Igama lomkhiqizo:I-Lithium Orotate99%

Synonyms:i-orotic acid lithium usawoti monohydrate;

i-lithium, i-2,4-dioxo-1H-pyrimidine-6-carboxylate;4-Pyrimidinecarboxylic acid;1,2,3,6-tetrahydro-2,6-dioxo-, usawoti we-lithium (1: 1);I-C5H3LiN2O4Molecular Formula:C₅H₃LiN₂O₄

Isisindo se-molecule: 162.03

Inombolo ye-CAS:5266-20-6

Ukubukeka/umbala:Impushana ecwebezelayo emhlophe ukuya kokumhlophe

Izinzuzo: Isimo esinempilo nengqondo

I-Lithium orotate iyinhlanganisela ye-lithium ethandwa phakathi kwabasebenzisi bokwengeza.Sekuvele kukhona usawoti we-lithium amaningana emakethe, njenge-lithium aspartate, i-lithium carbonate, ne-lithium chloride, njll. Yebo, i-lithium orotate iyona kuphela i-lithium enomsoco yezithako zokudla, futhi abasebenzisi bayakwazi ukuthenga amaphilisi e-lithium orotate ku-amazon, Walmart. , Isitolo samavithamini ngokukhululeka ngaphandle kwencwadi kadokotela.

Ngakho-ke, kungani i-lithium orotate iyingqayizivele?
Ngaphambi kokuthi sifike ephuzwini, ake sibuyekeze izakhiwo eziyisisekelo zomzimba namakhemikhali ze-lithium orotate.

Impahla eluhlaza ye-lithum orotate (inombolo ye-CAS 5266-20-6), isesimweni se-crystalline powder emhlophe kuya kokumhlophe.

I-Lithium Citrate imvamisa iwuhlobo lweSiraphu ye-Lithium Citrate esixazululweni.U-5 mL ngamunye weSiraphu ye-Lithium Citrate equkethe u-8 mEq we-lithium ion (Li+), okulingana nenani le-lithium ku-300 mg we-lithium carbonate.Isiphuzo esithambile esingu-7Up of Coca-Cola sasivame ukuba ne-Lithium Citrate kufomula yaso, kodwa i-Coca yasisusa ku-7Up ngo-1948. Ngisho nanamuhla, i-Lithium citrate ayisetshenziswa ezinye izinhlobo zokudla noma zesiphuzo.

I-Lithium orotate VS I-Lithium aspartate

Njenge-Lithium orotate, i-lithium aspartate nayo ithathwa njengesithako sesengezo sokudla, kodwa azikho izinkampani eziningi ezisizayo eziyisebenzisayo.

Kungani?

I-lithium orotate ne-lithium aspartate cishe zinesisindo se-molecular (162.03 kanye ne-139.04 ngokulandelana).Zinezinzuzo ezifanayo zokusebenza, futhi imithamo yazo icishe ifane (130mg & 125mg ngokulandelana).Ochwepheshe abaningi bokudla okunomsoco, njengoDkt. Jonathan Wright, batusa i-lithium orotate ne-lithium aspartate ngokulinganayo.

Manje-ke, kungani i-lithium orotate idume kakhulu kune-lithium aspartate?

Izizathu zingase zibe ngenxa yemiphumela emibi enobuthi ebangelwa i-lithium aspartate.

I-Aspartate ithathwa njenge-excitotoxin.I-Excitotoxins yizinto ezibophezela ku-nerve cell receptor futhi zidale umonakalo ngokuvuselela ngokweqile.I-Lithium aspartate eyeqile ingase ibangele ukusabela kwe-excitotoxic kubantu abazwelayo, futhi imiphumela ihlanganisa ubuhlungu bekhanda, izinkinga ze-CNS, izinkinga zemithambo yegazi, njll. i-aspartate.Kungaba umqondo omuhle ukuthi bathathe i-lithium orotate esikhundleni.

I-Lithium orotate VS I-Lithium carbonate

I-lithium carbonate ne-lithium citrate yizidakamizwa kuyilapho i-lithium orotate iyisengezo sokudla.

I-Lithium carbonate iwuhlobo oluvame ukunqunywa lwe-lithium olugunyazwe yi-FDA ukwelapha isifo esiguquguqukayo, i-lithium citrate iwuhlobo lwesibili oluvame kakhulu lwe-lithium olunqunywe odokotela.

Ngenxa yokungatholakali kahle kwe-bioavailability, imithamo ephezulu ye-lithium carbonate ne-citrate ye-lithium ngokuvamile iyadingeka (2,400 mg-3,600 mg ngosuku) ukuze kuzuzwe izinzuzo ezifiselekayo.Ngokuphambene, i-lithium orotate engu-130 mg iyakwazi ukuhlinzeka cishe ngo-5 mg elemental lithium ngekhepsuli ngayinye.I-5 mg ye-lithium orotate supplement inhle ngokwanele ukuba nemiphumela emihle kumizwa nempilo yobuchopho.

Imithamo ephezulu ye-lithium carbonate kufanele ithathwe ukuze kutholwe umphumela owanelisayo wokwelapha.Ngeshwa, le mithamo yokwelapha iphakamisa amazinga egazi kangangokuthi asondele kumazinga anobuthi.Ngakho-ke, iziguli ezithatha incwadi kadokotela i-lithium carbonate noma i-lithium citrate kumele ziqashwe ngeso elibukhali ukuze kutholakale amazinga egazi anobuthi.Amazinga e-serum lithium kanye ne-serum creatinine ezigulini ezilashelwe i-lithium kufanele aqashwe njalo ezinyangeni ezi-3-6.

Kodwa-ke, i-lithium orotate, inhlanganisela ye-lithium ne-orotic aicd, ayinazo izinkinga ezinjalo.i-lithium orotate i-bioavailable ngaphezu kwamafomu e-carbonate ne-citrate, futhi iyakwazi ukuletha i-lithium yemvelo iqonde ngqo kumaseli obuchopho ayidinga kakhulu.Ngaphezu kwalokho, i-lithium orotate ayinayo imiphumela emibi ebalulekile futhi asikho isidingo sokuthi i-lithium orotate iqashelwe umthamo.

Izindlela Zokusebenza zeI-Lithium Orotate

I-Lithium orotate idlala indima enkulu ekusebenzeni kwengqondo okunempilo, isekela isimo sengqondo esinempilo, ukuphila kahle kwemizwelo, ukuziphatha kanye nenkumbulo.Isebenza kanjani i-lithium orotate?

Ngokusho kwe-Wikipedia, indlela ethile ye-biochemical yesenzo se-lithium ekuqiniseni isimo sengqondo ayaziwa.I-Lithium yenza imiphumela yayo emazingeni amaningi aqala ngezinguquko zomtholampilo ezithinta isimo sengqondo ngokulwisana nokusangana nokudangala kanye nokunciphisa ukuzibulala.Ubufakazi bemiphumela ye-lithium ekuqondeni okuvela ezifundweni ze-neuropsychological kanye ne-functional magnetic resonance imaging zikhomba jikelele ekuyekeleni kwengqondo;nokho, ubufakazi balokhu buye baxutshwa.Ucwaningo lwe-imaging yesakhiwo lunikeze ubufakazi bokuvikela i-neuroprotection ngevolumu yento empunga ekhuphukayo, ikakhulukazi ezindaweni ze-amygdala, i-hippocampus kanye ne-prefrontal cortical ezigulini ezilashwa nge-lithium.Izinguquko ku-neurotransmission ezinomthelela womtholampilo zingachazwa ngokwenyuka kokuvimbela kanye nokuncipha kwe-neurotransmission ejabulisayo ezigulini ezilashwa nge-lithium.Ezingeni le-intracellular, i-lithium ithonya izinhlelo zezithunywa zesibili, eziguqula i-neurotransmission futhi zenze ukusebenza kwamaselula ngokukhuthaza ukuzivikela okulwa ne-oxidant, ukuncipha kwe-apoptosis, nokwandisa amaprotheni e-neuroprotective.

Kodwa-ke, izindlela ezintathu eziyinhloko zikhonjwe eminyakeni engamashumi amabili edlule ngemiphumela ebanzi ye-neuroprotective ye-lithium ebuchosheni nasohlelweni lwezinzwa:

• ukuthuthukiswa kwephrotheni enkulu ye-neuroprotective Bcl-2,
• ukulawulwa kwe-BDNF,

I-Brain-Derived Neurotrophic Factor (BDNF) ijwayele ukubizwa ngokuthi "Isimangaliso Sokukhulisa ubuchopho" ngoba sandisa i-neurogenesis.I-Neurogenesis ukukhula kwama-neuron amasha, okunikeza ubuchopho bakho "ukuthuthukiswa kwamakhemikhali ezinto eziphilayo" okudingeka kakhulu ngenkathi uphuma kuma-opioid.I-BDNF iphinde ihlinzeke nge-antidepressant enamandla kanye

anti-ukukhathazeka imiphumela.

• kanye nokuvinjwa kwe-NMDA receptor-mediated excitotoxicity

Izinzuzo ze-Lithium Orotate

I-Lithium orotate iyisengezo sokudla esingokwemvelo esingasetshenziswa ngemithamo emincane ukuze ulawule ingcindezi futhi usekele isimo sengqondo esihle.

I-Lithium Orotate yesimo sengqondo esinempilo

I-lithium orotate ekuqaleni yatholwa yokwelapha ukudangala kwengqondo (manje eyaziwa ngokuthi i-bipolar disorder), iye yasetshenziswa isikhathi eside ukuze kuqiniswe isimo sengqondo nokwelapha izinhlobonhlobo zokuphazamiseka kwemizwa.

I-Lithium orotate ithuthukisa ukuhlanganiswa nokukhululwa kwe-hormone ejabulisayo i-serotonin.Ngesikhathi esifanayo, usawoti we-orotate nawo unciphisa i-hormone yokucindezeleka i-norepinephrine.

I-Lithium orotate iyakwazi ukusiza abantu ngokwehlisa ukuzwela kobuchopho kuma-norepinephrine receptors.Ivimbela ukukhiqizwa kwale neurotransmitter eyaziwa kakhulu ethinta isimo sethu sengqondo.Ngenxa yale miphumela eqinisa imizwa, imithamo ephansi iyahlolwa kubantu abanokukhathazeka.I-Lithium ikhonjisiwe ezifundweni zokuzolalisa ukuziphatha kwe-manic okuhambisana nokukhathazeka, i-bipolar disorder, ngisho ne-attention deficit disorder (ADHD).

I-Lithium Orotate yobuchopho obunempilo

I-Lithium orotate idumile kwamanye amafomula we-nootropic.Ama-Nootropics ayakwazi ukuthuthukisa inkumbulo neminye imisebenzi yokuqonda.

Ucwaningo oluningana lwesayensi lubonise ukuthi i-lithium orotate supplement ingakhuphula indaba empunga ebuchosheni bomuntu, ivimbele ukukhululwa kwe-beta-amyloid futhi ikhulise i-NAA.Enye indlela yokuvikela okuthiwa i-lithium orotate inciphisa ukusebenza ngokweqile kwephrotheni yeseli yobuchopho ebizwa ngokuthi i-tau protein ebuye ibe nomthelela ekuwohlokeni kwe-neuronal njengoba kwenza ukwakheka kwama-neurofibrillary tangles.Abantu abanezinhlobo ezahlukene zokulimala kobuchopho nezinkinga bangalindela intuthuko emisebenzini yabo yokuqonda.

I-Lithium orotate yotshwala

I-lithium orotate ingase ibe usizo ezifisweni zotshwala.Olunye ucwaningo lwathola ukuthi lapho iziguli ezifisa utshwala zinikezwa i-lithium orotate, zazikwazi ukugcina ukuhluzeka kwazo isikhathi eside nemiphumela emibi emincane.Ososayensi baye baphindaphinda lokhu okutholakele kwezinye izifundo, futhi.

Isilinganiso se-Lithium Orotate

Ngokuvamile, ziningi izithasiselo ze-lithium nezidakamizwa emakethe yokudla nemithi.I-lithium Li+ edlala indima ebalulekile yokusebenza.Umthamo ojwayelekile we-elemental lithium ngu-5mg.

Isisindo samangqamuzana e-Li yi-6.941, sibalwa ku-4% we-Lithium orotate (162.03).Ukuhlinzeka nge-5mg elemental lithium, umthamo we-lithium orotate ngu-125mg.Ngakho-ke uzothola ukuthi i-lithium orotate kuzithako eziningi ze-lithium i-colse kuya ku-125mg.Enye ifomula ingase ibe ngu-120mg, amanye abe ngu-130mg, futhi ngeke kube nomehluko omkhulu.

Ukuphepha kwe-Lithium orotate

Amabhrendi amaningi okungeza afuna ukuzama i-lithium orotate kumafomula awo angeziwe aphathelene nalo mbuzo.

Ngokuvamile, i-Lithium orotate iyisithako sokudla esingokwemvelo, akukho myalelo we-FDA odingekayo.Abasebenzisi bayakwazi ukuthenga izithasiselo eziqukethe i-lithium orotate ku-amazon, GNC, Iherb, Vitamin Shoppe, Swan, nezinye izinkundla ngokukhululeka.

Nokho, ukudosa umthamo kubaluleke kakhulu.I-Lithium iyasebenza kakhulu kumthamo ophansi ku-5mg.Ungeqi umthamo onconywayo wochwepheshe bakho bezempilo.Xhumana nodokotela wakho ukuze uthole ulwazi olwengeziwe.