Igama lomkhiqizo:I-Stearoyl Vanillylamide(I-SVA）
Elinye Igama:C18-VA, N-Vanillyloctadecanamide,Capsaicin AnalogI-CAS Number:58493-50-8
Umthombo Wezitshalo:Piper Longum Linn
Isilinganiso: 98%
Isampula yamahhala :Iyatholakala
Ukubukeka:kumhlophe kuye kumpushana omhlophe
Izinzuzo: Anti-cancer, anti-ukuguga, senolytic
Impilo yeshelufu: iminyaka emi-2
I-Stearoyl vanillylamide ingenye yama-analogue e-capsaicin adume kakhulu futhi iyi-analogue ye-capsaicin eyenzeka ngokwemvelo etholakala ohlotsheni lukapelepele obomvu.I-Capsaicin iyimbangela yokuzwa ukushisa/ukuvutha okubangelwa upelepele.Ngokungafani nezinye izinhlobo ze-capsaicin ezisesigabeni esifanayo, i-Stearoyl vanillylamide ihlukile ngoba ayiyona i-steroidal, okusho ukuthi ayikhiqizi imiphumela "ebabayo" noma ecasulayo ye-capsaicin.
Ngokuvamile, njengamanye ama-analogues e-capsaicin, le nhlanganisela isebenza ngokuthuthukisa ukukhululwa kwe-epinephrine ne-norepinephrine.Lawa ma-hormone ayadingeka ukuze enze kusebenze ukusabela okuhlukahlukene komzimba okuzwelayo njenge-metabolism.Ngakho-ke, i-stearoyl vanillylamide igcina inomthelela ekushisweni kwamafutha ansundu ezicutshini ze-adipose noma izicubu ezingaphansi kwesikhumba.
Yiziphi izinzuzo zokusebenzisa i-Stearoyl Vanillylamide?Ukufakwa kwe-stearic acid amide kunezinzuzo ezimbalwa ekulungiseleleni izithasiselo zezempilo.Njengoba ucwaningo oluningi lusaqhubeka, ososayensi babheke ngabomvu ukuthola izinzuzo eziningi zokusebenzisa lesi sithako.Okulandelayo ezinye zezinzuzo ezaziwa ngokusebenzisa i-Stearoyl vanillylamide:
Iphula ngokuphumelelayo amafutha e-belly
I-Stearoyl vanillylamide isebenza njenge-capsaicin engacasuli engashukumisa izicubu ze-adipose ensundu noma amafutha ansundu (amafutha atholakala ikakhulukazi ku-mitochondria futhi akhiqize ukushisa emzimbeni).Amafutha atholakala kuzo zonke izingxenye zomzimba, okuhlanganisa izingalo, amathanga, isisu kanye nemisipha ye-gluteal.Nakuba abantu abaningi bengakwazi ukuqeda ngokushesha amafutha kwezinye izindawo, ukushisa amafutha esiswini kubhekwa njengomthwalo wangempela.Ucwaningo luye lwabonisa ukuthi ukuthatha i-Stearoyl vanillylamide kungasiza ukudiliza amafutha atholakala ikakhulukazi esiswini.Lokhu kufezwa ngokuvula i-TRPV1, i-enzyme evimbela ukukhiqizwa kwamafutha esiswini kanye nokwakheka kwamafutha.Kanye ne-capsaicin, i-Stearoyl vanillylamide ibhekwa njengenye yama-ejenti aqondisa futhi avule i-TRPV1 (i-vanilloid engaba khona ye-receptor yesikhashana) etholakala kulwelwesi lwe-plasma (ngaphandle kwama-endogenous ligands, abalamuli bokuvuvukala kanye nezisusa ezingakhethi).Unomthwalo wemfanelo wokubhala ngekhodi iphrotheni ye-membrane ebalulekile njengeshaneli ye-ion.Uma i-TRPV1 icushiwe ngokuqondile kuma-sensory fibers namaseli angewona ama-neuronal, kuzoholela ekuthelelekeni kwe-calcium ne-sodium, okudingekayo ukuze i-membrane depolarization (inguquko ye-polarity; kusukela ku-negative kuya ku-positive, okuholela emiphumeleni emihle) Umsebenzi weseli kanye ne-depolarization yayo. ukuxhumana.
Iphula ngokuphumelelayo amafutha e-belly
I-Stearoyl vanillylamide isebenza njenge-capsaicin engacasuli engashukumisa izicubu ze-adipose ensundu noma amafutha ansundu (amafutha atholakala ikakhulukazi ku-mitochondria futhi akhiqize ukushisa emzimbeni).Amafutha atholakala kuzo zonke izingxenye zomzimba, okuhlanganisa izingalo, amathanga, isisu kanye nemisipha ye-gluteal.Nakuba abantu abaningi bengakwazi ukuqeda ngokushesha amafutha kwezinye izindawo, ukushisa amafutha esiswini kubhekwa njengomthwalo wangempela.Ucwaningo luye lwabonisa ukuthi ukuthatha i-Stearoyl vanillylamide kungasiza ukudiliza amafutha atholakala ikakhulukazi esiswini.Lokhu kufezwa ngokuvula i-TRPV1, i-enzyme evimbela ukukhiqizwa kwamafutha esiswini kanye nokwakheka kwamafutha.Kanye ne-capsaicin, i-Stearoyl vanillylamide ibhekwa njengenye yama-ejenti aqondisa futhi avule i-TRPV1 (i-vanilloid engaba khona ye-receptor yesikhashana) etholakala kulwelwesi lwe-plasma (ngaphandle kwama-endogenous ligands, abalamuli bokuvuvukala kanye nezisusa ezingakhethi).Unomthwalo wemfanelo wokubhala ngekhodi iphrotheni ye-membrane ebalulekile njengeshaneli ye-ion.Uma i-TRPV1 icushiwe ngokuqondile kuma-sensory fibers namaseli angewona ama-neuronal, kuzoholela ekuthelelekeni kwe-calcium ne-sodium, okudingekayo ukuze i-membrane depolarization (inguquko ye-polarity; kusukela ku-negative kuya ku-positive, okuholela emiphumeleni emihle) Umsebenzi weseli kanye ne-depolarization yayo. ukuxhumana.
