I-Apigenin 98%

I-Apigenin, njenge-bioflavonoid eyaziwayo, iboniswe ukuthi ibonise imisebenzi ehlukahlukene yezinto eziphilayo, kuhlanganise ne-antioxidant, anti-inflammatory, antitumor, ant-genotoxic, anti-allergic, neuroprotective, cardioprotective, kanye ne-antimicrobial.Nokho, Omunye wemithombo evame kakhulu ye-apigenin isilimo esidliwayo esinamagatsha anamanzi (Apium graveolens), isitshalo se-marsh emndenini we-Apiaceae esitshalwe njengemifino kusukela kudala.I-Apigenin iyisakhi esikhishwe kakhulu ku-celery, equkethe i-apigenin engu-108 mg nge-kg.I-Apigenin ingenye ye-flavonoids yokudla evamile, etholakala kakhulu ezithelweni eziningi, imifino, namakhambi okwelapha.Isebenza imisebenzi ehlukahlukene yomzimba, njenge-antioxidant, anti-inflammatory enamandla, imisebenzi elwa namagciwane, i-antibacterial kanye nokunciphisa umfutho wegazi.

Igama Lomkhiqizo:Ukukhishwa kweqabunga lecelery i-Apigenin 98%

Igama lesiLatini: Apium graveolens L.

Inombolo ye-CAS: 520-36-5

Ingxenye Yesitshalo Esetshenzisiwe:Leaf

Isithako:Apigenin

I-Assay:Apigenin 98.0% nge-HPLC

Umbala:Impushana ensundu kuya kokuphuzi enephunga elibonakalayo kanye nokunambitha

Isimo se-GMO:GMO Mahhala

Ukupakisha: ku-25kgs fiber drums

Isitoreji: Gcina isitsha singavulwa endaweni epholile, eyomile, gwema ukukhanya okuqinile

Impilo Yeshelufu: Izinyanga ezingama-24 kusukela ngosuku lokukhiqiza

Umphumela we-Anti-tumor

I-Apigenin idlala indima ebalulekile ekuvimbeleni umdlavuza ngokufaka i-apoptosis emigqeni yamaseli ehlukahlukene.

Umdlavuza wesibeletho:

Olunye ucwaningo lwatholakala ukuthi i-apigenin ingavimbela ukukhula, ukwanda, nokudluliselwa kwe-ca-ov3 (iseli lomdlavuza we-ovarian womuntu);idala i-apoptosis ye-ca-ov3 ngokugcina amangqamuzana omdlavuza emile esigabeni se-G2/M.Umphumela uhlobene nesikhathi nomthamo.

Umdlavuza we-pancreatic:

I-Apigenin ingavimbela ukwanda kwamaseli omdlavuza we-pancreatic.I-Apigenin ilambisa isimila ngokunciphisa umthombo weglucose, okuwukudla okuhlala kukho amangqamuzana omdlavuza.Ngaphandle kwalokho, i-Apigenin ingathuthukisa ukusebenza kwe-chemotherapy drug- gemcitabine.

I-Chemo-sensitization

Kutholwe ukuthi i-apigenin kokuqukethwe okuphansi inomphumela ophansi we-cytotoxic futhi ayikwazanga ukunxenxa amaseli e-acute myeloid leukemia (hl-60) ku-apoptosis ngempumelelo.Kodwa-ke, i-apigenin ingathuthukisa umphumela we-inhibitory we-cisplatin (DDP) ekwandeni kwamaseli e-hl-60 ngenkathi ihlanganiswa nokugxila okuhlukile kwe-DDP.Ngakho i-Apigenin ingase ibe nomphumela wokuzwela ngamakhemikhali ku-hl-60;Ukugxila okuphansi kwe-apigenin nakho kunganciphisa ukumelana kwamaseli e-hl-60 ku-apoptosis eyenziwe ngamakhemikhali, okungenzeka ihlotshaniswe nokulawulwa phansi kwe-NF-κB ne-BCL-2.(I-NF-KB iwuhlobo lwe-protein complex elawula ukubhalwa kwe-DNA, ukukhiqizwa kwama-cytokines nokusinda kweseli; i-BCL-2 ifakwe ikhodi emzimbeni ngofuzo lwe-BCL2, iyilungu lokuqala lomndeni wamaprotheni alawulayo we-BCL-2 ingalawula ukufa kwamaseli)

Ukuvikelwa kwesibindi

I-Apigenin inganciphisa ukulimala kwesibindi okudalwe i-ischemia-reperfusion ngokusebenzisa i-lipid peroxidation ephikisayo kanye nokukhipha ama-radicals mahhala.

I-Apigenin inganciphisa ukulimala kwesibindi okubangelwa ukucindezeleka kwe-oxidative ngenxa yemisebenzi yayo enamandla ye-antioxidant kanye ne-anti-inflammatory.

Ukuhlolwa kwe-Pharmacological kuye kwafakazela ukuthi i-apigenin inomphumela obonakalayo wokuvikela ekulimazeni kwesibindi / i-hepatocyte okubangelwa utshwala, futhi indlela yayo eyinhloko ihlobene nokuvinjelwa kwenkulumo ye-CYP2E1 esibindini/hepatocyte.

Vimbela i-osteoporosis

I-Apigenin ivimbela i-osteoblastogenesis, i-osteoclastogenesis, futhi ivimbela ukulahleka kwamathambo.

I-Apigenin ivikela izicubu zethambo ngokunciphisa ukulahleka kwamathambo emzimbeni.

Ezinye izifundo ezihlobene ne-MC3T3-E1, i-osteoblast precursor cell line etholakala ku-Mus musculus (igundane) calvaria, ithole ukuthi i-apigenin ingavimbela i-TNF-α, IFN-γ, bese idala ukukhishwa kwama-cytokines amaningana akhuthaza ukwakheka kwe-osteoclast.

I-Apigenin iphinde yavimbela ukuhlukaniswa kwamaseli we-3T3-L1 adipose precursor ku-adipocyte ngokuqinile, ngakho-ke ivimbele ukuhlukaniswa kwe-adipocyte inhibition-induced adipocyte differentiation-induced IL-6, MCP-1, umkhiqizo we-lectin.

I-Apigenin ivimbela ukuhlukaniswa kwama-osteoclasts kusuka kumigqa yamaseli angu-RAW264.7 bese ivimbela ukwakheka kwama-osteoclast ane-multinucleated.Ingase futhi ibangele i-osteoclast apoptosis futhi ivimbele ukubuyiswa kwamathambo.

Umsebenzi wokulwa nokuvuvukala kanye ne-antioxidant

I-Apigenin ivimbela inqubo yokuvuvukala, inyusa amazinga e-IL-10 futhi ijwayele imingcele ye-oxidative stress.

I-Apigenin ivimbela ukuvuvukala kwama-cytokines futhi ikhuthaza ukukhiqizwa kwe-cytokine elwa nokuvuvukala.

Ezinye izincwadi ziphakamisa ukuthi i-apigenin inciphisa ukuvuvukala kwezicubu okubangelwa ukucindezeleka kwe-oxidative ezicutshini ngokushintsha izimpawu zokucindezeleka ze-oxidative, ama-interleukin, izimpawu ze-enzyme yegazi, nokuvezwa kwamanye ama-enzyme amaningana ahlobene.

Ukulawulwa kwe-endocrine

I-Apigenin ingalawula ushukela osegazini, yelaphe ukwehluleka kwe-thyroid futhi ilawule i-lipid peroxidation. Kwatholakala ukuthi i-apigenin ingakhuphula amazinga e-insulini ne-thyroxine ezilwaneni ezinesifo sikashukela, futhi yehlise ukugcwala kushukela egazini kanye nomsebenzi we-glucose-6-phosphorylase (G- 6-Pase).

I-Apigenin iguqule imiphumela yokwanda kwe-serum cholesterol, ukwanda kwe-lipid peroxidation yesibindi (LPO) kanye nokuncipha kwemisebenzi yama-antioxidants njenge-catalase (CAT) ne-superoxide dismutase (SOD) ezilwaneni ezibangelwa i-alloxan.

Ezilwaneni ezinoshukela wegazi ojwayelekile, i-apigenin nayo inganciphisa i-serum cholesterol kanye ne-lipid peroxidation yesibindi, futhi ikhulise umsebenzi wama-antioxidants kumaseli.

Izici ze-Pharmacological ze-apigenin

I-Apigenin inanyathiselwe ukubaluleka okukhulu eminyakeni yamuva nje, njengomgqugquzeli wezempilo ozuzisayo ngenxa yobuthi bayo obuphansi bangaphakathi kanye nemiphumela yayo yezempilo kumaseli omdlavuza avamile uma kuqhathaniswa namanye ama-flavonoid ahlobene nesakhiwo.Kunobufakazi obuningi bocwaningo obubonise ukuthi i-apigenin inamandla amakhulu okwelapha izifo eziningi

Umsebenzi:

-Avimbe ukukhula kwamangqamuzana omdlavuza.

-Yehlisa umfutho wegazi

-Ivikela uhlelo lwenhliziyo nemithambo yegazi

-Siza ukulala, ukuthulisa izinzwa, ukuqeda ukucasuka

-Melana nokuvuvukala

- Vimbela i-osteoporosis

- Umphumela we-diuretic.

- Thinta ukuhlangana kweplatelet.

Isicelo:

-Insimu yezokwelapha, inkambu yokunakekelwa kwezempilo