Oleoylethanolamide(OEA)

Lebitso la sehlahisoa:Oleoylethanolamide, N-Oleoylethanolamide, OEA
Lebitso le leng:N-(2-Hydroxyethyl)-9-Z-octadecenamide, N-oleoyl ethanolamide, Oleoyl monoethanolamide, 9-Octadecenamide , N-(2-Hydroxyethyl)oleamide
Nomoro ea CAS:111-58-0
Foromo ea molek'hule:C₂₀H₃₉NO₂
Boima ba Molek'hule:325.5
Tlhahlobo:90%,95%, 85% min
Ponahalo :phofshoana e mmala wa tranelate

Oleoylethanolamideke ntho e ncha 'marakeng oa phepo e nepahetseng e le motsoako o tummeng oa lijo tse sebelisoang ho fokotsa boima ba' mele.Balateli ba bangata ba ho haha ​​​​'mele ba buisana ka oleoylethanolamide ho reddit le li-platform tse ling tsa marang-rang.

Oleoylethanolamide ke metabolite ea tlhaho ea oleic acid e entsoeng ka maleng a manyenyane ka har'a 'mele oa motho.E etsahala ka tlhaho, 'me litsebi li e bitsa "endogenous".

OEA ke taolo ea tlhaho ea takatso ea lijo, boima ba 'mele le k'holeseterole.Ke metabolite ea tlhaho e entsoeng ka tekanyo e nyane ka maleng a hau a manyane.OEA e thusa ho laola tlala, boima ba 'mele, mafura a' mele le k'holeseterole ka ho tlama ho receptor e tsejoang e le PPAR-Alpha (Peroxisome proliferator-activated receptor alpha).Ha e le hantle, OEA e eketsa metabolism ea mafura a 'mele' me e bolella boko ba hao hore u khotše 'me ke nako ea ho khaotsa ho ja.OEA e boetse e tsejoa ka ho eketsa litšenyehelo tsa khalori tse amanang le ho se ikoetlise.

Histori ea Oleylethanolamide

Mesebetsi ea tlhaho ea Oleoylethanolamide e ile ea sibolloa lilemong tse 50 tse fetileng.Pele ho 2001, ho ne ho se na lipatlisiso tse ngata ka OEA.Leha ho le joalo, selemong seo, bafuputsi ba Masepanishe ba ile ba roba lipid 'me ba ithuta hore na e etsoa joang, e sebelisoa hokae le hore na e etsa eng.Ba ile ba leka phello ea OEA bokong (ba likhoto) ka ho e kenya ka ho toba li-ventricle tsa boko.Ha baa ka ba fumana phello ea ho ja 'me ba tiisa hore OEA ha e sebetse bokong, empa ho e-na le hoo, e hlahisa pontšo e fapaneng e amang tlala le boitšoaro ba ho ja.

Oleylethanolamide VS cannabinoid anandamide

Litlamorao tsa OEA li ile tsa ithutoa pele hobane e arolelana lintho tse tšoanang le k'hemik'hale e 'ngoe, cannabinoid e tsejoang e le anandamide.Li-Cannabinoids li amana le semela sa Cannabis, 'me li-anandamide tse teng semeleng (le matekoane) li ka eketsa takatso ea motho ea ho ja lijo tse bobebe ka ho tsosa karabelo ea phepo.Ho latela Wikipedia, Oleoylethanolamide ke analogue ea monounsaturated ea endocannabinoid anandamide.Leha OEA e na le sebopeho sa lik'hemik'hale se ts'oanang le anandamide, litlamorao tsa eona mabapi le ho ja le ho laola boima ba 'mele li fapane.Ho fapana le anandamide, OEA e sebetsa ntle le tsela ea cannabinoid, e laola ts'ebetso ea PPAR-α ho susumetsa lipolysis.

Mehaho ea mefuta e fapaneng ea ethanolamide ea mafura-acid: oleoylethanolamide (OEA), palmitoylethanolamide (PEA) le anandamide (arachidonoylethanolamide, AEA).(Cima Science Co., Ltd ke eona feela moetsi oa thepa e tala ea OEA, PEA le AEA naheng ea China, haeba u hloka sampole le quote ea litheko, ka kopo re romelle lengolo-tsoibila leqepheng la rona.)

OEA e tlama ka kamano e phahameng le peroxisome-proliferator-activated receptor-a (PPAR-a), seamoheli sa nyutlelie se laolang likarolo tse 'maloa tsa metabolism ea lipid.

Mehloli ea tlhaho ea oleoylethanolamide

Oleoylethanolamide ke metabolite ea tlhaho ea oleic acid.Ka hona, lijo tse nang le oleic acid ke mohloli o tobileng oa OEA.

Oleic acid ke mafura a mantlha a oli ea meroho joalo ka mohloaare, canola le soneblomo.Oleic acid e ka boela ea fumanoa ka oli ea linate, nama, likhoho, chisi, joalo-joalo.

Mehloli ea lijo e ruileng ka oleic acid e kenyelletsa: Oli ea Canola, Oli ea Mohloaare, Oli ea Avocado, Oli ea Almond, Avocados, High Oleic Safflower Oli.

Lintlha tse ling ka Oleic Acid:

E 'ngoe ea mafura a tloaelehileng lebeseng la motho

E etsa 25% ea mafura lebeseng la khomo

Monounsaturated

Omega-9 fatty acid

Foromo ea lik'hemik'hale ke C18H34O2(CAS 112-80-1)

E tsamaea le triglycerides

E sebelisoa ka litlolo tse theko e phahameng joalo ka moisturizer e sebetsang haholo

E fumanoa ka mafura a lebese, chisi, oli ea mohloaare, oli ea morara, linate, li-avocado, mahe le nama.

E ka ba le boikarabello bakeng sa boholo ba melemo ea bophelo bo botle ea oli ea mohloaare!

E theha li-super hero complexes le liprotheine tse ling tsa lebese ho loantša lisele tsa mofetše

Melemo ea Oleoylethanolamide

Oleoylethanolamide (OEA) e ntle ho theola boima ba 'mele joalo ka taolo ea takatso ea lijo mme e ts'ehetsa maemo a cholesterol a phetseng hantle ho batho ba baholo.

OEA joalo ka khatello ea takatso ea lijo

Khatello ea takatso ea lijo ke ntlha e kholo ea taolo ea matla (lijo), ho laola takatso ea lijo ho bohlokoa ho laola boima ba 'mele bo phetseng hantle.OEA e laola takatso ea hau ea lijo joang?U ka sheba mokhoa oa ts'ebetso ka tlase.

OEA le k'holeseterole

Oli ea mohloaare ke naleli ea phepo e nepahetseng, 'me e thusa ho theola cholesterol e "mpe" ea LDL le ho eketsa "ntle" HDL.Hobaneng?Ho fihla ho 85% ea oli ea mohloaare ke oleic acid, 'me metabolite e ka sehloohong e phetseng hantle ea oleic acid ke OEA (Oleoylethanolamide ke lebitso le feletseng).Ka hona, ha ho na pelaelo ea hore OEA e thusa k'holeseterole e phetseng hantle.

Lipatlisiso tse ling li bonts'a hore oleoylethanolamide e na le litlamorao tse ntle ho tšoenyeha, 'me ho hlokahala litsela le bopaki bo eketsehileng ho tšehetsa.

Mokhoa oa tlhahiso ea Oleoylethanolamide

Phallo ea phallo ea Oleoylethanolamide e ka tlase:

Mehato e akaretsang ke: karabelog→Mokhoa oa tlhoekiso→ Setlhoe→E qhibilihisoa hape ka ethanol→hydrogenation →Sefa Mokelikeli o Hlakileng →crystallization→Sefe →Teko→Ho paka → Sehlahisoa sa ho qetela

Mokhoa oa ts'ebetso oa oleoylethanolamide

Ka mantsoe a bonolo, oleoylethanolamide e sebetsa e le molaoli oa tlala.OEA e khona ho laola lijo tseo u li jang ka ho bolella boko hore 'mele o tletse, 'me ha ho sa hlokahala lijo.U ja hanyenyane letsatsi le leng le le leng, ’me ’mele oa hao o ka ’na oa se be boima bo feteletseng ka nako e telele.

Liketso tse khahlanong le botenya ba oleoylethanolamide (OEA) li bontšoa setšoantšong.OEA e entsoe le ho bokelloa ka har'a mala a manyane a proximal ho tsoa ho oleic acid e nkiloeng lijong, joalo ka oli ea mohloaare.Lijo tse nang le mafura a mangata li ka thibela tlhahiso ea OEA ka maleng.OEA e fokotsa ho jeoa ha lijo ka ho kenya tšebetsong homeostatic oxytocin le histamine boko circuitry hammoho le hedonic dopamine pathways.Ho na le bopaki ba hore OEA e ka boela ea fokotsa pontšo ea hedonic cannabinoid receptor 1 (CB1R), ts'ebetso ea eona e amanang le ho eketseha ha lijo.OEA e fokotsa ho tsamaisoa ha lipid ho adipocyte ho fokotsa boima ba mafura.Tlhaloso e eketsehileng ea litlamorao tsa OEA mabapi le ho ja lijo le metabolism ea lipid e tla thusa ho tseba mekhoa ea 'mele e ka lebisitsoeng ho nts'etsapele liphekolo tse sebetsang hantle tsa botenya.

OEA e sebetsa ho kenya tšebetsong ntho e bitsoang PPAR mme ka nako e ts'oanang e nyolla ho chesa mafura le ho fokotsa polokelo ea mafura.Ha u ja, maemo a OEA aa eketseha 'me takatso ea hau ea lijo ea fokotseha ha methapo ea kutlo e hokahanyang le boko ba hao e bolela hore u khotše.PPAR-α ke sehlopha sa li-receptor tsa nyutlelie tse kentsoeng ke ligand tse amehang tlhahisong ea liphatsa tsa lefutso tsa lipid metabolism le litsela tsa energyhomeostasis.

OEA e bonts'a litšobotsi tsohle tse hlalosang ntho ea satiety:

(1) E thibela ho fepa ka ho lelefatsa nako ea lijo tse latelang;

(2) Tšimoloho ea eona e laoloa ke ho fumaneha ha limatlafatsi le

(3) Maemo a eona a ba le liphetoho tsa circadian.

Litla-morao tsa Oleoylethanolamide

Tšireletseho ea Oleoylethanolamide ke ntho e tšoenyang haholo har'a lihlahisoa tsa tlatsetso tse batlang ho leka motsoako ona o mocha liforomong tsa bona tsa ho theola boima ba 'mele.

Kamora tlhahlobo e felletseng ea lingoliloeng le datha tsohle tse fumanehang, Tsamaiso ea Lijo le Lithethefatsi ea US (FDA) ha ea ka ea tšoenyeha ka polokeho ea OEA.RiduZone ke motsoako oa pele o bitsoang oleoylethanolamide phofo ho tloha 2015.

Oleoylethanolamide ke metabolite ea oleic acid, e leng karolo ea lijo tse phetseng hantle tsa letsatsi le letsatsi.Ho bolokehile ho leka lisebelisoa tsa OEA, 'me ha ho litlamorao tse mpe tse tlalehiloeng.

litlamorao li tlalehiloe.

Oleoylethanolamide liteko tsa batho

Phuputsong e 'ngoe, batho ba mashome a mahlano (n = 50) ba nang le thahasello ea ho theola boima ba 'mele ba ile ba eletsoa ho nka OEA makhetlo a 2-3 / letsatsi, metsotso e 15-30 pele ho lijo bakeng sa libeke tse 4-12.Lihlooho li ne li kenyelletsa ba neng ba e-s'o sebelise lihlahisoa tsa ho theola boima ba 'mele pele, ba ileng ba hlaheloa ke liketsahalo tse bohloko ka lihlahisoa tse ling tsa ho theola boima ba' mele, bao boima ba bona bo neng bo e-na le lisebelisoa tse ling tsa ho theola boima ba 'mele tse kang phentermine, ba lekang ho kenya ts'ebetsong liphetoho tsa mokhoa oa bophelo (taolo ea karolo le boikoetliso ba kamehla. ), le ba tsamaisoang ka mafolofolo bakeng sa maemo a bongaka a kenyelletsang ho se mamelle tsoekere, dyslipidemia, khatello ea mali le mafu a pelo.

Phuputsong ea bobeli, lithuto tsa 4 tse nang le litekanyo tsa motheo tsa 229, 242, 375 le 193 lbs ka ho latellana, li ile tsa laeloa ho nka li-capsules tsa Oleoylethanolamide (capsule e le 'ngoe e nang le 200mg 90% OEA).Barupeluoa ba ile ba nka li-capsules tse 4 (1 capsule 15-30 metsotso pele ho lijo 'me ba ne ba lokela ho nka capsule e eketsehileng pele ho lijo tsa bona tse kholo ka ho fetisisa tsa letsatsi) letsatsi le leng le le leng bakeng sa matsatsi a 28.Taba ea ho qetela e ne e kile ea etsoa lap band.Barupeluoa ba ile ba laeloa hore ba se ke ba fetola lijo le mekhoa ea bona ea ho ikoetlisa.

Liphetho

Thutong ea pele, batho ba ile ba lahleheloa ke karolelano ea 1-2 lbs / beke.Ha hoa ka ha e-ba le litla-morao ntle le ho mokuli a le mong ea neng a na le ho nyekeloa ke pelo ka nakoana e ileng ea rarolloa ka nako e ka tlase ho beke.Phuputsong ea bobeli, batho ba 3 ho ba 4 ba tlalehile tahlehelo ea boima ba 'mele (3, 7, 15 le 0 lbs ka ho latellana).Lithuto tsohle tsa 4 li tlalehile ho fokotseha ha 10-15% ka boholo ba karolo, nako e telele ea nako ea lijo, 'me ha ho na litla-morao.

Haeba u thahasella lingoliloeng tse ling tsa liteko tsa batho le OEA, ka kopo etela likhokahano tsa PDF tse jarollotsoeng.

Oleoylethanolamide tekanyo

Ho na le lintlha tse fokolang tsa lipatlisiso mabapi le tlatsetso ea hajoale ea OEA bathong, mme leha e nkuoa e bolokehile, ha ho na litekanyetso tse khothaletsoang.Leha ho le joalo, ho na le lisebelisoa tse ling 'marakeng,' me u ka fumana tse ling bakeng sa litšupiso tsa hau.

The dosing ka letsatsi ea RiduZone (branded OEA/Oleoylethanolamide 90%) ke 200mg (1capsule e nang le OEA feela ho eona).Haeba e kopantsoe hammoho le lisebelisoa tse ling tsa ho theola boima ba 'mele, tekanyetso ea letsatsi le letsatsi e bonahala e fokola, ho re 100mg kapa 150mg.Lisebelisoa tse ling

Ho kgothaletswa ho nka oleoylethanolamide supplements 30 metsotso pele ho lijo tsa hoseng le tsa mantsiboea, u tla ikutloa u khotše haholo nakong ea lijo 'me ka lebaka leo u ka ja hanyenyane.

Lingoliloeng tsa lipatlisiso mabapi le oleoylethanolamide

Oleoylethanolamide: sebapali se secha taolong ea metabolism ea matla.Karolo ea ho ja lijo

Oleoylethanolamide e eketsa polelo ea PPAR-Α mme e fokotsa takatso ea lijo le boima ba 'mele ho batho ba batenya: teko ea bongaka.

Limolek'hule tsa boko le takatso ea lijo: Taba ea Oleoylethanolamide

Oleylethanolamide e laola phepelo le boima ba 'mele ka ho kenya tšebetsong receptor ea nyutlelie PPAR-a

Ts'ebetso ea TRPV1 ke Satiety Factor Oleoylethanolamide

Taolo ea ho ja lijo ka oleoylethanolamide

Mokhoa oa oleoylethanolamide ho nka mafura a acid ka maleng a manyane kamora ho ja lijo le ho fokotsa boima ba 'mele.

Oleoylethanolamide: Karolo ea bioactive lipid amidein e fetolang boitšoaro ba ho ja

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Oleoylethanolamide: Novel e ka 'nang ea E-ba Pharmacological Alternative ho Cannabinoid Antagonists bakeng sa Taolo ea Takatso ea Lijo