IAzelaic Acid 98%ngu HPLC | IBanga lezaMachiza kunye nezokuThatha
1. Isishwankathelo seMveliso
Azelaic Acid(CAS123-99-9) yindalo ye-dicarboxylic acid egcweleyo ene-molecular formula C₉H₁₆O₄ kunye ne-molecular weight 188.22 g / mol. Ibakala lethu le-HPLC elingqinisiswe yi-98% yococeko liyahlangabezana nemigangatho ye-USP/EP, elungiselelwe ukwenziwa kwedermatological kunye nokusetyenziswa kwemizi-mveliso.
IiNgcaciso eziphambili
- Ubunyulu: ≥98% (HPLC-ELSD iqinisekisiwe, ukungcola okupheleleyo <0.2%)
- Imbonakalo: Umgubo omhlophe wekristale
- Indawo yokunyibilika: 109-111°C
- Indawo yokuBilisa: 286 ° C kwi-100 mmHg
- Ukunyibilika: 2.14 g/L emanzini (25°C), ukunyibilika kwizisombululo ze-ethanol/alkaline
2. Ukubonakaliswa kwemichiza
2.1 Ukuqinisekiswa koLwakhiwo
- Iprofayile ye-NMR:
¹H NMR (300 MHz, CDCl₃): δ 1.23 (t, J=7.1Hz, 3H), 1.26-1.39 (m, 6H), 1.51-1.69 (m, 4H), 2.26/2.32 (q, 4.10H), nganye s, COOH) - HPLC Chromatogram:
Ixesha lokugcinwa: I-20.5 min (incopho enkulu), incopho yokungcola <0.1% kwi-31.5 / 41.5 min
2.2 Inkqubo yoLawulo loMgangatho
| Ipharamitha | Indlela | Iinqobo zokwamkeleka |
|---|---|---|
| Isivavanyi | I-HPLC-ELSD (Agilent 1200) Ikholamu: IPurospher Star RP-C18 ISigaba seMobile: I-Methanol / Amanzi / i-Acetic Acid gradient | 98.0-102.0% |
| Iintsimbi ezinzima | I-ICP-MS | ≤10 ppm |
| Izinyibilikisi ezishiyekileyo | I-GC-FID (ikholamu ye-HP-5MS) Ukuphuma kwi-HMDS | I-Ethanol <0.5% |
3. Ukusetyenziswa kwezamayeza
3.1 Ukusebenza kakuhle kweDermatological
- I-Acne Vulgaris:
Yehlisa i-comedones nge-65% kwizilingo zeeveki ezili-12 (20% cream) ngokusebenzisa:- Isenzo sokulwa ne-antimicrobialC. amaqhakuva(MIC₅₀ 256 μg/mL)
- I-Tyrosinase inhibition (IC₅₀ 3.8 mM) ye-post-inflammatory hyperpigmentation
- IRosacea:
I-15% yejeli ibonisa ukuncipha kwe-72% kwi-erythema (vs 43% placebo) ngokusebenzisa:- I-Antioxidant ROS scavenging (EC₅₀ 8.3 μM)
- Ukunyanzeliswa kwe-MMP-9 kwiikeratinocytes
3.2 Izikhokelo zokuqulunqa
| Ifomu yomthamo | eCetyisiweyo % | Amanqaku okuhambelana |
|---|---|---|
| Ikhilimu / ijeli | 15-20% | Gwema i-methylparaben (ibangela i-42% ukuthotywa) |
| Liposomal | 5-10% | Sebenzisa iphosphate buffer pH7.4 + lecithin yesoya |
4. Izicelo zokuthambisa
4.1 I-Whitening Synergy
- Udibaniso olululo:
- I-2% ye-AzA + 5% i-Vitamin C: i-31% yokunciphisa i-melanin vs i-monotherapy
- 1% AzA + 0.01% Retinol: 2x collagen synthesis boost
4.2 Uzinzo Data
| Imeko | Ireyithi yokuthotywa |
|---|---|
| 40°C/75% RH (3M) | <0.5% |
| Ukubonakaliswa kweUV | I-1.2% (ngokhuseleko lwe-TiO₂) |
5. Ukusetyenziswa kwamashishini
- I-Polymer Precursor:
- Inayiloni-6,9 synthesis (imveliso yokusabela>85% kwi 220°C)
- I-Corrosion inhibitor ye-alloys yensimbi (isisombululo se-0.1M sinciphisa ukubola nge-92%).
6. Ukhuseleko kunye noLawulo
6.1 Iprofayili yeToxicological
| Ipharamitha | Isiphumo |
|---|---|
| I-Acute Oral LD₅₀ (Ibuzi) | > 5000 mg/kg |
| Ukucaphuka kolusu | Lula (OECD 404) |
| Umngcipheko we-Ocular | Udidi 2B |
6.2 Ukuthotyelwa kweHlabathi
- Iziqinisekiso:
- IFayile eyiNkosi ye-US ye-FDA
- I-EU REACH ibhalisiwe
- ISO 9001:2015 Inkqubo yoMgangatho
7. Ukupakishwa kunye noGcino
| Ubungakanani | Isingxobo | Ixabiso (EXW) |
|---|---|---|
| 25kg | HDPE igubu + Alu bag | $4,800 |
| 1 kg | Ibhotile yeglasi yeAmber | $220 |
| 100 g | Isingxobo esitywinwe kabini | $65 |
Ukugcinwa: 2-8°C kwindawo eyomileyo (igumbi lobushushu liyamkeleka ukuba <25°C/60% RH)
8. Ii-FAQs
Umbuzo: Ndingasebenzisa i-azelaic acid nge-niacinamide?
A: Ewe, idatha yeklinikhi ibonisa i-10% ye-AzA + 4% i-niacinamide iphucula ukunyamezela i-37% vs i-AzA yodwa
Umbuzo: Yintoni ubomi beshelufu?
A: Iinyanga ezingama-36 xa zigcinwe kakuhle. I-Batch-specific COA inikezelwe
9. Iimbekiselo
- NMR iinkcukacha zophawu
- Indlela ye-HPLC-ELSD
- Izifundo zokuzinza
- Ukusebenza kweklinikhi
