ʻO Arachidonoyl Ethanolamide, arachidonoylethanolamide, N-arachidonoylethanolamine, a me AEA ua like ia me ka anandamide iho.Ma ke ala, (5Z,8Z,11Z,14Z) -N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide ka inoa kemika o anandamide (inoa IUPAC) a hiki ke hoʻohana wale ʻia i ka palapala ʻepekema.Eia nō naʻe, ʻo 94421-68-8 kāna ID kemika kūʻokoʻa (CAS Registry Number).No ka mea ʻo AEA ka manawa pōkole loa no ka anandamide, hiki iā mākou ke hoʻohana pinepine iā AEA e kuhikuhi i ka anandamide ma nā kikokikona a me nā kiʻi.
inoa mea kūʻai：NuiʻO ka pauka Anandamide
Nā huaʻōlelo like: Arachidonoyl Ethanolamide, AEA pauka, arachidonoylethanolamide, (5Z,8Z,11Z,14Z) -N-(2-hydroxyethyl)icosa-5,8,11,14-tetraenamide, N-arachidonoylethanolamine
No CAS: 94421-68-8
Māhele Mea kanu i hoʻohana ʻia:Leaf
Mea komo: Apigenin
Hōʻike: ʻaila AEA: 90%
AEA pauka: 50%
kala: pauda melemele
ʻaila ʻulaʻula melemele
Hoʻopili: ma 25kgs fiber drums
Ka mālama ʻana: E mālama i ka pahu i wehe ʻole ʻia ma kahi maloʻo a maloʻo, e haʻalele i ka mālamalama ikaika
Ola Ola: 24 mahina mai ka lā i hana ʻia
Wahi a Wikipedia, ʻo ka anandamide kahi hopena cannabinoid neurotransmitter i loko o ka lolo, ʻo ia ka mea hiki i ka lolo kanaka ke hana i ka anandamide me ka ʻole o ka ʻai ʻana i nā meaʻai i loaʻa iā AEA.Hoʻopaʻa ʻia ka lolo o nā ʻano mammal a me ka cacao maka i loaʻa i kahi nui o ka anandamide.
Nā kumu meaʻai o ka anandamide
ʻAʻole nui nā kumu kūlohelohe maoli no ka anandamide, a aia ke kokoleka a me nā truffles ma luna o lākou.ʻOi aku ke kumukūʻai o Truffle no ka anandamide, a ʻo ke kokoleka ke kumu hilinaʻi loa no ka nui o nā meaʻai.
Anandamidea me nā kokoleka
ʻO nā pīni Cacao, ke kumu o nā kokoleka, he kumu waiwai hoʻi ia o ka anandamide.Aia ma mua o 300 mau mea kemika i loko o ke kokoleka.ʻO ka caffeine, theobromine, a me ka phenylethylamine nā mea ʻike e hoʻokiʻekiʻe i ko mākou ʻano.ʻO ka theobromine ke kōkua maoli i ka hoʻoulu ʻana i ka lolo e hoʻokuʻu i nā anandamide hou aʻe e hauʻoli ai mākou.
No ke aha i kaulana nui ai ka anandamide i nā makahiki i hala iho nei?
Ma mua o ka pane ʻana i kēia nīnau, pono mākou e haʻi mua i ka cannabis, THC & CBD (Cannabidiol).
ʻO Cannabis, ka mea i kapa ʻia ʻo marijuana, he mea kanu pua, a hoʻohana nā kānaka ia mea ma ke ʻano he lāʻau pāʻina a puhi paha ia e hana i kahi manaʻo "kiʻekiʻe" a i ʻole "pōhaku".
ʻO ka mea hana i ka cannabis e hoʻokiʻekiʻe iā ʻoe ʻo THC, me ka inoa piha ʻo delta 9-Tetrahydrocannabinol.Ke puhi ka poʻe i ka mariuana, hoʻoulu ka tetrahydrocannabinol i ka cannabis i ka mea hoʻokipa cannabis, e ʻike ai ka poʻe i ka hauʻoli a me ka maikaʻi o ka noʻonoʻo.
He kānāwai ʻole ʻo Cannabis i nā ʻāina he nui no ka mea he nui ka poʻe e hoʻohui iā ia.
Eia naʻe, ʻo Uruguay ka ʻāina mua i hoʻopaʻa i ka cannabis i ka makahiki 2013.
Ma ʻOkakopa 17 o 2018, ua hoʻolaha ke aupuni Kanada e lilo ka cannabis i kānāwai ma Kanada a pau.
Ma ʻAmelika Hui Pū ʻIa, 10 mau mokuʻāina a me ka Apana o Columbia ua ʻae i ka hoʻohana leʻaleʻa o ka cannabis ʻoiai ke kū mau nei ia i ke kānāwai federally.
ʻO Anandamide vs THC
ʻO Cannabis kahi kumu kanu o THC.
ʻO Anandamide ka mana kanaka o THC.
Ua ʻike ʻia e ka ʻepekema ʻo AEA i ka makahiki 1992 a me THC i ka makahiki 1964.
Hoʻokuʻu ʻo Anandamide i nā kinikona e hoʻonui ai i ka naʻau mai ka lolo, a ua like kona ʻano hana ola me ka tetrahydrocannabinol i ka cannabis.
ʻAe, ke kuhikuhi nei lākou i ka mea hoʻokipa cannabis like, a e kamaʻilio mākou e pili ana i ke ʻano o ka AEA.
Eia naʻe, ʻoi aku ka ikaika o ka THC ma mua o AEA.ʻO ka manaʻo o ka lawe ʻana i ka AEA ʻoi aku ka maikaʻi ma mua o ka puhi ʻana i ka cannabis no ka mea e hoʻopili koke ʻia ka anandamide i ke kino, i loko paha o 30 mau minuke.
No ka mea ua pāpā ʻia ka cannabis ma ka hapa nui o nā ʻāina, ʻaʻole kānāwai nā mea hoʻohui, nā meaʻai, nā mea inu a i ʻole nā mea hoʻonaninani i loaʻa THC.Ma kēia ʻano, ʻo anandamide ka wā e hiki mai ana.
ʻO Anandamide vs CBD
He 400+ mau pūhui ka lāʻau mariuana, a ʻoi aku ma mua o 60 mau cannabinoids like ʻole e hoʻopaʻa i nā mea hoʻokipa i loko o ko mākou kino.
ʻO CBD ka ʻano pōkole o cannabidiol a ʻo ia kekahi o kēlā mau cannabinoids 60.ʻO CBD kahi phytocannabinoid i ka cannabis.ʻOi aku ma mua o 40% o ka cannabis extract ʻo CBD.
Ua ʻike nā kānaka ʻepekema a me nā kauka hiki i ka CBD ke hoʻomaikaʻi i ka pae o anandamide i nā synapses o ka lolo ma ke ʻano he anandamide reuptake a breakdown inhibitor.ʻO Fatty acid amide hydrolase, i ʻike ʻia ʻo FAAH no ka pōkole, he enzyme e wāwahi i ka AEA.ʻO ia ke ʻano o ka CBD e kāohi ai i ka FAAH a hoʻomaikaʻi i ka AEA kūlohelohe.
Hiki i ka CBD ke hana i nā mea ʻoi aku ma mua o kēlā.Hiki i ka CBD ke kōkua i ka ʻōnaehana Endocannabinoid holoʻokoʻa
ʻO ka hana o ka anandamide
Pehea e hana ai ka anandamide?He paʻakikī maoli nō.Pono paha ʻoe e ʻike mua e pili ana i ka ʻōnaehana endocannabinoid, ka mea hoʻokipa CB1, a me ka mea loaʻa CB2.
CB1
Loaʻa i ka THC kahi pilina kiʻekiʻe no ka mea loaʻa CB1, pili ikaika i ka mea loaʻa.
Eia kekahi, hoʻopilikia ka anandamide i kahi manaʻo "kiʻekiʻe" ma o ka hoʻopili ʻana i ka mea loaʻa CB1, hoʻāla i ka ʻōnaehana uku o ka lolo a hana i nā mea leʻaleʻa e like me dopamine Hormone.
CB2
Loaʻa paha iā ʻoe nā mea loaʻa CB2 i loko o nā cell immune a puni kou kino.ʻO ka CB2 receptor ke kuleana o nā pane neuroprotective a me ka hakakā ʻana i ka mumū.Manaʻo nā kānaka ʻepekema he mea pono ka CB2 receptor i ka hōʻeha ʻana i ka ʻeha.
Hoʻopili nui ʻia nā mea hoʻokipa CB1 i ka lolo a me ka ʻōnaehana CNS, ʻoiai ʻo CB2 ka mea i loaʻa i ka ʻōnaehana pale.
Pūnaehana Endocannabinoid (ECS)
Ma mua o ke kūkākūkā ʻana i nā hana o ka ʻōnaehana endocannabinoid (ECS), he mea nui e hoʻomaopopo i kāna mau ʻāpana.Aia ka ECS i nā mea hoʻokipa cannabinoid, nā ligand endogenous (nā molekala paʻa) no kēlā mau mea loaʻa, a me nā enzymes e synthesize a hoʻohaʻahaʻa i nā ligands.
| ECS kahiko | ECS i hooloihiia | |
| nā mea loaʻa cannabinoid | CB1, CB2 | PPAR,GPR,TRPV,FLAT,FABP |
| nā ligands endogenous | AEA, 2-AG | OEA,PEA,2-AGE,NADA,VA,EPEA,SEA,OA,DHEA |
| ʻO nā ligands hoʻohaʻahaʻa i nā enzyme | FAAH,MAGL | ABHD6,COX-2,ABHD12 |
| ʻO nā enzyme e hana ana i nā ligands | DAGL, NAT, NAPE-PLD | MOKU1,PTPN22,PLC,GDEI,ABHD4 |
ʻo ka pōʻai i loko (hinahinahina) e hōʻike ana i ka ʻōnaehana endocannabinoid 'classical'.ʻO ka pōʻai o waho (ʻeleʻele hina) nā ʻāpana o ka ʻōnaehana endocannabinoid lōʻihi.E like me kāu e ʻike ai, ua hoʻokomo pū ʻia ʻo PEA, SEA, a me OEA i ka ʻōnaehana endocannabinoid.
Loaʻa i nā EC kahi pūnaeho koʻikoʻi (CNS) kumu a me ka anandamide (AEA), 2-arachidonoylglycerol (2-AG), noladin ether, virodhamine a me N-arachidonylodopamine (NADA).A ʻo anandamide ka mea mua a me ka ligand koʻikoʻi loa i ka ʻōnaehana endocannabinoid.
ʻO Anandamide a me 2-AG
E like me ka mea i ʻōlelo ʻia ma luna nei, ʻo anandamide (AEA) a me 2-arachidonoylglycerol (2-AG) nā ligand mua ʻelua i ka ʻōnaehana ECS.Kōkua ka ECS i ka hoʻoponopono ʻana i nā hana e like me ka hiamoe, ka ʻōnaehana pale, a me ka hoʻololi ʻana i ka ʻeha.
Ua ʻike nā kānaka ʻepekema ʻo Anandamide i ka makahiki o 1992 a me 2-AG 3 mau makahiki ma hope.He like loa ko AEA a me 2-AG i ke ano o ke kino a me ke kemika.
Kuhi nui ʻo Anandamide i ka mea hoʻokipa CB1 i loko o ka lolo, ʻoiai ʻo 2-AG e hoʻopaʻa i nā mea hoʻokipa CB1 a me CB2 (i ka ʻōnaehana immune).
Hoʻohui ʻia ʻo Anandamide a me 2-AG mai ka arachidonic acid, kahi momona momona Omega-6, me nā ala like ʻole a me ka synthesizing enzymes.Hoʻohaʻahaʻa i ka enzyme FAAH (Fatty Acid Amide Hydrolase) no ka AEA a me 2-AG e MAGL enzyme (Monoacylglycerol Lipase).
Nā Pono Anandamide
Hōʻike nā hōʻike ʻepekema he maikaʻi paha ka anandamide no ka anti-anxiety, ke olakino noʻonoʻo, ka hoʻomanaʻo hoʻomanaʻo, ka mana o ka makemake, ka hōʻeha ʻeha, ka neuroprotection, a me nā mea hou aku.
Anandamide a me ka hopohopo
Kapa ka poʻe iā Anandamide "mole hauʻoli" no ka mea hiki iā AEA ke hauʻoli iā ʻoe.
Hōʻike nā hōʻike hoʻohuli i ka ʻōnaehana endocannabinoid he mea koʻikoʻi o nā substrates neuronal e pili ana i nā kaʻina hana uku a me nā pane o ka naʻau i ke kaumaha.
ʻO ka poloka Pharmacological o ka enzyme fatty acid amide hydrolase (FAAH), nona ke kuleana no ka intracellular anandamide degradation, e hoʻopuka i nā hopena e like me anxiolytic i nā ʻiole me ka ʻole o ka hana ʻana i ka laulā ākea o nā pane ʻano maʻamau o nā agonists cannabinoid hana pololei.
Hōʻike kēia mau ʻike e hāʻawi ka anandamide i ka hoʻoponopono ʻana i ka manaʻo a me ka hopohopo a ʻo FAAH paha ka pahuhopu no kahi papa hou o nā lāʻau anxiolytic.
No ka ʻike kikoʻī hou aku no nā hopena anandamide i ka hopohopo, e ʻoluʻolu e heluhelu i ka palapala ma lalo nei:
- Loaʻa ka hopena cannabinoid anandamide i ka hoʻoikaika a me ka hopohopo i hōʻike ʻia e ka fatty acid amide hydrolase (FAAH) inhibition.
- Anandamide hydrolysis: kahi pahuhopu hou no nā lāʻau anti-anxiety?
- ʻO ka hoʻohaʻahaʻa ʻana i ka hopohopo e like me ke ʻano i hoʻoulu ʻia e ka genetic and pharmacological inhibition o ka endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) i hoʻopili ʻia e CB1 receptors.
Anandamide a me ka ʻeha
ʻO kekahi mau hōʻike ʻepekema e hōʻike ana i ka hoʻopaʻa ʻana i ka FAAH (ka enzyme e hoʻohaʻahaʻa i ka anandamide i loko o ka lolo) i hōʻemi nui i nā pane nociceptive i nā ʻano ʻeha he nui.
Hoʻonui nui ka FAAH inhibitors i nā pae anandamide i loko o ka lolo a hoʻokomo mua i ka CB1ka mea hoʻokipa-mediated antinociception, e hōʻike ana i ka anandamide endogenous, ke pale ʻia mai ka hōʻino ʻana, hiki ke hana i ka antinociception ma o CB1nā mea hoʻokipa.
ʻO ka Palmitoylethanolamide (PEA) kahi mea hana endogenous e hoʻonui ai i ka hana anandamide.Hāʻawi maoli ke kino kanaka i ka PEA e hakakā i ka ʻeha a me ka ʻeha.ʻOi aku ma mua o 800,000 mau mea maʻi i loaʻa i nā hua PEA a me nā meaʻai meaʻai e mālama ai i ka ʻeha ma ka honua.
No ka ʻike hou aku e pili ana i ka PEA, e kipa i kā mākouʻaoʻao PEA.
Anandamide a me ka mea holo kiʻekiʻe
E nānā mua kākou i ka wehewehe ʻana o ke kiʻekiʻe o ka mea kukini: ka manaʻo o ka euphoria me ka emi ʻana o ka hopohopo a me ka emi ʻana o ka hiki ke ʻeha.Ma hope o ka hoʻoikaika kino aerobic lōʻihi, e ʻike ʻoe i kahi mea ʻoluʻolu i ka wā o ka holo lōʻihi.
I nā makahiki i hala iho nei, ua manaʻo ka poʻe noiʻi ʻo ka endorphin wale nō ke kumu no ka poʻe holo kiʻekiʻe mai ka mea maʻalahi ka loaʻa ʻana o nā pae kiʻekiʻe o β-endorphins i ke koko.E like me kāu e ʻike ai, hiki i ka endorphin ke hoʻonui i ko mākou ʻano a hana i kahi manaʻo euphoric.
Eia nō naʻe, ke manaʻoʻiʻo nei nā ʻepekema ʻo ia ka endocannabinoid system (ECS) a me ka anandamide e kumu kiʻekiʻe ai ka mea holo.Hiki iā Anandamide ke hele i ka pale koko-lolo a hāʻawi i nā hopena koʻikoʻi o nā opioids peripheral.Akā ʻaʻole hiki i ka endorphins.
Inā makemake ʻoe e aʻo e pili ana i ka hoʻokolohua e pili ana i ke kiʻekiʻe o ka runner, e heluhelu i kēia palapala:ʻO ke kiʻekiʻe o ka mea holo e pili ana i ka cannabinoid receptors i nā ʻiole
ʻIke ʻia nā mea ʻai meaʻai ʻo anandamide hiki ke lilo i mea hoʻoponopono ʻai maikaʻi.Hiki i ka Anandamide ke hoʻoulu i kou pōloli a me ka makemake e ʻai hou aku.Inā ʻoe ma ke ala e lilo ai ke kaumaha, e noʻonoʻo pono ma mua o ka lawe ʻana iā AEA.
Nā mea hoʻohui i loaʻa ka anandamide
Ke ʻimi nei ʻoe i nā mea hoʻohui anandamide a i ʻole nā pills anandamide?
ʻO ka mea pōʻino, ʻaʻohe mea no ka manawa.ʻO Anandamide kahi mea hana hou i hoʻāʻo ʻole ʻia e nā mea hoʻohui meaʻai i kā lākou mau ʻano o kēia manawa.
Hiki iā ʻoe ke ʻike i kahi hui i kapa ʻia ʻo Sun Potion ke kūʻai aku nei i ka pauka anandamide ma Amazon.Eia naʻe, ʻaʻole ʻo ia ka ʻoiaʻiʻo.ʻO ia wale nō ka pauka cacao maka, akā ʻaʻole i hoʻohālikelike ʻia ka anandamide extract.A he haʻahaʻa loa ka maʻiʻo ikaika o ka pauda, a ʻaʻole paha ʻoe e ʻike i ka pono o AEA.
ʻOiaʻiʻo, ʻike paha ʻoe e kūʻai aku ana kekahi mau mea kūʻai aku i nā kūlana kuhikuhi anandamide a i ʻole reagents.ʻO ka mea ʻino, kūʻai wale lākou ma 5mg, 25mg, a no ka noiʻi wale nō.ʻAʻole loaʻa ka ʻike aila AEA nui loa.
ʻO ka nūhou maikaʻi ke kauoha nei nā mea hana hoʻohui ma ʻAmelika Hui Pū ʻIa a me ʻEulopa e like me Kelemānia, Farani, Netherland, UK, Sepania, Italia, etc. .
Nā kikoʻī o Anandamide
Loaʻa ka ʻaila anandamide nui a me ka pauka anandamide ma Cima Science.
ʻO ka aila Anandamide: 70%, 90%
