I-Oleanolic Acid Powder

I-Oleanolic acid eyi-pentacyclic triterpenoids emithathu ehlukanisiwe ezitshalweni ze-Gentianaceae zase-Swertia mileensis utshani bonke noma isithelo sangasese, esinomzimba okhululekile kanye nama-glycosides ezitshalweni eziningi.I-Oleanolic acid inohlu olubanzi ezitshalweni, kanti okuqukethwe okujwayelekile kungu-0.2% - 2%.I-Cucurbitaceae ephezulu ingu-1.5% ~ hunchback bottom 2%, isithelo sangasese esingu-0.6% ~ 0.7%.I-Oleanolic acid iwuhlobo lwenhlanganisela ye-pentacyclic triterpenoid ehlukanisiwe nesithelo sohlobo lwe-Asteraceae, i-Syzygium sylvestris, noma i-Ligustrum lucidum.Kuyi-adjuvant yesifo sesibindi futhi esetshenziselwa ukwelapha izifo zokwelashwa.I-acute jaundice hepatitis inemiphumela esobala ekwehliseni i-alanine aminotransferase kanye nokuphuzi.I-Oolic acid iyi-pentacyclic triterpenoids ehlukanisiwe nesithelo se-swertia chinensis noma i-fructus ligustris esitshalweni se-gentianaceae.I-oleanolic acid itholakala kabanzi ezitshalweni, ngokuqukethwe okuvamile okungu-0.2% ~ 2% [1].Okuqukethwe phansi kwe-calabash bekuyi-1.5% ~ 2%, kanti okuqukethwe kwesithelo se-fructus ligustris kwaba ngu-0.6% ~ 0.7%.I-Oleanolic acid i-white acicular crystal (ethanol), ayinaphunga futhi ayinambitheki.Ayizinzile kuma-asidi nezisekelo.Iphuzu elincibilikayo lika-308 ~ 310 ℃, [alpha] 20 d + 73.3 ° (c = 0.15, i-chloroform, engancibiliki emanzini, encibilika ku-methanol, i-ethanol, i-ethyl ether, i-acetone ne-chloroform.I-Oleanolic acid i-triter eyenzeka ngokwemvelo, ngokujwayelekile ekudleni nasezitshalweni zokwelapha, ezihlobene ne-betulinic acid Ingatholakala ku-Phytolacca americana (i-American pokeweed), ne-Syzygium spp, i-garlic, njll. Ayinabuthi, i-hepatoprotective, futhi ibonisa izakhiwo ze-antitumor kanye ne-antiviral.
I-Oleanolic acid yatholakala ibonisa umsebenzi oqinile wokulwa ne-HIV, i-betulinic acid eyinhlanganisela ehlobene yasetshenziswa ukuze kwakhiwe umuthi wokuqala wokuvuthwa we-commercial maturation inhibitor.Yaqale yafundwa futhi yahlukaniswa nezitshalo eziningana, kuhlanganise i-Rosa woodsii (amaqabunga), i-Prosopis glandulosa (amaqabunga namagatsha), i-Phordendron juniperinum (isitshalo sonke), i-Syzygium claviflorum (amaqabunga), i-Hyptis capitata (isitshalo sonke), kanye ne-Ternstromia gymnanthera (emoyeni). ingxenye).Ezinye izinhlobo ze-Syzygium ezihlanganisa i-java apple (Syzygium samarangense) kanye nama-rose apula aqukethe.

Igama lomkhiqizo: I-Oleanolic Acid98%

Ukucaciswa:98% nge-HPLC

Umthombo we-Botanic:Olea Europea Extract

Igama Lekhemikhali:(3β)-3-Hydroxyolean-12-en-28-oic acid

Inombolo ye-CAS:508-02-1

Ingxenye Esetshenzisiwe:Leaf

Umbala:Impushana emhlophe enephunga nokunambitha

Isimo se-GMO:GMO Mahhala

Ukupakisha: ku-25kgs fiber drums

Isitoreji: Gcina isitsha singavulwa endaweni epholile, eyomile, gwema ukukhanya okuqinile

Impilo Yeshelufu: Izinyanga ezingama-24 kusukela ngosuku lokukhiqiza

Yinii-oleanolic acid?

I-Oleanolic acid (OA), i-hydroxyl pentacyclic triterpenoid acid (HPTA) yemvelo efana ne-betulinic acid, i-ursolic acid;inezinzuzo ezifana ne-antibacterial, anti-inflammatory, antitumor activities.

Ungathola kuphii-oleanolic acid?

I-Oleanolic acid isetshenziswe ngokwesiko ukwelapha izifo ezahlukahlukene, ungayithola ekudleni nasezitshalweni kabanzi.

Ezinye izithelo ezifana nama-apula, ihalananda, ulamula, ama-bilberry, iminqumo iqukethe i-oleanolic acid futhi.

Okwamanje, imifino ChineseHemsley Chinensis Cognkuseyimpahla eluhlaza ethengiswa kakhulu yokukhipha i-oleanolic acid.

Hemsley Chinensis Cogn.Isingeniso

I-Hemsleya chinensis Cogn.iyikhambi elikhuphuka njalo, futhi liwumuthi wendabuko waseShayina.

Umndeni: Cucurbitaceae

I-Tribus: Gomphogyneae

Uhlobo: Hemsleya

Izinhlobo: H. amabilis

Umuthi usatshalaliswa ezifundazweni iGuangxi, Sichuan, Guizhou, Yunnan, Hubei, njll. Wazalelwa onqenqemeni lwehlathi kanye nezihlahla zesigodi endaweni engamamitha angaba ngu-2,000.

Izithako ezisebenzayo: iqukethe iHemslolide Mal, Ma3, H1;Chikusesusaponin-Iva;i-dihydro cucurbitacin F-25-acetate;i-dilydrocucurbitacin F;i-oleanolic acid-beta-Hlucosyloleanolate;Hemsamabilinin A;I-Cu-curbitacinⅡb-2-beta-D-glucopyranoside.

Amanani Okwelapha:

I-Hemsleya chinensis Cogn.ikakhulukazi i-detoxification, inzalo, ukulwa nokuvuvukala, ukuqinisa isisu kanye nokukhulula ubuhlungu.Njengamanje, kukhona i-powder ekhishwe, noma amalungiselelo ahlanganisiwe njengama-capsules, amaphilisi, amaphilisi amathumbu, njll, asetshenziswa kabanzi emisebenzini yomtholampilo.

Ukukhishwa kwe-Oleanolic acid kusukaHemsleya Chinensis Cogn.

Amafomula aqukethe i-Oleanolic acid kwizithako zokudla

Sithole ukuthi i-oleanolic acid esetshenziswa ezithasiselweni zezempilo ikakhulukazi ivela ezinhlotsheni ezintathu zezitshalo ezikhishwe: i-Loquat leaf extract, i-Hemsley Chinensis extract, kanye ne-holy basil extract.

• I-Holy Basil powder (iqabunga) (0.4% i-Ursolic acid ne-Oleanolic acid, 2.0 mg)
• Ukukhishwa kwe-Holy Basil supercritical CO2 (iqabunga) (Ocimum tenuiflorum Linn.) (2.5% Ursolic acid ne-Oleanolic acid, 1.5 mg)
• I-Loquat Extract (isithelo) (ihlinzeka nge-Ursolic acid, i-Oleanolic Acid) (Ijwayele ukuya ku-Ursolic acid Ngokukhonza ngo-125mg)

I-Oleanolic acid VS Ursolic acid

I-Oleanolic acid (OA) ne-ursolic acid (UA) ama-triterpenoid emvelo anokwakheka kwamakhemikhali okufanayo.

Lezi zinhlanganisela ze-triterpenoids ziyaziwa ukuthi zikhona emakhambi okwelapha nokudla.

Zinezinto eziningi ezivamile zemithi: i-hepatoprotective, anti-inflammatory, antimicrobial, hypoglycemic, antimutagenic, anti-HIV umsebenzi, i-antioxidant, kanye nemisebenzi ye-antifertility.

Umehluko we-OA ne-UA:

Imisebenzi ye-Biological ye-Oleanolic Acid

1. I-Anti-Tumor/Anti-Cancer Effects

Umphumela ovimbelayo we-oleanolic acid ku-hepatocellular carcinoma nge-ERK-p53-mediated cell cycle ukuboshwa kanye ne-apoptosis encike emitochondrial

– ngu-Xin Wang, u-Hua Bai, njll. Abacwaningi

I-OA ibonise umphumela ovimbelayo ku-HCC ngokungeniswa kwe-apoptosis nokuboshwa komjikelezo wamaseli kokubili kumathumba atshaliwe kanye namaseli e-HepG2.

I-OA idale i-apoptosis ngokusebenzisa indlela ye-mitochondrial, okufakazelwa ukuvinjwa kwethagethi ye-Akt/mammalian ye-rapamycin pathway.

I-OA iyenge ukuboshwa komjikelezo weseli ye-G2/M ngokusebenzisa i-p21-mediated down-regulation ye-cyclin B1/cdc2.

I-OA ibonise imisebenzi ebalulekile ye-antitumor ku-HCC in vivo kanye namamodeli we-in vitro.Le datha inikeza ukuqonda okusha ezindleleni ezingaphansi komphumela we-antitumor we-OA.

Ngaphezu kwalokho, ucwaningo lukhombisa ukuthi i-OA kanye nokuphuma kwayo kwe-Oleanolic acid methyl ester nakho kunemiphumela kumdlavuza webele, umdlavuza wamaphaphu, umdlavuza wesinye, umdlavuza womlomo wesibeletho, amaseli omdlavuza we-pancreatic…

2. Umsebenzi we-Antimicrobial

I-OA kulindeleke ukuthi ibe nomsebenzi wokulwa namagciwane ezinhlobonhlobo eziningi zamagciwane ngoba idlala indima ebalulekile ekuvikeleni amagciwane ezitshalweni.

I-OA ibonise umsebenzi omaphakathi ngokumelene ne-Staphylococcus aureus ne-Bacillus Thuringiensis ku-62.5 µg/mL ne-Escherichia coli, i-Salmonella Enterica, ne-Shigella dyssenteriae ku-31.2 µg/mL minimum inhibitory concentration (MIC).

3. Amandla we-Hepatoprotective

Enye yezinto eziphilayo eziphawulekayo ze-OA ukuvikelwa kwesibindi ebungozini futhi okwamanje isetshenziswa njengomuthi ongaphezu kwe-hepatic counter e-China.

Emagundaneni e-Wistar albino, i-OA evela ku-Flaveria Trinervia yasetshenziswa futhi yaba nomthelela omkhulu wokuvikela esibindini esibangelwa i-ethanol ngokubuyisela amazinga e-enzyme ye-hepatotoxic serum marker.Lolu cwaningo luphakamise ikhono le-antioxidant le-OA njengenye indlela engenzeka yekhono layo le-hepatoprotective.

I-Oleanolic Acid kanye nokuphuma kwayo

I-Oleanolic Acid Clinical Trials

I-Oleanolic acid (ethathwe kumnqumo), kunezinhlolo zomtholampilo ezibhalisiwe ezingaba ngu-500, ibonise ukuthi ibe nemiphumela enenzuzo ezivivinyweni zomtholampilo zesifo sezinso esingamahlalakhona, isifo sikashukela sohlobo 2, kanye nezinye izimo ezivuvukalayo ezifana nesifo samathambo.

Okuphuma kokunye okudume kakhulu ezivivinyweni zomtholampilo yi-bardoxolone methyl (CDDO-Me).I-CDDO-Me yahlolwa kuma-tumor biopsies, futhi ingase ikwazi ukudlala indima ekwelapheni isifo sezinso esingamahlalakhona, okwamanje iyahlolwa ngemiphumela yomfutho wegazi ophezulu.

I-Chinese Pharmacopoeia Standard ye-Oleanolic Acid

I-Oleanolic acid incoma umthamo

Ngokusho kwe-Chinese Pharmacopoeia Standard, i-Oleanolic acid Oral dose ingu-20~80mg ngesikhathi, 60 ~ 240mg ngosuku.

Imiphumela emibi ye-oleanolic acid

I-Oleanolic acid esetshenziswa njenge-over the counter (OTC) isidakamizwa se-hepatoprotective amashumi eminyaka e-China.

Uma i-overdose noma ingalungile, inani elincane leziguli linomlomo owomile, isifo sohudo, ukungakhululeki kwesisu esingenhla, futhi linganyamalala ngemva kokwelashwa okunezimpawu.

Sicela uxhumane nodokotela wakho noma usokhemisi ngaphambi kokusebenzisa lo mkhiqizo.

Umsebenzi:

I-1.I-Oleanolic acid ayinabo ubuthi uma kuqhathaniswa, i-antitumor, ne-hepatoprotective, kanye nokubonisa izinto ezilwa namagciwane.
I-2.Oleanolic acid itholakale ibonisa umsebenzi onamandla wokulwa ne-HIV.
I-3.Oleanolic acid ingumvikeli omkhulu wamaseli ngokumelene nokucindezeleka kwe-oxidative kanye ne-electrophile.
I-4.Oleanolic acid inomphumela omuhle ekubambeni i-virus i-hepatitis, i-icteric hepatitis kanye ne-hepatitis engapheli.
Isicelo:
1. Isetshenziswa ensimini yokudla, ingasebenza njengezinto zokusetshenziswa zetiye ukunciphisa i-phlegm;
2. Isetshenziswa emkhakheni wezokwelapha, iba umuthi omusha wokulwa nomdlavuza onobuthi obuphansi;
3. Isetshenziswa emkhakheni wezimonyo, ingavuselela ukujikeleza kwegazi futhi isuse isiphuzo.