Inositol

I-Inositol (i-hexahydroxycyclohexane) iyingxenye yemvelo esatshalaliswa kabanzi yezicubu zezitshalo nezilwane.Izicubu zezilwane ezicebile kakhuluinositolubuchopho, inhliziyo, isisu, izinso, ubende, nesibindi, lapho kwenzeka mahhala noma njengengxenye ye-phospholipids.Phakathi kwezitshalo, okusanhlamvu kuyimithombo ecebile ye-inositol, ikakhulukazi ngesimo se-polyphosphoric acid esters, ebizwa ngokuthi ama-phytic acid.Nakuba kunama-isomer amaningana asebenza ngokubonakalayo nangasebenzi, ukucatshangelwa kwe-inositol njengesengezo sokudla kubhekisela ngokukhethekile ku-cis-1,2,3,5-trans-4,6-cyclohexanehexol engasebenzi kahle, ekhethwa ngokukhethekile ukuthi i-myo-inositol.I-inositol ehlanzekile iyinhlanganisela ezinzile, emhlophe, emnandi, ecwebezelayo.I-Codex Yamakhemikhali Okudla icacisa ukuthi ayilinganisi ngaphansi kwamaphesenti angama-97.0, iyancibilika phakathi kuka-224 no-227°, futhi iqukethe i-arsenic engaphezu kuka-3 ppm, 10 ppm lead, 20 ppm izinsimbi ezisindayo (as Pb), 60 ppm sulfate, kanye no-50 ppm. i-chloride.I-Inositol yacatshangelwa isikhathi sokuba ivithamini ngoba izilwane zokuhlola ekudleni kokwenziwa zakha izimpawu zomtholampilo ezalungiswa nge-inositol supplementation.Kodwa-ke, akukho cofactor noma umsebenzi we-catalytic we-inositol otholakele;ingahlanganiswa futhi yenzeke ekugxilweni okuphakeme kakhulu ezicutshini zezilwane.Lezi zici ziphikisana nokuhlukaniswa kwayo njengevithamini.Isidingo sokudla kumuntu asikasungulwa.

Igama lomkhiqizo:Inositol

Ukucaciswa: Okuncane okungu-97.0%

Izakhiwo Zamakhemikhali:Ikristalu emhlophe noma impushana ecwebezelayo, ayinaphunga, futhi imnandi;Ukuminyana okuhlobene: 1.752 (anhydrous), 1.524(dihydrate), mp 225~227 ℃ (anhydrous), 218 °C (dihydrate), indawo yokubilisa 319 °C.Incibilike emanzini (25 °C, 14g/100mL; 60 °C, 28g/100mL), incibilika kancane ku-ethanol, i-acetic acid, i-ethylene glycol ne-glycerol, engancibiliki ku-ether, i-acetone ne-chloroform.Izinzile emoyeni;Izinzile ekushiseni, i-asidi ne-alkali, kodwa i-hygroscopic.

Inombolo ye-CAS:87-89-8

Ukuhlaziywa kokuqukethwe:Kala ngokunembile isampula engu-200 mg (omiswe ngaphambilini ku-105°C amahora angu-4), bese uyibeka kubhikhayi engu-250ml.Engeza u-5ml wengxube phakathi kwesisombululo esisodwa sokuhlola se-sulfuric acid (TS-241) kanye ne-acetic anhydride engu-50, bese uvala ingilazi yewashi.Ngemuva kokushisa kubhavu we-steam imizuzu engu-20, yipholise emanzini e-ice, engeza amanzi ayi-100ml, bese ubilisa i-20min.Ngemva kokupholisa, dlulisela isampula kufaneli ehlukanisayo engu-250 mL usebenzisa inani elincane lamanzi.Sebenzisa ngempumelelo u-30, 25, 20, 15, 10 kanye no-5 mL we-chloroform ukuze ukhiphe ikhambi izikhathi eziyisithupha (qala ngokuswapha ibhekha).Konke okukhishwe kwe-chloroform kuqoqwe kufaneli yesibili ehlukanisayo engu-250m1.Geza i-extract exutshwe ngamanzi angu-10ml.Faka ikhambi le-chloroform ngefaneli kakotini woboya bese uyidlulisela ku-150ml yefulaski ye-Soxhlet ekale isisindo sangaphambilini.Sebenzisa u-10ml we-chloroform ukuze ugeze ifaneli ehlukanisayo kanye nefaneli, futhi ifakwe esitokisini.Ihwamulise ukuze yome endaweni yokugeza ngesitimu, bese uyidlulisela kuhhavini ongu-105 °C ukuze yome ihora elingu-1.Yipholise ku-desiccator, bese uyikala.Sebenzisa inani elitholiwe le-inositol acetate eyisithupha phindaphinda ngo-0.4167, okuyinani elihambisanayo le-inositol (C6H12O6).

Umsebenzi:

1. Njengezithako zokudla, kunomphumela ofanayo kuvithamini B1.Ingasetshenziselwa ukudla kwezinsana futhi isetshenziswe inani le-210 ~ 250mg / kg;Isetshenziswa ekuphuzeni inani lama-25 ~ 30mg/kg.
2. I-Inositol iyivithamini ebaluleke kakhulu ekusebenzeni kwe-lipid metabolism emzimbeni.Ingakhuthaza ukumuncwa kwemithi ye-hypolipidemic namavithamini.Ngaphezu kwalokho, kungakhuthaza ukukhula kwamaseli kanye ne-fat metabolism esibindini nakwezinye izicubu.Ingasetshenziselwa ukwelashwa kwe-adjuvant yesibindi esinamafutha, i-cholesterol ephezulu.Isetshenziswa kakhulu ezithasiselweni zokudla nasekuphakeleni, futhi ivame ukungezwa ezinhlanzi, izimfanzi kanye nokudla kwemfuyo.Inani lingama-350-500mg/kg.
3. Umkhiqizo uwuhlobo olulodwa lwevithamini B eyinkimbinkimbi, engakhuthaza umzimba weseli, ithuthukise izimo zezakhi zamangqamuzana, futhi ingaba nomthelela ekuthuthukisweni, ukwandisa isifiso sokudla, ukululama.Ngaphezu kwalokho, kungavimbela ukunqwabelana kwamafutha esibindi, futhi kusheshise inqubo yokukhipha amafutha amaningi enhliziyweni.Inesenzo esifanayo se-lipid-chemotactic njenge-choline, ngakho-ke iwusizo ekwelapheni isifo se-hepatic fat ngokweqile kanye ne-cirrhosis yesifo sesibindi.Ngokusho "kokusetshenziswa kokuqinisa ukudla kwamazinga ezempilo (1993)" (Kukhishwe uMnyango Wezempilo waseShayina), kungasetshenziselwa ukudla kwezingane kanye neziphuzo eziqinisiwe ngenani elingu-380-790mg/kg.Kuyimithi yesigaba samavithamini kanye nomuthi owehlisa i-lipid okhuthaza ukugaywa kwamafutha esibindini nezinye izicubu, futhi ube wusizo ekwelashweni kwe-adjuvant yesibindi esinamafutha kanye ne-cholesterol ephezulu.Isetshenziswa kabanzi ezithasiselweni zokudla nesiphuzo.
4. I-Inositol isetshenziswa kabanzi kwezemithi, amakhemikhali, ekudleni, njll. Inomphumela omuhle ekwelapheni izifo ezifana ne-cirrhosis yesibindi.Ingase futhi isetshenziselwe izinto zokusetshenziswa ezithuthukisiwe zezimonyo, ezinenani eliphezulu lezomnotho.
5. Ingasetshenziswa njenge-reagent ye-biochemical kanye nokuhlanganiswa kwemithi kanye ne-organic synthesis;Inganciphisa izinga le-cholesterol futhi ibe nomphumela wokudambisa.