tiisang hore e bolokehile hore e ka sebelisoa ke batho.
Ho hlahlobisisa le ho hatisa lintlha tsohle tsa tlhahlobo le tsa bongaka tse fumanehang ho NR ho netefatsa hore e bolokehile ebile e mamelloa hantle.
Niagen e bolokehile ebile e na le GRAS, e sebelisa mekhoa ea mahlale, tlasa Molao oa Federal Food, Drug, and Cosmetic Act (FFDCA).
Liteko tsa Batho tsa Nicotinamide Riboside
Ho na le liphuputso tse ngata tsa pele ho tleliniki tse entsoeng liteko tsa NR mekhoeng e fapaneng ea mehlala.
Ka 2015, lithuto tsa pele tsa bongaka tsa batho li ile tsa phethoa, 'me liphetho li bontšitse hore NR ka mokhoa o sireletsehileng le ka katleho e eketsa maemo a NAD ho baithaopi ba phetseng hantle ba batho.
Teko ea kliniki e laoloang ke placebo ea nicotinamide riboside ho banna ba batenya ka mokhoa o sa reroang: polokeho, insulin-sensitivity, le litlamorao tsa lipid-mobilizing.
-E hatisitsoe ho The American/Journal of Clinical Nutrition
Liphello: 12 wk ea NR supplementation ka tekanyo ea 2000 mg / d e bonahala e sireletsehile, empa ha e ntlafatse kutloisiso ea insulin le metabolism ea 'mele oohle oa glucose ho banna ba batenya, ba hanyetsang insulin.
Tlatsetso e sa foleng ea nicotinamide riboside e mamelloa hantle mme e phahamisa NAD+ ho batho ba baholo ba phetseng hantle ba lilemo tse mahareng le ba baholo.
-E hatisitsoe ho Tlhaho ea puisano
Nicotinamide Riboside e Haholo-holo le ka Molomo Bioavailable ho Litoeba le Batho.
-E hatisitsoe ho Tlhaho ea puisano
Mona re hlalosa nako le litlamorao tse itšetlehileng ka tekanyetso ea NR ho metabolism ea mali ea NAD ho batho.Tlaleho e bontša hore mali a motho NAD a ka phahama ka makhetlo a 2.7 ka tekanyo e le 'ngoe ea molomo ea NR lipatlisisong tsa lifofane tsa motho a le mong le hore molomo oa NR o phahamisa panya ea hepatic NAD ka pharm e bonahalang le e phahameng.
